UniProtKB - Q9Y3D2 (MSRB2_HUMAN)
Protein
Methionine-R-sulfoxide reductase B2, mitochondrial
Gene
MSRB2
Organism
Homo sapiens (Human)
Status
Functioni
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.1 Publication
Catalytic activityi
- [thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]By similarityEC:1.8.4.12By similarity
- [thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (R)-S-oxideBy similarityEC:1.8.4.14By similarity
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 90 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 93 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 146 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 149 | ZincPROSITE-ProRule annotation | 1 | |
Active sitei | 169 | NucleophilePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- actin binding Source: UniProtKB
- L-methionine-(R)-S-oxide reductase activity Source: UniProtKB-EC
- peptide-methionine (R)-S-oxide reductase activity Source: UniProtKB
- zinc ion binding Source: HGNC-UCL
GO - Biological processi
- actin filament polymerization Source: UniProtKB
- protein repair Source: HGNC-UCL
- response to oxidative stress Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 1.8.4.12, 2681 1.8.4.B3, 2681 |
PathwayCommonsi | Q9Y3D2 |
Reactomei | R-HSA-5676934, Protein repair |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:MSRB2 Synonyms:CBS-1, MSRB ORF Names:CGI-131 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17061, MSRB2 |
MIMi | 613782, gene |
neXtProti | NX_Q9Y3D2 |
VEuPathDBi | HostDB:ENSG00000148450.12 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Cytosol
- cytosol Source: Reactome
Mitochondrion
- mitochondrion Source: HGNC-UCL
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 22921 |
OpenTargetsi | ENSG00000148450 |
PharmGKBi | PA134979691 |
Miscellaneous databases
Pharosi | Q9Y3D2, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3509603 |
DrugBanki | DB00134, Methionine |
Genetic variation databases
BioMutai | MSRB2 |
DMDMi | 182676405 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 20 | MitochondrionSequence analysisAdd BLAST | 20 | |
ChainiPRO_0000140324 | 21 – 182 | Methionine-R-sulfoxide reductase B2, mitochondrialAdd BLAST | 162 |
Proteomic databases
EPDi | Q9Y3D2 |
jPOSTi | Q9Y3D2 |
MassIVEi | Q9Y3D2 |
MaxQBi | Q9Y3D2 |
PaxDbi | Q9Y3D2 |
PeptideAtlasi | Q9Y3D2 |
PRIDEi | Q9Y3D2 |
ProteomicsDBi | 86019 |
PTM databases
iPTMneti | Q9Y3D2 |
PhosphoSitePlusi | Q9Y3D2 |
SwissPalmi | Q9Y3D2 |
Expressioni
Tissue specificityi
Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate.2 Publications
Gene expression databases
Bgeei | ENSG00000148450, Expressed in heart and 248 other tissues |
ExpressionAtlasi | Q9Y3D2, baseline and differential |
Genevisiblei | Q9Y3D2, HS |
Organism-specific databases
HPAi | ENSG00000148450, Tissue enhanced (heart) |
Interactioni
Binary interactionsi
Hide detailsQ9Y3D2
GO - Molecular functioni
- actin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116583, 49 interactors |
IntActi | Q9Y3D2, 16 interactors |
STRINGi | 9606.ENSP00000365693 |
Miscellaneous databases
RNActi | Q9Y3D2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 180 | MsrBPROSITE-ProRule annotationAdd BLAST | 130 |
Sequence similaritiesi
Belongs to the MsrB Met sulfoxide reductase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0856, Eukaryota |
GeneTreei | ENSGT00940000161673 |
HOGENOMi | CLU_031040_8_2_1 |
InParanoidi | Q9Y3D2 |
OMAi | EVGMYHC |
OrthoDBi | 1549489at2759 |
PhylomeDBi | Q9Y3D2 |
TreeFami | TF329147 |
Family and domain databases
InterProi | View protein in InterPro IPR028427, Met_Sox_Rdtase IPR002579, Met_Sox_Rdtase_MsrB IPR011057, Mss4-like_sf |
PANTHERi | PTHR10173, PTHR10173, 1 hit |
Pfami | View protein in Pfam PF01641, SelR, 1 hit |
SUPFAMi | SSF51316, SSF51316, 1 hit |
TIGRFAMsi | TIGR00357, TIGR00357, 1 hit |
PROSITEi | View protein in PROSITE PS51790, MSRB, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9Y3D2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARLLWLLRG LTLGTAPRRA VRGQAGGGGP GTGPGLGEAG SLATCELPLA
60 70 80 90 100
KSEWQKKLTP EQFYVTREKG TEPPFSGIYL NNKEAGMYHC VCCDSPLFSS
110 120 130 140 150
EKKYCSGTGW PSFSEAHGTS GSDESHTGIL RRLDTSLGSA RTEVVCKQCE
160 170 180
AHLGHVFPDG PGPNGQRFCI NSVALKFKPR KH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YE51 | H0YE51_HUMAN | L-methionine (R)-S-oxide reductase | MSRB2 | 120 | Annotation score: |
Sequence cautioni
The sequence AAD34126 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 63 | F → L in AAH18030 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050448 | 46 | E → G. Corresponds to variant dbSNP:rs2296466Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF122004 mRNA Translation: AAD38899.1 AF151889 mRNA Translation: AAD34126.1 Frameshift. EF444983 Genomic DNA Translation: ACA05998.1 AL139281 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86135.1 BC018030 mRNA Translation: AAH18030.1 BC117471 mRNA Translation: AAI17472.1 BC130380 mRNA Translation: AAI30381.1 |
CCDSi | CCDS41495.1 |
RefSeqi | NP_036360.3, NM_012228.3 |
Genome annotation databases
Ensembli | ENST00000376510; ENSP00000365693; ENSG00000148450 |
GeneIDi | 22921 |
KEGGi | hsa:22921 |
UCSCi | uc001iro.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF122004 mRNA Translation: AAD38899.1 AF151889 mRNA Translation: AAD34126.1 Frameshift. EF444983 Genomic DNA Translation: ACA05998.1 AL139281 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86135.1 BC018030 mRNA Translation: AAH18030.1 BC117471 mRNA Translation: AAI17472.1 BC130380 mRNA Translation: AAI30381.1 |
CCDSi | CCDS41495.1 |
RefSeqi | NP_036360.3, NM_012228.3 |
3D structure databases
SMRi | Q9Y3D2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116583, 49 interactors |
IntActi | Q9Y3D2, 16 interactors |
STRINGi | 9606.ENSP00000365693 |
Chemistry databases
ChEMBLi | CHEMBL3509603 |
DrugBanki | DB00134, Methionine |
PTM databases
iPTMneti | Q9Y3D2 |
PhosphoSitePlusi | Q9Y3D2 |
SwissPalmi | Q9Y3D2 |
Genetic variation databases
BioMutai | MSRB2 |
DMDMi | 182676405 |
Proteomic databases
EPDi | Q9Y3D2 |
jPOSTi | Q9Y3D2 |
MassIVEi | Q9Y3D2 |
MaxQBi | Q9Y3D2 |
PaxDbi | Q9Y3D2 |
PeptideAtlasi | Q9Y3D2 |
PRIDEi | Q9Y3D2 |
ProteomicsDBi | 86019 |
Protocols and materials databases
Antibodypediai | 25752, 170 antibodies |
DNASUi | 22921 |
Genome annotation databases
Ensembli | ENST00000376510; ENSP00000365693; ENSG00000148450 |
GeneIDi | 22921 |
KEGGi | hsa:22921 |
UCSCi | uc001iro.4, human |
Organism-specific databases
CTDi | 22921 |
DisGeNETi | 22921 |
GeneCardsi | MSRB2 |
HGNCi | HGNC:17061, MSRB2 |
HPAi | ENSG00000148450, Tissue enhanced (heart) |
MIMi | 613782, gene |
neXtProti | NX_Q9Y3D2 |
OpenTargetsi | ENSG00000148450 |
PharmGKBi | PA134979691 |
VEuPathDBi | HostDB:ENSG00000148450.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0856, Eukaryota |
GeneTreei | ENSGT00940000161673 |
HOGENOMi | CLU_031040_8_2_1 |
InParanoidi | Q9Y3D2 |
OMAi | EVGMYHC |
OrthoDBi | 1549489at2759 |
PhylomeDBi | Q9Y3D2 |
TreeFami | TF329147 |
Enzyme and pathway databases
BRENDAi | 1.8.4.12, 2681 1.8.4.B3, 2681 |
PathwayCommonsi | Q9Y3D2 |
Reactomei | R-HSA-5676934, Protein repair |
Miscellaneous databases
BioGRID-ORCSi | 22921, 4 hits in 874 CRISPR screens |
ChiTaRSi | MSRB2, human |
GeneWikii | MSRB2 |
GenomeRNAii | 22921 |
Pharosi | Q9Y3D2, Tbio |
PROi | PR:Q9Y3D2 |
RNActi | Q9Y3D2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000148450, Expressed in heart and 248 other tissues |
ExpressionAtlasi | Q9Y3D2, baseline and differential |
Genevisiblei | Q9Y3D2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028427, Met_Sox_Rdtase IPR002579, Met_Sox_Rdtase_MsrB IPR011057, Mss4-like_sf |
PANTHERi | PTHR10173, PTHR10173, 1 hit |
Pfami | View protein in Pfam PF01641, SelR, 1 hit |
SUPFAMi | SSF51316, SSF51316, 1 hit |
TIGRFAMsi | TIGR00357, TIGR00357, 1 hit |
PROSITEi | View protein in PROSITE PS51790, MSRB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MSRB2_HUMAN | |
Accessioni | Q9Y3D2Primary (citable) accession number: Q9Y3D2 Secondary accession number(s): Q17R44, Q4G1C7, Q9Y5W6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | April 8, 2008 | |
Last modified: | February 10, 2021 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants