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UniProtKB - Q9Y2Y9 (KLF13_HUMAN)
Protein
Krueppel-like factor 13
Gene
KLF13
Organism
Homo sapiens (Human)
Status
Functioni
Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 167 – 191 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 197 – 221 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 227 – 249 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of erythrocyte differentiation Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- transcription by RNA polymerase II Source: ProtInc
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2Y9 |
SignaLinki | Q9Y2Y9 |
SIGNORi | Q9Y2Y9 |
Names & Taxonomyi
Protein namesi | Recommended name: Krueppel-like factor 13Alternative name(s): Basic transcription element-binding protein 3 Short name: BTE-binding protein 3 Novel Sp1-like zinc finger transcription factor 1 RANTES factor of late activated T-lymphocytes 1 Short name: RFLAT-1 Transcription factor BTEB3 Transcription factor NSLP1 |
Gene namesi | Name:KLF13 Synonyms:BTEB3, NSLP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13672, KLF13 |
MIMi | 605328, gene |
neXtProti | NX_Q9Y2Y9 |
VEuPathDBi | HostDB:ENSG00000169926 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 51621 |
GeneReviewsi | KLF13 |
MalaCardsi | KLF13 |
OpenTargetsi | ENSG00000169926 |
PharmGKBi | PA30133 |
Miscellaneous databases
Pharosi | Q9Y2Y9, Tbio |
Genetic variation databases
BioMutai | KLF13 |
DMDMi | 17369913 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047184 | 1 – 288 | Krueppel-like factor 13Add BLAST | 288 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 268 | PhosphoserineCombined sources | 1 | |
Modified residuei | 270 | PhosphoserineCombined sources | 1 | |
Modified residuei | 279 | PhosphoserineBy similarity | 1 | |
Modified residuei | 283 | PhosphoserineBy similarity | 1 | |
Modified residuei | 287 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylated.
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Y2Y9 |
jPOSTi | Q9Y2Y9 |
MassIVEi | Q9Y2Y9 |
PaxDbi | Q9Y2Y9 |
PeptideAtlasi | Q9Y2Y9 |
PRIDEi | Q9Y2Y9 |
ProteomicsDBi | 85939 |
PTM databases
iPTMneti | Q9Y2Y9 |
PhosphoSitePlusi | Q9Y2Y9 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSG00000169926, Expressed in cerebellum and 224 other tissues |
ExpressionAtlasi | Q9Y2Y9, baseline and differential |
Genevisiblei | Q9Y2Y9, HS |
Organism-specific databases
HPAi | ENSG00000169926, Low tissue specificity |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 119642, 15 interactors |
ELMi | Q9Y2Y9 |
IntActi | Q9Y2Y9, 6 interactors |
MINTi | Q9Y2Y9 |
STRINGi | 9606.ENSP00000302456 |
Miscellaneous databases
RNActi | Q9Y2Y9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 23 – 57 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 71 – 166 | DisorderedSequence analysisAdd BLAST | 96 | |
Regioni | 249 – 288 | DisorderedSequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 148 – 166 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 263 – 288 | Polar residuesSequence analysisAdd BLAST | 26 |
Domaini
The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.
Sequence similaritiesi
Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 167 – 191 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 197 – 221 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 227 – 249 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161911 |
HOGENOMi | CLU_002678_33_2_1 |
InParanoidi | Q9Y2Y9 |
OMAi | WQGCNKK |
OrthoDBi | 1308225at2759 |
PhylomeDBi | Q9Y2Y9 |
TreeFami | TF351003 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9Y2Y9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAAYVDHF AAECLVSMSS RAVVHGPREG PESRPEGAAV AATPTLPRVE
60 70 80 90 100
ERRDGKDSAS LFVVARILAD LNQQAPAPAP AERREGAAAR KARTPCRLPP
110 120 130 140 150
PAPEPTSPGA EGAAAAPPSP AWSEPEPEAG LEPEREPGPA GSGEPGLRQR
160 170 180 190 200
VRRGRSRADL ESPQRKHKCH YAGCEKVYGK SSHLKAHLRT HTGERPFACS
210 220 230 240 250
WQDCNKKFAR SDELARHYRT HTGEKKFSCP ICEKRFMRSD HLTKHARRHA
260 270 280
NFHPGMLQRR GGGSRTGSLS DYSRSDASSP TISPASSP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YK05 | H0YK05_HUMAN | Krueppel-like factor 13 | KLF13 | 100 | Annotation score: | ||
A0A087X1K6 | A0A087X1K6_HUMAN | Krueppel-like factor 13 | KLF13 | 286 | Annotation score: | ||
H0YKM8 | H0YKM8_HUMAN | Krueppel-like factor 13 | KLF13 | 14 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 39 | A → S in AAD34020 (PubMed:10415854).Curated | 1 | |
Sequence conflicti | 104 – 114 | EPTSPGAEGAA → MSPPPPALKARR in AAD34020 (PubMed:10415854).CuratedAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF132599 mRNA Translation: AAD26864.1 AF150628 mRNA Translation: AAD34020.1 BC013946 mRNA Translation: AAH13946.1 BC010438 mRNA Translation: AAH10438.1 BC012741 mRNA Translation: AAH12741.1 |
CCDSi | CCDS10025.1 |
RefSeqi | NP_001289390.1, NM_001302461.1 NP_057079.2, NM_015995.3 |
Genome annotation databases
Ensembli | ENST00000307145; ENSP00000302456; ENSG00000169926 ENST00000621843; ENSP00000484904; ENSG00000275746 |
GeneIDi | 51621 |
KEGGi | hsa:51621 |
MANE-Selecti | ENST00000307145.4; ENSP00000302456.3; NM_015995.4; NP_057079.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF132599 mRNA Translation: AAD26864.1 AF150628 mRNA Translation: AAD34020.1 BC013946 mRNA Translation: AAH13946.1 BC010438 mRNA Translation: AAH10438.1 BC012741 mRNA Translation: AAH12741.1 |
CCDSi | CCDS10025.1 |
RefSeqi | NP_001289390.1, NM_001302461.1 NP_057079.2, NM_015995.3 |
3D structure databases
SMRi | Q9Y2Y9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119642, 15 interactors |
ELMi | Q9Y2Y9 |
IntActi | Q9Y2Y9, 6 interactors |
MINTi | Q9Y2Y9 |
STRINGi | 9606.ENSP00000302456 |
PTM databases
iPTMneti | Q9Y2Y9 |
PhosphoSitePlusi | Q9Y2Y9 |
Genetic variation databases
BioMutai | KLF13 |
DMDMi | 17369913 |
Proteomic databases
EPDi | Q9Y2Y9 |
jPOSTi | Q9Y2Y9 |
MassIVEi | Q9Y2Y9 |
PaxDbi | Q9Y2Y9 |
PeptideAtlasi | Q9Y2Y9 |
PRIDEi | Q9Y2Y9 |
ProteomicsDBi | 85939 |
Protocols and materials databases
Antibodypediai | 9456, 183 antibodies from 32 providers |
DNASUi | 51621 |
Genome annotation databases
Ensembli | ENST00000307145; ENSP00000302456; ENSG00000169926 ENST00000621843; ENSP00000484904; ENSG00000275746 |
GeneIDi | 51621 |
KEGGi | hsa:51621 |
MANE-Selecti | ENST00000307145.4; ENSP00000302456.3; NM_015995.4; NP_057079.2 |
Organism-specific databases
CTDi | 51621 |
DisGeNETi | 51621 |
GeneCardsi | KLF13 |
GeneReviewsi | KLF13 |
HGNCi | HGNC:13672, KLF13 |
HPAi | ENSG00000169926, Low tissue specificity |
MalaCardsi | KLF13 |
MIMi | 605328, gene |
neXtProti | NX_Q9Y2Y9 |
OpenTargetsi | ENSG00000169926 |
PharmGKBi | PA30133 |
VEuPathDBi | HostDB:ENSG00000169926 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161911 |
HOGENOMi | CLU_002678_33_2_1 |
InParanoidi | Q9Y2Y9 |
OMAi | WQGCNKK |
OrthoDBi | 1308225at2759 |
PhylomeDBi | Q9Y2Y9 |
TreeFami | TF351003 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2Y9 |
SignaLinki | Q9Y2Y9 |
SIGNORi | Q9Y2Y9 |
Miscellaneous databases
BioGRID-ORCSi | 51621, 13 hits in 1067 CRISPR screens |
ChiTaRSi | KLF13, human |
GeneWikii | KLF13 |
GenomeRNAii | 51621 |
Pharosi | Q9Y2Y9, Tbio |
PROi | PR:Q9Y2Y9 |
RNActi | Q9Y2Y9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169926, Expressed in cerebellum and 224 other tissues |
ExpressionAtlasi | Q9Y2Y9, baseline and differential |
Genevisiblei | Q9Y2Y9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KLF13_HUMAN | |
Accessioni | Q9Y2Y9Primary (citable) accession number: Q9Y2Y9 Secondary accession number(s): Q9Y356 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 2, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families