UniProtKB - Q9Y376 (CAB39_HUMAN)
Protein
Calcium-binding protein 39
Gene
CAB39
Organism
Homo sapiens (Human)
Status
Functioni
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.1 Publication
GO - Molecular functioni
- kinase binding Source: BHF-UCL
- protein kinase activator activity Source: UniProtKB
- protein serine/threonine kinase activator activity Source: ParkinsonsUK-UCL
GO - Biological processi
- cell cycle arrest Source: Reactome
- cellular hypotonic response Source: ParkinsonsUK-UCL
- intracellular signal transduction Source: ParkinsonsUK-UCL
- negative regulation of potassium ion transmembrane transport Source: ParkinsonsUK-UCL
- negative regulation of potassium ion transmembrane transporter activity Source: ParkinsonsUK-UCL
- neutrophil degranulation Source: Reactome
- peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
- positive regulation of peptidyl-threonine phosphorylation Source: ParkinsonsUK-UCL
- positive regulation of protein serine/threonine kinase activity Source: ParkinsonsUK-UCL
- response to activity Source: Ensembl
- response to thyroid hormone Source: Ensembl
- signal transduction Source: ParkinsonsUK-UCL
Enzyme and pathway databases
PathwayCommonsi | Q9Y376 |
Reactomei | R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium-binding protein 39Alternative name(s): MO25alpha Protein Mo25 |
Gene namesi | Name:CAB39 Synonyms:MO25 ORF Names:CGI-66 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20292, CAB39 |
MIMi | 612174, gene |
neXtProti | NX_Q9Y376 |
VEuPathDBi | HostDB:ENSG00000135932.10 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Other locations
- ficolin-1-rich granule lumen Source: Reactome
- membrane Source: Ensembl
- secretory granule lumen Source: Reactome
- serine/threonine protein kinase complex Source: ParkinsonsUK-UCL
- Z disc Source: Ensembl
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 240 | R → A: Abolishes activation of STK11/LKB1; when associated with A-243. 1 Publication | 1 | |
Mutagenesisi | 243 | F → A: Abolishes activation of STK11/LKB1; when associated with A-240. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 51719 |
OpenTargetsi | ENSG00000135932 |
PharmGKBi | PA128394663 |
Miscellaneous databases
Pharosi | Q9Y376, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3885534 |
Genetic variation databases
BioMutai | CAB39 |
DMDMi | 15214082 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209824 | 1 – 341 | Calcium-binding protein 39Add BLAST | 341 |
Proteomic databases
EPDi | Q9Y376 |
jPOSTi | Q9Y376 |
MassIVEi | Q9Y376 |
MaxQBi | Q9Y376 |
PaxDbi | Q9Y376 |
PeptideAtlasi | Q9Y376 |
PRIDEi | Q9Y376 |
ProteomicsDBi | 85981 |
PTM databases
iPTMneti | Q9Y376 |
PhosphoSitePlusi | Q9Y376 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135932, Expressed in middle temporal gyrus and 241 other tissues |
ExpressionAtlasi | Q9Y376, baseline and differential |
Genevisiblei | Q9Y376, HS |
Organism-specific databases
HPAi | ENSG00000135932, Low tissue specificity |
Interactioni
Subunit structurei
Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.
1 PublicationBinary interactionsi
Hide detailsQ9Y376
GO - Molecular functioni
- kinase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 119696, 54 interactors |
CORUMi | Q9Y376 |
DIPi | DIP-31316N |
IntActi | Q9Y376, 24 interactors |
MINTi | Q9Y376 |
STRINGi | 9606.ENSP00000258418 |
Miscellaneous databases
RNActi | Q9Y376, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9Y376 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y376 |
Family & Domainsi
Sequence similaritiesi
Belongs to the Mo25 family.Curated
Phylogenomic databases
eggNOGi | KOG1566, Eukaryota |
GeneTreei | ENSGT00390000004360 |
HOGENOMi | CLU_035755_0_0_1 |
InParanoidi | Q9Y376 |
OMAi | FPHYIET |
OrthoDBi | 865327at2759 |
PhylomeDBi | Q9Y376 |
TreeFami | TF314910 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR013878, Mo25 |
PANTHERi | PTHR10182, PTHR10182, 1 hit |
Pfami | View protein in Pfam PF08569, Mo25, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9Y376-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPFPFGKSHK SPADIVKNLK ESMAVLEKQD ISDKKAEKAT EEVSKNLVAM
60 70 80 90 100
KEILYGTNEK EPQTEAVAQL AQELYNSGLL STLVADLQLI DFEGKKDVAQ
110 120 130 140 150
IFNNILRRQI GTRTPTVEYI CTQQNILFML LKGYESPEIA LNCGIMLREC
160 170 180 190 200
IRHEPLAKII LWSEQFYDFF RYVEMSTFDI ASDAFATFKD LLTRHKLLSA
210 220 230 240 250
EFLEQHYDRF FSEYEKLLHS ENYVTKRQSL KLLGELLLDR HNFTIMTKYI
260 270 280 290 300
SKPENLKLMM NLLRDKSRNI QFEAFHVFKV FVANPNKTQP ILDILLKNQA
310 320 330 340
KLIEFLSKFQ NDRTEDEQFN DEKTYLVKQI RDLKRPAQQE A
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087X0K1 | A0A087X0K1_HUMAN | Calcium-binding protein 39 | CAB39 | 339 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151824 mRNA Translation: AAD34061.1 AF113536 mRNA Translation: AAF14873.1 AK292382 mRNA Translation: BAF85071.1 AK315692 mRNA Translation: BAG38055.1 CH471063 Genomic DNA Translation: EAW70932.1 BC020570 mRNA Translation: AAH20570.1 |
CCDSi | CCDS2478.1 |
RefSeqi | NP_001124321.1, NM_001130849.1 NP_001124322.1, NM_001130850.1 NP_057373.1, NM_016289.3 |
Genome annotation databases
Ensembli | ENST00000258418; ENSP00000258418; ENSG00000135932 ENST00000409788; ENSP00000386238; ENSG00000135932 ENST00000410084; ENSP00000386642; ENSG00000135932 |
GeneIDi | 51719 |
KEGGi | hsa:51719 |
UCSCi | uc002vqx.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151824 mRNA Translation: AAD34061.1 AF113536 mRNA Translation: AAF14873.1 AK292382 mRNA Translation: BAF85071.1 AK315692 mRNA Translation: BAG38055.1 CH471063 Genomic DNA Translation: EAW70932.1 BC020570 mRNA Translation: AAH20570.1 |
CCDSi | CCDS2478.1 |
RefSeqi | NP_001124321.1, NM_001130849.1 NP_001124322.1, NM_001130850.1 NP_057373.1, NM_016289.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UPK | X-ray | 1.85 | A | 1-341 | [»] | |
1UPL | X-ray | 2.60 | A/B | 1-341 | [»] | |
2WTK | X-ray | 2.65 | A/D | 1-341 | [»] | |
3GNI | X-ray | 2.35 | A | 1-341 | [»] | |
4FZA | X-ray | 3.15 | A | 11-334 | [»] | |
4FZD | X-ray | 3.25 | A | 11-334 | [»] | |
4FZF | X-ray | 3.64 | A | 11-334 | [»] | |
4NZW | X-ray | 3.58 | A | 8-334 | [»] | |
4O27 | X-ray | 3.18 | A | 11-333 | [»] | |
SMRi | Q9Y376 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119696, 54 interactors |
CORUMi | Q9Y376 |
DIPi | DIP-31316N |
IntActi | Q9Y376, 24 interactors |
MINTi | Q9Y376 |
STRINGi | 9606.ENSP00000258418 |
Chemistry databases
ChEMBLi | CHEMBL3885534 |
PTM databases
iPTMneti | Q9Y376 |
PhosphoSitePlusi | Q9Y376 |
Genetic variation databases
BioMutai | CAB39 |
DMDMi | 15214082 |
Proteomic databases
EPDi | Q9Y376 |
jPOSTi | Q9Y376 |
MassIVEi | Q9Y376 |
MaxQBi | Q9Y376 |
PaxDbi | Q9Y376 |
PeptideAtlasi | Q9Y376 |
PRIDEi | Q9Y376 |
ProteomicsDBi | 85981 |
Protocols and materials databases
Antibodypediai | 34407, 141 antibodies |
Genome annotation databases
Ensembli | ENST00000258418; ENSP00000258418; ENSG00000135932 ENST00000409788; ENSP00000386238; ENSG00000135932 ENST00000410084; ENSP00000386642; ENSG00000135932 |
GeneIDi | 51719 |
KEGGi | hsa:51719 |
UCSCi | uc002vqx.4, human |
Organism-specific databases
CTDi | 51719 |
DisGeNETi | 51719 |
GeneCardsi | CAB39 |
HGNCi | HGNC:20292, CAB39 |
HPAi | ENSG00000135932, Low tissue specificity |
MIMi | 612174, gene |
neXtProti | NX_Q9Y376 |
OpenTargetsi | ENSG00000135932 |
PharmGKBi | PA128394663 |
VEuPathDBi | HostDB:ENSG00000135932.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1566, Eukaryota |
GeneTreei | ENSGT00390000004360 |
HOGENOMi | CLU_035755_0_0_1 |
InParanoidi | Q9Y376 |
OMAi | FPHYIET |
OrthoDBi | 865327at2759 |
PhylomeDBi | Q9Y376 |
TreeFami | TF314910 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y376 |
Reactomei | R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 51719, 190 hits in 1004 CRISPR screens |
ChiTaRSi | CAB39, human |
EvolutionaryTracei | Q9Y376 |
GeneWikii | CAB39 |
GenomeRNAii | 51719 |
Pharosi | Q9Y376, Tbio |
PROi | PR:Q9Y376 |
RNActi | Q9Y376, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135932, Expressed in middle temporal gyrus and 241 other tissues |
ExpressionAtlasi | Q9Y376, baseline and differential |
Genevisiblei | Q9Y376, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR013878, Mo25 |
PANTHERi | PTHR10182, PTHR10182, 1 hit |
Pfami | View protein in Pfam PF08569, Mo25, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAB39_HUMAN | |
Accessioni | Q9Y376Primary (citable) accession number: Q9Y376 Secondary accession number(s): A8K8L7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 14, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 176 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families