UniProtKB - Q9Y394 (DHRS7_HUMAN)
Protein
Dehydrogenase/reductase SDR family member 7
Gene
DHRS7
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 190 | SubstrateBy similarity | 1 | |
Active sitei | 203 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 54 – 78 | NADBy similarityAdd BLAST | 25 |
GO - Molecular functioni
- oxidoreductase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
PathwayCommonsi | Q9Y394 |
Names & Taxonomyi
Protein namesi | Recommended name: Dehydrogenase/reductase SDR family member 7 (EC:1.1.-.-)Alternative name(s): Retinal short-chain dehydrogenase/reductase 4 Short name: retSDR4 Short chain dehydrogenase/reductase family 34C member 1 |
Gene namesi | Name:DHRS7 Synonyms:DHRS7A, RETSDR4, SDR34C1 ORF Names:CGI-86, UNQ285/PRO3448 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000100612.13 |
HGNCi | HGNC:21524, DHRS7 |
MIMi | 612833, gene |
neXtProti | NX_Q9Y394 |
Subcellular locationi
Other locations
- membrane Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 51635 |
OpenTargetsi | ENSG00000100612 |
PharmGKBi | PA134974539 |
Miscellaneous databases
Pharosi | Q9Y394, Tbio |
Polymorphism and mutation databases
BioMutai | DHRS7 |
DMDMi | 34395856 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000031968 | 29 – 339 | Dehydrogenase/reductase SDR family member 7Add BLAST | 311 |
Proteomic databases
EPDi | Q9Y394 |
jPOSTi | Q9Y394 |
MassIVEi | Q9Y394 |
PaxDbi | Q9Y394 |
PeptideAtlasi | Q9Y394 |
PRIDEi | Q9Y394 |
ProteomicsDBi | 85986 [Q9Y394-1] 85987 [Q9Y394-2] |
PTM databases
iPTMneti | Q9Y394 |
PhosphoSitePlusi | Q9Y394 |
SwissPalmi | Q9Y394 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100612, Expressed in prostate gland and 244 other tissues |
ExpressionAtlasi | Q9Y394, baseline and differential |
Genevisiblei | Q9Y394, HS |
Organism-specific databases
HPAi | ENSG00000100612, Tissue enhanced (skeletal) |
Interactioni
Binary interactionsi
Hide detailsQ9Y394
With | #Exp. | IntAct |
---|---|---|
SACM1L [Q9NTJ5] | 3 | EBI-1387800,EBI-3917235 |
TMEM120A [Q9BXJ8] | 3 | EBI-1387800,EBI-727322 |
Protein-protein interaction databases
BioGRIDi | 119649, 54 interactors |
IntActi | Q9Y394, 44 interactors |
MINTi | Q9Y394 |
STRINGi | 9606.ENSP00000216500 |
Miscellaneous databases
RNActi | Q9Y394, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1205, Eukaryota |
GeneTreei | ENSGT00940000155226 |
HOGENOMi | CLU_010194_2_1_1 |
InParanoidi | Q9Y394 |
OrthoDBi | 906746at2759 |
PhylomeDBi | Q9Y394 |
TreeFami | TF354276 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y394-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNWELLLWLL VLCALLLLLV QLLRFLRADG DLTLLWAEWQ GRRPEWELTD
60 70 80 90 100
MVVWVTGASS GIGEELAYQL SKLGVSLVLS ARRVHELERV KRRCLENGNL
110 120 130 140 150
KEKDILVLPL DLTDTGSHEA ATKAVLQEFG RIDILVNNGG MSQRSLCMDT
160 170 180 190 200
SLDVYRKLIE LNYLGTVSLT KCVLPHMIER KQGKIVTVNS ILGIISVPLS
210 220 230 240 250
IGYCASKHAL RGFFNGLRTE LATYPGIIVS NICPGPVQSN IVENSLAGEV
260 270 280 290 300
TKTIGNNGDQ SHKMTTSRCV RLMLISMAND LKEVWISEQP FLLVTYLWQY
310 320 330
MPTWAWWITN KMGKKRIENF KSGVDADSSY FKIFKTKHD
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YJ66 | H0YJ66_HUMAN | Dehydrogenase/reductase SDR family ... | DHRS7 | 399 | Annotation score: | ||
H0YJR8 | H0YJR8_HUMAN | Dehydrogenase/reductase SDR family ... | DHRS7 | 212 | Annotation score: | ||
H0YJE4 | H0YJE4_HUMAN | Dehydrogenase/reductase SDR family ... | DHRS7 | 160 | Annotation score: | ||
G3V5J0 | G3V5J0_HUMAN | Dehydrogenase/reductase SDR family ... | DHRS7 | 61 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052319 | 218 | R → Q. Corresponds to variant dbSNP:rs34583017Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008103 | 1 – 50 | Missing in isoform 2. 1 PublicationAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151844 mRNA Translation: AAD34081.1 AF126782 mRNA Translation: AAF06941.1 AY359031 mRNA Translation: AAQ89390.1 AK313285 mRNA Translation: BAG36093.1 AL163853 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW80770.1 BC000637 mRNA Translation: AAH00637.1 BC007337 mRNA Translation: AAH07337.1 |
CCDSi | CCDS81810.1 [Q9Y394-2] CCDS9743.1 [Q9Y394-1] |
RefSeqi | NP_001309209.1, NM_001322280.1 [Q9Y394-2] NP_057113.1, NM_016029.3 [Q9Y394-1] |
Genome annotation databases
Ensembli | ENST00000216500; ENSP00000216500; ENSG00000100612 [Q9Y394-1] ENST00000536410; ENSP00000442993; ENSG00000100612 [Q9Y394-2] ENST00000557185; ENSP00000451882; ENSG00000100612 [Q9Y394-1] |
GeneIDi | 51635 |
KEGGi | hsa:51635 |
UCSCi | uc001xes.5, human [Q9Y394-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151844 mRNA Translation: AAD34081.1 AF126782 mRNA Translation: AAF06941.1 AY359031 mRNA Translation: AAQ89390.1 AK313285 mRNA Translation: BAG36093.1 AL163853 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW80770.1 BC000637 mRNA Translation: AAH00637.1 BC007337 mRNA Translation: AAH07337.1 |
CCDSi | CCDS81810.1 [Q9Y394-2] CCDS9743.1 [Q9Y394-1] |
RefSeqi | NP_001309209.1, NM_001322280.1 [Q9Y394-2] NP_057113.1, NM_016029.3 [Q9Y394-1] |
3D structure databases
SMRi | Q9Y394 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119649, 54 interactors |
IntActi | Q9Y394, 44 interactors |
MINTi | Q9Y394 |
STRINGi | 9606.ENSP00000216500 |
PTM databases
iPTMneti | Q9Y394 |
PhosphoSitePlusi | Q9Y394 |
SwissPalmi | Q9Y394 |
Polymorphism and mutation databases
BioMutai | DHRS7 |
DMDMi | 34395856 |
Proteomic databases
EPDi | Q9Y394 |
jPOSTi | Q9Y394 |
MassIVEi | Q9Y394 |
PaxDbi | Q9Y394 |
PeptideAtlasi | Q9Y394 |
PRIDEi | Q9Y394 |
ProteomicsDBi | 85986 [Q9Y394-1] 85987 [Q9Y394-2] |
Protocols and materials databases
Antibodypediai | 24356, 229 antibodies |
DNASUi | 51635 |
Genome annotation databases
Ensembli | ENST00000216500; ENSP00000216500; ENSG00000100612 [Q9Y394-1] ENST00000536410; ENSP00000442993; ENSG00000100612 [Q9Y394-2] ENST00000557185; ENSP00000451882; ENSG00000100612 [Q9Y394-1] |
GeneIDi | 51635 |
KEGGi | hsa:51635 |
UCSCi | uc001xes.5, human [Q9Y394-1] |
Organism-specific databases
CTDi | 51635 |
DisGeNETi | 51635 |
EuPathDBi | HostDB:ENSG00000100612.13 |
GeneCardsi | DHRS7 |
HGNCi | HGNC:21524, DHRS7 |
HPAi | ENSG00000100612, Tissue enhanced (skeletal) |
MIMi | 612833, gene |
neXtProti | NX_Q9Y394 |
OpenTargetsi | ENSG00000100612 |
PharmGKBi | PA134974539 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1205, Eukaryota |
GeneTreei | ENSGT00940000155226 |
HOGENOMi | CLU_010194_2_1_1 |
InParanoidi | Q9Y394 |
OrthoDBi | 906746at2759 |
PhylomeDBi | Q9Y394 |
TreeFami | TF354276 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y394 |
Miscellaneous databases
BioGRID-ORCSi | 51635, 4 hits in 847 CRISPR screens |
ChiTaRSi | DHRS7, human |
GenomeRNAii | 51635 |
Pharosi | Q9Y394, Tbio |
PROi | PR:Q9Y394 |
RNActi | Q9Y394, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100612, Expressed in prostate gland and 244 other tissues |
ExpressionAtlasi | Q9Y394, baseline and differential |
Genevisiblei | Q9Y394, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DHRS7_HUMAN | |
Accessioni | Q9Y394Primary (citable) accession number: Q9Y394 Secondary accession number(s): B2R896, Q9UKU2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 29, 2003 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations