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Protein

Oligoribonuclease, mitochondrial

Gene

REXO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling.1 Publication

Miscellaneous

Depletion of REXO2 by RNA interference causes a strong morphological phenotype showing disorganized network of punctate and granular mitochondria. Lack of REXO2 protein also causes a substantial decrease of mitochondrial nucleic acid content and impaired de novo mitochondrial protein synthesis.

Cofactori

Enzyme regulationi

Inhibited by adenosine 3',5'-bisphosphate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei164Sequence analysis1

GO - Molecular functioni

  • 3'-5' exonuclease activity Source: MGI
  • 3'-5'-exoribonuclease activity Source: GO_Central
  • nucleic acid binding Source: InterPro

GO - Biological processi

  • nucleobase-containing compound metabolic process Source: MGI
  • nucleotide metabolic process Source: ProtInc

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
LigandManganese

Names & Taxonomyi

Protein namesi
Recommended name:
Oligoribonuclease, mitochondrial (EC:3.1.-.-)
Alternative name(s):
RNA exonuclease 2 homolog
Small fragment nuclease
Gene namesi
Name:REXO2
Synonyms:SFN, SMFN
ORF Names:CGI-114
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000076043.9
HGNCiHGNC:17851 REXO2
MIMi607149 gene
neXtProtiNX_Q9Y3B8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi168D → A: Abolishes activity. 1

Organism-specific databases

DisGeNETi25996
OpenTargetsiENSG00000076043
PharmGKBiPA142671085

Polymorphism and mutation databases

BioMutaiREXO2
DMDMi116242694

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionSequence analysisAdd BLAST25
ChainiPRO_000002027326 – 237Oligoribonuclease, mitochondrialAdd BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei92PhosphoserineCombined sources1
Modified residuei122PhosphotyrosineCombined sources1
Modified residuei173N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y3B8
PaxDbiQ9Y3B8
PeptideAtlasiQ9Y3B8
PRIDEiQ9Y3B8
ProteomicsDBi86006
86007 [Q9Y3B8-2]

PTM databases

iPTMnetiQ9Y3B8
PhosphoSitePlusiQ9Y3B8

Expressioni

Gene expression databases

BgeeiENSG00000076043
CleanExiHS_REXO2
HS_SFN
ExpressionAtlasiQ9Y3B8 baseline and differential
GenevisibleiQ9Y3B8 HS

Organism-specific databases

HPAiHPA038450
HPA038451

Interactioni

Subunit structurei

Homotetramer.Curated

Protein-protein interaction databases

BioGridi117473, 8 interactors
STRINGi9606.ENSP00000265881

Structurei

3D structure databases

ProteinModelPortaliQ9Y3B8
SMRiQ9Y3B8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 207ExonucleaseAdd BLAST165

Sequence similaritiesi

Belongs to the oligoribonuclease family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3242 Eukaryota
COG1949 LUCA
GeneTreeiENSGT00390000009255
HOGENOMiHOG000246596
HOVERGENiHBG002323
InParanoidiQ9Y3B8
KOiK13288
OMAiAFFHYRN
OrthoDBiEOG091G0LPG
PhylomeDBiQ9Y3B8
TreeFamiTF314084

Family and domain databases

CDDicd06135 Orn, 1 hit
Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00045 Oligoribonuclease, 1 hit
InterProiView protein in InterPro
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR022894 Oligoribonuclease
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF00929 RNase_T, 1 hit
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: Q9Y3B8-1) [UniParc]FASTAAdd to basket
Also known as: Sfn-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGGSLGSRL LRGVGGSHGR FGARGVREGG AAMAAGESMA QRMVWVDLEM
60 70 80 90 100
TGLDIEKDQI IEMACLITDS DLNILAEGPN LIIKQPDELL DSMSDWCKEH
110 120 130 140 150
HGKSGLTKAV KESTITLQQA EYEFLSFVRQ QTPPGLCPLA GNSVHEDKKF
160 170 180 190 200
LDKYMPQFMK HLHYRIIDVS TVKELCRRWY PEEYEFAPKK AASHRALDDI
210 220 230
SESIKELQFY RNNIFKKKID EKKRKIIENG ENEKTVS
Length:237
Mass (Da):26,833
Last modified:October 17, 2006 - v3
Checksum:iA0343A8918B11B82
GO
Isoform 2 (identifier: Q9Y3B8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Show »
Length:199
Mass (Da):23,208
Checksum:iE96469443EFF140A
GO
Isoform 3 (identifier: Q9Y3B8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Show »
Length:205
Mass (Da):23,754
Checksum:i77C526551A46BEFC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103K → R in CAB53690 (PubMed:11230166).Curated1
Sequence conflicti103K → R in CAG38531 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0037751 – 38Missing in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_0549541 – 32Missing in isoform 3. CuratedAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151872 mRNA Translation: AAD34109.1
AL110239 mRNA Translation: CAB53690.1
AK312042 mRNA Translation: BAG34979.1
CR533500 mRNA Translation: CAG38531.1
AK223200 mRNA Translation: BAD96920.1
CH471065 Genomic DNA Translation: EAW67250.1
BC105024 mRNA Translation: AAI05025.1
BC105026 mRNA Translation: AAI05027.1
BC107887 mRNA Translation: AAI07888.1
BC143701 mRNA Translation: AAI43702.1
CCDSiCCDS8371.1 [Q9Y3B8-1]
PIRiT14770
RefSeqiNP_056338.2, NM_015523.3 [Q9Y3B8-1]
UniGeneiHs.677190
Hs.714231

Genome annotation databases

EnsembliENST00000265881; ENSP00000265881; ENSG00000076043 [Q9Y3B8-1]
ENST00000611665; ENSP00000480535; ENSG00000076043 [Q9Y3B8-1]
GeneIDi25996
KEGGihsa:25996
UCSCiuc001poy.4 human [Q9Y3B8-1]

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiORN_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3B8
Secondary accession number(s): B2R532
, Q32Q18, Q53FT1, Q6FIC6, Q9UFY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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