UniProtKB - Q9Y383 (LC7L2_HUMAN)
Protein
Putative RNA-binding protein Luc7-like 2
Gene
LUC7L2
Organism
Homo sapiens (Human)
Status
Functioni
May bind to RNA via its Arg/Ser-rich domain.
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- mRNA binding Source: GO_Central
- RNA binding Source: UniProtKB
GO - Biological processi
- mRNA splice site selection Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9Y383 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative RNA-binding protein Luc7-like 2 |
Gene namesi | Name:LUC7L2 ORF Names:CGI-59, CGI-74 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21608, LUC7L2 |
MIMi | 613056, gene |
neXtProti | NX_Q9Y383 |
VEuPathDBi | HostDB:ENSG00000146963.17 |
Subcellular locationi
Nucleus
- Nucleus speckle By similarity
- nucleoplasm By similarity
Note: Colocalizes with SCNM1 and SNRNP70 in nuclear speckles.By similarity
Nucleus
- nuclear speck Source: UniProtKB
- U1 snRNP Source: GO_Central
- U2-type prespliceosome Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 266 | K → R: Induces a decrease in lysyl-hydroxylation. Abolishes lysyl-hydroxylation; when associated with R-269. 1 Publication | 1 | |
Mutagenesisi | 269 | K → R: Induces a decrease in lysyl-hydroxylation. Abolishes lysyl-hydroxylation; when associated with R-266. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 51631 |
OpenTargetsi | ENSG00000146963 |
PharmGKBi | PA134873425 |
Miscellaneous databases
Pharosi | Q9Y383, Tdark |
Genetic variation databases
BioMutai | LUC7L2 |
DMDMi | 47116960 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000187282 | 1 – 392 | Putative RNA-binding protein Luc7-like 2Add BLAST | 392 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 18 | PhosphoserineCombined sources | 1 | |
Modified residuei | 266 | 5-hydroxylysine; by JMJD61 Publication | 1 | |
Modified residuei | 269 | 5-hydroxylysine; by JMJD61 Publication | 1 |
Keywords - PTMi
Hydroxylation, PhosphoproteinProteomic databases
EPDi | Q9Y383 |
jPOSTi | Q9Y383 |
MassIVEi | Q9Y383 |
PaxDbi | Q9Y383 |
PeptideAtlasi | Q9Y383 |
PRIDEi | Q9Y383 |
ProteomicsDBi | 6647 85982 [Q9Y383-1] 85983 [Q9Y383-2] |
PTM databases
iPTMneti | Q9Y383 |
MetOSitei | Q9Y383 |
PhosphoSitePlusi | Q9Y383 |
SwissPalmi | Q9Y383 |
Expressioni
Gene expression databases
Bgeei | ENSG00000146963, Expressed in left lobe of thyroid gland and 231 other tissues |
ExpressionAtlasi | Q9Y383, baseline and differential |
Genevisiblei | Q9Y383, HS |
Organism-specific databases
HPAi | ENSG00000146963, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with SCNM1.
By similarityBinary interactionsi
Hide detailsQ9Y383
GO - Molecular functioni
- enzyme binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119646, 215 interactors |
CORUMi | Q9Y383 |
DIPi | DIP-32513N |
IntActi | Q9Y383, 130 interactors |
MINTi | Q9Y383 |
STRINGi | 9606.ENSP00000347005 |
Miscellaneous databases
RNActi | Q9Y383, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 102 – 177 | Sequence analysisAdd BLAST | 76 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 239 – 388 | Arg/Ser-richAdd BLAST | 150 |
Sequence similaritiesi
Belongs to the Luc7 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0796, Eukaryota |
GeneTreei | ENSGT00950000183213 |
HOGENOMi | CLU_030397_3_0_1 |
InParanoidi | Q9Y383 |
PhylomeDBi | Q9Y383 |
TreeFami | TF317607 |
Family and domain databases
InterProi | View protein in InterPro IPR004882, Luc7-rel |
PANTHERi | PTHR12375, PTHR12375, 1 hit |
Pfami | View protein in Pfam PF03194, LUC7, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y383-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAQAQMRAM LDQLMGTSRD GDTTRQRIKF SDDRVCKSHL LNCCPHDVLS
60 70 80 90 100
GTRMDLGECL KVHDLALRAD YEIASKEQDF FFELDAMDHL QSFIADCDRR
110 120 130 140 150
TEVAKKRLAE TQEEISAEVA AKAERVHELN EEIGKLLAKV EQLGAEGNVE
160 170 180 190 200
ESQKVMDEVE KARAKKREAE EVYRNSMPAS SFQQQKLRVC EVCSAYLGLH
210 220 230 240 250
DNDRRLADHF GGKLHLGFIE IREKLEELKR VVAEKQEKRN QERLKRREER
260 270 280 290 300
EREEREKLRR SRSHSKNPKR SRSREHRRHR SRSMSRERKR RTRSKSREKR
310 320 330 340 350
HRHRSRSSSR SRSRSHQRSR HSSRDRSRER SKRRSSKERF RDQDLASCDR
360 370 380 390
DRSSRDRSPR DRDRKDKKRS YESANGRSED RRSSEEREAG EI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A6YYJ8 | A0A0A6YYJ8_HUMAN | Putative RNA-binding protein Luc7-l... | LUC7L2 | 458 | Annotation score: | ||
F8WEU3 | F8WEU3_HUMAN | Putative RNA-binding protein Luc7-l... | LUC7L2 | 83 | Annotation score: | ||
V9GZ75 | V9GZ75_HUMAN | Putative RNA-binding protein Luc7-l... | LUC7L2 | 54 | Annotation score: |
Sequence cautioni
The sequence AAD34069 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 | R → Q in BAA91737 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 389 – 390 | AG → QR in AAD34054 (PubMed:10810093).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034067 | 361 | D → E. Corresponds to variant dbSNP:rs3757435Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010217 | 1 – 21 | MSAQA…TSRDG → MPAYLNLQGSVRKAPHSPSR in isoform 2. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_044896 | 1 – 20 | MSAQA…GTSRD → MVIHSQLKKIQGASERM in isoform 3. 1 PublicationAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151817 mRNA Translation: AAD34054.1 AF151832 mRNA Translation: AAD34069.1 Frameshift. AK001476 mRNA Translation: BAA91713.1 AK001519 mRNA Translation: BAA91737.1 AK022895 mRNA Translation: BAB14297.1 AK298166 mRNA Translation: BAH12736.1 BC017163 mRNA Translation: AAH17163.1 BC042625 mRNA Translation: AAH42625.1 BC050708 mRNA Translation: AAH50708.1 BC056886 mRNA Translation: AAH56886.1 |
CCDSi | CCDS43656.1 [Q9Y383-1] CCDS59085.1 [Q9Y383-3] CCDS59510.1 [Q9Y383-2] |
RefSeqi | NP_001231514.1, NM_001244585.1 [Q9Y383-3] NP_001257572.1, NM_001270643.1 [Q9Y383-2] NP_057103.2, NM_016019.4 [Q9Y383-1] |
Genome annotation databases
Ensembli | ENST00000263545; ENSP00000263545; ENSG00000146963 [Q9Y383-3] ENST00000354926; ENSP00000347005; ENSG00000146963 [Q9Y383-1] ENST00000541170; ENSP00000441604; ENSG00000146963 [Q9Y383-3] ENST00000619796; ENSP00000483438; ENSG00000146963 [Q9Y383-2] |
GeneIDi | 51631 |
KEGGi | hsa:51631 |
UCSCi | uc003vux.5, human [Q9Y383-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151817 mRNA Translation: AAD34054.1 AF151832 mRNA Translation: AAD34069.1 Frameshift. AK001476 mRNA Translation: BAA91713.1 AK001519 mRNA Translation: BAA91737.1 AK022895 mRNA Translation: BAB14297.1 AK298166 mRNA Translation: BAH12736.1 BC017163 mRNA Translation: AAH17163.1 BC042625 mRNA Translation: AAH42625.1 BC050708 mRNA Translation: AAH50708.1 BC056886 mRNA Translation: AAH56886.1 |
CCDSi | CCDS43656.1 [Q9Y383-1] CCDS59085.1 [Q9Y383-3] CCDS59510.1 [Q9Y383-2] |
RefSeqi | NP_001231514.1, NM_001244585.1 [Q9Y383-3] NP_001257572.1, NM_001270643.1 [Q9Y383-2] NP_057103.2, NM_016019.4 [Q9Y383-1] |
3D structure databases
SMRi | Q9Y383 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119646, 215 interactors |
CORUMi | Q9Y383 |
DIPi | DIP-32513N |
IntActi | Q9Y383, 130 interactors |
MINTi | Q9Y383 |
STRINGi | 9606.ENSP00000347005 |
PTM databases
iPTMneti | Q9Y383 |
MetOSitei | Q9Y383 |
PhosphoSitePlusi | Q9Y383 |
SwissPalmi | Q9Y383 |
Genetic variation databases
BioMutai | LUC7L2 |
DMDMi | 47116960 |
Proteomic databases
EPDi | Q9Y383 |
jPOSTi | Q9Y383 |
MassIVEi | Q9Y383 |
PaxDbi | Q9Y383 |
PeptideAtlasi | Q9Y383 |
PRIDEi | Q9Y383 |
ProteomicsDBi | 6647 85982 [Q9Y383-1] 85983 [Q9Y383-2] |
Protocols and materials databases
Antibodypediai | 53629, 131 antibodies |
DNASUi | 51631 |
Genome annotation databases
Ensembli | ENST00000263545; ENSP00000263545; ENSG00000146963 [Q9Y383-3] ENST00000354926; ENSP00000347005; ENSG00000146963 [Q9Y383-1] ENST00000541170; ENSP00000441604; ENSG00000146963 [Q9Y383-3] ENST00000619796; ENSP00000483438; ENSG00000146963 [Q9Y383-2] |
GeneIDi | 51631 |
KEGGi | hsa:51631 |
UCSCi | uc003vux.5, human [Q9Y383-1] |
Organism-specific databases
CTDi | 51631 |
DisGeNETi | 51631 |
GeneCardsi | LUC7L2 |
HGNCi | HGNC:21608, LUC7L2 |
HPAi | ENSG00000146963, Low tissue specificity |
MIMi | 613056, gene |
neXtProti | NX_Q9Y383 |
OpenTargetsi | ENSG00000146963 |
PharmGKBi | PA134873425 |
VEuPathDBi | HostDB:ENSG00000146963.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0796, Eukaryota |
GeneTreei | ENSGT00950000183213 |
HOGENOMi | CLU_030397_3_0_1 |
InParanoidi | Q9Y383 |
PhylomeDBi | Q9Y383 |
TreeFami | TF317607 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y383 |
Miscellaneous databases
BioGRID-ORCSi | 51631, 82 hits in 856 CRISPR screens |
ChiTaRSi | LUC7L2, human |
GeneWikii | LUC7L2 |
GenomeRNAii | 51631 |
Pharosi | Q9Y383, Tdark |
PROi | PR:Q9Y383 |
RNActi | Q9Y383, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000146963, Expressed in left lobe of thyroid gland and 231 other tissues |
ExpressionAtlasi | Q9Y383, baseline and differential |
Genevisiblei | Q9Y383, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004882, Luc7-rel |
PANTHERi | PTHR12375, PTHR12375, 1 hit |
Pfami | View protein in Pfam PF03194, LUC7, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LC7L2_HUMAN | |
Accessioni | Q9Y383Primary (citable) accession number: Q9Y383 Secondary accession number(s): B7Z500 Q9UQN1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | May 10, 2004 | |
Last modified: | February 10, 2021 | |
This is version 176 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families