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Protein

Peptidyl-prolyl cis-trans isomerase-like 1

Gene

PPIL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by Cyclosporin A.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=230 µM for N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei119Cyclosporin A1 Publication1
    Binding sitei125Cyclosporin A1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • cyclosporin A binding Source: UniProtKB
    • disordered domain specific binding Source: CAFA
    • peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionIsomerase, Rotamase
    Biological processmRNA processing, mRNA splicing

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    5.2.1.8 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-72163 mRNA Splicing - Major Pathway

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 1 (EC:5.2.1.81 Publication)
    Short name:
    PPIase
    Alternative name(s):
    Rotamase PPIL1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PPIL1
    Synonyms:CYPL1
    ORF Names:CGI-124, UNQ2425/PRO4984
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000137168.7

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:9260 PPIL1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    601301 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9Y3C6

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    51645

    Open Targets

    More...
    OpenTargetsi
    ENSG00000137168

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA33587

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PPIL1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    20177874

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000641641 – 166Peptidyl-prolyl cis-trans isomerase-like 1Add BLAST166

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei149PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9Y3C6

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9Y3C6

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9Y3C6

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9Y3C6

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9Y3C6

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    86015

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9Y3C6

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9Y3C6

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitous, with the most abundant expression in heart and skeletal muscle.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000137168 Expressed in 197 organ(s), highest expression level in heart right ventricle

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_PPIL1

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9Y3C6 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9Y3C6 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA062916

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Identified in the spliceosome C complex (PubMed:11991638, PubMed:28502770, PubMed:28076346). Interacts with SNW1 (PubMed:16595688, PubMed:20368803).5 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    119654, 31 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    Q9Y3C6

    Protein interaction database and analysis system

    More...
    IntActi
    Q9Y3C6, 31 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q9Y3C6

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000362803

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q9Y3C6

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1166
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q9Y3C6

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9Y3C6

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q9Y3C6

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 164PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST155

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni54 – 65Cyclosporin A binding1 PublicationAdd BLAST12
    Regioni70 – 71Cyclosporin A binding1 Publication2
    Regioni99 – 104Cyclosporin A binding1 Publication6
    Regioni109 – 113Cyclosporin A binding1 Publication5

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0881 Eukaryota
    COG0652 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000153189

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000065981

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG001065

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9Y3C6

    KEGG Orthology (KO)

    More...
    KOi
    K12733

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HNPNKHK

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G0NXS

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9Y3C6

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300200

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.40.100.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR029000 Cyclophilin-like_dom_sf
    IPR024936 Cyclophilin-type_PPIase
    IPR020892 Cyclophilin-type_PPIase_CS
    IPR002130 Cyclophilin-type_PPIase_dom

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11071 PTHR11071, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00160 Pro_isomerase, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF001467 Peptidylpro_ismrse, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00153 CSAPPISMRASE

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF50891 SSF50891, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00170 CSA_PPIASE_1, 1 hit
    PS50072 CSA_PPIASE_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q9Y3C6-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAAIPPDSWQ PPNVYLETSM GIIVLELYWK HAPKTCKNFA ELARRGYYNG
    60 70 80 90 100
    TKFHRIIKDF MIQGGDPTGT GRGGASIYGK QFEDELHPDL KFTGAGILAM
    110 120 130 140 150
    ANAGPDTNGS QFFVTLAPTQ WLDGKHTIFG RVCQGIGMVN RVGMVETNSQ
    160
    DRPVDDVKII KAYPSG
    Length:166
    Mass (Da):18,237
    Last modified:November 1, 1999 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2872DC3336CD05E4
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05177236C → S. Corresponds to variant dbSNP:rs12194408Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF151882 mRNA Translation: AAD34119.1
    AY359032 mRNA Translation: AAQ89391.1
    Z85996 Genomic DNA No translation available.
    AL122034 Genomic DNA No translation available.
    CH471081 Genomic DNA Translation: EAX03916.1
    BC003048 mRNA Translation: AAH03048.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS4826.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_057143.1, NM_016059.4

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.27693

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000373699; ENSP00000362803; ENSG00000137168

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    51645

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:51645

    UCSC genome browser

    More...
    UCSCi
    uc003omu.3 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF151882 mRNA Translation: AAD34119.1
    AY359032 mRNA Translation: AAQ89391.1
    Z85996 Genomic DNA No translation available.
    AL122034 Genomic DNA No translation available.
    CH471081 Genomic DNA Translation: EAX03916.1
    BC003048 mRNA Translation: AAH03048.1
    CCDSiCCDS4826.1
    RefSeqiNP_057143.1, NM_016059.4
    UniGeneiHs.27693

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1XWNNMR-A1-166[»]
    2K7NNMR-A1-166[»]
    2X7KX-ray1.15A1-166[»]
    5MQFelectron microscopy5.90V1-166[»]
    5XJCelectron microscopy3.60S1-166[»]
    5YZGelectron microscopy4.10S1-166[»]
    5Z56electron microscopy5.10S1-166[»]
    5Z57electron microscopy6.50S1-166[»]
    6FF4electron microscopy16.00V1-166[»]
    ProteinModelPortaliQ9Y3C6
    SMRiQ9Y3C6
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi119654, 31 interactors
    CORUMiQ9Y3C6
    IntActiQ9Y3C6, 31 interactors
    MINTiQ9Y3C6
    STRINGi9606.ENSP00000362803

    Chemistry databases

    BindingDBiQ9Y3C6

    PTM databases

    iPTMnetiQ9Y3C6
    PhosphoSitePlusiQ9Y3C6

    Polymorphism and mutation databases

    BioMutaiPPIL1
    DMDMi20177874

    Proteomic databases

    EPDiQ9Y3C6
    MaxQBiQ9Y3C6
    PaxDbiQ9Y3C6
    PeptideAtlasiQ9Y3C6
    PRIDEiQ9Y3C6
    ProteomicsDBi86015

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    51645
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000373699; ENSP00000362803; ENSG00000137168
    GeneIDi51645
    KEGGihsa:51645
    UCSCiuc003omu.3 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    51645
    DisGeNETi51645
    EuPathDBiHostDB:ENSG00000137168.7

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PPIL1
    HGNCiHGNC:9260 PPIL1
    HPAiHPA062916
    MIMi601301 gene
    neXtProtiNX_Q9Y3C6
    OpenTargetsiENSG00000137168
    PharmGKBiPA33587

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0881 Eukaryota
    COG0652 LUCA
    GeneTreeiENSGT00940000153189
    HOGENOMiHOG000065981
    HOVERGENiHBG001065
    InParanoidiQ9Y3C6
    KOiK12733
    OMAiHNPNKHK
    OrthoDBiEOG091G0NXS
    PhylomeDBiQ9Y3C6
    TreeFamiTF300200

    Enzyme and pathway databases

    BRENDAi5.2.1.8 2681
    ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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    ChiTaRSi
    PPIL1 human
    EvolutionaryTraceiQ9Y3C6

    The Gene Wiki collection of pages on human genes and proteins

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    GeneWikii
    PPIL1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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    GenomeRNAii
    51645

    Protein Ontology

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    PROi
    PR:Q9Y3C6

    The Stanford Online Universal Resource for Clones and ESTs

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    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000137168 Expressed in 197 organ(s), highest expression level in heart right ventricle
    CleanExiHS_PPIL1
    ExpressionAtlasiQ9Y3C6 baseline and differential
    GenevisibleiQ9Y3C6 HS

    Family and domain databases

    Gene3Di2.40.100.10, 1 hit
    InterProiView protein in InterPro
    IPR029000 Cyclophilin-like_dom_sf
    IPR024936 Cyclophilin-type_PPIase
    IPR020892 Cyclophilin-type_PPIase_CS
    IPR002130 Cyclophilin-type_PPIase_dom
    PANTHERiPTHR11071 PTHR11071, 1 hit
    PfamiView protein in Pfam
    PF00160 Pro_isomerase, 1 hit
    PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
    PRINTSiPR00153 CSAPPISMRASE
    SUPFAMiSSF50891 SSF50891, 1 hit
    PROSITEiView protein in PROSITE
    PS00170 CSA_PPIASE_1, 1 hit
    PS50072 CSA_PPIASE_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPIL1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y3C6
    Secondary accession number(s): O15001, Q5TDC9
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: November 1, 1999
    Last modified: December 5, 2018
    This is version 174 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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