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Protein

Transmembrane emp24 domain-containing protein 5

Gene

TMED5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.1 Publication

GO - Biological processi

  • Golgi ribbon formation Source: UniProtKB
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-3238698 WNT ligand biogenesis and trafficking

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein 5
Alternative name(s):
p24 family protein gamma-2
Short name:
p24gamma2
p28
Gene namesi
Name:TMED5
ORF Names:CGI-100, UNQ397/PRO733
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117500.12
HGNCiHGNC:24251 TMED5
MIMi616876 gene
neXtProtiNX_Q9Y3A6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 196LumenalSequence analysisAdd BLAST169
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 229CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi50999
OpenTargetsiENSG00000117500
PharmGKBiPA134942067

Polymorphism and mutation databases

BioMutaiTMED5
DMDMi12585534

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisCombined sourcesAdd BLAST27
ChainiPRO_000001038928 – 229Transmembrane emp24 domain-containing protein 5Add BLAST202

Proteomic databases

EPDiQ9Y3A6
PaxDbiQ9Y3A6
PeptideAtlasiQ9Y3A6
PRIDEiQ9Y3A6
ProteomicsDBi85998
TopDownProteomicsiQ9Y3A6-1 [Q9Y3A6-1]

PTM databases

iPTMnetiQ9Y3A6
PhosphoSitePlusiQ9Y3A6

Expressioni

Gene expression databases

BgeeiENSG00000117500 Expressed in 233 organ(s), highest expression level in biceps brachii
CleanExiHS_TMED5
ExpressionAtlasiQ9Y3A6 baseline and differential
GenevisibleiQ9Y3A6 HS

Organism-specific databases

HPAiHPA050289

Interactioni

Subunit structurei

Interacts with TMED9 and TMED10.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PRMT6Q96LA82EBI-7560959,EBI-912440

Protein-protein interaction databases

BioGridi119207, 7 interactors
IntActiQ9Y3A6, 6 interactors
MINTiQ9Y3A6
STRINGi9606.ENSP00000359305

Structurei

3D structure databases

ProteinModelPortaliQ9Y3A6
SMRiQ9Y3A6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 126GOLDPROSITE-ProRule annotationAdd BLAST82

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3287 Eukaryota
ENOG410Z18S LUCA
GeneTreeiENSGT00670000097656
HOGENOMiHOG000039809
HOVERGENiHBG000271
InParanoidiQ9Y3A6
KOiK14825
OMAiYDMKVQD
OrthoDBiEOG091G0RNG
PhylomeDBiQ9Y3A6
TreeFamiTF313000

Family and domain databases

InterProiView protein in InterPro
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
IPR015717 TMED5
IPR015720 TMP21-related
PANTHERiPTHR22811 PTHR22811, 1 hit
PTHR22811:SF41 PTHR22811:SF41, 1 hit
PfamiView protein in Pfam
PF01105 EMP24_GP25L, 1 hit
SMARTiView protein in SMART
SM01190 EMP24_GP25L, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
PROSITEiView protein in PROSITE
PS50866 GOLD, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9Y3A6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDKIWLPFP VLLLAALPPV LLPGAAGFTP SLDSDFTFTL PAGQKECFYQ
60 70 80 90 100
PMPLKASLEI EYQVLDGAGL DIDFHLASPE GKTLVFEQRK SDGVHTVETE
110 120 130 140 150
VGDYMFCFDN TFSTISEKVI FFELILDNMG EQAQEQEDWK KYITGTDILD
160 170 180 190 200
MKLEDILESI NSIKSRLSKS GHIQTLLRAF EARDRNIQES NFDRVNFWSM
210 220
VNLVVMVVVS AIQVYMLKSL FEDKRKSRT
Length:229
Mass (Da):26,005
Last modified:November 1, 1999 - v1
Checksum:i6973E0DACBF15B19
GO
Isoform 2 (identifier: Q9Y3A6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-229: ESINSIKSRL...LFEDKRKSRT → DPIIKIASDV...KQKWAHTNSA

Note: No experimental confirmation available.
Show »
Length:193
Mass (Da):21,727
Checksum:i5A2B00CBE9704452
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AKT3B1AKT3_HUMAN
Transmembrane emp24 domain-containi...
TMED5
162Annotation score:
M0R072M0R072_HUMAN
Transmembrane emp24 domain-containi...
TMED5
120Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017150175T → I3 PublicationsCorresponds to variant dbSNP:rs1060622Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046365158 – 229ESINS…RKSRT → DPIIKIASDVQIRLHLGIHQ QHQVQTKQKWAHTNSA in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151858 mRNA Translation: AAD34095.1
AY359039 mRNA Translation: AAQ89398.1
BX379269 mRNA No translation available.
AK312787 mRNA Translation: BAG35650.1
AC126124 Genomic DNA No translation available.
AL117354 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73081.1
CH471097 Genomic DNA Translation: EAW73082.1
BC016365 mRNA Translation: AAH16365.1
BC016556 mRNA Translation: AAH16556.1
BC070051 mRNA Translation: AAH70051.1
CCDSiCCDS53342.1 [Q9Y3A6-2]
CCDS743.1 [Q9Y3A6-1]
RefSeqiNP_001161302.1, NM_001167830.1 [Q9Y3A6-2]
NP_057124.3, NM_016040.4 [Q9Y3A6-1]
UniGeneiHs.482873

Genome annotation databases

EnsembliENST00000370282; ENSP00000359305; ENSG00000117500 [Q9Y3A6-1]
ENST00000479918; ENSP00000418992; ENSG00000117500 [Q9Y3A6-2]
GeneIDi50999
KEGGihsa:50999
UCSCiuc001dpn.4 human [Q9Y3A6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTMED5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3A6
Secondary accession number(s): B1AKT4
, B2R703, D3DT38, Q96AX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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