Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein SGT1 homolog

Gene

SUGT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.

GO - Biological processi

  • mitotic cell cycle Source: ProtInc
  • positive regulation by host of symbiont catalytic activity Source: AgBase
  • protein stabilization Source: GO_Central
  • regulation of protein stability Source: AgBase

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-844456 The NLRP3 inflammasome

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SGT1 homologBy similarity
Alternative name(s):
Protein 40-6-3Imported
Sgt11 Publication
Suppressor of G2 allele of SKP1 homologBy similarity
Gene namesi
Name:SUGT1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000165416.14
HGNCiHGNC:16987 SUGT1
MIMi604098 gene
neXtProtiNX_Q9Y2Z0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10910
OpenTargetsiENSG00000165416
PharmGKBiPA134880121

Polymorphism and mutation databases

BioMutaiSUGT1
DMDMi62512186

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00001063322 – 365Protein SGT1 homologAdd BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei265PhosphothreonineCombined sources1
Modified residuei281Phosphoserine1 Publication1
Modified residuei284PhosphothreonineCombined sources1
Cross-linki295Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki295Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei331PhosphoserineCombined sources1 Publication1

Post-translational modificationi

Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y2Z0
PaxDbiQ9Y2Z0
PeptideAtlasiQ9Y2Z0
PRIDEiQ9Y2Z0
ProteomicsDBi85940
85941 [Q9Y2Z0-2]

PTM databases

GlyConnecti638
iPTMnetiQ9Y2Z0
PhosphoSitePlusiQ9Y2Z0
SwissPalmiQ9Y2Z0
UniCarbKBiQ9Y2Z0

Expressioni

Gene expression databases

BgeeiENSG00000165416 Expressed in 204 organ(s), highest expression level in testis
CleanExiHS_SUGT1
GenevisibleiQ9Y2Z0 HS

Organism-specific databases

HPAiCAB015942
HPA043949

Interactioni

Subunit structurei

Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts with S100A6. Interacts with HSP90.4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi116115, 112 interactors
DIPiDIP-53799N
IntActiQ9Y2Z0, 50 interactors
MINTiQ9Y2Z0
STRINGi9606.ENSP00000367208

Structurei

Secondary structure

1365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y2Z0
SMRiQ9Y2Z0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y2Z0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 44TPR 1Add BLAST34
Repeati45 – 78TPR 2Add BLAST34
Repeati79 – 112TPR 3Add BLAST34
Domaini169 – 258CSPROSITE-ProRule annotationAdd BLAST90
Domaini276 – 365SGSPROSITE-ProRule annotationAdd BLAST90

Domaini

The CS domain mediates interaction with HSP90.

Sequence similaritiesi

Belongs to the SGT1 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0548 Eukaryota
KOG1309 Eukaryota
COG5091 LUCA
GeneTreeiENSGT00390000013700
HOGENOMiHOG000248210
HOVERGENiHBG055080
InParanoidiQ9Y2Z0
KOiK12795
OMAiTKVEIKM
OrthoDBiEOG091G0QQH
PhylomeDBiQ9Y2Z0
TreeFamiTF105979

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR007699 SGS_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF04969 CS, 1 hit
PF05002 SGS, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 2 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit
PS51048 SGS, 1 hit
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y2Z0-1) [UniParc]FASTAAdd to basket
Also known as: SGT1B1 Publication, SUGT1B1 Publication, SGT1.21 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAAGTAT SQRFFQSFSD ALIDEDPQAA LEELTKALEQ KPDDAQYYCQ
60 70 80 90 100
RAYCHILLGN YCVAVADAKK SLELNPNNST AMLRKGICEY HEKNYAAALE
110 120 130 140 150
TFTEGQKLDI ETGFHRVGQA GLQLLTSSDP PALDSQSAGI TGADANFSVW
160 170 180 190 200
IKRCQEAQNG SESEVWTHQS KIKYDWYQTE SQVVITLMIK NVQKNDVNVE
210 220 230 240 250
FSEKELSALV KLPSGEDYNL KLELLHPIIP EQSTFKVLST KIEIKLKKPE
260 270 280 290 300
AVRWEKLEGQ GDVPTPKQFV ADVKNLYPSS SPYTRNWDKL VGEIKEEEKN
310 320 330 340 350
EKLEGDAALN RLFQQIYSDG SDEVKRAMNK SFMESGGTVL STNWSDVGKR
360
KVEINPPDDM EWKKY
Length:365
Mass (Da):41,024
Last modified:January 23, 2007 - v3
Checksum:i4A5A413E70561D9A
GO
Isoform 2 (identifier: Q9Y2Z0-2) [UniParc]FASTAAdd to basket
Also known as: SGT1A, SUGT1A1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     110-142: IETGFHRVGQAGLQLLTSSDPPALDSQSAGITG → S

Show »
Length:333
Mass (Da):37,805
Checksum:i14DE069A1623DB53
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120A → V in AAQ01749 (PubMed:15346769).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013420110 – 142IETGF…AGITG → S in isoform 2. 4 PublicationsAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132856 mRNA Translation: AAD30062.1
AJ344097 mRNA Translation: CAC51433.1
AY321358 mRNA Translation: AAQ76039.1
AY271314 mRNA Translation: AAQ01749.1
BT009798 mRNA Translation: AAP88800.1
AL139089 Genomic DNA No translation available.
CH471124 Genomic DNA Translation: EAW52045.1
BC000911 mRNA Translation: AAH00911.1
CCDSiCCDS45050.1 [Q9Y2Z0-1]
CCDS9436.1 [Q9Y2Z0-2]
RefSeqiNP_001124384.1, NM_001130912.2 [Q9Y2Z0-1]
NP_001307760.1, NM_001320831.1
NP_006695.1, NM_006704.4 [Q9Y2Z0-2]
UniGeneiHs.281902

Genome annotation databases

EnsembliENST00000310528; ENSP00000308067; ENSG00000165416 [Q9Y2Z0-2]
ENST00000343788; ENSP00000367208; ENSG00000165416 [Q9Y2Z0-1]
GeneIDi10910
KEGGihsa:10910
UCSCiuc001vhb.3 human [Q9Y2Z0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132856 mRNA Translation: AAD30062.1
AJ344097 mRNA Translation: CAC51433.1
AY321358 mRNA Translation: AAQ76039.1
AY271314 mRNA Translation: AAQ01749.1
BT009798 mRNA Translation: AAP88800.1
AL139089 Genomic DNA No translation available.
CH471124 Genomic DNA Translation: EAW52045.1
BC000911 mRNA Translation: AAH00911.1
CCDSiCCDS45050.1 [Q9Y2Z0-1]
CCDS9436.1 [Q9Y2Z0-2]
RefSeqiNP_001124384.1, NM_001130912.2 [Q9Y2Z0-1]
NP_001307760.1, NM_001320831.1
NP_006695.1, NM_006704.4 [Q9Y2Z0-2]
UniGeneiHs.281902

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RL1NMR-A167-276[»]
ProteinModelPortaliQ9Y2Z0
SMRiQ9Y2Z0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116115, 112 interactors
DIPiDIP-53799N
IntActiQ9Y2Z0, 50 interactors
MINTiQ9Y2Z0
STRINGi9606.ENSP00000367208

PTM databases

GlyConnecti638
iPTMnetiQ9Y2Z0
PhosphoSitePlusiQ9Y2Z0
SwissPalmiQ9Y2Z0
UniCarbKBiQ9Y2Z0

Polymorphism and mutation databases

BioMutaiSUGT1
DMDMi62512186

Proteomic databases

EPDiQ9Y2Z0
PaxDbiQ9Y2Z0
PeptideAtlasiQ9Y2Z0
PRIDEiQ9Y2Z0
ProteomicsDBi85940
85941 [Q9Y2Z0-2]

Protocols and materials databases

DNASUi10910
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310528; ENSP00000308067; ENSG00000165416 [Q9Y2Z0-2]
ENST00000343788; ENSP00000367208; ENSG00000165416 [Q9Y2Z0-1]
GeneIDi10910
KEGGihsa:10910
UCSCiuc001vhb.3 human [Q9Y2Z0-1]

Organism-specific databases

CTDi10910
DisGeNETi10910
EuPathDBiHostDB:ENSG00000165416.14
GeneCardsiSUGT1
H-InvDBiHIX0026254
HIX0201992
HGNCiHGNC:16987 SUGT1
HPAiCAB015942
HPA043949
MIMi604098 gene
neXtProtiNX_Q9Y2Z0
OpenTargetsiENSG00000165416
PharmGKBiPA134880121
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0548 Eukaryota
KOG1309 Eukaryota
COG5091 LUCA
GeneTreeiENSGT00390000013700
HOGENOMiHOG000248210
HOVERGENiHBG055080
InParanoidiQ9Y2Z0
KOiK12795
OMAiTKVEIKM
OrthoDBiEOG091G0QQH
PhylomeDBiQ9Y2Z0
TreeFamiTF105979

Enzyme and pathway databases

ReactomeiR-HSA-844456 The NLRP3 inflammasome

Miscellaneous databases

ChiTaRSiSUGT1 human
EvolutionaryTraceiQ9Y2Z0
GeneWikiiSUGT1
GenomeRNAii10910
PROiPR:Q9Y2Z0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165416 Expressed in 204 organ(s), highest expression level in testis
CleanExiHS_SUGT1
GenevisibleiQ9Y2Z0 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR007699 SGS_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF04969 CS, 1 hit
PF05002 SGS, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 2 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit
PS51048 SGS, 1 hit
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSGT1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2Z0
Secondary accession number(s): A2A303
, Q5JAK5, Q5TAM6, Q6VXY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 175 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again