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Entry version 147 (10 Feb 2021)
Sequence version 1 (01 Nov 1999)
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Protein

EKC/KEOPS complex subunit TPRKB

Gene

TPRKB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:28805828). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:28805828). TPRKB acts as an allosteric effector that regulates the t6A activity of the complex. TPRKB is not required for tRNA modification (PubMed:22912744, PubMed:28805828).1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processtRNA processing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9Y3C4

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6782315, tRNA modification in the nucleus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
EKC/KEOPS complex subunit TPRKBCurated
Alternative name(s):
PRPK-binding protein1 Publication
TP53RK-binding protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPRKBImported
ORF Names:CGI-1212 Publications, My019
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:24259, TPRKB

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608680, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9Y3C4

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000144034.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Galloway-Mowat syndrome 5 (GAMOS5)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of Galloway-Mowat syndrome, a severe renal-neurological disease characterized by early-onset nephrotic syndrome associated with microcephaly, central nervous system abnormalities, developmental delays, and a propensity for seizures. Brain anomalies include gyration defects ranging from lissencephaly to pachygyria and polymicrogyria, and cerebellar hypoplasia. Most patients show facial dysmorphism characterized by a small, narrow forehead, large/floppy ears, deep-set eyes, hypertelorism and micrognathia. Additional variable features are visual impairment and arachnodactyly. Most patients die in early childhood.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080355136L → P in GAMOS5. 1 PublicationCorresponds to variant dbSNP:rs1553433412EnsemblClinVar.1
Natural variantiVAR_080356149Y → C in GAMOS5. 1 PublicationCorresponds to variant dbSNP:rs1233885358EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Epilepsy, Mental retardation

Organism-specific databases

DisGeNET

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DisGeNETi
51002

MalaCards human disease database

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MalaCardsi
TPRKB
MIMi617731, phenotype

Open Targets

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OpenTargetsi
ENSG00000144034

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
2065, Galloway-Mowat syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA143485660

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9Y3C4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TPRKB

Domain mapping of disease mutations (DMDM)

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DMDMi
74735252

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002792201 – 175EKC/KEOPS complex subunit TPRKBAdd BLAST175

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y3C4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y3C4

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9Y3C4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y3C4

PeptideAtlas

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PeptideAtlasi
Q9Y3C4

PRoteomics IDEntifications database

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PRIDEi
Q9Y3C4

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
86011 [Q9Y3C4-1]
86012 [Q9Y3C4-2]
86013 [Q9Y3C4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y3C4

MetOSite database of methionine sulfoxide sites

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MetOSitei
Q9Y3C4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y3C4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000144034, Expressed in quadriceps femoris and 238 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y3C4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000144034, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes (PubMed:22912744, PubMed:28805828).

Interacts with TP53RK/PRPK (PubMed:12659830).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
119210, 46 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9Y3C4

Protein interaction database and analysis system

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IntActi
Q9Y3C4, 11 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000272424

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q9Y3C4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1175
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y3C4

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9Y3C4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CGI121/TPRKB family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4066, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000012942

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_065847_2_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y3C4

Identification of Orthologs from Complete Genome Data

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OMAi
VCRMATK

Database of Orthologous Groups

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OrthoDBi
1360669at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y3C4

TreeFam database of animal gene trees

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TreeFami
TF315098

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.2380.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013926, CGI121/TPRKB
IPR036504, CGI121/TPRKB_sf

The PANTHER Classification System

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PANTHERi
PTHR15840, PTHR15840, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08617, CGI-121, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF143870, SSF143870, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y3C4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQLTHQLDLF PECRVTLLLF KDVKNAGDLR RKAMEGTIDG SLINPTVIVD
60 70 80 90 100
PFQILVAANK AVHLYKLGKM KTRTLSTEII FNLSPNNNIS EALKKFGISA
110 120 130 140 150
NDTSILIVYI EEGEKQINQE YLISQVEGHQ VSLKNLPEIM NITEVKKIYK
160 170
LSSQEESIGT LLDAIICRMS TKDVL
Length:175
Mass (Da):19,661
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB13C0923148C157
GO
Isoform 2 (identifier: Q9Y3C4-2) [UniParc]FASTAAdd to basket
Also known as: S1

The sequence of this isoform differs from the canonical sequence as follows:
     15-47: Missing.

Show »
Length:142
Mass (Da):16,093
Checksum:i12388A00E0205E07
GO
Isoform 3 (identifier: Q9Y3C4-3) [UniParc]FASTAAdd to basket
Also known as: L1

The sequence of this isoform differs from the canonical sequence as follows:
     47-47: V → VFHSCCPGWSAMARSWLTATSASRVQAIVLPQPPELLGLQ

Show »
Length:214
Mass (Da):23,854
Checksum:i8961692D7DF630C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti147K → R in AAG43133 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080355136L → P in GAMOS5. 1 PublicationCorresponds to variant dbSNP:rs1553433412EnsemblClinVar.1
Natural variantiVAR_080356149Y → C in GAMOS5. 1 PublicationCorresponds to variant dbSNP:rs1233885358EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02341415 – 47Missing in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_02341547V → VFHSCCPGWSAMARSWLTAT SASRVQAIVLPQPPELLGLQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY157986 mRNA Translation: AAN76356.1
AY157987 mRNA Translation: AAN76357.1
AF060921 mRNA Translation: AAG43133.1
AF151879 mRNA Translation: AAD34116.1
CH471053 Genomic DNA Translation: EAW99720.1
CH471053 Genomic DNA Translation: EAW99722.1
BC029492 mRNA Translation: AAH29492.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1927.1 [Q9Y3C4-1]
CCDS82471.1 [Q9Y3C4-3]

NCBI Reference Sequences

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RefSeqi
NP_001317315.1, NM_001330386.1 [Q9Y3C4-3]
NP_001317316.1, NM_001330387.1 [Q9Y3C4-3]
NP_001317317.1, NM_001330388.1 [Q9Y3C4-1]
NP_001317318.1, NM_001330389.1 [Q9Y3C4-1]
NP_001317320.1, NM_001330391.1 [Q9Y3C4-2]
NP_001317321.1, NM_001330392.1 [Q9Y3C4-2]
NP_057142.1, NM_016058.3 [Q9Y3C4-1]
XP_006712090.1, XM_006712027.3
XP_011531179.1, XM_011532877.2
XP_011531180.1, XM_011532878.2
XP_016859721.1, XM_017004232.1
XP_016859722.1, XM_017004233.1
XP_016859723.1, XM_017004234.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000272424; ENSP00000272424; ENSG00000144034 [Q9Y3C4-1]
ENST00000318190; ENSP00000325398; ENSG00000144034 [Q9Y3C4-3]
ENST00000409716; ENSP00000386936; ENSG00000144034 [Q9Y3C4-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51002

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51002

UCSC genome browser

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UCSCi
uc002sjn.3, human [Q9Y3C4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157986 mRNA Translation: AAN76356.1
AY157987 mRNA Translation: AAN76357.1
AF060921 mRNA Translation: AAG43133.1
AF151879 mRNA Translation: AAD34116.1
CH471053 Genomic DNA Translation: EAW99720.1
CH471053 Genomic DNA Translation: EAW99722.1
BC029492 mRNA Translation: AAH29492.1
CCDSiCCDS1927.1 [Q9Y3C4-1]
CCDS82471.1 [Q9Y3C4-3]
RefSeqiNP_001317315.1, NM_001330386.1 [Q9Y3C4-3]
NP_001317316.1, NM_001330387.1 [Q9Y3C4-3]
NP_001317317.1, NM_001330388.1 [Q9Y3C4-1]
NP_001317318.1, NM_001330389.1 [Q9Y3C4-1]
NP_001317320.1, NM_001330391.1 [Q9Y3C4-2]
NP_001317321.1, NM_001330392.1 [Q9Y3C4-2]
NP_057142.1, NM_016058.3 [Q9Y3C4-1]
XP_006712090.1, XM_006712027.3
XP_011531179.1, XM_011532877.2
XP_011531180.1, XM_011532878.2
XP_016859721.1, XM_017004232.1
XP_016859722.1, XM_017004233.1
XP_016859723.1, XM_017004234.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ENPX-ray2.48A/B1-175[»]
SMRiQ9Y3C4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119210, 46 interactors
CORUMiQ9Y3C4
IntActiQ9Y3C4, 11 interactors
STRINGi9606.ENSP00000272424

PTM databases

iPTMnetiQ9Y3C4
MetOSiteiQ9Y3C4
PhosphoSitePlusiQ9Y3C4

Genetic variation databases

BioMutaiTPRKB
DMDMi74735252

Proteomic databases

EPDiQ9Y3C4
jPOSTiQ9Y3C4
MassIVEiQ9Y3C4
PaxDbiQ9Y3C4
PeptideAtlasiQ9Y3C4
PRIDEiQ9Y3C4
ProteomicsDBi86011 [Q9Y3C4-1]
86012 [Q9Y3C4-2]
86013 [Q9Y3C4-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31361, 215 antibodies

The DNASU plasmid repository

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DNASUi
51002

Genome annotation databases

EnsembliENST00000272424; ENSP00000272424; ENSG00000144034 [Q9Y3C4-1]
ENST00000318190; ENSP00000325398; ENSG00000144034 [Q9Y3C4-3]
ENST00000409716; ENSP00000386936; ENSG00000144034 [Q9Y3C4-3]
GeneIDi51002
KEGGihsa:51002
UCSCiuc002sjn.3, human [Q9Y3C4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51002
DisGeNETi51002

GeneCards: human genes, protein and diseases

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GeneCardsi
TPRKB
HGNCiHGNC:24259, TPRKB
HPAiENSG00000144034, Low tissue specificity
MalaCardsiTPRKB
MIMi608680, gene
617731, phenotype
neXtProtiNX_Q9Y3C4
OpenTargetsiENSG00000144034
Orphaneti2065, Galloway-Mowat syndrome
PharmGKBiPA143485660
VEuPathDBiHostDB:ENSG00000144034.14

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4066, Eukaryota
GeneTreeiENSGT00390000012942
HOGENOMiCLU_065847_2_0_1
InParanoidiQ9Y3C4
OMAiVCRMATK
OrthoDBi1360669at2759
PhylomeDBiQ9Y3C4
TreeFamiTF315098

Enzyme and pathway databases

PathwayCommonsiQ9Y3C4
ReactomeiR-HSA-6782315, tRNA modification in the nucleus and cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
51002, 411 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TPRKB, human
EvolutionaryTraceiQ9Y3C4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51002
PharosiQ9Y3C4, Tbio

Protein Ontology

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PROi
PR:Q9Y3C4
RNActiQ9Y3C4, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000144034, Expressed in quadriceps femoris and 238 other tissues
GenevisibleiQ9Y3C4, HS

Family and domain databases

Gene3Di3.30.2380.10, 1 hit
InterProiView protein in InterPro
IPR013926, CGI121/TPRKB
IPR036504, CGI121/TPRKB_sf
PANTHERiPTHR15840, PTHR15840, 1 hit
PfamiView protein in Pfam
PF08617, CGI-121, 1 hit
SUPFAMiSSF143870, SSF143870, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPRKB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y3C4
Secondary accession number(s): D6W5H6
, Q8IWR6, Q8IWR7, Q9H3K4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: November 1, 1999
Last modified: February 10, 2021
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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