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Protein

Calcium-binding protein 39

Gene

CAB39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.1 Publication

GO - Molecular functioni

  • kinase binding Source: BHF-UCL
  • protein kinase activator activity Source: UniProtKB
  • protein serine/threonine kinase activator activity Source: ParkinsonsUK-UCL
  • protein serine/threonine kinase activity Source: Ensembl

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 39
Alternative name(s):
MO25alpha
Protein Mo25
Gene namesi
Name:CAB39
Synonyms:MO25
ORF Names:CGI-66
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000135932.10
HGNCiHGNC:20292 CAB39
MIMi612174 gene
neXtProtiNX_Q9Y376

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi240R → A: Abolishes activation of STK11/LKB1; when associated with A-243. 1 Publication1
Mutagenesisi243F → A: Abolishes activation of STK11/LKB1; when associated with A-240. 1 Publication1

Organism-specific databases

DisGeNETi51719
OpenTargetsiENSG00000135932
PharmGKBiPA128394663

Chemistry databases

ChEMBLiCHEMBL3885534

Polymorphism and mutation databases

BioMutaiCAB39
DMDMi15214082

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002098241 – 341Calcium-binding protein 39Add BLAST341

Proteomic databases

EPDiQ9Y376
MaxQBiQ9Y376
PaxDbiQ9Y376
PeptideAtlasiQ9Y376
PRIDEiQ9Y376
ProteomicsDBi85981

PTM databases

iPTMnetiQ9Y376
PhosphoSitePlusiQ9Y376

Expressioni

Gene expression databases

BgeeiENSG00000135932 Expressed in 230 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_CAB39
ExpressionAtlasiQ9Y376 baseline and differential
GenevisibleiQ9Y376 HS

Organism-specific databases

HPAiCAB037112

Interactioni

Subunit structurei

Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119696, 39 interactors
CORUMiQ9Y376
DIPiDIP-31316N
IntActiQ9Y376, 16 interactors
MINTiQ9Y376
STRINGi9606.ENSP00000258418

Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y376
SMRiQ9Y376
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y376

Family & Domainsi

Sequence similaritiesi

Belongs to the Mo25 family.Curated

Phylogenomic databases

eggNOGiKOG1566 Eukaryota
ENOG410XP4S LUCA
GeneTreeiENSGT00390000004360
HOGENOMiHOG000234711
HOVERGENiHBG050757
InParanoidiQ9Y376
KOiK08272
OMAiKNYDRFF
OrthoDBiEOG091G0DTL
PhylomeDBiQ9Y376
TreeFamiTF314910

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013878 Mo25
PANTHERiPTHR10182 PTHR10182, 1 hit
PfamiView protein in Pfam
PF08569 Mo25, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y376-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPFPFGKSHK SPADIVKNLK ESMAVLEKQD ISDKKAEKAT EEVSKNLVAM
60 70 80 90 100
KEILYGTNEK EPQTEAVAQL AQELYNSGLL STLVADLQLI DFEGKKDVAQ
110 120 130 140 150
IFNNILRRQI GTRTPTVEYI CTQQNILFML LKGYESPEIA LNCGIMLREC
160 170 180 190 200
IRHEPLAKII LWSEQFYDFF RYVEMSTFDI ASDAFATFKD LLTRHKLLSA
210 220 230 240 250
EFLEQHYDRF FSEYEKLLHS ENYVTKRQSL KLLGELLLDR HNFTIMTKYI
260 270 280 290 300
SKPENLKLMM NLLRDKSRNI QFEAFHVFKV FVANPNKTQP ILDILLKNQA
310 320 330 340
KLIEFLSKFQ NDRTEDEQFN DEKTYLVKQI RDLKRPAQQE A
Length:341
Mass (Da):39,869
Last modified:November 1, 1999 - v1
Checksum:iEC710A528B6F9811
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0K1A0A087X0K1_HUMAN
Calcium-binding protein 39
CAB39
339Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151824 mRNA Translation: AAD34061.1
AF113536 mRNA Translation: AAF14873.1
AK292382 mRNA Translation: BAF85071.1
AK315692 mRNA Translation: BAG38055.1
CH471063 Genomic DNA Translation: EAW70932.1
BC020570 mRNA Translation: AAH20570.1
CCDSiCCDS2478.1
RefSeqiNP_001124321.1, NM_001130849.1
NP_001124322.1, NM_001130850.1
NP_057373.1, NM_016289.3
UniGeneiHs.603930

Genome annotation databases

EnsembliENST00000258418; ENSP00000258418; ENSG00000135932
ENST00000409788; ENSP00000386238; ENSG00000135932
ENST00000410084; ENSP00000386642; ENSG00000135932
GeneIDi51719
KEGGihsa:51719
UCSCiuc002vqx.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151824 mRNA Translation: AAD34061.1
AF113536 mRNA Translation: AAF14873.1
AK292382 mRNA Translation: BAF85071.1
AK315692 mRNA Translation: BAG38055.1
CH471063 Genomic DNA Translation: EAW70932.1
BC020570 mRNA Translation: AAH20570.1
CCDSiCCDS2478.1
RefSeqiNP_001124321.1, NM_001130849.1
NP_001124322.1, NM_001130850.1
NP_057373.1, NM_016289.3
UniGeneiHs.603930

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UPKX-ray1.85A1-341[»]
1UPLX-ray2.60A/B1-341[»]
2WTKX-ray2.65A/D1-341[»]
3GNIX-ray2.35A1-341[»]
4FZAX-ray3.15A11-334[»]
4FZDX-ray3.25A11-334[»]
4FZFX-ray3.64A11-334[»]
4NZWX-ray3.58A8-334[»]
4O27X-ray3.18A11-333[»]
ProteinModelPortaliQ9Y376
SMRiQ9Y376
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119696, 39 interactors
CORUMiQ9Y376
DIPiDIP-31316N
IntActiQ9Y376, 16 interactors
MINTiQ9Y376
STRINGi9606.ENSP00000258418

Chemistry databases

ChEMBLiCHEMBL3885534

PTM databases

iPTMnetiQ9Y376
PhosphoSitePlusiQ9Y376

Polymorphism and mutation databases

BioMutaiCAB39
DMDMi15214082

Proteomic databases

EPDiQ9Y376
MaxQBiQ9Y376
PaxDbiQ9Y376
PeptideAtlasiQ9Y376
PRIDEiQ9Y376
ProteomicsDBi85981

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258418; ENSP00000258418; ENSG00000135932
ENST00000409788; ENSP00000386238; ENSG00000135932
ENST00000410084; ENSP00000386642; ENSG00000135932
GeneIDi51719
KEGGihsa:51719
UCSCiuc002vqx.4 human

Organism-specific databases

CTDi51719
DisGeNETi51719
EuPathDBiHostDB:ENSG00000135932.10
GeneCardsiCAB39
HGNCiHGNC:20292 CAB39
HPAiCAB037112
MIMi612174 gene
neXtProtiNX_Q9Y376
OpenTargetsiENSG00000135932
PharmGKBiPA128394663
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1566 Eukaryota
ENOG410XP4S LUCA
GeneTreeiENSGT00390000004360
HOGENOMiHOG000234711
HOVERGENiHBG050757
InParanoidiQ9Y376
KOiK08272
OMAiKNYDRFF
OrthoDBiEOG091G0DTL
PhylomeDBiQ9Y376
TreeFamiTF314910

Enzyme and pathway databases

ReactomeiR-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiCAB39 human
EvolutionaryTraceiQ9Y376
GeneWikiiCAB39
GenomeRNAii51719
PROiPR:Q9Y376
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135932 Expressed in 230 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_CAB39
ExpressionAtlasiQ9Y376 baseline and differential
GenevisibleiQ9Y376 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013878 Mo25
PANTHERiPTHR10182 PTHR10182, 1 hit
PfamiView protein in Pfam
PF08569 Mo25, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAB39_HUMAN
AccessioniPrimary (citable) accession number: Q9Y376
Secondary accession number(s): A8K8L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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