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Protein

Krueppel-like factor 13

Gene

KLF13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri167 – 191C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri197 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ9Y2Y9

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 13
Alternative name(s):
Basic transcription element-binding protein 3
Short name:
BTE-binding protein 3
Novel Sp1-like zinc finger transcription factor 1
RANTES factor of late activated T-lymphocytes 1
Short name:
RFLAT-1
Transcription factor BTEB3
Transcription factor NSLP1
Gene namesi
Name:KLF13
Synonyms:BTEB3, NSLP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000169926.9
HGNCiHGNC:13672 KLF13
MIMi605328 gene
neXtProtiNX_Q9Y2Y9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51621
MalaCardsiKLF13
OpenTargetsiENSG00000169926
PharmGKBiPA30133

Polymorphism and mutation databases

BioMutaiKLF13
DMDMi17369913

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471841 – 288Krueppel-like factor 13Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei268PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei279PhosphoserineBy similarity1
Modified residuei283PhosphoserineBy similarity1
Modified residuei287PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y2Y9
PaxDbiQ9Y2Y9
PeptideAtlasiQ9Y2Y9
PRIDEiQ9Y2Y9
ProteomicsDBi85939

PTM databases

iPTMnetiQ9Y2Y9
PhosphoSitePlusiQ9Y2Y9

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000169926
CleanExiHS_KLF13
ExpressionAtlasiQ9Y2Y9 baseline and differential
GenevisibleiQ9Y2Y9 HS

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119642, 11 interactors
ELMiQ9Y2Y9
IntActiQ9Y2Y9, 4 interactors
MINTiQ9Y2Y9
STRINGi9606.ENSP00000302456

Structurei

3D structure databases

ProteinModelPortaliQ9Y2Y9
SMRiQ9Y2Y9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 145Ala/Pro-richAdd BLAST144
Compositional biasi2 – 5Poly-Ala4
Compositional biasi113 – 116Poly-Ala4
Compositional biasi148 – 168Arg/Lys-rich (basic)Add BLAST21
Compositional biasi264 – 287Ser-richAdd BLAST24

Domaini

The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri167 – 191C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri197 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000233575
HOVERGENiHBG050746
InParanoidiQ9Y2Y9
KOiK09208
OMAiQRKHKCH
OrthoDBiEOG091G1BN0
PhylomeDBiQ9Y2Y9
TreeFamiTF351003

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q9Y2Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAYVDHF AAECLVSMSS RAVVHGPREG PESRPEGAAV AATPTLPRVE
60 70 80 90 100
ERRDGKDSAS LFVVARILAD LNQQAPAPAP AERREGAAAR KARTPCRLPP
110 120 130 140 150
PAPEPTSPGA EGAAAAPPSP AWSEPEPEAG LEPEREPGPA GSGEPGLRQR
160 170 180 190 200
VRRGRSRADL ESPQRKHKCH YAGCEKVYGK SSHLKAHLRT HTGERPFACS
210 220 230 240 250
WQDCNKKFAR SDELARHYRT HTGEKKFSCP ICEKRFMRSD HLTKHARRHA
260 270 280
NFHPGMLQRR GGGSRTGSLS DYSRSDASSP TISPASSP
Length:288
Mass (Da):31,180
Last modified:November 1, 1999 - v1
Checksum:iDD2765EE00E9C049
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39A → S in AAD34020 (PubMed:10415854).Curated1
Sequence conflicti104 – 114EPTSPGAEGAA → MSPPPPALKARR in AAD34020 (PubMed:10415854).CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132599 mRNA Translation: AAD26864.1
AF150628 mRNA Translation: AAD34020.1
BC013946 mRNA Translation: AAH13946.1
BC010438 mRNA Translation: AAH10438.1
BC012741 mRNA Translation: AAH12741.1
CCDSiCCDS10025.1
RefSeqiNP_001289390.1, NM_001302461.1
NP_057079.2, NM_015995.3
UniGeneiHs.376443
Hs.525752
Hs.585100

Genome annotation databases

EnsembliENST00000307145; ENSP00000302456; ENSG00000169926
ENST00000621843; ENSP00000484904; ENSG00000275746
GeneIDi51621
KEGGihsa:51621

Similar proteinsi

Entry informationi

Entry nameiKLF13_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2Y9
Secondary accession number(s): Q9Y356
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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