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Protein

rRNA-processing protein FCF1 homolog

Gene

FCF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA-processing protein FCF1 homolog
Gene namesi
Name:FCF1
Synonyms:C14orf111
ORF Names:CGI-35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000119616.11
HGNCiHGNC:20220 FCF1
neXtProtiNX_Q9Y324

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119616
PharmGKBiPA162388159

Polymorphism and mutation databases

BioMutaiFCF1
DMDMi34582346

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899201 – 198rRNA-processing protein FCF1 homologAdd BLAST198

Proteomic databases

EPDiQ9Y324
MaxQBiQ9Y324
PaxDbiQ9Y324
PeptideAtlasiQ9Y324
PRIDEiQ9Y324
ProteomicsDBi85964

PTM databases

iPTMnetiQ9Y324
PhosphoSitePlusiQ9Y324

Expressioni

Gene expression databases

BgeeiENSG00000119616 Expressed in 226 organ(s), highest expression level in germinal epithelium of ovary
CleanExiHS_FCF1
ExpressionAtlasiQ9Y324 baseline and differential
GenevisibleiQ9Y324 HS

Organism-specific databases

HPAiHPA046681

Interactioni

Protein-protein interaction databases

BioGridi119268, 73 interactors
IntActiQ9Y324, 1 interactor
STRINGi9606.ENSP00000344393

Structurei

3D structure databases

ProteinModelPortaliQ9Y324
SMRiQ9Y324
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 166PINcAdd BLAST100

Sequence similaritiesi

Belongs to the UTP23/FCF1 family. FCF1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG3165 Eukaryota
COG1412 LUCA
GeneTreeiENSGT00550000074979
HOGENOMiHOG000183747
HOVERGENiHBG051022
InParanoidiQ9Y324
KOiK14566
OMAiRVMQHKC
OrthoDBiEOG091G0KRZ
PhylomeDBiQ9Y324
TreeFamiTF314992

Family and domain databases

CDDicd09864 PIN_Fcf1, 1 hit
InterProiView protein in InterPro
IPR006984 Fcf1/Utp23
IPR037503 Fcf1_PIN
IPR029060 PIN-like_dom_sf
IPR002716 PIN_dom
PANTHERiPTHR12416 PTHR12416, 1 hit
PfamiView protein in Pfam
PF04900 Fcf1, 1 hit
SMARTiView protein in SMART
SM00670 PINc, 1 hit
SUPFAMiSSF88723 SSF88723, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9Y324-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKQKKTRKY ATMKRMLSLR DQRLKEKDRL KPKKKEKKDP SALKEREVPQ
60 70 80 90 100
HPSCLFFQYN TQLGPPYHIL VDTNFINFSI KAKLDLVQSM MDCLYAKCIP
110 120 130 140 150
CITDCVMAEI EKLGQKYRVA LRIAKDPRFE RLPCTHKGTY ADDCLVQRVT
160 170 180 190
QHKCYIVATV DRDLKRRIRK IPGVPIMYIS NHRYNIERMP DDYGAPRF
Length:198
Mass (Da):23,370
Last modified:November 1, 1999 - v1
Checksum:iA0C98414C21F16AE
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1S4G3V1S4_HUMAN
Chromosome 14 open reading frame 11...
FCF1 C14orf111, hCG_22352
186Annotation score:
G3V5S9G3V5S9_HUMAN
rRNA-processing protein FCF1 homolo...
FCF1
183Annotation score:
G3V2M5G3V2M5_HUMAN
rRNA-processing protein FCF1 homolo...
FCF1
61Annotation score:
G3V3N8G3V3N8_HUMAN
rRNA-processing protein FCF1 homolo...
FCF1
65Annotation score:
G3V5D2G3V5D2_HUMAN
rRNA-processing protein FCF1 homolo...
FCF1
40Annotation score:
G3V5L8G3V5L8_HUMAN
rRNA-processing protein FCF1 homolo...
FCF1
52Annotation score:

Sequence cautioni

The sequence CAD62599 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132969 mRNA Translation: AAD27744.1
BX248271 mRNA Translation: CAD62599.1 Different initiation.
AC007956 Genomic DNA No translation available.
CCDSiCCDS9832.1
RefSeqiNP_057046.1, NM_015962.4
UniGeneiHs.579828
Hs.711584

Genome annotation databases

EnsembliENST00000341162; ENSP00000344393; ENSG00000119616
GeneIDi51077
KEGGihsa:51077
UCSCiuc001xqh.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132969 mRNA Translation: AAD27744.1
BX248271 mRNA Translation: CAD62599.1 Different initiation.
AC007956 Genomic DNA No translation available.
CCDSiCCDS9832.1
RefSeqiNP_057046.1, NM_015962.4
UniGeneiHs.579828
Hs.711584

3D structure databases

ProteinModelPortaliQ9Y324
SMRiQ9Y324
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119268, 73 interactors
IntActiQ9Y324, 1 interactor
STRINGi9606.ENSP00000344393

PTM databases

iPTMnetiQ9Y324
PhosphoSitePlusiQ9Y324

Polymorphism and mutation databases

BioMutaiFCF1
DMDMi34582346

Proteomic databases

EPDiQ9Y324
MaxQBiQ9Y324
PaxDbiQ9Y324
PeptideAtlasiQ9Y324
PRIDEiQ9Y324
ProteomicsDBi85964

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341162; ENSP00000344393; ENSG00000119616
GeneIDi51077
KEGGihsa:51077
UCSCiuc001xqh.4 human

Organism-specific databases

CTDi51077
EuPathDBiHostDB:ENSG00000119616.11
GeneCardsiFCF1
HGNCiHGNC:20220 FCF1
HPAiHPA046681
neXtProtiNX_Q9Y324
OpenTargetsiENSG00000119616
PharmGKBiPA162388159
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3165 Eukaryota
COG1412 LUCA
GeneTreeiENSGT00550000074979
HOGENOMiHOG000183747
HOVERGENiHBG051022
InParanoidiQ9Y324
KOiK14566
OMAiRVMQHKC
OrthoDBiEOG091G0KRZ
PhylomeDBiQ9Y324
TreeFamiTF314992

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiFCF1 human
GeneWikiiFCF1
GenomeRNAii51077
PROiPR:Q9Y324

Gene expression databases

BgeeiENSG00000119616 Expressed in 226 organ(s), highest expression level in germinal epithelium of ovary
CleanExiHS_FCF1
ExpressionAtlasiQ9Y324 baseline and differential
GenevisibleiQ9Y324 HS

Family and domain databases

CDDicd09864 PIN_Fcf1, 1 hit
InterProiView protein in InterPro
IPR006984 Fcf1/Utp23
IPR037503 Fcf1_PIN
IPR029060 PIN-like_dom_sf
IPR002716 PIN_dom
PANTHERiPTHR12416 PTHR12416, 1 hit
PfamiView protein in Pfam
PF04900 Fcf1, 1 hit
SMARTiView protein in SMART
SM00670 PINc, 1 hit
SUPFAMiSSF88723 SSF88723, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFCF1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y324
Secondary accession number(s): Q86TW8, Q8TBL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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