UniProtKB - Q9Y342 (PLLP_HUMAN)
Protein
Plasmolipin
Gene
PLLP
Organism
Homo sapiens (Human)
Status
Functioni
Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K+-selective (By similarity).By similarity
GO - Molecular functioni
- structural constituent of myelin sheath Source: GO_Central
GO - Biological processi
- ion transport Source: UniProtKB-KW
- myelination Source: GO_Central
- response to wounding Source: Ensembl
Keywordsi
Molecular function | Ion channel |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9Y342 |
Names & Taxonomyi
Protein namesi | Recommended name: PlasmolipinAlternative name(s): Plasma membrane proteolipid |
Gene namesi | Name:PLLP Synonyms:PMLP, TM4SF11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000102934.9 |
HGNCi | HGNC:18553, PLLP |
MIMi | 600340, gene |
neXtProti | NX_Q9Y342 |
Subcellular locationi
Other locations
Other locations
- compact myelin Source: Ensembl
- integral component of membrane Source: GO_Central
- membrane raft Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 35 | CytoplasmicSequence analysisAdd BLAST | 35 | |
Transmembranei | 36 – 56 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 57 – 68 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 69 – 89 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 90 – 99 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 100 – 120 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 121 – 141 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 142 – 162 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 163 – 182 | CytoplasmicSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 51090 |
OpenTargetsi | ENSG00000102934 |
PharmGKBi | PA38572 |
Miscellaneous databases
Pharosi | Q9Y342, Tbio |
Polymorphism and mutation databases
BioMutai | PLLP |
DMDMi | 12229882 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000156813 | 1 – 182 | PlasmolipinAdd BLAST | 182 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 9 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Y342 |
jPOSTi | Q9Y342 |
MassIVEi | Q9Y342 |
MaxQBi | Q9Y342 |
PaxDbi | Q9Y342 |
PeptideAtlasi | Q9Y342 |
PRIDEi | Q9Y342 |
ProteomicsDBi | 85972 |
PTM databases
iPTMneti | Q9Y342 |
PhosphoSitePlusi | Q9Y342 |
Expressioni
Gene expression databases
Bgeei | ENSG00000102934, Expressed in corpus callosum and 215 other tissues |
ExpressionAtlasi | Q9Y342, baseline and differential |
Genevisiblei | Q9Y342, HS |
Organism-specific databases
HPAi | ENSG00000102934, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Hexamer arranged as a trimer of two plasmolipin subunits.
By similarityBinary interactionsi
Hide detailsQ9Y342
Protein-protein interaction databases
BioGRIDi | 119279, 48 interactors |
IntActi | Q9Y342, 50 interactors |
MINTi | Q9Y342 |
STRINGi | 9606.ENSP00000219207 |
Miscellaneous databases
RNActi | Q9Y342, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 166 | MARVELPROSITE-ProRule annotationAdd BLAST | 135 |
Sequence similaritiesi
Belongs to the MAL family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4788, Eukaryota |
GeneTreei | ENSGT00940000156011 |
HOGENOMi | CLU_103581_2_0_1 |
InParanoidi | Q9Y342 |
OMAi | IYLFQLH |
OrthoDBi | 1455336at2759 |
PhylomeDBi | Q9Y342 |
TreeFami | TF316174 |
Family and domain databases
InterProi | View protein in InterPro IPR013295, MAL IPR008253, Marvel |
Pfami | View protein in Pfam PF01284, MARVEL, 1 hit |
PRINTSi | PR01884, MALPROTEIN |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9Y342-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEFPSKVST RTSSPAQGAE ASVSALRPDL GFVRSRLGAL MLLQLVLGLL
60 70 80 90 100
VWALIADTPY HLYPAYGWVM FVAVFLWLVT IVLFNLYLFQ LHMKLYMVPW
110 120 130 140 150
PLVLMIFNIS ATVLYITAFI ACSAAVDLTS LRGTRPYNQR AAASFFACLV
160 170 180
MIAYGVSAFF SYQAWRGVGS NAATSQMAGG YA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3QLJ3 | J3QLJ3_HUMAN | Plasmolipin | PLLP | 91 | Annotation score: | ||
A0A087WYE0 | A0A087WYE0_HUMAN | Plasmolipin | PLLP | 161 | Annotation score: | ||
H3BN27 | H3BN27_HUMAN | Plasmolipin | PLLP | 124 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF137386 mRNA Translation: AAD33060.1 AK313910 mRNA Translation: BAG36633.1 CH471092 Genomic DNA Translation: EAW82915.1 BC002760 mRNA Translation: AAH02760.1 |
CCDSi | CCDS10777.1 |
RefSeqi | NP_057077.1, NM_015993.2 |
Genome annotation databases
Ensembli | ENST00000219207; ENSP00000219207; ENSG00000102934 |
GeneIDi | 51090 |
KEGGi | hsa:51090 |
UCSCi | uc002elg.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF137386 mRNA Translation: AAD33060.1 AK313910 mRNA Translation: BAG36633.1 CH471092 Genomic DNA Translation: EAW82915.1 BC002760 mRNA Translation: AAH02760.1 |
CCDSi | CCDS10777.1 |
RefSeqi | NP_057077.1, NM_015993.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119279, 48 interactors |
IntActi | Q9Y342, 50 interactors |
MINTi | Q9Y342 |
STRINGi | 9606.ENSP00000219207 |
PTM databases
iPTMneti | Q9Y342 |
PhosphoSitePlusi | Q9Y342 |
Polymorphism and mutation databases
BioMutai | PLLP |
DMDMi | 12229882 |
Proteomic databases
EPDi | Q9Y342 |
jPOSTi | Q9Y342 |
MassIVEi | Q9Y342 |
MaxQBi | Q9Y342 |
PaxDbi | Q9Y342 |
PeptideAtlasi | Q9Y342 |
PRIDEi | Q9Y342 |
ProteomicsDBi | 85972 |
Protocols and materials databases
Antibodypediai | 44063, 93 antibodies |
DNASUi | 51090 |
Genome annotation databases
Ensembli | ENST00000219207; ENSP00000219207; ENSG00000102934 |
GeneIDi | 51090 |
KEGGi | hsa:51090 |
UCSCi | uc002elg.3, human |
Organism-specific databases
CTDi | 51090 |
DisGeNETi | 51090 |
EuPathDBi | HostDB:ENSG00000102934.9 |
GeneCardsi | PLLP |
HGNCi | HGNC:18553, PLLP |
HPAi | ENSG00000102934, Tissue enhanced (brain) |
MIMi | 600340, gene |
neXtProti | NX_Q9Y342 |
OpenTargetsi | ENSG00000102934 |
PharmGKBi | PA38572 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4788, Eukaryota |
GeneTreei | ENSGT00940000156011 |
HOGENOMi | CLU_103581_2_0_1 |
InParanoidi | Q9Y342 |
OMAi | IYLFQLH |
OrthoDBi | 1455336at2759 |
PhylomeDBi | Q9Y342 |
TreeFami | TF316174 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y342 |
Miscellaneous databases
BioGRID-ORCSi | 51090, 5 hits in 843 CRISPR screens |
ChiTaRSi | PLLP, human |
GenomeRNAii | 51090 |
Pharosi | Q9Y342, Tbio |
PROi | PR:Q9Y342 |
RNActi | Q9Y342, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102934, Expressed in corpus callosum and 215 other tissues |
ExpressionAtlasi | Q9Y342, baseline and differential |
Genevisiblei | Q9Y342, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013295, MAL IPR008253, Marvel |
Pfami | View protein in Pfam PF01284, MARVEL, 1 hit |
PRINTSi | PR01884, MALPROTEIN |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLLP_HUMAN | |
Accessioni | Q9Y342Primary (citable) accession number: Q9Y342 Secondary accession number(s): B2R9T6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM