MEMO1

Functionⁱ

May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.2 Publications

GO - Biological processⁱ

regulation of cell motility Source: Reactome
regulation of microtubule-based process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20937854

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6785631 ERBB2 Regulates Cell Motility

Reactomeⁱ

R-HSA-6785631 ERBB2 Regulates Cell Motility

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein MEMO1 Alternative name(s): C21orf19-like protein Hepatitis C virus NS5A-transactivated protein 7 Short name: HCV NS5A-transactivated protein 7 Mediator of ErbB2-driven cell motility 1 Short name: Mediator of cell motility 1 Short name: Memo-1
Gene namesⁱ	Name:MEMO1 Synonyms:C2orf4, MEMO, NS5ATP7 ORF Names:CGI-27
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162959.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14014 MEMO1
MIMⁱ	611786 gene
neXtProtⁱ	NX_Q9Y316

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	16	W → A: Abolishes interaction with ERBB2. 1 Publication	1
Mutagenesisⁱ	49	H → A: Abolishes interaction with ERBB2. 1 Publication	1
Mutagenesisⁱ	54	Y → A: Diminishes interaction with ERBB2. 1 Publication	1
Mutagenesisⁱ	81	H → A: Abolishes interaction with ERBB2. 1 Publication	1
Mutagenesisⁱ	192	H → A: Abolishes interaction with ERBB2. 1 Publication	1
Mutagenesisⁱ	244	C → A: Abolishes interaction with ERBB2. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51072
Open Targets More...OpenTargetsⁱ	ENSG00000162959
PharmGKBⁱ	PA162395745

Polymorphism and mutation databases

BioMutaⁱ	MEMO1
DMDMⁱ	7388490

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000134394	1 – 297	Protein MEMO1Add BLAST		297

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	210	PhosphotyrosineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y316
PaxDbⁱ	Q9Y316
PeptideAtlas More...PeptideAtlasⁱ	Q9Y316
PRIDEⁱ	Q9Y316
ProteomicsDBⁱ	85960 85961 [Q9Y316-2]

PTM databases

iPTMnetⁱ	Q9Y316
PhosphoSitePlusⁱ	Q9Y316

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000162959 Expressed in 90 organ(s), highest expression level in right testis
CleanExⁱ	HS_MEMO1
ExpressionAtlasⁱ	Q9Y316 baseline and differential
Genevisibleⁱ	Q9Y316 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042603 HPA057952

HPAⁱ

HPA042603
HPA057952

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ERBB2	P04626	6	EBI-1104564,EBI-641062
LNX1	Q8TBB1	5	EBI-1104564,EBI-739832
LZTS2	Q9BRK4	3	EBI-1104564,EBI-741037
RBM45	Q8IUH3	3	EBI-1104564,EBI-2512147
REL	Q04864	3	EBI-1104564,EBI-307352
TACC1	O75410	4	EBI-1104564,EBI-624237
TCF4	P15884	3	EBI-1104564,EBI-533224
TRIM27	P14373	3	EBI-1104564,EBI-719493
TRIP6	Q15654	3	EBI-1104564,EBI-742327

Protein-protein interaction databases

BioGridⁱ	119263, 37 interactors
CORUMⁱ	Q9Y316
IntActⁱ	Q9Y316, 19 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y316
STRINGⁱ	9606.ENSP00000295065

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	11 – 15	Combined sources	5
Helixⁱ	21 – 32	Combined sources	12
Beta strandⁱ	43 – 47	Combined sources	5
Helixⁱ	52 – 63	Combined sources	12
Turnⁱ	68 – 70	Combined sources	3
Beta strandⁱ	73 – 79	Combined sources	7
Beta strandⁱ	81 – 83	Combined sources	3
Beta strandⁱ	86 – 90	Combined sources	5
Beta strandⁱ	94 – 96	Combined sources	3
Beta strandⁱ	103 – 105	Combined sources	3
Helixⁱ	107 – 115	Combined sources	9
Beta strandⁱ	119 – 121	Combined sources	3
Helixⁱ	124 – 129	Combined sources	6
Helixⁱ	134 – 136	Combined sources	3
Helixⁱ	137 – 143	Combined sources	7
Helixⁱ	145 – 147	Combined sources	3
Beta strandⁱ	152 – 158	Combined sources	7
Helixⁱ	163 – 177	Combined sources	15
Beta strandⁱ	182 – 187	Combined sources	6
Beta strandⁱ	192 – 194	Combined sources	3
Helixⁱ	195 – 197	Combined sources	3
Helixⁱ	204 – 206	Combined sources	3
Helixⁱ	209 – 225	Combined sources	17
Helixⁱ	229 – 239	Combined sources	11
Helixⁱ	246 – 261	Combined sources	16
Beta strandⁱ	266 – 277	Combined sources	12
Beta strandⁱ	286 – 296	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9Y316
SMRⁱ	Q9Y316
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9Y316

EvolutionaryTraceⁱ

Q9Y316

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the MEMO1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3086 Eukaryota COG1355 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006408
HOGENOMⁱ	HOG000225260
HOVERGENⁱ	HBG050811
InParanoidⁱ	Q9Y316
KEGG Orthology (KO) More...KOⁱ	K06990
OMAⁱ	YTYCGAC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GVZ
PhylomeDBⁱ	Q9Y316
TreeFamⁱ	TF300014

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07361 MEMO_like, 1 hit
HAMAPⁱ	MF_00055 MEMO1, 1 hit
InterProⁱ	View protein in InterPro IPR002737 MEMO1_fam
PANTHERⁱ	PTHR11060 PTHR11060, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01875 Memo, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q9Y316-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNRVVCREA SHAGSWYTAS GPQLNAQLEG WLSQVQSTKR PARAIIAPHA 
        60         70         80         90        100
GYTYCGSCAA HAYKQVDPSI TRRIFILGPS HHVPLSRCAL SSVDIYRTPL 
       110        120        130        140        150
YDLRIDQKIY GELWKTGMFE RMSLQTDEDE HSIEMHLPYT AKAMESHKDE 
       160        170        180        190        200
FTIIPVLVGA LSESKEQEFG KLFSKYLADP SNLFVVSSDF CHWGQRFRYS 
       210        220        230        240        250
YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH NTICGRHPIG 
       260        270        280        290 
VLLNAITELQ KNGMNMSFSF LNYAQSSQCR NWQDSSVSYA AGALTVH

Length:297

Mass (Da):33,733

Last modified:November 1, 1999 - v1

Checksum:ⁱE315FD5587776211

GO

Isoform 2 (identifier: Q9Y316-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
49-71: Missing.

« Hide

        10         20         30         40         50
MSNRVVCREA SHAGSWYTAS GPQLNAQLEG WLSQVQSTKR PARAIIAPRR 
        60         70         80         90        100
IFILGPSHHV PLSRCALSSV DIYRTPLYDL RIDQKIYGEL WKTGMFERMS 
       110        120        130        140        150
LQTDEDEHSI EMHLPYTAKA MESHKDEFTI IPVLVGALSE SKEQEFGKLF 
       160        170        180        190        200
SKYLADPSNL FVVSSDFCHW GQRFRYSYYD ESQGEIYRSI EHLDKMGMSI 
       210        220        230        240        250
IEQLDPVSFS NYLKKYHNTI CGRHPIGVLL NAITELQKNG MNMSFSFLNY 
       260        270 
AQSSQCRNWQ DSSVSYAAGA LTVH

Show »

Length:274

Mass (Da):31,307

Checksum:ⁱ1BE5B4A07A5D44D8

GO

Isoform 3 (identifier: Q9Y316-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-20: MSNRVVCREASHAGSWYTAS → MPLWRADKCQDVQSASWRPRRAD

« Hide

        10         20         30         40         50
MPLWRADKCQ DVQSASWRPR RADGPQLNAQ LEGWLSQVQS TKRPARAIIA 
        60         70         80         90        100
PHAGYTYCGS CAAHAYKQVD PSITRRIFIL GPSHHVPLSR CALSSVDIYR 
       110        120        130        140        150
TPLYDLRIDQ KIYGELWKTG MFERMSLQTD EDEHSIEMHL PYTAKAMESH 
       160        170        180        190        200
KDEFTIIPVL VGALSESKEQ EFGKLFSKYL ADPSNLFVVS SDFCHWGQRF 
       210        220        230        240        250
RYSYYDESQG EIYRSIEHLD KMGMSIIEQL DPVSFSNYLK KYHNTICGRH 
       260        270        280        290        300
PIGVLLNAIT ELQKNGMNMS FSFLNYAQSS QCRNWQDSSV SYAAGALTVH

Show »

Length:300

Mass (Da):34,294

Checksum:ⁱ0778186B7CCA0ADA

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	B5MCI6	B5MCI6_HUMAN		Protein MEMO1 Protein MEMO1	MEMO1	100	Annotation score:
	C9JSD7	C9JSD7_HUMAN		Protein MEMO1 Protein MEMO1	MEMO1	20	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	23	Q → H in AAH70046 (PubMed:15489334).Curated		1
Sequence conflictⁱ	172	L → P in BAG59632 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047693	1 – 20	MSNRV…WYTAS → MPLWRADKCQDVQSASWRPR RAD in isoform 3. 1 PublicationAdd BLAST		20
Alternative sequenceⁱVSP_041092	49 – 71	Missing in isoform 2. 1 PublicationAdd BLAST		23

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF363446 mRNA Translation: AAL34462.1 AB041018 mRNA Translation: BAD74066.1 AB041019 mRNA Translation: BAD74067.1 AF529368 mRNA Translation: AAQ09602.1 AF132961 mRNA Translation: AAD27736.1 AK297128 mRNA Translation: BAG59632.1 AL121652 Genomic DNA No translation available. AL121655 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAX00467.1 CH471053 Genomic DNA Translation: EAX00469.1 CH471053 Genomic DNA Translation: EAX00470.1 CH471053 Genomic DNA Translation: EAX00472.1 BC018733 mRNA Translation: AAH18733.1 BC070046 mRNA Translation: AAH70046.1 BC094681 mRNA Translation: AAH94681.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1776.1 [Q9Y316-1] CCDS46255.1 [Q9Y316-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001131074.1, NM_001137602.2 [Q9Y316-2] NP_001288762.1, NM_001301833.1 [Q9Y316-1] NP_001288781.1, NM_001301852.1 NP_057039.1, NM_015955.3 [Q9Y316-1] XP_011531194.1, XM_011532892.2 [Q9Y316-1] XP_016859744.1, XM_017004255.1 [Q9Y316-1]
UniGeneⁱ	Hs.444969

Genome annotation databases

Ensemblⁱ	ENST00000295065; ENSP00000295065; ENSG00000162959 [Q9Y316-1] ENST00000379383; ENSP00000368691; ENSG00000162959 [Q9Y316-3] ENST00000404530; ENSP00000385557; ENSG00000162959 [Q9Y316-1] ENST00000426310; ENSP00000400795; ENSG00000162959 [Q9Y316-2]
GeneIDⁱ	51072
KEGGⁱ	hsa:51072
UCSC genome browser More...UCSCⁱ	uc002rnx.4 human [Q9Y316-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q9Y316	Protein MEMO1		MACFA		297	UniRef100_Q9Y316
Mediator of cell motility 1		MACMU		297
MEMO1 isoform 1		PANTR		297
Protein MEMO1 isoform 1		CALJA		297
Uncharacterized protein		MACNE		297
+20
Q9Y316-2	MEMO1 isoform 5		PANTR		274	UniRef100_K7AQ89
Mediator of cell motility 1		PROCO		274
Mediator of cell motility 1		MACMU		274
Uncharacterized protein		CALJA		274
Uncharacterized protein		COLAP		274
+10
Q9Y316-3	MEMO1 isoform 3		PANTR		300	UniRef100_A0A2I3RAT9
Uncharacterized protein		PANPA		300

Protein	Similar proteins		Species	Score	Length	Source
Q9Y316	Protein MEMO1		MACFA		297	UniRef90_Q9Y316
Protein MEMO1		XENTR		297
Protein MEMO1		XENLA		297
Protein MEMO1		BOVIN		285
Mediator of cell motility 1		MACMU		297
+38
Q9Y316-2	MEMO1 isoform 5		PANTR		274	UniRef90_K7AQ89
Mediator of cell motility 1		PROCO		274
Mediator of cell motility 1		MACMU		274
Uncharacterized protein		CALJA		274
Uncharacterized protein		COLAP		274
+21
Q9Y316-3	Mediator of cell motility 1		MELGA		301	UniRef90_G1NFS7
Uncharacterized protein		MOUSE		302
MEMO1 isoform 3		PANTR		300
Uncharacterized protein		PANPA		300
Protein MEMO1 (Fragment)		CHEMY		277
+9

Protein	Similar proteins		Species	Score	Length	Source
Q9Y316	Protein MEMO1		MACFA		297	UniRef50_Q9Y316
Protein MEMO1		XENLA		297
Protein MEMO1		XENTR		297
Protein MEMO1		BOVIN		285
Protein MEMO1		RAT		297
+181
Q9Y316-2	MEMO1 isoform 5		PANTR		274	UniRef50_K7AQ89
Mediator of cell motility 1		PROCO		274
Mediator of cell motility 1		MACMU		274
Uncharacterized protein		CALJA		274
Uncharacterized protein		COLAP		274
+30
Q9Y316-3	Uncharacterized protein		ONCFA		315	UniRef50_A0A2R7XZX8
Protein MEMO1-like protein		MICFL		297
Uncharacterized protein (Fragment)		Micrurus paraensis		389
Protein MEMO1-like protein		CROHD		297
Protein MEMO1-like protein		AGKCO		297
+24

Entry informationⁱ

Entry nameⁱ	MEMO1_HUMAN
Accessionⁱ	Q9Y316Primary (citable) accession number: Q9Y316 Secondary accession number(s): B4DLS0 , D6W575, Q5R2V8, Q5R2V9, Q6NSL5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1999
	Last modified:	September 12, 2018
	This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y316 (MEMO1_HUMAN)

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Protein MEMO1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ