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Protein

Peptidyl-prolyl cis-trans isomerase-like 1

Gene

PPIL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688).4 Publications

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).1 Publication

Activity regulationi

Inhibited by Cyclosporin A.1 Publication

Kineticsi

  1. KM=230 µM for N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei119Cyclosporin A1 Publication1
    Binding sitei125Cyclosporin A1 Publication1

    GO - Molecular functioni

    • cyclosporin A binding Source: UniProtKB
    • disordered domain specific binding Source: CAFA
    • peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB

    GO - Biological processi

    Keywordsi

    Molecular functionIsomerase, Rotamase
    Biological processmRNA processing, mRNA splicing

    Enzyme and pathway databases

    BRENDAi5.2.1.8 2681
    ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 1 (EC:5.2.1.81 Publication)
    Short name:
    PPIase
    Alternative name(s):
    Rotamase PPIL1
    Gene namesi
    Name:PPIL1
    Synonyms:CYPL1
    ORF Names:CGI-124, UNQ2425/PRO4984
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 6

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000137168.7
    HGNCiHGNC:9260 PPIL1
    MIMi601301 gene
    neXtProtiNX_Q9Y3C6

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi51645
    OpenTargetsiENSG00000137168
    PharmGKBiPA33587

    Polymorphism and mutation databases

    BioMutaiPPIL1
    DMDMi20177874

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000641641 – 166Peptidyl-prolyl cis-trans isomerase-like 1Add BLAST166

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei149PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    EPDiQ9Y3C6
    MaxQBiQ9Y3C6
    PaxDbiQ9Y3C6
    PeptideAtlasiQ9Y3C6
    PRIDEiQ9Y3C6
    ProteomicsDBi86015

    PTM databases

    iPTMnetiQ9Y3C6
    PhosphoSitePlusiQ9Y3C6

    Expressioni

    Tissue specificityi

    Ubiquitous, with the most abundant expression in heart and skeletal muscle.

    Gene expression databases

    BgeeiENSG00000137168 Expressed in 197 organ(s), highest expression level in heart right ventricle
    CleanExiHS_PPIL1
    ExpressionAtlasiQ9Y3C6 baseline and differential
    GenevisibleiQ9Y3C6 HS

    Organism-specific databases

    HPAiHPA062916

    Interactioni

    Subunit structurei

    Identified in the spliceosome C complex (PubMed:11991638, PubMed:28502770, PubMed:28076346). Interacts with SNW1 (PubMed:16595688, PubMed:20368803).5 Publications

    Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    BioGridi119654, 31 interactors
    CORUMiQ9Y3C6
    IntActiQ9Y3C6, 30 interactors
    MINTiQ9Y3C6
    STRINGi9606.ENSP00000362803

    Chemistry databases

    BindingDBiQ9Y3C6

    Structurei

    Secondary structure

    1166
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    ProteinModelPortaliQ9Y3C6
    SMRiQ9Y3C6
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y3C6

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini10 – 164PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST155

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni54 – 65Cyclosporin A binding1 PublicationAdd BLAST12
    Regioni70 – 71Cyclosporin A binding1 Publication2
    Regioni99 – 104Cyclosporin A binding1 Publication6
    Regioni109 – 113Cyclosporin A binding1 Publication5

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiKOG0881 Eukaryota
    COG0652 LUCA
    GeneTreeiENSGT00760000119072
    HOGENOMiHOG000065981
    HOVERGENiHBG001065
    InParanoidiQ9Y3C6
    KOiK12733
    OMAiHNPNKHK
    OrthoDBiEOG091G0NXS
    PhylomeDBiQ9Y3C6
    TreeFamiTF300200

    Family and domain databases

    Gene3Di2.40.100.10, 1 hit
    InterProiView protein in InterPro
    IPR029000 Cyclophilin-like_dom_sf
    IPR024936 Cyclophilin-type_PPIase
    IPR020892 Cyclophilin-type_PPIase_CS
    IPR002130 Cyclophilin-type_PPIase_dom
    PANTHERiPTHR11071 PTHR11071, 1 hit
    PfamiView protein in Pfam
    PF00160 Pro_isomerase, 1 hit
    PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
    PRINTSiPR00153 CSAPPISMRASE
    SUPFAMiSSF50891 SSF50891, 1 hit
    PROSITEiView protein in PROSITE
    PS00170 CSA_PPIASE_1, 1 hit
    PS50072 CSA_PPIASE_2, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q9Y3C6-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAAIPPDSWQ PPNVYLETSM GIIVLELYWK HAPKTCKNFA ELARRGYYNG
    60 70 80 90 100
    TKFHRIIKDF MIQGGDPTGT GRGGASIYGK QFEDELHPDL KFTGAGILAM
    110 120 130 140 150
    ANAGPDTNGS QFFVTLAPTQ WLDGKHTIFG RVCQGIGMVN RVGMVETNSQ
    160
    DRPVDDVKII KAYPSG
    Length:166
    Mass (Da):18,237
    Last modified:November 1, 1999 - v1
    Checksum:i2872DC3336CD05E4
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_05177236C → S. Corresponds to variant dbSNP:rs12194408Ensembl.1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF151882 mRNA Translation: AAD34119.1
    AY359032 mRNA Translation: AAQ89391.1
    Z85996 Genomic DNA No translation available.
    AL122034 Genomic DNA No translation available.
    CH471081 Genomic DNA Translation: EAX03916.1
    BC003048 mRNA Translation: AAH03048.1
    CCDSiCCDS4826.1
    RefSeqiNP_057143.1, NM_016059.4
    UniGeneiHs.27693

    Genome annotation databases

    EnsembliENST00000373699; ENSP00000362803; ENSG00000137168
    GeneIDi51645
    KEGGihsa:51645
    UCSCiuc003omu.3 human

    Keywords - Coding sequence diversityi

    Polymorphism

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF151882 mRNA Translation: AAD34119.1
    AY359032 mRNA Translation: AAQ89391.1
    Z85996 Genomic DNA No translation available.
    AL122034 Genomic DNA No translation available.
    CH471081 Genomic DNA Translation: EAX03916.1
    BC003048 mRNA Translation: AAH03048.1
    CCDSiCCDS4826.1
    RefSeqiNP_057143.1, NM_016059.4
    UniGeneiHs.27693

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1XWNNMR-A1-166[»]
    2K7NNMR-A1-166[»]
    2X7KX-ray1.15A1-166[»]
    5MQFelectron microscopy5.90V1-166[»]
    5XJCelectron microscopy3.60S1-166[»]
    5YZGelectron microscopy4.10S1-166[»]
    5Z56electron microscopy5.10S1-166[»]
    5Z57electron microscopy6.50S1-166[»]
    6FF4electron microscopy16.00V1-166[»]
    ProteinModelPortaliQ9Y3C6
    SMRiQ9Y3C6
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi119654, 31 interactors
    CORUMiQ9Y3C6
    IntActiQ9Y3C6, 30 interactors
    MINTiQ9Y3C6
    STRINGi9606.ENSP00000362803

    Chemistry databases

    BindingDBiQ9Y3C6

    PTM databases

    iPTMnetiQ9Y3C6
    PhosphoSitePlusiQ9Y3C6

    Polymorphism and mutation databases

    BioMutaiPPIL1
    DMDMi20177874

    Proteomic databases

    EPDiQ9Y3C6
    MaxQBiQ9Y3C6
    PaxDbiQ9Y3C6
    PeptideAtlasiQ9Y3C6
    PRIDEiQ9Y3C6
    ProteomicsDBi86015

    Protocols and materials databases

    DNASUi51645
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000373699; ENSP00000362803; ENSG00000137168
    GeneIDi51645
    KEGGihsa:51645
    UCSCiuc003omu.3 human

    Organism-specific databases

    CTDi51645
    DisGeNETi51645
    EuPathDBiHostDB:ENSG00000137168.7
    GeneCardsiPPIL1
    HGNCiHGNC:9260 PPIL1
    HPAiHPA062916
    MIMi601301 gene
    neXtProtiNX_Q9Y3C6
    OpenTargetsiENSG00000137168
    PharmGKBiPA33587
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG0881 Eukaryota
    COG0652 LUCA
    GeneTreeiENSGT00760000119072
    HOGENOMiHOG000065981
    HOVERGENiHBG001065
    InParanoidiQ9Y3C6
    KOiK12733
    OMAiHNPNKHK
    OrthoDBiEOG091G0NXS
    PhylomeDBiQ9Y3C6
    TreeFamiTF300200

    Enzyme and pathway databases

    BRENDAi5.2.1.8 2681
    ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

    Miscellaneous databases

    ChiTaRSiPPIL1 human
    EvolutionaryTraceiQ9Y3C6
    GeneWikiiPPIL1
    GenomeRNAii51645
    PROiPR:Q9Y3C6
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000137168 Expressed in 197 organ(s), highest expression level in heart right ventricle
    CleanExiHS_PPIL1
    ExpressionAtlasiQ9Y3C6 baseline and differential
    GenevisibleiQ9Y3C6 HS

    Family and domain databases

    Gene3Di2.40.100.10, 1 hit
    InterProiView protein in InterPro
    IPR029000 Cyclophilin-like_dom_sf
    IPR024936 Cyclophilin-type_PPIase
    IPR020892 Cyclophilin-type_PPIase_CS
    IPR002130 Cyclophilin-type_PPIase_dom
    PANTHERiPTHR11071 PTHR11071, 1 hit
    PfamiView protein in Pfam
    PF00160 Pro_isomerase, 1 hit
    PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
    PRINTSiPR00153 CSAPPISMRASE
    SUPFAMiSSF50891 SSF50891, 1 hit
    PROSITEiView protein in PROSITE
    PS00170 CSA_PPIASE_1, 1 hit
    PS50072 CSA_PPIASE_2, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiPPIL1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y3C6
    Secondary accession number(s): O15001, Q5TDC9
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: November 1, 1999
    Last modified: November 7, 2018
    This is version 173 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
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