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UniProtKB - Q9Y316 (MEMO1_HUMAN)

Entry version 163 (12 Aug 2020)
Sequence version 1 (01 Nov 1999)
Previous versions | rss
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Protein

Protein MEMO1

Gene

MEMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y316

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6785631, ERBB2 Regulates Cell Motility

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein MEMO1
Alternative name(s):
C21orf19-like protein
Hepatitis C virus NS5A-transactivated protein 7
Short name:
HCV NS5A-transactivated protein 7
Mediator of ErbB2-driven cell motility 1
Short name:
Mediator of cell motility 1
Short name:
Memo-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEMO1
Synonyms:C2orf4, MEMO, NS5ATP7
ORF Names:CGI-27
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000162959.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:14014, MEMO1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611786, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y316

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi16W → A: Abolishes interaction with ERBB2. 1 Publication1
Mutagenesisi49H → A: Abolishes interaction with ERBB2. 1 Publication1
Mutagenesisi54Y → A: Diminishes interaction with ERBB2. 1 Publication1
Mutagenesisi81H → A: Abolishes interaction with ERBB2. 1 Publication1
Mutagenesisi192H → A: Abolishes interaction with ERBB2. 1 Publication1
Mutagenesisi244C → A: Abolishes interaction with ERBB2. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		51072

Open Targets

More...OpenTargetsi		ENSG00000162959

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162395745

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y316, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MEMO1

Domain mapping of disease mutations (DMDM)

More...DMDMi		7388490

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001343941 – 297Protein MEMO1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei210PhosphotyrosineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y316

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y316

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y316

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y316

PeptideAtlas

More...PeptideAtlasi		Q9Y316

PRoteomics IDEntifications database

More...PRIDEi		Q9Y316

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		63699
85960 [Q9Y316-1]
85961 [Q9Y316-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y316

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y316

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000162959, Expressed in testis and 114 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y316, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y316, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000162959, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ERBB2 phosphorylated on 'Tyr-1248'.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1297
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y316

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Y316

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MEMO1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3086, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006408

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_038085_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y316

KEGG Orthology (KO)

More...KOi		K06990

Identification of Orthologs from Complete Genome Data

More...OMAi		EQEAQYG

Database of Orthologous Groups

More...OrthoDBi		1057950at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y316

TreeFam database of animal gene trees

More...TreeFami		TF300014

Family and domain databases

Conserved Domains Database

More...CDDi		cd07361, MEMO_like, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00055, MEMO1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002737, MEMO1_fam

The PANTHER Classification System

More...PANTHERi		PTHR11060, PTHR11060, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01875, Memo, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y316-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNRVVCREA SHAGSWYTAS GPQLNAQLEG WLSQVQSTKR PARAIIAPHA 
        60         70         80         90        100
GYTYCGSCAA HAYKQVDPSI TRRIFILGPS HHVPLSRCAL SSVDIYRTPL 
       110        120        130        140        150
YDLRIDQKIY GELWKTGMFE RMSLQTDEDE HSIEMHLPYT AKAMESHKDE 
       160        170        180        190        200
FTIIPVLVGA LSESKEQEFG KLFSKYLADP SNLFVVSSDF CHWGQRFRYS 
       210        220        230        240        250
YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH NTICGRHPIG 
       260        270        280        290 
VLLNAITELQ KNGMNMSFSF LNYAQSSQCR NWQDSSVSYA AGALTVH
Length:297
Mass (Da):33,733
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE315FD5587776211
GO
Isoform 2 (identifier: Q9Y316-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-71: Missing.

Show »
Length:274
Mass (Da):31,307
Checksum:i1BE5B4A07A5D44D8
GO
Isoform 3 (identifier: Q9Y316-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MSNRVVCREASHAGSWYTAS → MPLWRADKCQDVQSASWRPRRAD

Show »
Length:300
Mass (Da):34,294
Checksum:i0778186B7CCA0ADA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MCI6B5MCI6_HUMAN
Mediator of ErbB2-driven cell motil...
MEMO1
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JSD7C9JSD7_HUMAN
Protein MEMO1
MEMO1
20Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23Q → H in AAH70046 (PubMed:15489334).Curated1
Sequence conflicti172L → P in BAG59632 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0476931 – 20MSNRV…WYTAS → MPLWRADKCQDVQSASWRPR RAD in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_04109249 – 71Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF363446 mRNA Translation: AAL34462.1
AB041018 mRNA Translation: BAD74066.1
AB041019 mRNA Translation: BAD74067.1
AF529368 mRNA Translation: AAQ09602.1
AF132961 mRNA Translation: AAD27736.1
AK297128 mRNA Translation: BAG59632.1
AL121652 Genomic DNA No translation available.
AL121655 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00467.1
CH471053 Genomic DNA Translation: EAX00469.1
CH471053 Genomic DNA Translation: EAX00470.1
CH471053 Genomic DNA Translation: EAX00472.1
BC018733 mRNA Translation: AAH18733.1
BC070046 mRNA Translation: AAH70046.1
BC094681 mRNA Translation: AAH94681.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1776.1 [Q9Y316-1]
CCDS46255.1 [Q9Y316-2]

NCBI Reference Sequences

More...RefSeqi		NP_001131074.1, NM_001137602.2 [Q9Y316-2]
NP_001288762.1, NM_001301833.1 [Q9Y316-1]
NP_001288781.1, NM_001301852.1
NP_057039.1, NM_015955.3 [Q9Y316-1]
XP_011531194.1, XM_011532892.2
XP_016859744.1, XM_017004255.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295065; ENSP00000295065; ENSG00000162959 [Q9Y316-1]
ENST00000379383; ENSP00000368691; ENSG00000162959 [Q9Y316-3]
ENST00000404530; ENSP00000385557; ENSG00000162959 [Q9Y316-1]
ENST00000426310; ENSP00000400795; ENSG00000162959 [Q9Y316-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51072

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51072

UCSC genome browser

More...UCSCi		uc002rnx.4, human [Q9Y316-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363446 mRNA Translation: AAL34462.1
AB041018 mRNA Translation: BAD74066.1
AB041019 mRNA Translation: BAD74067.1
AF529368 mRNA Translation: AAQ09602.1
AF132961 mRNA Translation: AAD27736.1
AK297128 mRNA Translation: BAG59632.1
AL121652 Genomic DNA No translation available.
AL121655 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00467.1
CH471053 Genomic DNA Translation: EAX00469.1
CH471053 Genomic DNA Translation: EAX00470.1
CH471053 Genomic DNA Translation: EAX00472.1
BC018733 mRNA Translation: AAH18733.1
BC070046 mRNA Translation: AAH70046.1
BC094681 mRNA Translation: AAH94681.1
CCDSiCCDS1776.1 [Q9Y316-1]
CCDS46255.1 [Q9Y316-2]
RefSeqiNP_001131074.1, NM_001137602.2 [Q9Y316-2]
NP_001288762.1, NM_001301833.1 [Q9Y316-1]
NP_001288781.1, NM_001301852.1
NP_057039.1, NM_015955.3 [Q9Y316-1]
XP_011531194.1, XM_011532892.2
XP_016859744.1, XM_017004255.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BCZX-ray2.10A/B/C/D5-297[»]
3BD0X-ray3.01A/B/C/D5-297[»]
SMRiQ9Y316
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119263, 40 interactors
CORUMiQ9Y316
IntActiQ9Y316, 29 interactors
MINTiQ9Y316
STRINGi9606.ENSP00000295065

PTM databases

iPTMnetiQ9Y316
PhosphoSitePlusiQ9Y316

Polymorphism and mutation databases

BioMutaiMEMO1
DMDMi7388490

Proteomic databases

EPDiQ9Y316
jPOSTiQ9Y316
MassIVEiQ9Y316
PaxDbiQ9Y316
PeptideAtlasiQ9Y316
PRIDEiQ9Y316
ProteomicsDBi63699
85960 [Q9Y316-1]
85961 [Q9Y316-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		47374, 153 antibodies

The DNASU plasmid repository

More...DNASUi		51072

Genome annotation databases

EnsembliENST00000295065; ENSP00000295065; ENSG00000162959 [Q9Y316-1]
ENST00000379383; ENSP00000368691; ENSG00000162959 [Q9Y316-3]
ENST00000404530; ENSP00000385557; ENSG00000162959 [Q9Y316-1]
ENST00000426310; ENSP00000400795; ENSG00000162959 [Q9Y316-2]
GeneIDi51072
KEGGihsa:51072
UCSCiuc002rnx.4, human [Q9Y316-1]

Organism-specific databases

DisGeNETi51072
EuPathDBiHostDB:ENSG00000162959.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		MEMO1
HGNCiHGNC:14014, MEMO1
HPAiENSG00000162959, Low tissue specificity
MIMi611786, gene
neXtProtiNX_Q9Y316
OpenTargetsiENSG00000162959
PharmGKBiPA162395745

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3086, Eukaryota
GeneTreeiENSGT00390000006408
HOGENOMiCLU_038085_0_1_1
InParanoidiQ9Y316
KOiK06990
OMAiEQEAQYG
OrthoDBi1057950at2759
PhylomeDBiQ9Y316
TreeFamiTF300014

Enzyme and pathway databases

PathwayCommonsiQ9Y316
ReactomeiR-HSA-6785631, ERBB2 Regulates Cell Motility

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51072, 12 hits in 403 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MEMO1, human
EvolutionaryTraceiQ9Y316

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51072
PharosiQ9Y316, Tbio

Protein Ontology

More...PROi		PR:Q9Y316
RNActiQ9Y316, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000162959, Expressed in testis and 114 other tissues
ExpressionAtlasiQ9Y316, baseline and differential
GenevisibleiQ9Y316, HS

Family and domain databases

CDDicd07361, MEMO_like, 1 hit
HAMAPiMF_00055, MEMO1, 1 hit
InterProiView protein in InterPro
IPR002737, MEMO1_fam
PANTHERiPTHR11060, PTHR11060, 1 hit
PfamiView protein in Pfam
PF01875, Memo, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEMO1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y316
Secondary accession number(s): B4DLS0
, D6W575, Q5R2V8, Q5R2V9, Q6NSL5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: August 12, 2020
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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