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Protein

Zinc finger and BTB domain-containing protein 12

Gene

ZBTB12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri333 – 356C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri359 – 381C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri387 – 409C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri415 – 438C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 12
Alternative name(s):
Protein G10
Gene namesi
Name:ZBTB12
Synonyms:C6orf46, G10, NG35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204366.3
HGNCiHGNC:19066 ZBTB12
neXtProtiNX_Q9Y330

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204366
PharmGKBiPA38784

Polymorphism and mutation databases

BioMutaiZBTB12
DMDMi38257796

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477281 – 459Zinc finger and BTB domain-containing protein 12Add BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y330
PaxDbiQ9Y330
PeptideAtlasiQ9Y330
PRIDEiQ9Y330
ProteomicsDBi85966

PTM databases

iPTMnetiQ9Y330
PhosphoSitePlusiQ9Y330

Expressioni

Gene expression databases

BgeeiENSG00000204366 Expressed in 91 organ(s), highest expression level in temporal lobe
CleanExiHS_ZBTB12
GenevisibleiQ9Y330 HS

Organism-specific databases

HPAiHPA047161

Interactioni

Protein-protein interaction databases

BioGridi128737, 1 interactor
IntActiQ9Y330, 3 interactors
STRINGi9606.ENSP00000364677

Structurei

3D structure databases

ProteinModelPortaliQ9Y330
SMRiQ9Y330
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 97BTBPROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi155 – 179Pro-richAdd BLAST25
Compositional biasi227 – 327Gly-richAdd BLAST101

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri333 – 356C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri359 – 381C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri387 – 409C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri415 – 438C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000232051
HOVERGENiHBG056199
InParanoidiQ9Y330
KOiK10499
OMAiSEERFCD
OrthoDBiEOG091G11CA
PhylomeDBiQ9Y330
TreeFamiTF333162

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q9Y330-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGVEVLRF QLPGHEAATL RNMNQLRAEE RFCDVTIVAD SLKFRGHKVI
60 70 80 90 100
LAACSPFLRD QFLLNPSSEL QVSLMHSARI VADLLLSCYT GALEFAVRDI
110 120 130 140 150
VNYLTAASYL QMEHVVEKCR NALSQFIEPK IGLKEDGVSE ASLVSSISAT
160 170 180 190 200
KSLLPPARTP KPAPKPPPPP PLPPPLLRPV KLEFPLDEDL ELKAEEEDED
210 220 230 240 250
EDEDVSDICI VKVESALEVA HRLKPPGGLG GGLGIGGSVG GHLGELAQSS
260 270 280 290 300
VPPSTVAPPQ GVVKACYSLS EDAEGEGLLL IPGGRASVGA TSGLVEAAAV
310 320 330 340 350
AMAARGAGGS LGAGGSRGPL PGGFSGGNPL KNIKCTKCPE VFQGVEKLVF
360 370 380 390 400
HMRAQHFIFM CPRCGKQFNH SSNLNRHMNV HRGVKSHSCG ICGKCFTQKS
410 420 430 440 450
TLHDHLNLHS GARPYRCSYC DVRFAHKPAI RRHLKEQHGK TTAENVLEAS

VAEINVLIR
Length:459
Mass (Da):49,148
Last modified:November 1, 1999 - v1
Checksum:iEF6DD3FCC888E86F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134726 Genomic DNA Translation: AAD21810.1
BA000025 Genomic DNA Translation: BAB63293.1
AL671762 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
AL662834 Genomic DNA No translation available.
CR388219 Genomic DNA No translation available.
CR759784 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03546.1
BC043609 mRNA Translation: AAH43609.1
CCDSiCCDS4727.1
RefSeqiNP_862825.1, NM_181842.2
XP_011512685.2, XM_011514383.2
UniGeneiHs.234027

Genome annotation databases

EnsembliENST00000375525; ENSP00000364675; ENSG00000206366
ENST00000375527; ENSP00000364677; ENSG00000204366
ENST00000432044; ENSP00000392328; ENSG00000234196
ENST00000441555; ENSP00000414777; ENSG00000237900
ENST00000458242; ENSP00000391563; ENSG00000234852
GeneIDi221527
KEGGihsa:221527
UCSCiuc003nyd.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134726 Genomic DNA Translation: AAD21810.1
BA000025 Genomic DNA Translation: BAB63293.1
AL671762 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
AL662834 Genomic DNA No translation available.
CR388219 Genomic DNA No translation available.
CR759784 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03546.1
BC043609 mRNA Translation: AAH43609.1
CCDSiCCDS4727.1
RefSeqiNP_862825.1, NM_181842.2
XP_011512685.2, XM_011514383.2
UniGeneiHs.234027

3D structure databases

ProteinModelPortaliQ9Y330
SMRiQ9Y330
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128737, 1 interactor
IntActiQ9Y330, 3 interactors
STRINGi9606.ENSP00000364677

PTM databases

iPTMnetiQ9Y330
PhosphoSitePlusiQ9Y330

Polymorphism and mutation databases

BioMutaiZBTB12
DMDMi38257796

Proteomic databases

EPDiQ9Y330
PaxDbiQ9Y330
PeptideAtlasiQ9Y330
PRIDEiQ9Y330
ProteomicsDBi85966

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375525; ENSP00000364675; ENSG00000206366
ENST00000375527; ENSP00000364677; ENSG00000204366
ENST00000432044; ENSP00000392328; ENSG00000234196
ENST00000441555; ENSP00000414777; ENSG00000237900
ENST00000458242; ENSP00000391563; ENSG00000234852
GeneIDi221527
KEGGihsa:221527
UCSCiuc003nyd.2 human

Organism-specific databases

CTDi221527
EuPathDBiHostDB:ENSG00000204366.3
GeneCardsiZBTB12
HGNCiHGNC:19066 ZBTB12
HPAiHPA047161
neXtProtiNX_Q9Y330
OpenTargetsiENSG00000204366
PharmGKBiPA38784
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000232051
HOVERGENiHBG056199
InParanoidiQ9Y330
KOiK10499
OMAiSEERFCD
OrthoDBiEOG091G11CA
PhylomeDBiQ9Y330
TreeFamiTF333162

Miscellaneous databases

GenomeRNAii221527
PROiPR:Q9Y330

Gene expression databases

BgeeiENSG00000204366 Expressed in 91 organ(s), highest expression level in temporal lobe
CleanExiHS_ZBTB12
GenevisibleiQ9Y330 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT12_HUMAN
AccessioniPrimary (citable) accession number: Q9Y330
Secondary accession number(s): B0UY00, Q5JQ98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 1, 1999
Last modified: October 10, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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