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Protein

Acyl-coenzyme A thioesterase 9, mitochondrial

Gene

ACOT9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

ReactomeiR-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A thioesterase 9, mitochondrial (EC:3.1.2.-)
Short name:
Acyl-CoA thioesterase 9
Alternative name(s):
Acyl-CoA thioester hydrolase 9
Gene namesi
Name:ACOT9
ORF Names:CGI-16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000123130.16
HGNCiHGNC:17152 ACOT9
MIMi300862 gene
neXtProtiNX_Q9Y305

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi23597
OpenTargetsiENSG00000123130
PharmGKBiPA142672656

Polymorphism and mutation databases

BioMutaiACOT9
DMDMi224471815

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 21MitochondrionBy similarityAdd BLAST21
ChainiPRO_000005381222 – 439Acyl-coenzyme A thioesterase 9, mitochondrialAdd BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei103N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y305
PaxDbiQ9Y305
PeptideAtlasiQ9Y305
PRIDEiQ9Y305
ProteomicsDBi85953
85954 [Q9Y305-2]
85955 [Q9Y305-3]
85956 [Q9Y305-4]

PTM databases

iPTMnetiQ9Y305
PhosphoSitePlusiQ9Y305
SwissPalmiQ9Y305

Expressioni

Gene expression databases

BgeeiENSG00000123130
CleanExiHS_ACOT9
ExpressionAtlasiQ9Y305 baseline and differential
GenevisibleiQ9Y305 HS

Organism-specific databases

HPAiHPA035533

Interactioni

Subunit structurei

Interacts with NYAP1, NYAP2 and MYO16.By similarity

Protein-protein interaction databases

BioGridi117132, 50 interactors
IntActiQ9Y305, 22 interactors
MINTiQ9Y305
STRINGi9606.ENSP00000368605

Structurei

3D structure databases

ProteinModelPortaliQ9Y305
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 209HotDog ACOT-type 1PROSITE-ProRule annotationAdd BLAST126
Domaini289 – 401HotDog ACOT-type 2PROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Belongs to the acyl coenzyme A hydrolase family.Curated

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG2763 Eukaryota
ENOG410XSYM LUCA
GeneTreeiENSGT00390000005330
HOGENOMiHOG000188398
HOVERGENiHBG004168
InParanoidiQ9Y305
KOiK17361
OMAiNSCLFTF
OrthoDBiEOG091G06UC
PhylomeDBiQ9Y305
TreeFamiTF313352

Family and domain databases

InterProiView protein in InterPro
IPR033120 HOTDOG_ACOT
IPR029069 HotDog_dom_sf
SUPFAMiSSF54637 SSF54637, 2 hits
PROSITEiView protein in PROSITE
PS51770 HOTDOG_ACOT, 2 hits

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y305-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRAALRLCA LGKGQLTPGR GLTQGPQNPK KQGIFHIHEV RDKLREIVGA
60 70 80 90 100
STNWRDHVKA MEERKLLHSF LAKSQDGLPP RRMKDSYIEV LLPLGSEPEL
110 120 130 140 150
REKYLTVQNT VRFGRILEDL DSLGVLICYM HNKIHSAKMS PLSIVTALVD
160 170 180 190 200
KIDMCKKSLS PEQDIKFSGH VSWVGKTSME VKMQMFQLHG DEFCPVLDAT
210 220 230 240 250
FVMVARDSEN KGPAFVNPLI PESPEEEELF RQGELNKGRR IAFSSTSLLK
260 270 280 290 300
MAPSAEERTT IHEMFLSTLD PKTISFRSRV LPSNAVWMEN SKLKSLEICH
310 320 330 340 350
PQERNIFNRI FGGFLMRKAY ELAWATACSF GGSRPFVVAV DDIMFQKPVE
360 370 380 390 400
VGSLLFLSSQ VCFTQNNYIQ VRVHSEVASL QEKQHTTTNV FHFTFMSEKE
410 420 430
VPLVFPKTYG ESMLYLDGQR HFNSMSGPAT LRKDYLVEP
Note: No experimental confirmation available.
Length:439
Mass (Da):49,902
Last modified:March 3, 2009 - v2
Checksum:i1CE2158D4F83D4D6
GO
Isoform 2 (identifier: Q9Y305-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     5-39: ALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHE → PC

Note: No experimental confirmation available.
Show »
Length:406
Mass (Da):46,355
Checksum:i99ADE404D472CEEB
GO
Isoform 3 (identifier: Q9Y305-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Note: No experimental confirmation available.
Show »
Length:379
Mass (Da):43,207
Checksum:iAC76325AB9264911
GO
Isoform 4 (identifier: Q9Y305-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-39: E → EACSSIHVNH

Show »
Length:448
Mass (Da):50,851
Checksum:iAA20C18EF239983D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188L → S in BAG51291 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062668305N → H in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0364201 – 60Missing in isoform 3. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_0364195 – 39ALRLC…FHIHE → PC in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_04109339E → EACSSIHVNH in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132950 mRNA Translation: AAD27725.1
AK024337 mRNA Translation: BAG51291.1
BX648512 mRNA No translation available.
AC093011 Genomic DNA No translation available.
AC131011 Genomic DNA No translation available.
CH471074 Genomic DNA Translation: EAW98998.1
BC136671 mRNA Translation: AAI36672.1
BC144360 mRNA Translation: AAI44361.1
CCDSiCCDS35216.1 [Q9Y305-1]
CCDS43924.1 [Q9Y305-4]
CCDS83460.1 [Q9Y305-3]
RefSeqiNP_001028755.2, NM_001033583.2 [Q9Y305-1]
NP_001032248.1, NM_001037171.1 [Q9Y305-4]
NP_001317188.1, NM_001330259.1 [Q9Y305-3]
UniGeneiHs.298885

Genome annotation databases

EnsembliENST00000336430; ENSP00000336580; ENSG00000123130 [Q9Y305-1]
ENST00000379295; ENSP00000368597; ENSG00000123130 [Q9Y305-3]
ENST00000379303; ENSP00000368605; ENSG00000123130 [Q9Y305-4]
GeneIDi23597
KEGGihsa:23597
UCSCiuc004dao.4 human [Q9Y305-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiACOT9_HUMAN
AccessioniPrimary (citable) accession number: Q9Y305
Secondary accession number(s): B3KNC9, B7ZM94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: March 3, 2009
Last modified: July 18, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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