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Protein

Protein MEMO1

Gene

MEMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.2 Publications

GO - Biological processi

  • regulation of cell motility Source: Reactome
  • regulation of microtubule-based process Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-6785631 ERBB2 Regulates Cell Motility

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MEMO1
Alternative name(s):
C21orf19-like protein
Hepatitis C virus NS5A-transactivated protein 7
Short name:
HCV NS5A-transactivated protein 7
Mediator of ErbB2-driven cell motility 1
Short name:
Mediator of cell motility 1
Short name:
Memo-1
Gene namesi
Name:MEMO1
Synonyms:C2orf4, MEMO, NS5ATP7
ORF Names:CGI-27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000162959.13
HGNCiHGNC:14014 MEMO1
MIMi611786 gene
neXtProtiNX_Q9Y316

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi16W → A: Abolishes interaction with ERBB2. 1 Publication1
Mutagenesisi49H → A: Abolishes interaction with ERBB2. 1 Publication1
Mutagenesisi54Y → A: Diminishes interaction with ERBB2. 1 Publication1
Mutagenesisi81H → A: Abolishes interaction with ERBB2. 1 Publication1
Mutagenesisi192H → A: Abolishes interaction with ERBB2. 1 Publication1
Mutagenesisi244C → A: Abolishes interaction with ERBB2. 1 Publication1

Organism-specific databases

DisGeNETi51072
OpenTargetsiENSG00000162959
PharmGKBiPA162395745

Polymorphism and mutation databases

BioMutaiMEMO1
DMDMi7388490

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001343941 – 297Protein MEMO1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei210PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y316
PaxDbiQ9Y316
PeptideAtlasiQ9Y316
PRIDEiQ9Y316
ProteomicsDBi85960
85961 [Q9Y316-2]

PTM databases

iPTMnetiQ9Y316
PhosphoSitePlusiQ9Y316

Expressioni

Gene expression databases

BgeeiENSG00000162959
CleanExiHS_MEMO1
ExpressionAtlasiQ9Y316 baseline and differential
GenevisibleiQ9Y316 HS

Organism-specific databases

HPAiHPA042603
HPA057952

Interactioni

Subunit structurei

Interacts with ERBB2 phosphorylated on 'Tyr-1248'.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119263, 37 interactors
CORUMiQ9Y316
IntActiQ9Y316, 18 interactors
MINTiQ9Y316
STRINGi9606.ENSP00000295065

Structurei

Secondary structure

1297
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni11 – 15Combined sources5
Helixi21 – 32Combined sources12
Beta strandi43 – 47Combined sources5
Helixi52 – 63Combined sources12
Turni68 – 70Combined sources3
Beta strandi73 – 79Combined sources7
Beta strandi81 – 83Combined sources3
Beta strandi86 – 90Combined sources5
Beta strandi94 – 96Combined sources3
Beta strandi103 – 105Combined sources3
Helixi107 – 115Combined sources9
Beta strandi119 – 121Combined sources3
Helixi124 – 129Combined sources6
Helixi134 – 136Combined sources3
Helixi137 – 143Combined sources7
Helixi145 – 147Combined sources3
Beta strandi152 – 158Combined sources7
Helixi163 – 177Combined sources15
Beta strandi182 – 187Combined sources6
Beta strandi192 – 194Combined sources3
Helixi195 – 197Combined sources3
Helixi204 – 206Combined sources3
Helixi209 – 225Combined sources17
Helixi229 – 239Combined sources11
Helixi246 – 261Combined sources16
Beta strandi266 – 277Combined sources12
Beta strandi286 – 296Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BCZX-ray2.10A/B/C/D5-297[»]
3BD0X-ray3.01A/B/C/D5-297[»]
ProteinModelPortaliQ9Y316
SMRiQ9Y316
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y316

Family & Domainsi

Sequence similaritiesi

Belongs to the MEMO1 family.Curated

Phylogenomic databases

eggNOGiKOG3086 Eukaryota
COG1355 LUCA
GeneTreeiENSGT00390000006408
HOGENOMiHOG000225260
HOVERGENiHBG050811
InParanoidiQ9Y316
KOiK06990
OMAiYTYCGAC
OrthoDBiEOG091G0GVZ
PhylomeDBiQ9Y316
TreeFamiTF300014

Family and domain databases

CDDicd07361 MEMO_like, 1 hit
HAMAPiMF_00055 MEMO1, 1 hit
InterProiView protein in InterPro
IPR002737 MEMO1_fam
PANTHERiPTHR11060 PTHR11060, 1 hit
PfamiView protein in Pfam
PF01875 Memo, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y316-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNRVVCREA SHAGSWYTAS GPQLNAQLEG WLSQVQSTKR PARAIIAPHA
60 70 80 90 100
GYTYCGSCAA HAYKQVDPSI TRRIFILGPS HHVPLSRCAL SSVDIYRTPL
110 120 130 140 150
YDLRIDQKIY GELWKTGMFE RMSLQTDEDE HSIEMHLPYT AKAMESHKDE
160 170 180 190 200
FTIIPVLVGA LSESKEQEFG KLFSKYLADP SNLFVVSSDF CHWGQRFRYS
210 220 230 240 250
YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH NTICGRHPIG
260 270 280 290
VLLNAITELQ KNGMNMSFSF LNYAQSSQCR NWQDSSVSYA AGALTVH
Length:297
Mass (Da):33,733
Last modified:November 1, 1999 - v1
Checksum:iE315FD5587776211
GO
Isoform 2 (identifier: Q9Y316-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-71: Missing.

Show »
Length:274
Mass (Da):31,307
Checksum:i1BE5B4A07A5D44D8
GO
Isoform 3 (identifier: Q9Y316-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MSNRVVCREASHAGSWYTAS → MPLWRADKCQDVQSASWRPRRAD

Show »
Length:300
Mass (Da):34,294
Checksum:i0778186B7CCA0ADA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23Q → H in AAH70046 (PubMed:15489334).Curated1
Sequence conflicti172L → P in BAG59632 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0476931 – 20MSNRV…WYTAS → MPLWRADKCQDVQSASWRPR RAD in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_04109249 – 71Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363446 mRNA Translation: AAL34462.1
AB041018 mRNA Translation: BAD74066.1
AB041019 mRNA Translation: BAD74067.1
AF529368 mRNA Translation: AAQ09602.1
AF132961 mRNA Translation: AAD27736.1
AK297128 mRNA Translation: BAG59632.1
AL121652 Genomic DNA No translation available.
AL121655 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00467.1
CH471053 Genomic DNA Translation: EAX00469.1
CH471053 Genomic DNA Translation: EAX00470.1
CH471053 Genomic DNA Translation: EAX00472.1
BC018733 mRNA Translation: AAH18733.1
BC070046 mRNA Translation: AAH70046.1
BC094681 mRNA Translation: AAH94681.1
CCDSiCCDS1776.1 [Q9Y316-1]
CCDS46255.1 [Q9Y316-2]
RefSeqiNP_001131074.1, NM_001137602.2 [Q9Y316-2]
NP_001288762.1, NM_001301833.1 [Q9Y316-1]
NP_001288781.1, NM_001301852.1
NP_057039.1, NM_015955.3 [Q9Y316-1]
XP_011531194.1, XM_011532892.2 [Q9Y316-1]
XP_016859744.1, XM_017004255.1 [Q9Y316-1]
UniGeneiHs.444969

Genome annotation databases

EnsembliENST00000295065; ENSP00000295065; ENSG00000162959 [Q9Y316-1]
ENST00000379383; ENSP00000368691; ENSG00000162959 [Q9Y316-3]
ENST00000404530; ENSP00000385557; ENSG00000162959 [Q9Y316-1]
ENST00000426310; ENSP00000400795; ENSG00000162959 [Q9Y316-2]
GeneIDi51072
KEGGihsa:51072
UCSCiuc002rnx.4 human [Q9Y316-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMEMO1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y316
Secondary accession number(s): B4DLS0
, D6W575, Q5R2V8, Q5R2V9, Q6NSL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

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