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Protein

Ribosomal RNA-processing protein 7 homolog A

Gene

RRP7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA-processing protein 7 homolog A
Alternative name(s):
Gastric cancer antigen Zg14
Gene namesi
Name:RRP7A
ORF Names:CGI-96
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000189306.10
HGNCiHGNC:24286 RRP7A
neXtProtiNX_Q9Y3A4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189306
PharmGKBiPA162402175

Polymorphism and mutation databases

BioMutaiRRP7A
DMDMi66774227

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000820081 – 280Ribosomal RNA-processing protein 7 homolog AAdd BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y3A4
MaxQBiQ9Y3A4
PaxDbiQ9Y3A4
PeptideAtlasiQ9Y3A4
PRIDEiQ9Y3A4
ProteomicsDBi85996

PTM databases

iPTMnetiQ9Y3A4
PhosphoSitePlusiQ9Y3A4

Expressioni

Gene expression databases

BgeeiENSG00000189306
CleanExiHS_RRP7A
ExpressionAtlasiQ9Y3A4 baseline and differential
GenevisibleiQ9Y3A4 HS

Organism-specific databases

HPAiHPA001586
HPA046768

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TFIP11Q9UBB93EBI-7223720,EBI-1105213

Protein-protein interaction databases

BioGridi118153, 60 interactors
IntActiQ9Y3A4, 5 interactors
MINTiQ9Y3A4
STRINGi9606.ENSP00000321449

Structurei

3D structure databases

ProteinModelPortaliQ9Y3A4
SMRiQ9Y3A4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 90RRMAdd BLAST30

Sequence similaritiesi

Belongs to the RRP7 family.Curated

Phylogenomic databases

eggNOGiKOG4008 Eukaryota
ENOG410YHJN LUCA
GeneTreeiENSGT00390000018482
HOVERGENiHBG054483
InParanoidiQ9Y3A4
KOiK14545
OMAiFIRLMDP
OrthoDBiEOG091G0JTG
PhylomeDBiQ9Y3A4
TreeFamiTF313949

Family and domain databases

CDDicd12294 RRM_Rrp7A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR024326 RRP7
IPR034890 Rrp7A_RRM
PANTHERiPTHR13191 PTHR13191, 1 hit
PfamiView protein in Pfam
PF12923 RRP7, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y3A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVARRRKCAA RDPEDRIPSP LGYAAIPIKF SEKQQASHYL YVRAHGVRQG
60 70 80 90 100
TKSTWPQKRT LFVLNVPPYC TEESLSRLLS TCGLVQSVEL QEKPDLAESP
110 120 130 140 150
KESRSKFFHP KPVPGFQVAY VVFQKPSGVS AALALKGPLL VSTESHPVKS
160 170 180 190 200
GIHKWISDYA DSVPDPEALR VEVDTFMEAY DQKIAEEEAK AKEEEGVPDE
210 220 230 240 250
EGWVKVTRRG RRPVLPRTEA ASLRVLERER RKRSRKELLN FYAWQHRESK
260 270 280
MEHLAQLRKK FEEDKQRIEL LRAQRKFRPY
Length:280
Mass (Da):32,334
Last modified:May 24, 2005 - v2
Checksum:i3625D609B0FF2F76
GO

Sequence cautioni

The sequence AAH31838 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102E → K in BAG37211 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05222775L → M. Corresponds to variant dbSNP:rs8139383Ensembl.1
Natural variantiVAR_05222885V → I1 PublicationCorresponds to variant dbSNP:rs1812240Ensembl.1
Natural variantiVAR_05222988V → I. Corresponds to variant dbSNP:rs11553441Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022316 Genomic DNA No translation available.
AK314650 mRNA Translation: BAG37211.1
BC031838 mRNA Translation: AAH31838.1 Different initiation.
BC041639 mRNA Translation: AAH41639.1
BC042335 mRNA Translation: AAH42335.1
BC063537 mRNA Translation: AAH63537.1
BC073834 mRNA Translation: AAH73834.1
BC121118 mRNA Translation: AAI21119.1
BC121119 mRNA Translation: AAI21120.1
AY039240 mRNA Translation: AAK68659.1
CCDSiCCDS14036.1
RefSeqiNP_056518.2, NM_015703.4
UniGeneiHs.745006

Genome annotation databases

EnsembliENST00000323013; ENSP00000321449; ENSG00000189306
GeneIDi27341
KEGGihsa:27341
UCSCiuc003bcq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRRP7A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3A4
Secondary accession number(s): A4FTX2
, B2RBG4, Q0VAD0, Q5JZ94, Q6P4B5, Q8IVR9, Q8IVY0, Q8N5Q3, Q8NEY6, Q9Y3H5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 24, 2005
Last modified: June 20, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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