UniProtKB - Q9Y394 (DHRS7_HUMAN)

BLAST

>sp|Q9Y394|DHRS7_HUMAN Dehydrogenase/reductase SDR family member 7 OS=Homo sapiens OX=9606 GN=DHRS7 PE=1 SV=1
MNWELLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASS
GIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEA
ATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIER
KQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPVQSN
IVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQY
MPTWAWWITNKMGKKRIENFKSGVDADSSYFKIFKTKHD

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History
Entry version 145 (07 Nov 2018)
Sequence version 1 (01 Nov 1999)
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Protein

Dehydrogenase/reductase SDR family member 7

Gene

DHRS7

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	190	SubstrateBy similarity		1
Active siteⁱ	203	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	54 – 78	NADBy similarityAdd BLAST		25

GO - Molecular functionⁱ

oxidoreductase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	NAD

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dehydrogenase/reductase SDR family member 7 (EC:1.1.-.-) Alternative name(s): Retinal short-chain dehydrogenase/reductase 4 Short name: retSDR4 Short chain dehydrogenase/reductase family 34C member 1
Gene namesⁱ	Name:DHRS7 Synonyms:DHRS7A, RETSDR4, SDR34C1 ORF Names:CGI-86, UNQ285/PRO3448
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100612.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21524 DHRS7
MIMⁱ	612833 gene
neXtProtⁱ	NX_Q9Y394

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51635
Open Targets More...OpenTargetsⁱ	ENSG00000100612
PharmGKBⁱ	PA134974539

Polymorphism and mutation databases

BioMutaⁱ	DHRS7
DMDMⁱ	34395856

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 28	Sequence analysisAdd BLAST		28
ChainⁱPRO_0000031968	29 – 339	Dehydrogenase/reductase SDR family member 7Add BLAST		311

Proteomic databases

EPDⁱ	Q9Y394
PaxDbⁱ	Q9Y394
PeptideAtlas More...PeptideAtlasⁱ	Q9Y394
PRIDEⁱ	Q9Y394
ProteomicsDBⁱ	85986 85987 [Q9Y394-2]

PTM databases

iPTMnetⁱ	Q9Y394
PhosphoSitePlusⁱ	Q9Y394
SwissPalmⁱ	Q9Y394

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000100612 Expressed in 232 organ(s), highest expression level in gastrocnemius
CleanExⁱ	HS_DHRS7
ExpressionAtlasⁱ	Q9Y394 baseline and differential
Genevisibleⁱ	Q9Y394 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA031121

HPAⁱ

HPA031121

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	119649, 42 interactors
IntActⁱ	Q9Y394, 13 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y394
STRINGⁱ	9606.ENSP00000216500

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y394
SMRⁱ	Q9Y394
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IUBT Eukaryota COG0300 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150823
HOVERGENⁱ	HBG054346
InParanoidⁱ	Q9Y394
KEGG Orthology (KO) More...KOⁱ	K11165
PhylomeDBⁱ	Q9Y394
TreeFamⁱ	TF354276

Family and domain databases

InterProⁱ	View protein in InterPro IPR036291 NAD(P)-bd_dom_sf IPR020904 Sc_DH/Rdtase_CS IPR002347 SDR_fam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00106 adh_short, 1 hit
PRINTSⁱ	PR00081 GDHRDH PR00080 SDRFAMILY
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
PROSITEⁱ	View protein in PROSITE PS00061 ADH_SHORT, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y394-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNWELLLWLL VLCALLLLLV QLLRFLRADG DLTLLWAEWQ GRRPEWELTD 
        60         70         80         90        100
MVVWVTGASS GIGEELAYQL SKLGVSLVLS ARRVHELERV KRRCLENGNL 
       110        120        130        140        150
KEKDILVLPL DLTDTGSHEA ATKAVLQEFG RIDILVNNGG MSQRSLCMDT 
       160        170        180        190        200
SLDVYRKLIE LNYLGTVSLT KCVLPHMIER KQGKIVTVNS ILGIISVPLS 
       210        220        230        240        250
IGYCASKHAL RGFFNGLRTE LATYPGIIVS NICPGPVQSN IVENSLAGEV 
       260        270        280        290        300
TKTIGNNGDQ SHKMTTSRCV RLMLISMAND LKEVWISEQP FLLVTYLWQY 
       310        320        330 
MPTWAWWITN KMGKKRIENF KSGVDADSSY FKIFKTKHD

Length:339

Mass (Da):38,299

Last modified:November 1, 1999 - v1

Checksum:ⁱ7B251CE5894ED70C

Isoform 2 (identifier: Q9Y394-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-50: Missing.

« Hide

        10         20         30         40         50
MVVWVTGASS GIGEELAYQL SKLGVSLVLS ARRVHELERV KRRCLENGNL 
        60         70         80         90        100
KEKDILVLPL DLTDTGSHEA ATKAVLQEFG RIDILVNNGG MSQRSLCMDT 
       110        120        130        140        150
SLDVYRKLIE LNYLGTVSLT KCVLPHMIER KQGKIVTVNS ILGIISVPLS 
       160        170        180        190        200
IGYCASKHAL RGFFNGLRTE LATYPGIIVS NICPGPVQSN IVENSLAGEV 
       210        220        230        240        250
TKTIGNNGDQ SHKMTTSRCV RLMLISMAND LKEVWISEQP FLLVTYLWQY 
       260        270        280 
MPTWAWWITN KMGKKRIENF KSGVDADSSY FKIFKTKHD

Note: No experimental confirmation available.

Show »

Length:289

Mass (Da):32,268

Checksum:ⁱ051AF9154FB0DEDF

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YJ66	H0YJ66_HUMAN	Dehydrogenase/reductase SDR family ... Dehydrogenase/reductase SDR family member 7	DHRS7	399	Annotation score:
A0A087X0Z7	A0A087X0Z7_HUMAN	Dehydrogenase/reductase SDR family ... Dehydrogenase/reductase SDR family member 7	DHRS7	376	Annotation score:
H0YJR8	H0YJR8_HUMAN	Dehydrogenase/reductase SDR family ... Dehydrogenase/reductase SDR family member 7	DHRS7	212	Annotation score:
H0YJE4	H0YJE4_HUMAN	Dehydrogenase/reductase SDR family ... Dehydrogenase/reductase SDR family member 7	DHRS7	160	Annotation score:
G3V5J0	G3V5J0_HUMAN	Dehydrogenase/reductase SDR family ... Dehydrogenase/reductase SDR family member 7	DHRS7	61	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052319	218	R → Q. Corresponds to variant dbSNP:rs34583017Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_008103	1 – 50	Missing in isoform 2. 1 PublicationAdd BLAST		50

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF151844 mRNA Translation: AAD34081.1 AF126782 mRNA Translation: AAF06941.1 AY359031 mRNA Translation: AAQ89390.1 AK313285 mRNA Translation: BAG36093.1 AL163853 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW80770.1 BC000637 mRNA Translation: AAH00637.1 BC007337 mRNA Translation: AAH07337.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS81810.1 [Q9Y394-2] CCDS9743.1 [Q9Y394-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001309209.1, NM_001322280.1 [Q9Y394-2] NP_057113.1, NM_016029.3 [Q9Y394-1]
UniGeneⁱ	Hs.59719

Genome annotation databases

Ensemblⁱ	ENST00000216500; ENSP00000216500; ENSG00000100612 [Q9Y394-1] ENST00000536410; ENSP00000442993; ENSG00000100612 [Q9Y394-2] ENST00000557185; ENSP00000451882; ENSG00000100612 [Q9Y394-1]
GeneIDⁱ	51635
KEGGⁱ	hsa:51635
UCSC genome browser More...UCSCⁱ	uc001xes.5 human [Q9Y394-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9Y394	Dehydrogenase/reductase 7		GORGO		289	UniRef100_Q9Y394
Isoform 2 of Dehydrogenase/reductase SDR family member 7		HUMAN		289
UPI00024CFF90		HUMAN		199

Protein	Similar proteins		Species	Score	Length	Source
Q9Y394	Dehydrogenase/reductase 7		GORGO		289	UniRef90_Q9Y394
Isoform 2 of Dehydrogenase/reductase SDR family member 7		HUMAN		289
DHRS7 isoform 6 (Fragment)		PANTR		398
DHRS7 isoform 6 (Fragment)		PONAB		398
Dehydrogenase/reductase SDR family member 7		MACMU		339
+39

Protein	Similar proteins		Species	Score	Length	Source
Q9Y394	Dehydrogenase/reductase 7		GORGO		289	UniRef50_Q9Y394
Isoform 2 of Dehydrogenase/reductase SDR family member 7		HUMAN		289
DHRS7 isoform 6 (Fragment)		PONAB		398
DHRS7 isoform 6 (Fragment)		PANTR		398
Dehydrogenase/reductase SDR family member 7		MACMU		339
+50

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF151844 mRNA Translation: AAD34081.1 AF126782 mRNA Translation: AAF06941.1 AY359031 mRNA Translation: AAQ89390.1 AK313285 mRNA Translation: BAG36093.1 AL163853 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW80770.1 BC000637 mRNA Translation: AAH00637.1 BC007337 mRNA Translation: AAH07337.1
CCDSⁱ	CCDS81810.1 [Q9Y394-2] CCDS9743.1 [Q9Y394-1]
RefSeqⁱ	NP_001309209.1, NM_001322280.1 [Q9Y394-2] NP_057113.1, NM_016029.3 [Q9Y394-1]
UniGeneⁱ	Hs.59719

3D structure databases

ProteinModelPortalⁱ	Q9Y394
SMRⁱ	Q9Y394
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119649, 42 interactors
IntActⁱ	Q9Y394, 13 interactors
MINTⁱ	Q9Y394
STRINGⁱ	9606.ENSP00000216500

PTM databases

iPTMnetⁱ	Q9Y394
PhosphoSitePlusⁱ	Q9Y394
SwissPalmⁱ	Q9Y394

Polymorphism and mutation databases

BioMutaⁱ	DHRS7
DMDMⁱ	34395856

Proteomic databases

EPDⁱ	Q9Y394
PaxDbⁱ	Q9Y394
PeptideAtlasⁱ	Q9Y394
PRIDEⁱ	Q9Y394
ProteomicsDBⁱ	85986 85987 [Q9Y394-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51635
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000216500; ENSP00000216500; ENSG00000100612 [Q9Y394-1] ENST00000536410; ENSP00000442993; ENSG00000100612 [Q9Y394-2] ENST00000557185; ENSP00000451882; ENSG00000100612 [Q9Y394-1]
GeneIDⁱ	51635
KEGGⁱ	hsa:51635
UCSCⁱ	uc001xes.5 human [Q9Y394-1]

Organism-specific databases

CTDⁱ	51635
DisGeNETⁱ	51635
EuPathDBⁱ	HostDB:ENSG00000100612.13
GeneCardsⁱ	DHRS7
H-InvDBⁱ	HIX0011708
HGNCⁱ	HGNC:21524 DHRS7
HPAⁱ	HPA031121
MIMⁱ	612833 gene
neXtProtⁱ	NX_Q9Y394
OpenTargetsⁱ	ENSG00000100612
PharmGKBⁱ	PA134974539
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IUBT Eukaryota COG0300 LUCA
GeneTreeⁱ	ENSGT00930000150823
HOVERGENⁱ	HBG054346
InParanoidⁱ	Q9Y394
KOⁱ	K11165
PhylomeDBⁱ	Q9Y394
TreeFamⁱ	TF354276

Miscellaneous databases

GenomeRNAiⁱ	51635
Protein Ontology More...PROⁱ	PR:Q9Y394
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100612 Expressed in 232 organ(s), highest expression level in gastrocnemius
CleanExⁱ	HS_DHRS7
ExpressionAtlasⁱ	Q9Y394 baseline and differential
Genevisibleⁱ	Q9Y394 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036291 NAD(P)-bd_dom_sf IPR020904 Sc_DH/Rdtase_CS IPR002347 SDR_fam
Pfamⁱ	View protein in Pfam PF00106 adh_short, 1 hit
PRINTSⁱ	PR00081 GDHRDH PR00080 SDRFAMILY
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
PROSITEⁱ	View protein in PROSITE PS00061 ADH_SHORT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DHRS7_HUMAN
Accessionⁱ	Q9Y394Primary (citable) accession number: Q9Y394 Secondary accession number(s): B2R896, Q9UKU2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniProtKB - Q9Y394 (DHRS7_HUMAN)

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Dehydrogenase/reductase SDR family member 7

DHRS7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ