Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative RNA-binding protein Luc7-like 2

Gene

LUC7L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May bind to RNA via its Arg/Ser-rich domain.

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • mRNA binding Source: GO_Central
  • RNA binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA-binding protein Luc7-like 2
Gene namesi
Name:LUC7L2
ORF Names:CGI-59, CGI-74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000146963.17
HGNCiHGNC:21608 LUC7L2
MIMi613056 gene
neXtProtiNX_Q9Y383

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi266K → R: Induces a decrease in lysyl-hydroxylation. Abolishes lysyl-hydroxylation; when associated with R-269. 1 Publication1
Mutagenesisi269K → R: Induces a decrease in lysyl-hydroxylation. Abolishes lysyl-hydroxylation; when associated with R-266. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000146963
PharmGKBiPA134873425

Polymorphism and mutation databases

BioMutaiLUC7L2
DMDMi47116960

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001872821 – 392Putative RNA-binding protein Luc7-like 2Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei2665-hydroxylysine; by JMJD61 Publication1
Modified residuei2695-hydroxylysine; by JMJD61 Publication1

Keywords - PTMi

Hydroxylation, Phosphoprotein

Proteomic databases

EPDiQ9Y383
PaxDbiQ9Y383
PeptideAtlasiQ9Y383
PRIDEiQ9Y383
ProteomicsDBi85982
85983 [Q9Y383-2]

PTM databases

iPTMnetiQ9Y383
PhosphoSitePlusiQ9Y383
SwissPalmiQ9Y383

Miscellaneous databases

PMAP-CutDBiQ9Y383

Expressioni

Gene expression databases

BgeeiENSG00000146963 Expressed in 221 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_LUC7L2
ExpressionAtlasiQ9Y383 baseline and differential
GenevisibleiQ9Y383 HS

Organism-specific databases

HPAiHPA051631

Interactioni

Subunit structurei

Interacts with SCNM1.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119646, 178 interactors
CORUMiQ9Y383
DIPiDIP-32513N
IntActiQ9Y383, 67 interactors
MINTiQ9Y383
STRINGi9606.ENSP00000347005

Structurei

3D structure databases

ProteinModelPortaliQ9Y383
SMRiQ9Y383
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili102 – 177Sequence analysisAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi239 – 388Arg/Ser-richAdd BLAST150

Sequence similaritiesi

Belongs to the Luc7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0796 Eukaryota
COG5200 LUCA
GeneTreeiENSGT00730000110670
HOVERGENiHBG062167
InParanoidiQ9Y383
KOiK13212
OrthoDBiEOG091G0PSO
PhylomeDBiQ9Y383
TreeFamiTF317607

Family and domain databases

InterProiView protein in InterPro
IPR004882 Luc7-rel
PANTHERiPTHR12375 PTHR12375, 1 hit
PfamiView protein in Pfam
PF03194 LUC7, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y383-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAQAQMRAM LDQLMGTSRD GDTTRQRIKF SDDRVCKSHL LNCCPHDVLS
60 70 80 90 100
GTRMDLGECL KVHDLALRAD YEIASKEQDF FFELDAMDHL QSFIADCDRR
110 120 130 140 150
TEVAKKRLAE TQEEISAEVA AKAERVHELN EEIGKLLAKV EQLGAEGNVE
160 170 180 190 200
ESQKVMDEVE KARAKKREAE EVYRNSMPAS SFQQQKLRVC EVCSAYLGLH
210 220 230 240 250
DNDRRLADHF GGKLHLGFIE IREKLEELKR VVAEKQEKRN QERLKRREER
260 270 280 290 300
EREEREKLRR SRSHSKNPKR SRSREHRRHR SRSMSRERKR RTRSKSREKR
310 320 330 340 350
HRHRSRSSSR SRSRSHQRSR HSSRDRSRER SKRRSSKERF RDQDLASCDR
360 370 380 390
DRSSRDRSPR DRDRKDKKRS YESANGRSED RRSSEEREAG EI
Length:392
Mass (Da):46,514
Last modified:May 10, 2004 - v2
Checksum:i1C559CCE0F23F693
GO
Isoform 2 (identifier: Q9Y383-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MSAQAQMRAMLDQLMGTSRDG → MPAYLNLQGSVRKAPHSPSR

Note: No experimental confirmation available.
Show »
Length:391
Mass (Da):46,425
Checksum:i68FBCFE447A3E0E5
GO
Isoform 3 (identifier: Q9Y383-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MSAQAQMRAMLDQLMGTSRD → MVIHSQLKKIQGASERM

Note: No experimental confirmation available.
Show »
Length:389
Mass (Da):46,229
Checksum:iA58A74530C83E98E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YYJ8A0A0A6YYJ8_HUMAN
Putative RNA-binding protein Luc7-l...
LUC7L2
458Annotation score:
V9GZ75V9GZ75_HUMAN
Putative RNA-binding protein Luc7-l...
LUC7L2
54Annotation score:
F8WEU3F8WEU3_HUMAN
Putative RNA-binding protein Luc7-l...
LUC7L2
83Annotation score:

Sequence cautioni

The sequence AAD34069 differs from that shown. Reason: Frameshift at position 388.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27R → Q in BAA91737 (PubMed:14702039).Curated1
Sequence conflicti389 – 390AG → QR in AAD34054 (PubMed:10810093).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034067361D → E. Corresponds to variant dbSNP:rs3757435Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0102171 – 21MSAQA…TSRDG → MPAYLNLQGSVRKAPHSPSR in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0448961 – 20MSAQA…GTSRD → MVIHSQLKKIQGASERM in isoform 3. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151817 mRNA Translation: AAD34054.1
AF151832 mRNA Translation: AAD34069.1 Frameshift.
AK001476 mRNA Translation: BAA91713.1
AK001519 mRNA Translation: BAA91737.1
AK022895 mRNA Translation: BAB14297.1
AK298166 mRNA Translation: BAH12736.1
BC017163 mRNA Translation: AAH17163.1
BC042625 mRNA Translation: AAH42625.1
BC050708 mRNA Translation: AAH50708.1
BC056886 mRNA Translation: AAH56886.1
CCDSiCCDS43656.1 [Q9Y383-1]
CCDS59085.1 [Q9Y383-3]
CCDS59510.1 [Q9Y383-2]
RefSeqiNP_001231514.1, NM_001244585.1 [Q9Y383-3]
NP_001257572.1, NM_001270643.1 [Q9Y383-2]
NP_057103.2, NM_016019.4 [Q9Y383-1]
UniGeneiHs.731488

Genome annotation databases

EnsembliENST00000263545; ENSP00000263545; ENSG00000146963 [Q9Y383-3]
ENST00000354926; ENSP00000347005; ENSG00000146963 [Q9Y383-1]
ENST00000541170; ENSP00000441604; ENSG00000146963 [Q9Y383-3]
ENST00000619796; ENSP00000483438; ENSG00000146963 [Q9Y383-2]
GeneIDi51631
KEGGihsa:51631
UCSCiuc003vux.5 human [Q9Y383-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151817 mRNA Translation: AAD34054.1
AF151832 mRNA Translation: AAD34069.1 Frameshift.
AK001476 mRNA Translation: BAA91713.1
AK001519 mRNA Translation: BAA91737.1
AK022895 mRNA Translation: BAB14297.1
AK298166 mRNA Translation: BAH12736.1
BC017163 mRNA Translation: AAH17163.1
BC042625 mRNA Translation: AAH42625.1
BC050708 mRNA Translation: AAH50708.1
BC056886 mRNA Translation: AAH56886.1
CCDSiCCDS43656.1 [Q9Y383-1]
CCDS59085.1 [Q9Y383-3]
CCDS59510.1 [Q9Y383-2]
RefSeqiNP_001231514.1, NM_001244585.1 [Q9Y383-3]
NP_001257572.1, NM_001270643.1 [Q9Y383-2]
NP_057103.2, NM_016019.4 [Q9Y383-1]
UniGeneiHs.731488

3D structure databases

ProteinModelPortaliQ9Y383
SMRiQ9Y383
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119646, 178 interactors
CORUMiQ9Y383
DIPiDIP-32513N
IntActiQ9Y383, 67 interactors
MINTiQ9Y383
STRINGi9606.ENSP00000347005

PTM databases

iPTMnetiQ9Y383
PhosphoSitePlusiQ9Y383
SwissPalmiQ9Y383

Polymorphism and mutation databases

BioMutaiLUC7L2
DMDMi47116960

Proteomic databases

EPDiQ9Y383
PaxDbiQ9Y383
PeptideAtlasiQ9Y383
PRIDEiQ9Y383
ProteomicsDBi85982
85983 [Q9Y383-2]

Protocols and materials databases

DNASUi51631
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263545; ENSP00000263545; ENSG00000146963 [Q9Y383-3]
ENST00000354926; ENSP00000347005; ENSG00000146963 [Q9Y383-1]
ENST00000541170; ENSP00000441604; ENSG00000146963 [Q9Y383-3]
ENST00000619796; ENSP00000483438; ENSG00000146963 [Q9Y383-2]
GeneIDi51631
KEGGihsa:51631
UCSCiuc003vux.5 human [Q9Y383-1]

Organism-specific databases

CTDi51631
EuPathDBiHostDB:ENSG00000146963.17
GeneCardsiLUC7L2
HGNCiHGNC:21608 LUC7L2
HPAiHPA051631
MIMi613056 gene
neXtProtiNX_Q9Y383
OpenTargetsiENSG00000146963
PharmGKBiPA134873425
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0796 Eukaryota
COG5200 LUCA
GeneTreeiENSGT00730000110670
HOVERGENiHBG062167
InParanoidiQ9Y383
KOiK13212
OrthoDBiEOG091G0PSO
PhylomeDBiQ9Y383
TreeFamiTF317607

Miscellaneous databases

ChiTaRSiLUC7L2 human
GeneWikiiLUC7L2
GenomeRNAii51631
PMAP-CutDBiQ9Y383
PROiPR:Q9Y383
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146963 Expressed in 221 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_LUC7L2
ExpressionAtlasiQ9Y383 baseline and differential
GenevisibleiQ9Y383 HS

Family and domain databases

InterProiView protein in InterPro
IPR004882 Luc7-rel
PANTHERiPTHR12375 PTHR12375, 1 hit
PfamiView protein in Pfam
PF03194 LUC7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLC7L2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y383
Secondary accession number(s): B7Z500
, Q8IUP9, Q9NVL3, Q9NVN7, Q9UQN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 12, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again