Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane emp24 domain-containing protein 7

Gene

TMED7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications.

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein 7
Alternative name(s):
p24 family protein gamma-3
Short name:
p24gamma3
p27
Gene namesi
Name:TMED7
ORF Names:CGI-109
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000134970.13
HGNCiHGNC:24253 TMED7
neXtProtiNX_Q9Y3B3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 187LumenalSequence analysisAdd BLAST153
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 224CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi100302736
353376
51014
OpenTargetsiENSG00000134970
ENSG00000251201
PharmGKBiPA134891536
PA165660570

Polymorphism and mutation databases

BioMutaiTMED7
DMDMi62299080

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001039535 – 224Transmembrane emp24 domain-containing protein 7Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-linked glycosylated in complex form containing terminal sialic acid.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y3B3
PaxDbiQ9Y3B3
PeptideAtlasiQ9Y3B3
PRIDEiQ9Y3B3
ProteomicsDBi86001
TopDownProteomicsiQ9Y3B3-1 [Q9Y3B3-1]

PTM databases

iPTMnetiQ9Y3B3
PhosphoSitePlusiQ9Y3B3
SwissPalmiQ9Y3B3

Expressioni

Gene expression databases

BgeeiENSG00000134970
CleanExiHS_TMED7
ExpressionAtlasiQ9Y3B3 baseline and differential
GenevisibleiQ9Y3B3 HS

Organism-specific databases

HPAiCAB025883
HPA008960

Interactioni

Subunit structurei

Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED9 and TMED10. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED7.3 Publications

Protein-protein interaction databases

BioGridi119221, 53 interactors
970651, 1 interactor
IntActiQ9Y3B3, 12 interactors
MINTiQ9Y3B3
STRINGi9606.ENSP00000405926

Structurei

3D structure databases

ProteinModelPortaliQ9Y3B3
SMRiQ9Y3B3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 128GOLDPROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi211 – 224COPI vesicle coat-bindingSequence analysisAdd BLAST14
Motifi211 – 212COPII vesicle coat-bindingSequence analysis2

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1693 Eukaryota
ENOG4111JPD LUCA
GeneTreeiENSGT00670000097656
HOGENOMiHOG000160229
HOVERGENiHBG000271
InParanoidiQ9Y3B3
KOiK20349
OMAiNAEDCFY
OrthoDBiEOG091G0LX8
PhylomeDBiQ9Y3B3
TreeFamiTF313000

Family and domain databases

InterProiView protein in InterPro
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
IPR015718 TMED7
IPR015720 TMP21-related
PANTHERiPTHR22811 PTHR22811, 1 hit
PTHR22811:SF49 PTHR22811:SF49, 1 hit
PfamiView protein in Pfam
PF01105 EMP24_GP25L, 1 hit
SMARTiView protein in SMART
SM01190 EMP24_GP25L, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
PROSITEiView protein in PROSITE
PS50866 GOLD, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y3B3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRPGSAQRW AAVAGRWGCR LLALLLLVPG PGGASEITFE LPDNAKQCFY
60 70 80 90 100
EDIAQGTKCT LEFQVITGGH YDVDCRLEDP DGKVLYKEMK KQYDSFTFTA
110 120 130 140 150
SKNGTYKFCF SNEFSTFTHK TVYFDFQVGE DPPLFPSENR VSALTQMESA
160 170 180 190 200
CVSIHEALKS VIDYQTHFRL REAQGRSRAE DLNTRVAYWS VGEALILLVV
210 220
SIGQVFLLKS FFSDKRTTTT RVGS
Length:224
Mass (Da):25,172
Last modified:March 29, 2005 - v2
Checksum:i9D0D2110579837B3
GO
Isoform 2 (identifier: Q9Y3B3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-224: Missing.

Note: No experimental confirmation available.
Show »
Length:188
Mass (Da):21,233
Checksum:i15A10CC4BD553DB3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 23MPRPG…CRLLA → MGSTVPRSASVLLLL in AAD34104 (PubMed:10810093).CuratedAdd BLAST23
Sequence conflicti27 – 37LVPGPGGASEI → RRAEQPCGAEL in AAD34104 (PubMed:10810093).CuratedAdd BLAST11
Sequence conflicti59C → S in AAD34104 (PubMed:10810093).Curated1
Sequence conflicti131 – 139DPPLFPSEN → THLCFLVD in AAD34104 (PubMed:10810093).Curated9
Sequence conflicti213S → P in BAB55166 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046247189 – 224Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151867 mRNA Translation: AAD34104.1
AK027512 mRNA Translation: BAB55166.1
AK074962 mRNA Translation: BAC11318.1
AK075218 mRNA Translation: BAC11479.1
AC010226 Genomic DNA No translation available.
BC019349 mRNA Translation: AAH19349.1
CCDSiCCDS4120.1 [Q9Y3B3-1]
RefSeqiNP_001157941.1, NM_001164469.3 [Q9Y3B3-2]
NP_861974.1, NM_181836.5 [Q9Y3B3-1]
UniGeneiHs.642817
Hs.718838

Genome annotation databases

EnsembliENST00000456936; ENSP00000405926; ENSG00000134970 [Q9Y3B3-1]
GeneIDi100302736
51014
KEGGihsa:100302736
hsa:51014
UCSCiuc003krf.4 human [Q9Y3B3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTMED7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3B3
Secondary accession number(s): Q8NBU8, Q8WUU6, Q96K51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: March 29, 2005
Last modified: June 20, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health