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UniProtKB - Q9Y371 (SHLB1_HUMAN)

Entry version 185 (07 Apr 2021)
Sequence version 1 (01 Nov 1999)
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Protein

Endophilin-B1

Gene

SH3GLB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity).By similarity5 Publications

Miscellaneous

HeLa cells lacking SH3GLB1 show dissociation of outer and inner mitochondrial membrane as well as abnormal mitochondrial morphology. Cells overexpressing SH3GLB1 lacking an N-terminal amphipathic helix show a similar phenotype.
SH3GLB1 binds liposomes and induces formation of tubules from liposomes. SH3GLB1 lacking the N-terminal amphipathic helix fails to induce liposome tubulation.

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated
Was originally thought to have lysophosphatidic acid acyltransferase activity, but by homology with SH3GL2/endophilin A1 is unlikely to have this activity.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Autophagy
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y371

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y371

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9Y371

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.34.1.4, the endophilin (endophilin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endophilin-B1
Alternative name(s):
Bax-interacting factor 1
Short name:
Bif-1
SH3 domain-containing GRB2-like protein B1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SH3GLB1
Synonyms:KIAA0491
ORF Names:CGI-61
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10833, SH3GLB1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609287, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y371

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000097033.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi8V → M: Abolishes interaction with BAX. 1 Publication1
Mutagenesisi145T → A: Reduced CDK5-mediated phosphorylation and impaired dimerization. 1 Publication1
Mutagenesisi145T → E: Spontaneous dimerization. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		51100

Open Targets

More...OpenTargetsi		ENSG00000097033

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35739

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y371, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SH3GLB1

Domain mapping of disease mutations (DMDM)

More...DMDMi		41018158

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001467531 – 365Endophilin-B1Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei145Phosphothreonine; by CDK51 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y371

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y371

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y371

PeptideAtlas

More...PeptideAtlasi		Q9Y371

PRoteomics IDEntifications database

More...PRIDEi		Q9Y371

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5734
85978 [Q9Y371-1]
85979 [Q9Y371-2]

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00006558

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y371

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y371

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000097033, Expressed in deltoid and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y371, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y371, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000097033, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, and heterodimer with SH3GLB2 (PubMed:11161816). Binds BAX; induction of apoptosis augments BAX binding (PubMed:11161816, PubMed:11259440). Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1 (By similarity).

Interacts with UVRAG; UVRAG bridges the interaction to BECN1 indicative for an association with the PI3K complex II (PI3KC3-C2) (PubMed:17891140, PubMed:20643123).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9Y371
With#Exp.IntAct
ABCG1 - isoform 6 [P45844-6]3EBI-2623095,EBI-25873349
ABHD12B - isoform 2 [Q7Z5M8-2]3EBI-2623095,EBI-21854797
ABHD5 [Q8WTS1]3EBI-2623095,EBI-2813554
ACSF2 [Q96CM8]3EBI-2623095,EBI-2876502
AGR2 [O95994]3EBI-2623095,EBI-712648
AGTRAP - isoform 2 [Q6RW13-2]3EBI-2623095,EBI-11522760
AK8 [Q96MA6]3EBI-2623095,EBI-8466265
AKR1C8P [Q5T2L2]3EBI-2623095,EBI-22006248
ALKBH3 - isoform 2 [Q96Q83-2]3EBI-2623095,EBI-9089544
ANKEF1 [Q9NU02]3EBI-2623095,EBI-8464238
APOA1 [P02647]3EBI-2623095,EBI-701692
APOA4 [P06727]3EBI-2623095,EBI-1222447
APOH [P02749]3EBI-2623095,EBI-2114682
ARFIP2 [P53365]6EBI-2623095,EBI-638194
ATF4 [P18848]3EBI-2623095,EBI-492498
ATG12 [C1IDX9]3EBI-2623095,EBI-25836940
ATP5MG [O75964]3EBI-2623095,EBI-1044001
BAAT [Q14032]3EBI-2623095,EBI-8994378
BSND [Q8WZ55]3EBI-2623095,EBI-7996695
C12orf4 [Q9NQ89]3EBI-2623095,EBI-11090973
C1D [Q13901]6EBI-2623095,EBI-3844053
C4orf33 [Q8N1A6]3EBI-2623095,EBI-10264911
CACFD1 [Q9UGQ2]3EBI-2623095,EBI-8652492
CAPN3 - isoform IV [P20807-4]3EBI-2623095,EBI-11532021
CCNC [P24863]3EBI-2623095,EBI-395261
CCNL1 - isoform 3 [Q9UK58-5]3EBI-2623095,EBI-25873837
CD4 [P01730]3EBI-2623095,EBI-353826
CETN3 [O15182]3EBI-2623095,EBI-712959
CIDEB [Q9UHD4]3EBI-2623095,EBI-7062247
CLTA - isoform Non-brain [P09496-2]3EBI-2623095,EBI-4401010
CMTM5 [Q96DZ9]3EBI-2623095,EBI-2548702
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-2623095,EBI-11522780
COQ8A [Q8NI60]11EBI-2623095,EBI-745535
CRCT1 [Q9UGL9]3EBI-2623095,EBI-713677
CYBRD1 [Q53TN4]3EBI-2623095,EBI-8637742
CYP2C8 [P10632]3EBI-2623095,EBI-2951522
DESI2 [Q9BSY9]3EBI-2623095,EBI-12878374
DHRS1 [Q96LJ7]3EBI-2623095,EBI-746300
DNAJC1 [Q96KC8]3EBI-2623095,EBI-296550
DOCK10 [Q96BY6]3EBI-2623095,EBI-748520
EIF3F [O00303]3EBI-2623095,EBI-711990
ELL2 [O00472]3EBI-2623095,EBI-395274
EPM2A - isoform 6 [O95278-6]3EBI-2623095,EBI-25836908
FAM114A2 [Q9NRY5]3EBI-2623095,EBI-10973142
FAM177A1 - isoform 2 [Q8N128-2]3EBI-2623095,EBI-12201693
FAM9A [Q8IZU1]3EBI-2623095,EBI-8468186
FASTKD2 [Q9NYY8]3EBI-2623095,EBI-1055752
FGA - isoform 2 [P02671-2]3EBI-2623095,EBI-9640259
FLT3LG - isoform 3 [P49771-3]3EBI-2623095,EBI-25872794
FUNDC1 [Q8IVP5]3EBI-2623095,EBI-3059266
FUT6 [Q6P7E6]3EBI-2623095,EBI-25872807
GADD45A [P24522]2EBI-2623095,EBI-448167
GHITM [Q9H3K2]3EBI-2623095,EBI-2868909
GIMAP1 [Q8WWP7]3EBI-2623095,EBI-11991950
GNB4 [Q9HAV0]3EBI-2623095,EBI-358539
GTF2H1 [P32780]3EBI-2623095,EBI-715539
H2AP [O75409]3EBI-2623095,EBI-6447217
H3-5 [Q6NXT2]3EBI-2623095,EBI-2868501
H3C12 [P68431]3EBI-2623095,EBI-79722
HCCS [P53701]3EBI-2623095,EBI-10763431
HTATIP2 - isoform 3 [Q9BUP3-3]3EBI-2623095,EBI-12937691
JMJD7 [P0C870]3EBI-2623095,EBI-9090173
JPT1 [Q9UK76]3EBI-2623095,EBI-720411
KCTD17 [Q8N5Z5]3EBI-2623095,EBI-743960
LGALS9C [Q6DKI2]3EBI-2623095,EBI-9088829
LY9 [Q5VYH9]3EBI-2623095,EBI-25872860
MAGEA8 [P43361]3EBI-2623095,EBI-10182930
MAGEB18 [Q96M61]3EBI-2623095,EBI-741835
MAL2 [Q969L2]6EBI-2623095,EBI-944295
MAOB [P27338]3EBI-2623095,EBI-3911344
MCFD2 [Q8NI22]3EBI-2623095,EBI-2689785
MIEF2 - isoform 3 [Q96C03-3]3EBI-2623095,EBI-11988931
MRI1 [Q9BV20]3EBI-2623095,EBI-747381
MUC15 [Q8N387]3EBI-2623095,EBI-17937277
MYC [P01106]3EBI-2623095,EBI-447544
NAA60 [Q9H7X0]3EBI-2623095,EBI-12260336
NAGK - isoform 2 [Q9UJ70-2]3EBI-2623095,EBI-11526455
NCBP2AS2 [Q69YL0]3EBI-2623095,EBI-10986258
NFYB [P25208]3EBI-2623095,EBI-389728
NPFF - isoform 2 [O15130-2]3EBI-2623095,EBI-25840002
PDE4A - isoform 4 [P27815-4]3EBI-2623095,EBI-12080840
PEDS1 [A5PLL7]3EBI-2623095,EBI-11337896
PITPNA [Q00169]3EBI-2623095,EBI-1042490
PITPNB [P48739]3EBI-2623095,EBI-1047143
PLIN3 [O60664]3EBI-2623095,EBI-725795
POLA2 [Q14181]3EBI-2623095,EBI-712752
PPBP [P02775]3EBI-2623095,EBI-718973
PPP1R21 - isoform 5 [Q6ZMI0-5]3EBI-2623095,EBI-25835994
PRPH2 [P23942]3EBI-2623095,EBI-25836834
PSMA1 [P25786]3EBI-2623095,EBI-359352
PTGDS [P41222]3EBI-2623095,EBI-948821
RABAC1 [Q9UI14]3EBI-2623095,EBI-712367
RBBP4 [Q09028]3EBI-2623095,EBI-620823
REEP6 - isoform 2 [Q96HR9-2]3EBI-2623095,EBI-14065960
RHEX [Q6ZWK4]3EBI-2623095,EBI-18304046
RIC8A - isoform 4 [Q9NPQ8-4]8EBI-2623095,EBI-9091816
RPS4X [P62701]3EBI-2623095,EBI-354303
SCAMP1 [O15126]3EBI-2623095,EBI-954338
SDF4 [Q9BRK5]3EBI-2623095,EBI-1389808
SERPINA3 [P01011]3EBI-2623095,EBI-296557
SFXN3 [A0A1P0AYU5]3EBI-2623095,EBI-14193895
SH3BP5L [Q7L8J4]3EBI-2623095,EBI-747389
itself8EBI-2623095,EBI-2623095
SH3GLB2 [Q9NR46]20EBI-2623095,EBI-749607
SHCBP1L [Q9BZQ2]3EBI-2623095,EBI-10818532
SIN3A [H3BQL7]3EBI-2623095,EBI-13384308
SMIM12 [Q96EX1]3EBI-2623095,EBI-2874543
SMIM5 [Q71RC9]3EBI-2623095,EBI-12334905
SMPD2 [O60906]3EBI-2623095,EBI-12828299
SNW1 [Q13573]3EBI-2623095,EBI-632715
SNX1 [Q13596]3EBI-2623095,EBI-2822329
SNX4 [O95219]3EBI-2623095,EBI-724909
SPART [Q8N0X7]3EBI-2623095,EBI-2643803
SPHK1 - isoform 2 [Q9NYA1-2]3EBI-2623095,EBI-12512419
SPIN2B [Q9BPZ2]3EBI-2623095,EBI-21726245
SUCNR1 [Q9BXA5]3EBI-2623095,EBI-17962797
SYNCRIP - isoform 4 [O60506-4]3EBI-2623095,EBI-11123832
SYNGR3 [O43761]6EBI-2623095,EBI-11321949
SYP [P08247]6EBI-2623095,EBI-9071725
SYT16 [Q17RD7]3EBI-2623095,EBI-10238936
TERF1 - isoform 2 [P54274-2]3EBI-2623095,EBI-711018
TFIP11 [Q9UBB9]7EBI-2623095,EBI-1105213
TGM1 [P22735]3EBI-2623095,EBI-2562368
TIGAR [Q9NQ88]3EBI-2623095,EBI-3920747
TIMM23 [O14925]3EBI-2623095,EBI-1047996
TMEM115 [Q12893]3EBI-2623095,EBI-8633987
TMEM171 - isoform 2 [Q8WVE6-2]3EBI-2623095,EBI-25874374
tmp_locus_54 [Q53NU3]3EBI-2623095,EBI-10242677
TOMM22 [Q9NS69]3EBI-2623095,EBI-1047508
TPD52 - isoform 2 [P55327-2]3EBI-2623095,EBI-12124194
TPD52L2 [O43399]3EBI-2623095,EBI-782604
TPD52L2 [Q6FGS1]3EBI-2623095,EBI-10327230
TRIM5 - isoform Gamma [Q9C035-3]3EBI-2623095,EBI-12840050
TRIM69 - isoform 2 [Q86WT6-2]3EBI-2623095,EBI-11525489
TTPA [P49638]3EBI-2623095,EBI-10210710
TTYH1 - isoform 4 [Q9H313-4]3EBI-2623095,EBI-17671298
TUBA1C [Q9BQE3]3EBI-2623095,EBI-1103245
UBE2G1 [P62253]3EBI-2623095,EBI-2340619
UVRAG [Q9P2Y5]11EBI-2623095,EBI-2952704
YIF1A [O95070]3EBI-2623095,EBI-2799703
ZBTB14 [O43829]3EBI-2623095,EBI-10176632
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-2623095,EBI-14104088
ZNF576 [Q9H609]6EBI-2623095,EBI-3921014
ZNF829 - isoform 3 [Q3KNS6-3]3EBI-2623095,EBI-18036029
Isoform 1 [Q9Y371-1]
With#Exp.IntAct
BAX [Q07812]2EBI-5291808,EBI-516580
SH3GLB1 - isoform 2 [Q9Y371-2]
With#Exp.IntAct
itself3EBI-5282812,EBI-5282812

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119289, 108 interactors

Database of interacting proteins

More...DIPi		DIP-41970N

Protein interaction database and analysis system

More...IntActi		Q9Y371, 186 interactors

Molecular INTeraction database

More...MINTi		Q9Y371

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000479919

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y371, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y371

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 261BARPROSITE-ProRule annotationAdd BLAST235
Domaini305 – 365SH3PROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 37Required for membrane binding1 PublicationAdd BLAST37
Regioni1 – 30Membrane-binding amphipathic helixAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili155 – 195Sequence analysisAdd BLAST41

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.1 Publication
The SH3 domain is required and sufficient for the interaction with UVRAG.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the endophilin family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3725, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155667

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_043817_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y371

Database of Orthologous Groups

More...OrthoDBi		803053at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y371

TreeFam database of animal gene trees

More...TreeFami		TF313281

Family and domain databases

Conserved Domains Database

More...CDDi		cd07616, BAR_Endophilin_B1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR004148, BAR_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR028503, SH3GLB1
IPR035695, SH3GLB1_BAR

The PANTHER Classification System

More...PANTHERi		PTHR14167:SF52, PTHR14167:SF52, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03114, BAR, 1 hit
PF14604, SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00721, BAR, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103657, SSF103657, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51021, BAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y371-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNIMDFNVKK LAADAGTFLS RAVQFTEEKL GQAEKTELDA HLENLLSKAE 
        60         70         80         90        100
CTKIWTEKIM KQTEVLLQPN PNARIEEFVY EKLDRKAPSR INNPELLGQY 
       110        120        130        140        150
MIDAGTEFGP GTAYGNALIK CGETQKRIGT ADRELIQTSA LNFLTPLRNF 
       160        170        180        190        200
IEGDYKTIAK ERKLLQNKRL DLDAAKTRLK KAKAAETRNS SEQELRITQS 
       210        220        230        240        250
EFDRQAEITR LLLEGISSTH AHHLRCLNDF VEAQMTYYAQ CYQYMLDLQK 
       260        270        280        290        300
QLGSFPSNYL SNNNQTSVTP VPSVLPNAIG SSAMASTSGL VITSPSNLSD 
       310        320        330        340        350
LKECSGSRKA RVLYDYDAAN STELSLLADE VITVFSVVGM DSDWLMGERG 
       360 
NQKGKVPITY LELLN
Length:365
Mass (Da):40,796
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42C2AEA57A0B350E
GO
Isoform 2 (identifier: Q9Y371-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-190: S → SQLNSARLEGDNIMIWAEEVTK

Show »
Length:386
Mass (Da):43,196
Checksum:i37C3D1F9338BCC5A
GO
Isoform 3 (identifier: Q9Y371-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Show »
Length:265
Mass (Da):29,318
Checksum:i200A8BB41A8ED20B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WW40A0A087WW40_HUMAN
Endophilin-B1
SH3GLB1
394Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF81225 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD88797 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0448951 – 100Missing in isoform 3. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_009276190S → SQLNSARLEGDNIMIWAEEV TK in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF257318 mRNA Translation: AAF81225.1 Different initiation.
AF350371 mRNA Translation: AAK27365.1
AF263293 mRNA Translation: AAF73017.1
AB007960 mRNA Translation: BAD88797.1 Different initiation.
AF151819 mRNA Translation: AAD34056.1
AK001954 mRNA Translation: BAA91999.1
AK303710 mRNA Translation: BAG64694.1
AL049597 Genomic DNA No translation available.
BC007455 mRNA Translation: AAH07455.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55612.1 [Q9Y371-2]
CCDS55613.1 [Q9Y371-3]
CCDS710.1 [Q9Y371-1]

NCBI Reference Sequences

More...RefSeqi		NP_001193580.1, NM_001206651.1
NP_001193581.1, NM_001206652.1 [Q9Y371-2]
NP_001193582.1, NM_001206653.1 [Q9Y371-3]
NP_057093.1, NM_016009.4 [Q9Y371-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370558; ENSP00000473267; ENSG00000097033 [Q9Y371-1]
ENST00000482504; ENSP00000418744; ENSG00000097033 [Q9Y371-2]
ENST00000535010; ENSP00000441355; ENSG00000097033 [Q9Y371-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51100

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51100

UCSC genome browser

More...UCSCi		uc001dlw.4, human [Q9Y371-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257318 mRNA Translation: AAF81225.1 Different initiation.
AF350371 mRNA Translation: AAK27365.1
AF263293 mRNA Translation: AAF73017.1
AB007960 mRNA Translation: BAD88797.1 Different initiation.
AF151819 mRNA Translation: AAD34056.1
AK001954 mRNA Translation: BAA91999.1
AK303710 mRNA Translation: BAG64694.1
AL049597 Genomic DNA No translation available.
BC007455 mRNA Translation: AAH07455.1
CCDSiCCDS55612.1 [Q9Y371-2]
CCDS55613.1 [Q9Y371-3]
CCDS710.1 [Q9Y371-1]
RefSeqiNP_001193580.1, NM_001206651.1
NP_001193581.1, NM_001206652.1 [Q9Y371-2]
NP_001193582.1, NM_001206653.1 [Q9Y371-3]
NP_057093.1, NM_016009.4 [Q9Y371-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6UP6electron microscopy9.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/V/W/a/b/c/d/e/f/g/h1-365[»]
6UPNelectron microscopy10.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/V/W/X/Y/a/b/c/d/e/f1-365[»]
SMRiQ9Y371
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119289, 108 interactors
DIPiDIP-41970N
IntActiQ9Y371, 186 interactors
MINTiQ9Y371
STRINGi9606.ENSP00000479919

Protein family/group databases

TCDBi8.A.34.1.4, the endophilin (endophilin) family

PTM databases

iPTMnetiQ9Y371
PhosphoSitePlusiQ9Y371

Genetic variation databases

BioMutaiSH3GLB1
DMDMi41018158

2D gel databases

REPRODUCTION-2DPAGEiIPI00006558

Proteomic databases

EPDiQ9Y371
jPOSTiQ9Y371
MassIVEiQ9Y371
PeptideAtlasiQ9Y371
PRIDEiQ9Y371
ProteomicsDBi5734
85978 [Q9Y371-1]
85979 [Q9Y371-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2824, 547 antibodies

The DNASU plasmid repository

More...DNASUi		51100

Genome annotation databases

EnsembliENST00000370558; ENSP00000473267; ENSG00000097033 [Q9Y371-1]
ENST00000482504; ENSP00000418744; ENSG00000097033 [Q9Y371-2]
ENST00000535010; ENSP00000441355; ENSG00000097033 [Q9Y371-3]
GeneIDi51100
KEGGihsa:51100
UCSCiuc001dlw.4, human [Q9Y371-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51100
DisGeNETi51100

GeneCards: human genes, protein and diseases

More...GeneCardsi		SH3GLB1
HGNCiHGNC:10833, SH3GLB1
HPAiENSG00000097033, Low tissue specificity
MIMi609287, gene
neXtProtiNX_Q9Y371
OpenTargetsiENSG00000097033
PharmGKBiPA35739
VEuPathDBiHostDB:ENSG00000097033.14

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3725, Eukaryota
GeneTreeiENSGT00940000155667
HOGENOMiCLU_043817_1_0_1
InParanoidiQ9Y371
OrthoDBi803053at2759
PhylomeDBiQ9Y371
TreeFamiTF313281

Enzyme and pathway databases

PathwayCommonsiQ9Y371
SignaLinkiQ9Y371
SIGNORiQ9Y371

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51100, 8 hits in 998 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SH3GLB1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SH3GLB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51100
PharosiQ9Y371, Tbio

Protein Ontology

More...PROi		PR:Q9Y371
RNActiQ9Y371, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000097033, Expressed in deltoid and 245 other tissues
ExpressionAtlasiQ9Y371, baseline and differential
GenevisibleiQ9Y371, HS

Family and domain databases

CDDicd07616, BAR_Endophilin_B1, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR004148, BAR_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR028503, SH3GLB1
IPR035695, SH3GLB1_BAR
PANTHERiPTHR14167:SF52, PTHR14167:SF52, 1 hit
PfamiView protein in Pfam
PF03114, BAR, 1 hit
PF14604, SH3_9, 1 hit
SMARTiView protein in SMART
SM00721, BAR, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF103657, SSF103657, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51021, BAR, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHLB1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y371
Secondary accession number(s): B4E182
, Q5H8U5, Q9H3Z0, Q9NR47, Q9NYA9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1999
Last modified: April 7, 2021
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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