SLC6A5

Functionⁱ

Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses.3 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	206	Sodium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	208	Sodium 2; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	209	Sodium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	213	Sodium 2By similarity	1
Metal bindingⁱ	477	Sodium 2By similarity	1
Metal bindingⁱ	509	Sodium 2By similarity	1
Metal bindingⁱ	574	Sodium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	577	Sodium 1By similarity	1

GO - Molecular functionⁱ

glycine:sodium symporter activity
Source: FlyBase
Inferred from direct assayⁱ
- 16751771
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chemical synaptic transmission
Source: ProtInc
Traceable author statementⁱ
- 9845349
glycine import across plasma membrane
Source: FlyBase
Inferred from direct assayⁱ
- 16751771
synaptic transmission, glycinergic
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 16751771

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Neurotransmitter transport, Symport, Transport
Ligand	Metal-binding, Sodium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters R-HSA-5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3)

Reactomeⁱ

R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3)

Protein family/group databases

TCDBⁱ	2.A.22.2.10 the neurotransmitter:sodium symporter (nss) family

TCDBⁱ

2.A.22.2.10 the neurotransmitter:sodium symporter (nss) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium- and chloride-dependent glycine transporter 2 Short name: GlyT-2 Short name: GlyT2 Alternative name(s): Solute carrier family 6 member 5
Gene namesⁱ	Name:SLC6A5 Synonyms:GLYT2, NET1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000165970.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11051 SLC6A5
MIMⁱ	604159 gene
neXtProtⁱ	NX_Q9Y345

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 199	CytoplasmicSequence analysisAdd BLAST	199
Transmembraneⁱ	200 – 220	Helical; Name=1Sequence analysisAdd BLAST	21
Transmembraneⁱ	228 – 247	Helical; Name=2Sequence analysisAdd BLAST	20
Transmembraneⁱ	271 – 291	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	292 – 393	ExtracellularSequence analysisAdd BLAST	102
Transmembraneⁱ	394 – 412	Helical; Name=4Sequence analysisAdd BLAST	19
Transmembraneⁱ	421 – 438	Helical; Name=5Sequence analysisAdd BLAST	18
Transmembraneⁱ	474 – 491	Helical; Name=6Sequence analysisAdd BLAST	18
Transmembraneⁱ	503 – 524	Helical; Name=7Sequence analysisAdd BLAST	22
Transmembraneⁱ	557 – 576	Helical; Name=8Sequence analysisAdd BLAST	20
Transmembraneⁱ	604 – 622	Helical; Name=9Sequence analysisAdd BLAST	19
Transmembraneⁱ	638 – 658	Helical; Name=10Sequence analysisAdd BLAST	21
Transmembraneⁱ	679 – 698	Helical; Name=11Sequence analysisAdd BLAST	20
Transmembraneⁱ	717 – 735	Helical; Name=12Sequence analysisAdd BLAST	19
Topological domainⁱ	736 – 797	CytoplasmicSequence analysisAdd BLAST	62

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hyperekplexia 3 (HKPX3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA neurologic disorder characterized by neonatal hypertonia, an exaggerated startle response to tactile or acoustic stimuli, and life-threatening neonatal apnea episodes. Notably, in some cases, symptoms resolved in the first year of life.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_044168	306	L → V in HKPX3; compound heterozygote with S-509; impairment of glycine transport when coexpressed with S-509 in vitro. 1 PublicationCorresponds to variant dbSNP:rs121908496EnsemblClinVar.	1
Natural variantⁱVAR_044169	425	T → M in HKPX3; no effect on subcellular location; impairs glycine transport. 1 PublicationCorresponds to variant dbSNP:rs121908498EnsemblClinVar.	1
Natural variantⁱVAR_044171	482	W → C in HKPX3; no effect on subcellular location; impairs glycine transport. 1 Publication	1
Natural variantⁱVAR_044172	491	Y → C in HKPX3; no effect on subcellular location; impairs glycine transport. 1 PublicationCorresponds to variant dbSNP:rs121908494EnsemblClinVar.	1
Natural variantⁱVAR_044174	509	N → S in HKPX3; compound heterozygote with V-306; no effect on subcellular location; impairs glycine transport. 1 PublicationCorresponds to variant dbSNP:rs121908497EnsemblClinVar.	1
Natural variantⁱVAR_044175	510	S → R in HKPX3; results in the formation of large aggregates in the cytoplasm; impairs glycine transport. 1 PublicationCorresponds to variant dbSNP:rs281864926EnsemblClinVar.	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9152
GeneReviewsⁱ	SLC6A5
MalaCards human disease database More...MalaCardsⁱ	SLC6A5
MIMⁱ	614618 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000165970
Orphanetⁱ	3197 Hereditary hyperekplexia
PharmGKBⁱ	PA35911

Chemistry databases

ChEMBLⁱ	CHEMBL3060
Drug and drug target database More...DrugBankⁱ	DB00145 Glycine
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	936

Polymorphism and mutation databases

BioMutaⁱ	SLC6A5
DMDMⁱ	296452967

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000214762	1 – 797	Sodium- and chloride-dependent glycine transporter 2Add BLAST		797

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	56	PhosphoserineBy similarity	1
Modified residueⁱ	57	PhosphothreonineBy similarity	1
Modified residueⁱ	84	PhosphoserineBy similarity	1
Disulfide bondⁱ	311 ↔ 320	By similarity
Glycosylationⁱ	343	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	353	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	358	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	364	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9Y345
PeptideAtlas More...PeptideAtlasⁱ	Q9Y345
PRIDEⁱ	Q9Y345
ProteomicsDBⁱ	85975

PTM databases

iPTMnetⁱ	Q9Y345
PhosphoSitePlusⁱ	Q9Y345

Expressionⁱ

Tissue specificityⁱ

Expressed in medulla, and to a lesser extent in spinal cord and cerebellum.

Gene expression databases

Bgeeⁱ	ENSG00000165970 Expressed in 25 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_NET1 HS_SLC6A5
ExpressionAtlasⁱ	Q9Y345 baseline and differential
Genevisibleⁱ	Q9Y345 HS

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	114599, 13 interactors
STRINGⁱ	9606.ENSP00000434364

Chemistry databases

BindingDBⁱ

Q9Y345

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y345
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A5 subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3659 Eukaryota COG0733 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118857
HOGENOMⁱ	HOG000116406
HOVERGENⁱ	HBG071421
InParanoidⁱ	Q9Y345
KEGG Orthology (KO) More...KOⁱ	K05038
OMAⁱ	VIWIPIM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08PX
PhylomeDBⁱ	Q9Y345
TreeFamⁱ	TF343812

Family and domain databases

InterProⁱ	View protein in InterPro IPR000175 Na/ntran_symport IPR037272 SNS_sf
PANTHERⁱ	PTHR11616 PTHR11616, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00209 SNF, 1 hit
PRINTSⁱ	PR00176 NANEUSMPORT
SUPFAMⁱ	SSF161070 SSF161070, 2 hits
PROSITEⁱ	View protein in PROSITE PS00610 NA_NEUROTRAN_SYMP_1, 1 hit PS00754 NA_NEUROTRAN_SYMP_2, 1 hit PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9Y345-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDCSAPKEMN KLPANSPEAA AAQGHPDGPC APRTSPEQEL PAAAAPPPPR 
        60         70         80         90        100
VPRSASTGAQ TFQSADARAC EAERPGVGSC KLSSPRAQAA SAALRDLREA 
       110        120        130        140        150
QGAQASPPPG SSGPGNALHC KIPFLRGPEG DANVSVGKGT LERNNTPVVG 
       160        170        180        190        200
WVNMSQSTVV LATDGITSVL PGSVATVATQ EDEQGDENKA RGNWSSKLDF 
       210        220        230        240        250
ILSMVGYAVG LGNVWRFPYL AFQNGGGAFL IPYLMMLALA GLPIFFLEVS 
       260        270        280        290        300
LGQFASQGPV SVWKAIPALQ GCGIAMLIIS VLIAIYYNVI ICYTLFYLFA 
       310        320        330        340        350
SFVSVLPWGS CNNPWNTPEC KDKTKLLLDS CVISDHPKIQ IKNSTFCMTA 
       360        370        380        390        400
YPNVTMVNFT SQANKTFVSG SEEYFKYFVL KISAGIEYPG EIRWPLALCL 
       410        420        430        440        450
FLAWVIVYAS LAKGIKTSGK VVYFTATFPY VVLVILLIRG VTLPGAGAGI 
       460        470        480        490        500
WYFITPKWEK LTDATVWKDA ATQIFFSLSA AWGGLITLSS YNKFHNNCYR 
       510        520        530        540        550
DTLIVTCTNS ATSIFAGFVI FSVIGFMANE RKVNIENVAD QGPGIAFVVY 
       560        570        580        590        600
PEALTRLPLS PFWAIIFFLM LLTLGLDTMF ATIETIVTSI SDEFPKYLRT 
       610        620        630        640        650
HKPVFTLGCC ICFFIMGFPM ITQGGIYMFQ LVDTYAASYA LVIIAIFELV 
       660        670        680        690        700
GISYVYGLQR FCEDIEMMIG FQPNIFWKVC WAFVTPTILT FILCFSFYQW 
       710        720        730        740        750
EPMTYGSYRY PNWSMVLGWL MLACSVIWIP IMFVIKMHLA PGRFIERLKL 
       760        770        780        790 
VCSPQPDWGP FLAQHRGERY KNMIDPLGTS SLGLKLPVKD LELGTQC

Length:797

Mass (Da):87,434

Last modified:May 18, 2010 - v3

Checksum:ⁱ47D8A9B179896CE0

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	J3KNC4	J3KNC4_HUMAN		Sodium- and chloride-dependent glyc... Sodium- and chloride-dependent glycine transporter 2	SLC6A5	187	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	24	G → S in AAD27892 (PubMed:10381548).Curated	1
Sequence conflictⁱ	155	S → G in AAD27892 (PubMed:10381548).Curated	1
Sequence conflictⁱ	188	N → D in AAD27892 (PubMed:10381548).Curated	1
Sequence conflictⁱ	362	Q → L in AAD27892 (PubMed:10381548).Curated	1
Sequence conflictⁱ	582	T → S in AAD27892 (PubMed:10381548).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_044163	89	A → E No effect on subcellular location; no effect on glycine transport. 1 PublicationCorresponds to variant dbSNP:rs61736602EnsemblClinVar.	1
Natural variantⁱVAR_044164	102	G → S1 PublicationCorresponds to variant dbSNP:rs1443547EnsemblClinVar.	1
Natural variantⁱVAR_044165	124	F → S5 PublicationsCorresponds to variant dbSNP:rs1443548EnsemblClinVar.	1
Natural variantⁱVAR_044166	132	A → G. Corresponds to variant dbSNP:rs34243519EnsemblClinVar.	1
Natural variantⁱVAR_044167	162	A → G5 PublicationsCorresponds to variant dbSNP:rs1443549Ensembl.	1
Natural variantⁱVAR_011591	184	Q → R1 Publication	1
Natural variantⁱVAR_044168	306	L → V in HKPX3; compound heterozygote with S-509; impairment of glycine transport when coexpressed with S-509 in vitro. 1 PublicationCorresponds to variant dbSNP:rs121908496EnsemblClinVar.	1
Natural variantⁱVAR_044169	425	T → M in HKPX3; no effect on subcellular location; impairs glycine transport. 1 PublicationCorresponds to variant dbSNP:rs121908498EnsemblClinVar.	1
Natural variantⁱVAR_044170	457	K → N. Corresponds to variant dbSNP:rs3740870EnsemblClinVar.	1
Natural variantⁱVAR_011592	463	D → N1 PublicationCorresponds to variant dbSNP:rs1805091EnsemblClinVar.	1
Natural variantⁱVAR_044171	482	W → C in HKPX3; no effect on subcellular location; impairs glycine transport. 1 Publication	1
Natural variantⁱVAR_044172	491	Y → C in HKPX3; no effect on subcellular location; impairs glycine transport. 1 PublicationCorresponds to variant dbSNP:rs121908494EnsemblClinVar.	1
Natural variantⁱVAR_044173	499	Y → F. Corresponds to variant dbSNP:rs7944684EnsemblClinVar.	1
Natural variantⁱVAR_044174	509	N → S in HKPX3; compound heterozygote with V-306; no effect on subcellular location; impairs glycine transport. 1 PublicationCorresponds to variant dbSNP:rs121908497EnsemblClinVar.	1
Natural variantⁱVAR_044175	510	S → R in HKPX3; results in the formation of large aggregates in the cytoplasm; impairs glycine transport. 1 PublicationCorresponds to variant dbSNP:rs281864926EnsemblClinVar.	1
Natural variantⁱVAR_036160	632	V → E in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_011593	751	V → A1 Publication	1
Natural variantⁱVAR_044176	767	G → R. Corresponds to variant dbSNP:rs16906628EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF085412 mRNA Translation: AAC95145.1 AF142501 mRNA Translation: AAD27892.1 AF352733 mRNA Translation: AAK29670.1 AF117999 mRNA Translation: AAK12641.1 AC090707 Genomic DNA No translation available. BC096319 mRNA Translation: AAH96319.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7854.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001305298.1, NM_001318369.1 NP_004202.3, NM_004211.4
UniGeneⁱ	Hs.136557

Genome annotation databases

Ensemblⁱ	ENST00000525748; ENSP00000434364; ENSG00000165970
GeneIDⁱ	9152
KEGGⁱ	hsa:9152
UCSC genome browser More...UCSCⁱ	uc001mqd.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y345	Sodium- and chloride-dependent glycine transporter 2		MOUSE		799	UniRef90_Q9Y345
Sodium- and chloride-dependent glycine transporter 2		RAT		799
Transporter		MACFA		957
Transporter		Enhydra lutris kenyoni		829
Transporter		MACMU		803
+152

Protein	Similar proteins		Species	Score	Length	Source
Q9Y345	Sodium- and chloride-dependent glycine transporter 2		MOUSE		799	UniRef50_Q9Y345
Sodium- and chloride-dependent glycine transporter 2		RAT		799
Transporter		MACFA		957
Transporter		Enhydra lutris kenyoni		829
Transporter		MACMU		803
+271

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF085412 mRNA Translation: AAC95145.1 AF142501 mRNA Translation: AAD27892.1 AF352733 mRNA Translation: AAK29670.1 AF117999 mRNA Translation: AAK12641.1 AC090707 Genomic DNA No translation available. BC096319 mRNA Translation: AAH96319.1
CCDSⁱ	CCDS7854.1
RefSeqⁱ	NP_001305298.1, NM_001318369.1 NP_004202.3, NM_004211.4
UniGeneⁱ	Hs.136557

3D structure databases

ProteinModelPortalⁱ	Q9Y345
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114599, 13 interactors
STRINGⁱ	9606.ENSP00000434364

Chemistry databases

BindingDBⁱ	Q9Y345
ChEMBLⁱ	CHEMBL3060
DrugBankⁱ	DB00145 Glycine
GuidetoPHARMACOLOGYⁱ	936

Protein family/group databases

TCDBⁱ	2.A.22.2.10 the neurotransmitter:sodium symporter (nss) family

TCDBⁱ

2.A.22.2.10 the neurotransmitter:sodium symporter (nss) family

PTM databases

iPTMnetⁱ	Q9Y345
PhosphoSitePlusⁱ	Q9Y345

Polymorphism and mutation databases

BioMutaⁱ	SLC6A5
DMDMⁱ	296452967

Proteomic databases

PaxDbⁱ	Q9Y345
PeptideAtlasⁱ	Q9Y345
PRIDEⁱ	Q9Y345
ProteomicsDBⁱ	85975

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000525748; ENSP00000434364; ENSG00000165970
GeneIDⁱ	9152
KEGGⁱ	hsa:9152
UCSCⁱ	uc001mqd.4 human

Organism-specific databases

CTDⁱ	9152
DisGeNETⁱ	9152
EuPathDBⁱ	HostDB:ENSG00000165970.11
GeneCardsⁱ	SLC6A5
GeneReviewsⁱ	SLC6A5
H-InvDBⁱ	HIX0035860
HGNCⁱ	HGNC:11051 SLC6A5
MalaCardsⁱ	SLC6A5
MIMⁱ	604159 gene 614618 phenotype
neXtProtⁱ	NX_Q9Y345
OpenTargetsⁱ	ENSG00000165970
Orphanetⁱ	3197 Hereditary hyperekplexia
PharmGKBⁱ	PA35911
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3659 Eukaryota COG0733 LUCA
GeneTreeⁱ	ENSGT00760000118857
HOGENOMⁱ	HOG000116406
HOVERGENⁱ	HBG071421
InParanoidⁱ	Q9Y345
KOⁱ	K05038
OMAⁱ	VIWIPIM
OrthoDBⁱ	EOG091G08PX
PhylomeDBⁱ	Q9Y345
TreeFamⁱ	TF343812

Enzyme and pathway databases

Reactomeⁱ	R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters R-HSA-5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3)

Reactomeⁱ

R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3)

Miscellaneous databases

GeneWikiⁱ	Glycine_transporter_2
GenomeRNAiⁱ	9152
Protein Ontology More...PROⁱ	PR:Q9Y345
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000165970 Expressed in 25 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_NET1 HS_SLC6A5
ExpressionAtlasⁱ	Q9Y345 baseline and differential
Genevisibleⁱ	Q9Y345 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000175 Na/ntran_symport IPR037272 SNS_sf
PANTHERⁱ	PTHR11616 PTHR11616, 1 hit
Pfamⁱ	View protein in Pfam PF00209 SNF, 1 hit
PRINTSⁱ	PR00176 NANEUSMPORT
SUPFAMⁱ	SSF161070 SSF161070, 2 hits
PROSITEⁱ	View protein in PROSITE PS00610 NA_NEUROTRAN_SYMP_1, 1 hit PS00754 NA_NEUROTRAN_SYMP_2, 1 hit PS50267 NA_NEUROTRAN_SYMP_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SC6A5_HUMAN
Accessionⁱ	Q9Y345Primary (citable) accession number: Q9Y345 Secondary accession number(s): O95288, Q4VAM7, Q9BX77
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
	Last sequence update:	May 18, 2010
	Last modified:	October 10, 2018
	This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniRef

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Supporting data

UniProtKB - Q9Y345 (SC6A5_HUMAN)

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Sodium- and chloride-dependent glycine transporter 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ