UniProtKB - Q9Y316 (MEMO1_HUMAN)
Protein
Protein MEMO1
Gene
MEMO1
Organism
Homo sapiens (Human)
Status
Functioni
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.2 Publications
GO - Biological processi
- regulation of cell motility Source: Reactome
- regulation of microtubule-based process Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q9Y316 |
Reactomei | R-HSA-6785631, ERBB2 Regulates Cell Motility |
Names & Taxonomyi
Protein namesi | Recommended name: Protein MEMO1Alternative name(s): C21orf19-like protein Hepatitis C virus NS5A-transactivated protein 7 Short name: HCV NS5A-transactivated protein 7 Mediator of ErbB2-driven cell motility 1 Short name: Mediator of cell motility 1 Short name: Memo-1 |
Gene namesi | Name:MEMO1 Synonyms:C2orf4, MEMO, NS5ATP7 ORF Names:CGI-27 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000162959.13 |
HGNCi | HGNC:14014, MEMO1 |
MIMi | 611786, gene |
neXtProti | NX_Q9Y316 |
Subcellular locationi
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 16 | W → A: Abolishes interaction with ERBB2. 1 Publication | 1 | |
Mutagenesisi | 49 | H → A: Abolishes interaction with ERBB2. 1 Publication | 1 | |
Mutagenesisi | 54 | Y → A: Diminishes interaction with ERBB2. 1 Publication | 1 | |
Mutagenesisi | 81 | H → A: Abolishes interaction with ERBB2. 1 Publication | 1 | |
Mutagenesisi | 192 | H → A: Abolishes interaction with ERBB2. 1 Publication | 1 | |
Mutagenesisi | 244 | C → A: Abolishes interaction with ERBB2. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 51072 |
OpenTargetsi | ENSG00000162959 |
PharmGKBi | PA162395745 |
Miscellaneous databases
Pharosi | Q9Y316, Tbio |
Polymorphism and mutation databases
BioMutai | MEMO1 |
DMDMi | 7388490 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000134394 | 1 – 297 | Protein MEMO1Add BLAST | 297 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 210 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Y316 |
jPOSTi | Q9Y316 |
MassIVEi | Q9Y316 |
PaxDbi | Q9Y316 |
PeptideAtlasi | Q9Y316 |
PRIDEi | Q9Y316 |
ProteomicsDBi | 63699 85960 [Q9Y316-1] 85961 [Q9Y316-2] |
PTM databases
iPTMneti | Q9Y316 |
PhosphoSitePlusi | Q9Y316 |
Expressioni
Gene expression databases
Bgeei | ENSG00000162959, Expressed in testis and 114 other tissues |
ExpressionAtlasi | Q9Y316, baseline and differential |
Genevisiblei | Q9Y316, HS |
Organism-specific databases
HPAi | ENSG00000162959, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with ERBB2 phosphorylated on 'Tyr-1248'.
2 PublicationsBinary interactionsi
Hide detailsQ9Y316
Protein-protein interaction databases
BioGRIDi | 119263, 49 interactors |
CORUMi | Q9Y316 |
IntActi | Q9Y316, 29 interactors |
MINTi | Q9Y316 |
STRINGi | 9606.ENSP00000295065 |
Miscellaneous databases
RNActi | Q9Y316, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9Y316 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y316 |
Family & Domainsi
Sequence similaritiesi
Belongs to the MEMO1 family.Curated
Phylogenomic databases
eggNOGi | KOG3086, Eukaryota |
GeneTreei | ENSGT00390000006408 |
HOGENOMi | CLU_038085_0_1_1 |
InParanoidi | Q9Y316 |
OMAi | EQEAQYG |
OrthoDBi | 1057950at2759 |
PhylomeDBi | Q9Y316 |
TreeFami | TF300014 |
Family and domain databases
CDDi | cd07361, MEMO_like, 1 hit |
HAMAPi | MF_00055, MEMO1, 1 hit |
InterProi | View protein in InterPro IPR002737, MEMO1_fam |
PANTHERi | PTHR11060, PTHR11060, 1 hit |
Pfami | View protein in Pfam PF01875, Memo, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y316-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSNRVVCREA SHAGSWYTAS GPQLNAQLEG WLSQVQSTKR PARAIIAPHA
60 70 80 90 100
GYTYCGSCAA HAYKQVDPSI TRRIFILGPS HHVPLSRCAL SSVDIYRTPL
110 120 130 140 150
YDLRIDQKIY GELWKTGMFE RMSLQTDEDE HSIEMHLPYT AKAMESHKDE
160 170 180 190 200
FTIIPVLVGA LSESKEQEFG KLFSKYLADP SNLFVVSSDF CHWGQRFRYS
210 220 230 240 250
YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH NTICGRHPIG
260 270 280 290
VLLNAITELQ KNGMNMSFSF LNYAQSSQCR NWQDSSVSYA AGALTVH
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB5MCI6 | B5MCI6_HUMAN | Mediator of ErbB2-driven cell motil... | MEMO1 | 100 | Annotation score: | ||
C9JSD7 | C9JSD7_HUMAN | Protein MEMO1 | MEMO1 | 20 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | Q → H in AAH70046 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 172 | L → P in BAG59632 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047693 | 1 – 20 | MSNRV…WYTAS → MPLWRADKCQDVQSASWRPR RAD in isoform 3. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_041092 | 49 – 71 | Missing in isoform 2. 1 PublicationAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF363446 mRNA Translation: AAL34462.1 AB041018 mRNA Translation: BAD74066.1 AB041019 mRNA Translation: BAD74067.1 AF529368 mRNA Translation: AAQ09602.1 AF132961 mRNA Translation: AAD27736.1 AK297128 mRNA Translation: BAG59632.1 AL121652 Genomic DNA No translation available. AL121655 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAX00467.1 CH471053 Genomic DNA Translation: EAX00469.1 CH471053 Genomic DNA Translation: EAX00470.1 CH471053 Genomic DNA Translation: EAX00472.1 BC018733 mRNA Translation: AAH18733.1 BC070046 mRNA Translation: AAH70046.1 BC094681 mRNA Translation: AAH94681.1 |
CCDSi | CCDS1776.1 [Q9Y316-1] CCDS46255.1 [Q9Y316-2] |
RefSeqi | NP_001131074.1, NM_001137602.2 [Q9Y316-2] NP_001288762.1, NM_001301833.1 [Q9Y316-1] NP_001288781.1, NM_001301852.1 NP_057039.1, NM_015955.3 [Q9Y316-1] XP_011531194.1, XM_011532892.2 XP_016859744.1, XM_017004255.1 |
Genome annotation databases
Ensembli | ENST00000295065; ENSP00000295065; ENSG00000162959 [Q9Y316-1] ENST00000379383; ENSP00000368691; ENSG00000162959 [Q9Y316-3] ENST00000404530; ENSP00000385557; ENSG00000162959 [Q9Y316-1] ENST00000426310; ENSP00000400795; ENSG00000162959 [Q9Y316-2] |
GeneIDi | 51072 |
KEGGi | hsa:51072 |
UCSCi | uc002rnx.4, human [Q9Y316-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF363446 mRNA Translation: AAL34462.1 AB041018 mRNA Translation: BAD74066.1 AB041019 mRNA Translation: BAD74067.1 AF529368 mRNA Translation: AAQ09602.1 AF132961 mRNA Translation: AAD27736.1 AK297128 mRNA Translation: BAG59632.1 AL121652 Genomic DNA No translation available. AL121655 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAX00467.1 CH471053 Genomic DNA Translation: EAX00469.1 CH471053 Genomic DNA Translation: EAX00470.1 CH471053 Genomic DNA Translation: EAX00472.1 BC018733 mRNA Translation: AAH18733.1 BC070046 mRNA Translation: AAH70046.1 BC094681 mRNA Translation: AAH94681.1 |
CCDSi | CCDS1776.1 [Q9Y316-1] CCDS46255.1 [Q9Y316-2] |
RefSeqi | NP_001131074.1, NM_001137602.2 [Q9Y316-2] NP_001288762.1, NM_001301833.1 [Q9Y316-1] NP_001288781.1, NM_001301852.1 NP_057039.1, NM_015955.3 [Q9Y316-1] XP_011531194.1, XM_011532892.2 XP_016859744.1, XM_017004255.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3BCZ | X-ray | 2.10 | A/B/C/D | 5-297 | [»] | |
3BD0 | X-ray | 3.01 | A/B/C/D | 5-297 | [»] | |
SMRi | Q9Y316 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119263, 49 interactors |
CORUMi | Q9Y316 |
IntActi | Q9Y316, 29 interactors |
MINTi | Q9Y316 |
STRINGi | 9606.ENSP00000295065 |
PTM databases
iPTMneti | Q9Y316 |
PhosphoSitePlusi | Q9Y316 |
Polymorphism and mutation databases
BioMutai | MEMO1 |
DMDMi | 7388490 |
Proteomic databases
EPDi | Q9Y316 |
jPOSTi | Q9Y316 |
MassIVEi | Q9Y316 |
PaxDbi | Q9Y316 |
PeptideAtlasi | Q9Y316 |
PRIDEi | Q9Y316 |
ProteomicsDBi | 63699 85960 [Q9Y316-1] 85961 [Q9Y316-2] |
Protocols and materials databases
Antibodypediai | 47374, 153 antibodies |
DNASUi | 51072 |
Genome annotation databases
Ensembli | ENST00000295065; ENSP00000295065; ENSG00000162959 [Q9Y316-1] ENST00000379383; ENSP00000368691; ENSG00000162959 [Q9Y316-3] ENST00000404530; ENSP00000385557; ENSG00000162959 [Q9Y316-1] ENST00000426310; ENSP00000400795; ENSG00000162959 [Q9Y316-2] |
GeneIDi | 51072 |
KEGGi | hsa:51072 |
UCSCi | uc002rnx.4, human [Q9Y316-1] |
Organism-specific databases
DisGeNETi | 51072 |
EuPathDBi | HostDB:ENSG00000162959.13 |
GeneCardsi | MEMO1 |
HGNCi | HGNC:14014, MEMO1 |
HPAi | ENSG00000162959, Low tissue specificity |
MIMi | 611786, gene |
neXtProti | NX_Q9Y316 |
OpenTargetsi | ENSG00000162959 |
PharmGKBi | PA162395745 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3086, Eukaryota |
GeneTreei | ENSGT00390000006408 |
HOGENOMi | CLU_038085_0_1_1 |
InParanoidi | Q9Y316 |
OMAi | EQEAQYG |
OrthoDBi | 1057950at2759 |
PhylomeDBi | Q9Y316 |
TreeFami | TF300014 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y316 |
Reactomei | R-HSA-6785631, ERBB2 Regulates Cell Motility |
Miscellaneous databases
BioGRID-ORCSi | 51072, 11 hits in 386 CRISPR screens |
ChiTaRSi | MEMO1, human |
EvolutionaryTracei | Q9Y316 |
GenomeRNAii | 51072 |
Pharosi | Q9Y316, Tbio |
PROi | PR:Q9Y316 |
RNActi | Q9Y316, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162959, Expressed in testis and 114 other tissues |
ExpressionAtlasi | Q9Y316, baseline and differential |
Genevisiblei | Q9Y316, HS |
Family and domain databases
CDDi | cd07361, MEMO_like, 1 hit |
HAMAPi | MF_00055, MEMO1, 1 hit |
InterProi | View protein in InterPro IPR002737, MEMO1_fam |
PANTHERi | PTHR11060, PTHR11060, 1 hit |
Pfami | View protein in Pfam PF01875, Memo, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MEMO1_HUMAN | |
Accessioni | Q9Y316Primary (citable) accession number: Q9Y316 Secondary accession number(s): B4DLS0 Q6NSL5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM