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UniProtKB - Q9Y3C8 (UFC1_HUMAN)

Entry version 179 (10 Feb 2021)
Sequence version 3 (17 Oct 2006)
Previous versions | rss
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Protein

Ubiquitin-fold modifier-conjugating enzyme 1

Gene

UFC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E1-like enzyme which specifically catalyzes the second step in ufmylation (PubMed:15071506, PubMed:29868776). Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage (PubMed:15071506, PubMed:29868776). Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (PubMed:32160526).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei116Glycyl thioester intermediate2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y3C8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin-fold modifier-conjugating enzyme 1Curated
Short name:
Ufm1-conjugating enzyme 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UFC11 PublicationImported
ORF Names:CGI-1261 Publication, HSPC1551 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26941, UFC1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610554, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y3C8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000143222.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neurodevelopmental disorder with spasticity and poor growth (NEDSG)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder apparent soon after birth or in early infancy. NEDSG is characterized by axial hypotonia, delayed psychomotor development, poor feeding, failure to thrive, peripheral spasticity with hyperreflexia, poor overall growth, and microcephaly in most patients. Additional variable features include contractures, facial dysmorphisms, and ocular movement abnormalities.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08121623R → Q in NEDSG; decreased ability to form thioester bond with UFM1; decreased protein ufmylation. 1 PublicationCorresponds to variant dbSNP:rs1181612302EnsemblClinVar.1
Natural variantiVAR_081217106T → I in NEDSG; decreased ability to form thioester bond with UFM1; decreased protein ufmylation. 1 PublicationCorresponds to variant dbSNP:rs1553232770EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi30Q → A: Does not affect neither UBA5-binding nor thioester formation with UFM1. 1 Publication1
Mutagenesisi33K → A: Impairs binding to UBA5 and thioester formation with UFM1. 1 Publication1
Mutagenesisi116C → S: Instead of the formation of an intermediate complex with a thiol ester bond between UFC1 (E2-like enzyme) and UFM1 (substrate), a stable complex with an O-ester bond is formed. 2 Publications1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		51506

MalaCards human disease database

More...MalaCardsi		UFC1
MIMi618076, phenotype

Open Targets

More...OpenTargetsi		ENSG00000143222

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670644

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y3C8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UFC1

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242840

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000826131 – 167Ubiquitin-fold modifier-conjugating enzyme 1Add BLAST167

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y3C8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y3C8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y3C8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y3C8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y3C8

PeptideAtlas

More...PeptideAtlasi		Q9Y3C8

PRoteomics IDEntifications database

More...PRIDEi		Q9Y3C8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86017

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y3C8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y3C8

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9Y3C8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143222, Expressed in bronchial epithelial cell and 235 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y3C8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143222, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with UBA5 (via C-terminus) (PubMed:17825256, PubMed:27653677, PubMed:29868776).

Interacts with UFL1 (PubMed:20018847, PubMed:30886146).

Interacts with KIRREL3 (PubMed:25902260).

Interacts with UFM1 (PubMed:29868776).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119577, 50 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y3C8, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356982

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y3C8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9Y3C8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y3C8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Y3C8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3357, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008196

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_101170_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y3C8

Identification of Orthologs from Complete Genome Data

More...OMAi		IKYVQNN

Database of Orthologous Groups

More...OrthoDBi		1339876at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y3C8

TreeFam database of animal gene trees

More...TreeFami		TF313587

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016135, UBQ-conjugating_enzyme/RWD
IPR014806, Ufc1

The PANTHER Classification System

More...PANTHERi		PTHR12921, PTHR12921, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08694, UFC1, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF008716, DUF1782, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54495, SSF54495, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9Y3C8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADEATRRVV SEIPVLKTNA GPRDRELWVQ RLKEEYQSLI RYVENNKNAD 
        60         70         80         90        100
NDWFRLESNK EGTRWFGKCW YIHDLLKYEF DIEFDIPITY PTTAPEIAVP 
       110        120        130        140        150
ELDGKTAKMY RGGKICLTDH FKPLWARNVP KFGLAHLMAL GLGPWLAVEI 
       160 
PDLIQKGVIQ HKEKCNQ
Length:167
Mass (Da):19,458
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1675D9187DC43E14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti159I → N in BAF85465 (PubMed:14702039).Curated1
Sequence conflicti160Q → H in BAD15374 (PubMed:15071506).Curated1
Sequence conflicti160Q → H in AAF29119 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08121623R → Q in NEDSG; decreased ability to form thioester bond with UFM1; decreased protein ufmylation. 1 PublicationCorresponds to variant dbSNP:rs1181612302EnsemblClinVar.1
Natural variantiVAR_02831290Y → C1 PublicationCorresponds to variant dbSNP:rs17849932Ensembl.1
Natural variantiVAR_081217106T → I in NEDSG; decreased ability to form thioester bond with UFM1; decreased protein ufmylation. 1 PublicationCorresponds to variant dbSNP:rs1553232770EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB154405 mRNA Translation: BAD15374.1
AF151884 mRNA Translation: AAD34121.1
AF161504 mRNA Translation: AAF29119.1
AK292776 mRNA Translation: BAF85465.1
AL590714 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52646.1
CH471121 Genomic DNA Translation: EAW52647.1
BC005187 mRNA Translation: AAH05187.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1220.1

NCBI Reference Sequences

More...RefSeqi		NP_057490.2, NM_016406.3
XP_016856939.1, XM_017001450.1
XP_016856940.1, XM_017001451.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000368003; ENSP00000356982; ENSG00000143222

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51506

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51506

UCSC genome browser

More...UCSCi		uc001fyd.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB154405 mRNA Translation: BAD15374.1
AF151884 mRNA Translation: AAD34121.1
AF161504 mRNA Translation: AAF29119.1
AK292776 mRNA Translation: BAF85465.1
AL590714 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52646.1
CH471121 Genomic DNA Translation: EAW52647.1
BC005187 mRNA Translation: AAH05187.1
CCDSiCCDS1220.1
RefSeqiNP_057490.2, NM_016406.3
XP_016856939.1, XM_017001450.1
XP_016856940.1, XM_017001451.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K07NMR-A1-167[»]
2Z6OX-ray1.60A1-167[»]
2Z6PX-ray1.80A1-167[»]
3EVXX-ray2.54A/B/C/D1-167[»]
BMRBiQ9Y3C8
SMRiQ9Y3C8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119577, 50 interactors
IntActiQ9Y3C8, 9 interactors
STRINGi9606.ENSP00000356982

PTM databases

iPTMnetiQ9Y3C8
PhosphoSitePlusiQ9Y3C8
SwissPalmiQ9Y3C8

Genetic variation databases

BioMutaiUFC1
DMDMi116242840

Proteomic databases

EPDiQ9Y3C8
jPOSTiQ9Y3C8
MassIVEiQ9Y3C8
MaxQBiQ9Y3C8
PaxDbiQ9Y3C8
PeptideAtlasiQ9Y3C8
PRIDEiQ9Y3C8
ProteomicsDBi86017

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34296, 207 antibodies

Genome annotation databases

EnsembliENST00000368003; ENSP00000356982; ENSG00000143222
GeneIDi51506
KEGGihsa:51506
UCSCiuc001fyd.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51506
DisGeNETi51506

GeneCards: human genes, protein and diseases

More...GeneCardsi		UFC1
HGNCiHGNC:26941, UFC1
HPAiENSG00000143222, Low tissue specificity
MalaCardsiUFC1
MIMi610554, gene
618076, phenotype
neXtProtiNX_Q9Y3C8
OpenTargetsiENSG00000143222
PharmGKBiPA142670644
VEuPathDBiHostDB:ENSG00000143222.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3357, Eukaryota
GeneTreeiENSGT00390000008196
HOGENOMiCLU_101170_0_0_1
InParanoidiQ9Y3C8
OMAiIKYVQNN
OrthoDBi1339876at2759
PhylomeDBiQ9Y3C8
TreeFamiTF313587

Enzyme and pathway databases

PathwayCommonsiQ9Y3C8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51506, 192 hits in 883 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UFC1, human
EvolutionaryTraceiQ9Y3C8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51506
PharosiQ9Y3C8, Tbio

Protein Ontology

More...PROi		PR:Q9Y3C8
RNActiQ9Y3C8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143222, Expressed in bronchial epithelial cell and 235 other tissues
GenevisibleiQ9Y3C8, HS

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR016135, UBQ-conjugating_enzyme/RWD
IPR014806, Ufc1
PANTHERiPTHR12921, PTHR12921, 1 hit
PfamiView protein in Pfam
PF08694, UFC1, 1 hit
PIRSFiPIRSF008716, DUF1782, 1 hit
SUPFAMiSSF54495, SSF54495, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUFC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y3C8
Secondary accession number(s): A8K9R1
, D3DVF9, Q549X0, Q5VTX1, Q9BS96, Q9P009
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 17, 2006
Last modified: February 10, 2021
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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