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Protein

39S ribosomal protein L11, mitochondrial

Gene

MRPL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L11, mitochondrial
Short name:
L11mt
Short name:
MRP-L11
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL11m1 Publication
Gene namesi
Name:MRPL11
ORF Names:CGI-113
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000174547.13
HGNCiHGNC:14042 MRPL11
MIMi611826 gene
neXtProtiNX_Q9Y3B7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi65003
OpenTargetsiENSG00000174547
PharmGKBiPA30940

Polymorphism and mutation databases

BioMutaiMRPL11
DMDMi22001931

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030443? – 19239S ribosomal protein L11, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ9Y3B7
PaxDbiQ9Y3B7
PeptideAtlasiQ9Y3B7
PRIDEiQ9Y3B7
ProteomicsDBi86004
86005 [Q9Y3B7-2]
TopDownProteomicsiQ9Y3B7-1 [Q9Y3B7-1]
Q9Y3B7-2 [Q9Y3B7-2]

PTM databases

iPTMnetiQ9Y3B7
PhosphoSitePlusiQ9Y3B7
SwissPalmiQ9Y3B7

Expressioni

Gene expression databases

BgeeiENSG00000174547 Expressed in 191 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_MRPL11
ExpressionAtlasiQ9Y3B7 baseline and differential
GenevisibleiQ9Y3B7 HS

Organism-specific databases

HPAiHPA057685

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi122369, 86 interactors
CORUMiQ9Y3B7
IntActiQ9Y3B7, 50 interactors
MINTiQ9Y3B7
STRINGi9606.ENSP00000308897

Structurei

Secondary structure

1192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y3B7
SMRiQ9Y3B7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3257 Eukaryota
COG0080 LUCA
GeneTreeiENSGT00390000003153
HOGENOMiHOG000082123
HOVERGENiHBG036110
InParanoidiQ9Y3B7
KOiK02867
OMAiCKQFNAK
OrthoDBiEOG091G0L5X
PhylomeDBiQ9Y3B7
TreeFamiTF313471

Family and domain databases

CDDicd00349 Ribosomal_L11, 1 hit
Gene3Di1.10.10.250, 1 hit
3.30.1550.10, 1 hit
HAMAPiMF_00736 Ribosomal_L11, 1 hit
InterProiView protein in InterPro
IPR000911 Ribosomal_L11/L12
IPR036796 Ribosomal_L11/L12_N_sf
IPR006519 Ribosomal_L11_bac-typ
IPR020783 Ribosomal_L11_C
IPR036769 Ribosomal_L11_C_sf
IPR020784 Ribosomal_L11_N
PANTHERiPTHR11661 PTHR11661, 1 hit
PfamiView protein in Pfam
PF00298 Ribosomal_L11, 1 hit
PF03946 Ribosomal_L11_N, 1 hit
SMARTiView protein in SMART
SM00649 RL11, 1 hit
SUPFAMiSSF46906 SSF46906, 1 hit
SSF54747 SSF54747, 1 hit
TIGRFAMsiTIGR01632 L11_bact, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y3B7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKLGRAARG LRKPEVGGVI RAIVRAGLAM PGPPLGPVLG QRGVSINQFC
60 70 80 90 100
KEFNERTKDI KEGIPLPTKI LVKPDRTFEI KIGQPTVSYF LKAAAGIEKG
110 120 130 140 150
ARQTGKEVAG LVTLKHVYEI ARIKAQDEAF ALQDVPLSSV VRSIIGSARS
160 170 180 190
LGIRVVKDLS SEELAAFQKE RAIFLAAQKE ADLAAQEEAA KK
Length:192
Mass (Da):20,683
Last modified:November 1, 1999 - v1
Checksum:i92506A20044BF278
GO
Isoform 2 (identifier: Q9Y3B7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-41: Missing.

Show »
Length:166
Mass (Da):18,205
Checksum:iA78DA10D323B1D24
GO
Isoform 3 (identifier: Q9Y3B7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-192: DLSSEELAAFQKERAIFLAAQKEADLAAQEEAAKK → ERCSANVLRNGKISMKDPSGRSSV

Note: No experimental confirmation available.Curated
Show »
Length:181
Mass (Da):19,454
Checksum:i578392577167303F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQB6E9PQB6_HUMAN
39S ribosomal protein L11, mitochon...
MRPL11
75Annotation score:
H0YCD5H0YCD5_HUMAN
39S ribosomal protein L11, mitochon...
MRPL11
63Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68T → I in BM554886 (PubMed:15489334).Curated1
Isoform 3 (identifier: Q9Y3B7-3)
Sequence conflicti181V → L in BM554886 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04107716 – 41Missing in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_045237158 – 192DLSSE…EAAKK → ERCSANVLRNGKISMKDPSG RSSV in isoform 3. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049638 mRNA Translation: BAB40843.1
AF151871 mRNA Translation: AAD34108.1
AK290084 mRNA Translation: BAF82773.1
AP002748 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74528.1
CH471076 Genomic DNA Translation: EAW74529.1
CH471076 Genomic DNA Translation: EAW74531.1
BC005002 mRNA Translation: AAH05002.1
BC108277 mRNA Translation: AAI08278.1
BM554886 mRNA No translation available.
AB051338 Genomic DNA Translation: BAB54928.1
CCDSiCCDS44655.1 [Q9Y3B7-2]
CCDS8139.1 [Q9Y3B7-1]
CCDS8140.1 [Q9Y3B7-3]
RefSeqiNP_057134.1, NM_016050.4 [Q9Y3B7-1]
NP_733934.1, NM_170738.3 [Q9Y3B7-2]
NP_733935.1, NM_170739.3 [Q9Y3B7-3]
UniGeneiHs.418450

Genome annotation databases

EnsembliENST00000310999; ENSP00000308897; ENSG00000174547 [Q9Y3B7-1]
ENST00000329819; ENSP00000329630; ENSG00000174547 [Q9Y3B7-3]
ENST00000430466; ENSP00000415356; ENSG00000174547 [Q9Y3B7-2]
GeneIDi65003
KEGGihsa:65003
UCSCiuc001ohy.5 human [Q9Y3B7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049638 mRNA Translation: BAB40843.1
AF151871 mRNA Translation: AAD34108.1
AK290084 mRNA Translation: BAF82773.1
AP002748 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74528.1
CH471076 Genomic DNA Translation: EAW74529.1
CH471076 Genomic DNA Translation: EAW74531.1
BC005002 mRNA Translation: AAH05002.1
BC108277 mRNA Translation: AAI08278.1
BM554886 mRNA No translation available.
AB051338 Genomic DNA Translation: BAB54928.1
CCDSiCCDS44655.1 [Q9Y3B7-2]
CCDS8139.1 [Q9Y3B7-1]
CCDS8140.1 [Q9Y3B7-3]
RefSeqiNP_057134.1, NM_016050.4 [Q9Y3B7-1]
NP_733934.1, NM_170738.3 [Q9Y3B7-2]
NP_733935.1, NM_170739.3 [Q9Y3B7-3]
UniGeneiHs.418450

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40J1-192[»]
3J9Melectron microscopy3.50J1-192[»]
5OOLelectron microscopy3.06J1-192[»]
5OOMelectron microscopy3.03J1-192[»]
ProteinModelPortaliQ9Y3B7
SMRiQ9Y3B7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122369, 86 interactors
CORUMiQ9Y3B7
IntActiQ9Y3B7, 50 interactors
MINTiQ9Y3B7
STRINGi9606.ENSP00000308897

PTM databases

iPTMnetiQ9Y3B7
PhosphoSitePlusiQ9Y3B7
SwissPalmiQ9Y3B7

Polymorphism and mutation databases

BioMutaiMRPL11
DMDMi22001931

Proteomic databases

EPDiQ9Y3B7
PaxDbiQ9Y3B7
PeptideAtlasiQ9Y3B7
PRIDEiQ9Y3B7
ProteomicsDBi86004
86005 [Q9Y3B7-2]
TopDownProteomicsiQ9Y3B7-1 [Q9Y3B7-1]
Q9Y3B7-2 [Q9Y3B7-2]

Protocols and materials databases

DNASUi65003
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310999; ENSP00000308897; ENSG00000174547 [Q9Y3B7-1]
ENST00000329819; ENSP00000329630; ENSG00000174547 [Q9Y3B7-3]
ENST00000430466; ENSP00000415356; ENSG00000174547 [Q9Y3B7-2]
GeneIDi65003
KEGGihsa:65003
UCSCiuc001ohy.5 human [Q9Y3B7-1]

Organism-specific databases

CTDi65003
DisGeNETi65003
EuPathDBiHostDB:ENSG00000174547.13
GeneCardsiMRPL11
HGNCiHGNC:14042 MRPL11
HPAiHPA057685
MIMi611826 gene
neXtProtiNX_Q9Y3B7
OpenTargetsiENSG00000174547
PharmGKBiPA30940
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3257 Eukaryota
COG0080 LUCA
GeneTreeiENSGT00390000003153
HOGENOMiHOG000082123
HOVERGENiHBG036110
InParanoidiQ9Y3B7
KOiK02867
OMAiCKQFNAK
OrthoDBiEOG091G0L5X
PhylomeDBiQ9Y3B7
TreeFamiTF313471

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL11 human
GeneWikiiMRPL11
GenomeRNAii65003
PROiPR:Q9Y3B7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174547 Expressed in 191 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_MRPL11
ExpressionAtlasiQ9Y3B7 baseline and differential
GenevisibleiQ9Y3B7 HS

Family and domain databases

CDDicd00349 Ribosomal_L11, 1 hit
Gene3Di1.10.10.250, 1 hit
3.30.1550.10, 1 hit
HAMAPiMF_00736 Ribosomal_L11, 1 hit
InterProiView protein in InterPro
IPR000911 Ribosomal_L11/L12
IPR036796 Ribosomal_L11/L12_N_sf
IPR006519 Ribosomal_L11_bac-typ
IPR020783 Ribosomal_L11_C
IPR036769 Ribosomal_L11_C_sf
IPR020784 Ribosomal_L11_N
PANTHERiPTHR11661 PTHR11661, 1 hit
PfamiView protein in Pfam
PF00298 Ribosomal_L11, 1 hit
PF03946 Ribosomal_L11_N, 1 hit
SMARTiView protein in SMART
SM00649 RL11, 1 hit
SUPFAMiSSF46906 SSF46906, 1 hit
SSF54747 SSF54747, 1 hit
TIGRFAMsiTIGR01632 L11_bact, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM11_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3B7
Secondary accession number(s): A6NLT0
, A8K219, Q32P46, Q96Q73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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