UniProtKB - Q9Y371 (SHLB1_HUMAN)
Endophilin-B1
SH3GLB1
Functioni
Miscellaneous
Caution
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- identical protein binding Source: IntAct
- lipid binding Source: UniProtKB-KW
- protein homodimerization activity Source: HGNC-UCL
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- autophagic cell death Source: UniProtKB
- autophagy Source: UniProtKB-KW
- cellular response to amino acid starvation Source: UniProtKB
- cellular response to glucose starvation Source: UniProtKB
- membrane fission Source: UniProtKB
- positive regulation of autophagosome assembly Source: UniProtKB
- positive regulation of autophagy Source: UniProtKB
- positive regulation of membrane tubulation Source: UniProtKB
- positive regulation of protein-containing complex assembly Source: UniProtKB
- positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
- protein localization to vacuolar membrane Source: UniProtKB
- receptor catabolic process Source: UniProtKB
- regulation of cytokinesis Source: UniProtKB
- regulation of macroautophagy Source: ParkinsonsUK-UCL
- regulation of protein stability Source: ParkinsonsUK-UCL
Keywordsi
Biological process | Apoptosis, Autophagy |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9Y371 |
SignaLinki | Q9Y371 |
SIGNORi | Q9Y371 |
Protein family/group databases
TCDBi | 8.A.34.1.4, the endophilin (endophilin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Endophilin-B1Alternative name(s): Bax-interacting factor 1 Short name: Bif-1 SH3 domain-containing GRB2-like protein B1 |
Gene namesi | Name:SH3GLB1 Synonyms:KIAA0491 ORF Names:CGI-61 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10833, SH3GLB1 |
MIMi | 609287, gene |
neXtProti | NX_Q9Y371 |
VEuPathDBi | HostDB:ENSG00000097033.14 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 1 Publication; Peripheral membrane protein 1 Publication
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Peripheral membrane protein By similarity
Other locations
- Cytoplasm 1 Publication
- autophagosome membrane 1 Publication
- Midbody 1 Publication
Note: Association with the Golgi apparatus depends on the cell type (By similarity). Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes (PubMed:17891140).By similarity1 Publication
Cytosol
- cytosol Source: HPA
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB-SubCell
Other locations
- autophagosome membrane Source: UniProtKB
- cytoplasm Source: HGNC-UCL
- cytoplasmic vesicle Source: UniProtKB-KW
- midbody Source: UniProtKB
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion outer membranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 8 | V → M: Abolishes interaction with BAX. 1 Publication | 1 | |
Mutagenesisi | 145 | T → A: Reduced CDK5-mediated phosphorylation and impaired dimerization. 1 Publication | 1 | |
Mutagenesisi | 145 | T → E: Spontaneous dimerization. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 51100 |
OpenTargetsi | ENSG00000097033 |
PharmGKBi | PA35739 |
Miscellaneous databases
Pharosi | Q9Y371, Tbio |
Genetic variation databases
BioMutai | SH3GLB1 |
DMDMi | 41018158 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000146753 | 1 – 365 | Endophilin-B1Add BLAST | 365 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 145 | Phosphothreonine; by CDK51 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9Y371 |
jPOSTi | Q9Y371 |
MassIVEi | Q9Y371 |
PeptideAtlasi | Q9Y371 |
PRIDEi | Q9Y371 |
ProteomicsDBi | 5734 85978 [Q9Y371-1] 85979 [Q9Y371-2] |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00006558 |
PTM databases
iPTMneti | Q9Y371 |
PhosphoSitePlusi | Q9Y371 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000097033, Expressed in deltoid and 245 other tissues |
ExpressionAtlasi | Q9Y371, baseline and differential |
Genevisiblei | Q9Y371, HS |
Organism-specific databases
HPAi | ENSG00000097033, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer, and heterodimer with SH3GLB2 (PubMed:11161816). Binds BAX; induction of apoptosis augments BAX binding (PubMed:11161816, PubMed:11259440). Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1 (By similarity).
Interacts with UVRAG; UVRAG bridges the interaction to BECN1 indicative for an association with the PI3K complex II (PI3KC3-C2) (PubMed:17891140, PubMed:20643123).
By similarity3 PublicationsBinary interactionsi
Q9Y371
Isoform 1 [Q9Y371-1]
With | #Exp. | IntAct |
---|---|---|
BAX [Q07812] | 2 | EBI-5291808,EBI-516580 |
SH3GLB1 - isoform 2 [Q9Y371-2]
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-5282812,EBI-5282812 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- identical protein binding Source: IntAct
- protein homodimerization activity Source: HGNC-UCL
Protein-protein interaction databases
BioGRIDi | 119289, 98 interactors |
DIPi | DIP-41970N |
IntActi | Q9Y371, 186 interactors |
MINTi | Q9Y371 |
STRINGi | 9606.ENSP00000479919 |
Miscellaneous databases
RNActi | Q9Y371, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 261 | BARPROSITE-ProRule annotationAdd BLAST | 235 | |
Domaini | 305 – 365 | SH3PROSITE-ProRule annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 37 | Required for membrane binding1 PublicationAdd BLAST | 37 | |
Regioni | 1 – 30 | Membrane-binding amphipathic helixAdd BLAST | 30 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 155 – 195 | Sequence analysisAdd BLAST | 41 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, SH3 domainPhylogenomic databases
eggNOGi | KOG3725, Eukaryota |
GeneTreei | ENSGT00940000155667 |
HOGENOMi | CLU_043817_1_0_1 |
InParanoidi | Q9Y371 |
OrthoDBi | 803053at2759 |
PhylomeDBi | Q9Y371 |
TreeFami | TF313281 |
Family and domain databases
CDDi | cd07616, BAR_Endophilin_B1, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR004148, BAR_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR028503, SH3GLB1 IPR035695, SH3GLB1_BAR |
PANTHERi | PTHR14167:SF52, PTHR14167:SF52, 1 hit |
Pfami | View protein in Pfam PF03114, BAR, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00721, BAR, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51021, BAR, 1 hit PS50002, SH3, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNIMDFNVKK LAADAGTFLS RAVQFTEEKL GQAEKTELDA HLENLLSKAE
60 70 80 90 100
CTKIWTEKIM KQTEVLLQPN PNARIEEFVY EKLDRKAPSR INNPELLGQY
110 120 130 140 150
MIDAGTEFGP GTAYGNALIK CGETQKRIGT ADRELIQTSA LNFLTPLRNF
160 170 180 190 200
IEGDYKTIAK ERKLLQNKRL DLDAAKTRLK KAKAAETRNS SEQELRITQS
210 220 230 240 250
EFDRQAEITR LLLEGISSTH AHHLRCLNDF VEAQMTYYAQ CYQYMLDLQK
260 270 280 290 300
QLGSFPSNYL SNNNQTSVTP VPSVLPNAIG SSAMASTSGL VITSPSNLSD
310 320 330 340 350
LKECSGSRKA RVLYDYDAAN STELSLLADE VITVFSVVGM DSDWLMGERG
360
NQKGKVPITY LELLN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WW40 | A0A087WW40_HUMAN | Endophilin-B1 | SH3GLB1 | 394 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044895 | 1 – 100 | Missing in isoform 3. 1 PublicationAdd BLAST | 100 | |
Alternative sequenceiVSP_009276 | 190 | S → SQLNSARLEGDNIMIWAEEV TK in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF257318 mRNA Translation: AAF81225.1 Different initiation. AF350371 mRNA Translation: AAK27365.1 AF263293 mRNA Translation: AAF73017.1 AB007960 mRNA Translation: BAD88797.1 Different initiation. AF151819 mRNA Translation: AAD34056.1 AK001954 mRNA Translation: BAA91999.1 AK303710 mRNA Translation: BAG64694.1 AL049597 Genomic DNA No translation available. BC007455 mRNA Translation: AAH07455.1 |
CCDSi | CCDS55612.1 [Q9Y371-2] CCDS55613.1 [Q9Y371-3] CCDS710.1 [Q9Y371-1] |
RefSeqi | NP_001193580.1, NM_001206651.1 NP_001193581.1, NM_001206652.1 [Q9Y371-2] NP_001193582.1, NM_001206653.1 [Q9Y371-3] NP_057093.1, NM_016009.4 [Q9Y371-1] |
Genome annotation databases
Ensembli | ENST00000370558; ENSP00000473267; ENSG00000097033 [Q9Y371-1] ENST00000482504; ENSP00000418744; ENSG00000097033 [Q9Y371-2] ENST00000535010; ENSP00000441355; ENSG00000097033 [Q9Y371-3] |
GeneIDi | 51100 |
KEGGi | hsa:51100 |
UCSCi | uc001dlw.4, human [Q9Y371-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF257318 mRNA Translation: AAF81225.1 Different initiation. AF350371 mRNA Translation: AAK27365.1 AF263293 mRNA Translation: AAF73017.1 AB007960 mRNA Translation: BAD88797.1 Different initiation. AF151819 mRNA Translation: AAD34056.1 AK001954 mRNA Translation: BAA91999.1 AK303710 mRNA Translation: BAG64694.1 AL049597 Genomic DNA No translation available. BC007455 mRNA Translation: AAH07455.1 |
CCDSi | CCDS55612.1 [Q9Y371-2] CCDS55613.1 [Q9Y371-3] CCDS710.1 [Q9Y371-1] |
RefSeqi | NP_001193580.1, NM_001206651.1 NP_001193581.1, NM_001206652.1 [Q9Y371-2] NP_001193582.1, NM_001206653.1 [Q9Y371-3] NP_057093.1, NM_016009.4 [Q9Y371-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6UP6 | electron microscopy | 9.00 | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/V/W/a/b/c/d/e/f/g/h | 1-365 | [»] | |
6UPN | electron microscopy | 10.00 | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/V/W/X/Y/a/b/c/d/e/f | 1-365 | [»] | |
SMRi | Q9Y371 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119289, 98 interactors |
DIPi | DIP-41970N |
IntActi | Q9Y371, 186 interactors |
MINTi | Q9Y371 |
STRINGi | 9606.ENSP00000479919 |
Protein family/group databases
TCDBi | 8.A.34.1.4, the endophilin (endophilin) family |
PTM databases
iPTMneti | Q9Y371 |
PhosphoSitePlusi | Q9Y371 |
Genetic variation databases
BioMutai | SH3GLB1 |
DMDMi | 41018158 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00006558 |
Proteomic databases
EPDi | Q9Y371 |
jPOSTi | Q9Y371 |
MassIVEi | Q9Y371 |
PeptideAtlasi | Q9Y371 |
PRIDEi | Q9Y371 |
ProteomicsDBi | 5734 85978 [Q9Y371-1] 85979 [Q9Y371-2] |
Protocols and materials databases
Antibodypediai | 2824, 539 antibodies |
DNASUi | 51100 |
Genome annotation databases
Ensembli | ENST00000370558; ENSP00000473267; ENSG00000097033 [Q9Y371-1] ENST00000482504; ENSP00000418744; ENSG00000097033 [Q9Y371-2] ENST00000535010; ENSP00000441355; ENSG00000097033 [Q9Y371-3] |
GeneIDi | 51100 |
KEGGi | hsa:51100 |
UCSCi | uc001dlw.4, human [Q9Y371-1] |
Organism-specific databases
CTDi | 51100 |
DisGeNETi | 51100 |
GeneCardsi | SH3GLB1 |
HGNCi | HGNC:10833, SH3GLB1 |
HPAi | ENSG00000097033, Low tissue specificity |
MIMi | 609287, gene |
neXtProti | NX_Q9Y371 |
OpenTargetsi | ENSG00000097033 |
PharmGKBi | PA35739 |
VEuPathDBi | HostDB:ENSG00000097033.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3725, Eukaryota |
GeneTreei | ENSGT00940000155667 |
HOGENOMi | CLU_043817_1_0_1 |
InParanoidi | Q9Y371 |
OrthoDBi | 803053at2759 |
PhylomeDBi | Q9Y371 |
TreeFami | TF313281 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y371 |
SignaLinki | Q9Y371 |
SIGNORi | Q9Y371 |
Miscellaneous databases
BioGRID-ORCSi | 51100, 7 hits in 878 CRISPR screens |
ChiTaRSi | SH3GLB1, human |
GeneWikii | SH3GLB1 |
GenomeRNAii | 51100 |
Pharosi | Q9Y371, Tbio |
PROi | PR:Q9Y371 |
RNActi | Q9Y371, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000097033, Expressed in deltoid and 245 other tissues |
ExpressionAtlasi | Q9Y371, baseline and differential |
Genevisiblei | Q9Y371, HS |
Family and domain databases
CDDi | cd07616, BAR_Endophilin_B1, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR004148, BAR_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR028503, SH3GLB1 IPR035695, SH3GLB1_BAR |
PANTHERi | PTHR14167:SF52, PTHR14167:SF52, 1 hit |
Pfami | View protein in Pfam PF03114, BAR, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00721, BAR, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51021, BAR, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SHLB1_HUMAN | |
Accessioni | Q9Y371Primary (citable) accession number: Q9Y371 Secondary accession number(s): B4E182 Q9NYA9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM