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Entry version 146 (07 Oct 2020)
Sequence version 1 (01 Nov 1999)
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Protein

WASH complex subunit 3

Gene

WASHC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.2 Publications

Caution

One study reported a nucleation-promoting factor (NPF) activity towards the Arp2/3 complex using partially purified samples of the WASH complex (PubMed:19922875). In another study, the in vitro reconstituted and purified recombinant WASH core complex, consisting of WASHC3, WASHC4, WASHC5, WASHC1 and the N-terminal residues 1-356 of WASHC2, did not show activity toward Arp2/3 complex (PubMed:20498093).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9Y3C0

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9Y3C0

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.3.1.2, the sorting nexin27 (snx27)-retromer assembly apparatus

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WASH complex subunit 3Imported
Alternative name(s):
Coiled-coil domain-containing protein 53
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WASHC3Imported
ORF Names:AD-016, CCDC53, CGI-116, x0009
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000120860.10

Human Gene Nomenclature Database

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HGNCi
HGNC:24256, WASHC3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y3C0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51019

Open Targets

More...
OpenTargetsi
ENSG00000120860

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672169

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y3C0, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WASHC3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6831732

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000762011 – 194WASH complex subunit 3Add BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y3C0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y3C0

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9Y3C0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9Y3C0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y3C0

PeptideAtlas

More...
PeptideAtlasi
Q9Y3C0

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y3C0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86009

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y3C0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y3C0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120860, Expressed in testis and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y3C0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y3C0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000120860, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the WASH core complex also described as WASH regulatory complex (SHRC) composed of WASH (WASHC1, WASH2P or WASH3P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. The WASH core complex associates via WASHC2 with the F-actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB) in a transient or substoichiometric manner which was initially described as WASH complex.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9Y3C0
With#Exp.IntAct
ABI2 [Q9NYB9]4EBI-712969,EBI-743598
ABI2 - isoform 2 [Q9NYB9-2]5EBI-712969,EBI-11096309
BFSP2 [Q13515]3EBI-712969,EBI-10229433
BLOC1S2 [Q6QNY1]4EBI-712969,EBI-465872
BLOC1S6 [Q9UL45]8EBI-712969,EBI-465781
C20orf202 [A1L168]3EBI-712969,EBI-18396958
CCDC197 [Q8NCU1]7EBI-712969,EBI-750686
CCHCR1 - isoform 3 [Q8TD31-3]6EBI-712969,EBI-10175300
CENPK [Q9BS16]3EBI-712969,EBI-6871750
CEP55 [Q53EZ4]7EBI-712969,EBI-747776
COG6 [Q9Y2V7]4EBI-712969,EBI-3866319
DTNBP1 [Q96EV8]3EBI-712969,EBI-465804
GNG13 [Q9P2W3]3EBI-712969,EBI-11427343
GOLGA2 [Q08379]6EBI-712969,EBI-618309
HAUS1 [Q96CS2]10EBI-712969,EBI-2514791
HSBP1 [O75506]13EBI-712969,EBI-748664
IFT20 [Q8IY31]4EBI-712969,EBI-744203
IKBIP - isoform 4 [Q70UQ0-4]4EBI-712969,EBI-12190633
INSYN1 [Q2T9L4]3EBI-712969,EBI-4311436
KDM1A [O60341]3EBI-712969,EBI-710124
KNSTRN [Q9Y448]6EBI-712969,EBI-373334
KRT27 [Q7Z3Y8]3EBI-712969,EBI-3044087
KRT71 [Q3SY84]3EBI-712969,EBI-2952676
KRT75 [O95678]3EBI-712969,EBI-2949715
LHX4 [Q969G2]3EBI-712969,EBI-2865388
LMNB2 [Q03252]3EBI-712969,EBI-2830427
MCRS1 [Q96EZ8]13EBI-712969,EBI-348259
MOB1A [Q9H8S9]3EBI-712969,EBI-748229
MOB1B [Q7L9L4]3EBI-712969,EBI-2558745
MYOZ1 [Q9NP98]3EBI-712969,EBI-744402
NDC80 [O14777]10EBI-712969,EBI-715849
NUP62 [P37198]8EBI-712969,EBI-347978
OPTN [Q96CV9]17EBI-712969,EBI-748974
PAX6 [P26367]3EBI-712969,EBI-747278
PBXIP1 [Q96AQ6]4EBI-712969,EBI-740845
PCM1 [Q15154]5EBI-712969,EBI-741421
PCM1 - isoform 3 [Q15154-3]3EBI-712969,EBI-11742977
PELI1 [Q96FA3]3EBI-712969,EBI-448369
PHOSPHO2 [Q8TCD6]5EBI-712969,EBI-2861380
RABEP1 [Q15276]3EBI-712969,EBI-447043
RNF8 [O76064]3EBI-712969,EBI-373337
SCARA5 - isoform 2 [Q6ZMJ2-2]3EBI-712969,EBI-12823227
SDCBP [O00560]6EBI-712969,EBI-727004
SNAPIN [O95295]3EBI-712969,EBI-296723
SRGAP2B [A0A286YEY3]3EBI-712969,EBI-17766455
SYCE1 [Q8N0S2]4EBI-712969,EBI-6872807
TEX35 - isoform 2 [Q5T0J7-2]3EBI-712969,EBI-12833746
TFIP11 [Q9UBB9]3EBI-712969,EBI-1105213
TXLNA [P40222]8EBI-712969,EBI-359793
TXLNB [Q8N3L3]4EBI-712969,EBI-6116822
VPS52 [Q8N1B4]3EBI-712969,EBI-2799833
A8K2R33EBI-712969,EBI-9977437

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119225, 101 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1163, WASH complex, variant WASHC1/WASHC2C
CPX-1168, WASH complex, variant WASH2P/WASHC2C
CPX-1169, WASH complex, variant WASH3P/WASHC2C
CPX-1170, WASH complex, variant WASH4P/WASHC2C
CPX-1171, WASH complex, variant WASH6P/WASHC2C
CPX-1172, WASH complex, variant WASHC1/WASHC2A
CPX-1173, WASH complex, variant WASH2P/WASHC2A
CPX-1174, WASH complex, variant WASH3P/WASHC2A
CPX-1175, WASH complex, variant WASH4P/WASHC2A
CPX-1176, WASH complex, variant WASH6P/WASHC2A

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9Y3C0

Protein interaction database and analysis system

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IntActi
Q9Y3C0, 100 interactors

Molecular INTeraction database

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MINTi
Q9Y3C0

STRING: functional protein association networks

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STRINGi
9606.ENSP00000240079

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y3C0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y3C0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili46 – 74Sequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCDC53 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4496, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000014084

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y3C0

KEGG Orthology (KO)

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KOi
K18463

Identification of Orthologs from Complete Genome Data

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OMAi
GCETKFV

Database of Orthologous Groups

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OrthoDBi
1425330at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y3C0

TreeFam database of animal gene trees

More...
TreeFami
TF318955

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019309, WASHC3

The PANTHER Classification System

More...
PANTHERi
PTHR13015, PTHR13015, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10152, CCDC53, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9Y3C0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEDGLPLMG SGIDLTKVPA IQQKRTVAFL NQFVVHTVQF LNRFSTVCEE
60 70 80 90 100
KLADLSLRIQ QIETTLNILD AKLSSIPGLD DVTVEVSPLN VTSVTNGAHP
110 120 130 140 150
EATSEQPQQN STQDSGLQES EVSAENILTV AKDPRYARYL KMVQVGVPVM
160 170 180 190
AIRNKMISEG LDPDLLERPD APVPDGESEK TVEESSDSES SFSD
Length:194
Mass (Da):21,173
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB0CCF1AE76CDA6D2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GZ97F5GZ97_HUMAN
Coiled-coil domain-containing prote...
WASHC3
193Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGN0H0YGN0_HUMAN
Coiled-coil domain-containing prote...
WASHC3
107Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWI9F5GWI9_HUMAN
Coiled-coil domain-containing prote...
WASHC3
169Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXZ7F5GXZ7_HUMAN
Coiled-coil domain-containing prote...
WASHC3
173Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0A7F5H0A7_HUMAN
Coiled-coil domain-containing prote...
WASHC3
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H2P1F5H2P1_HUMAN
Coiled-coil domain-containing prote...
WASHC3
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXZ4F5GXZ4_HUMAN
Coiled-coil domain-containing prote...
WASHC3
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81D → G in BAD97059 (Ref. 5) Curated1
Sequence conflicti110N → S in AAH10889 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF155655 mRNA Translation: AAF67012.1
AF151874 mRNA Translation: AAD34111.1
CR457171 mRNA Translation: CAG33452.1
AK223339 mRNA Translation: BAD97059.1
AK314970 mRNA Translation: BAG37471.1
CH471054 Genomic DNA Translation: EAW97687.1
BC010889 mRNA Translation: AAH10889.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44959.1

NCBI Reference Sequences

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RefSeqi
NP_057137.1, NM_016053.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000240079; ENSP00000240079; ENSG00000120860

Database of genes from NCBI RefSeq genomes

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GeneIDi
51019

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51019

UCSC genome browser

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UCSCi
uc010svw.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155655 mRNA Translation: AAF67012.1
AF151874 mRNA Translation: AAD34111.1
CR457171 mRNA Translation: CAG33452.1
AK223339 mRNA Translation: BAD97059.1
AK314970 mRNA Translation: BAG37471.1
CH471054 Genomic DNA Translation: EAW97687.1
BC010889 mRNA Translation: AAH10889.1
CCDSiCCDS44959.1
RefSeqiNP_057137.1, NM_016053.3

3D structure databases

SMRiQ9Y3C0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119225, 101 interactors
ComplexPortaliCPX-1163, WASH complex, variant WASHC1/WASHC2C
CPX-1168, WASH complex, variant WASH2P/WASHC2C
CPX-1169, WASH complex, variant WASH3P/WASHC2C
CPX-1170, WASH complex, variant WASH4P/WASHC2C
CPX-1171, WASH complex, variant WASH6P/WASHC2C
CPX-1172, WASH complex, variant WASHC1/WASHC2A
CPX-1173, WASH complex, variant WASH2P/WASHC2A
CPX-1174, WASH complex, variant WASH3P/WASHC2A
CPX-1175, WASH complex, variant WASH4P/WASHC2A
CPX-1176, WASH complex, variant WASH6P/WASHC2A
CORUMiQ9Y3C0
IntActiQ9Y3C0, 100 interactors
MINTiQ9Y3C0
STRINGi9606.ENSP00000240079

Protein family/group databases

TCDBi9.A.3.1.2, the sorting nexin27 (snx27)-retromer assembly apparatus

PTM databases

iPTMnetiQ9Y3C0
PhosphoSitePlusiQ9Y3C0

Polymorphism and mutation databases

BioMutaiWASHC3
DMDMi6831732

Proteomic databases

EPDiQ9Y3C0
jPOSTiQ9Y3C0
MassIVEiQ9Y3C0
MaxQBiQ9Y3C0
PaxDbiQ9Y3C0
PeptideAtlasiQ9Y3C0
PRIDEiQ9Y3C0
ProteomicsDBi86009

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
49055, 44 antibodies

The DNASU plasmid repository

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DNASUi
51019

Genome annotation databases

EnsembliENST00000240079; ENSP00000240079; ENSG00000120860
GeneIDi51019
KEGGihsa:51019
UCSCiuc010svw.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51019
DisGeNETi51019
EuPathDBiHostDB:ENSG00000120860.10

GeneCards: human genes, protein and diseases

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GeneCardsi
WASHC3
HGNCiHGNC:24256, WASHC3
HPAiENSG00000120860, Low tissue specificity
neXtProtiNX_Q9Y3C0
OpenTargetsiENSG00000120860
PharmGKBiPA142672169

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4496, Eukaryota
GeneTreeiENSGT00390000014084
InParanoidiQ9Y3C0
KOiK18463
OMAiGCETKFV
OrthoDBi1425330at2759
PhylomeDBiQ9Y3C0
TreeFamiTF318955

Enzyme and pathway databases

PathwayCommonsiQ9Y3C0
SIGNORiQ9Y3C0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
51019, 60 hits in 854 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CCDC53, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CCDC53

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51019
PharosiQ9Y3C0, Tdark

Protein Ontology

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PROi
PR:Q9Y3C0
RNActiQ9Y3C0, protein

Gene expression databases

BgeeiENSG00000120860, Expressed in testis and 236 other tissues
ExpressionAtlasiQ9Y3C0, baseline and differential
GenevisibleiQ9Y3C0, HS

Family and domain databases

InterProiView protein in InterPro
IPR019309, WASHC3
PANTHERiPTHR13015, PTHR13015, 1 hit
PfamiView protein in Pfam
PF10152, CCDC53, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWASC3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y3C0
Secondary accession number(s): B2RC74
, Q53FF0, Q6IAI4, Q96QK0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: October 7, 2020
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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