UniProtKB - Q9Y2Y9 (KLF13_HUMAN)

BLAST

>sp|Q9Y2Y9|KLF13_HUMAN Krueppel-like factor 13 OS=Homo sapiens OX=9606 GN=KLF13 PE=1 SV=1
MAAAAYVDHFAAECLVSMSSRAVVHGPREGPESRPEGAAVAATPTLPRVEERRDGKDSAS
LFVVARILADLNQQAPAPAPAERREGAAARKARTPCRLPPPAPEPTSPGAEGAAAAPPSP
AWSEPEPEAGLEPEREPGPAGSGEPGLRQRVRRGRSRADLESPQRKHKCHYAGCEKVYGK
SSHLKAHLRTHTGERPFACSWQDCNKKFARSDELARHYRTHTGEKKFSCPICEKRFMRSD
HLTKHARRHANFHPGMLQRRGGGSRTGSLSDYSRSDASSPTISPASSP

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History
Entry version 157 (07 Nov 2018)
Sequence version 1 (01 Nov 1999)
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Protein

Krueppel-like factor 13

Gene

KLF13

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	167 – 191	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	197 – 221	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	227 – 249	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of cell proliferation Source: Ensembl
negative regulation of erythrocyte differentiation Source: Ensembl
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 10023774

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SIGNORⁱ	Q9Y2Y9

SIGNORⁱ

Q9Y2Y9

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Krueppel-like factor 13 Alternative name(s): Basic transcription element-binding protein 3 Short name: BTE-binding protein 3 Novel Sp1-like zinc finger transcription factor 1 RANTES factor of late activated T-lymphocytes 1 Short name: RFLAT-1 Transcription factor BTEB3 Transcription factor NSLP1
Gene namesⁱ	Name:KLF13 Synonyms:BTEB3, NSLP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000169926.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13672 KLF13
MIMⁱ	605328 gene
neXtProtⁱ	NX_Q9Y2Y9

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51621
MalaCards human disease database More...MalaCardsⁱ	KLF13
Open Targets More...OpenTargetsⁱ	ENSG00000169926
PharmGKBⁱ	PA30133

Polymorphism and mutation databases

BioMutaⁱ	KLF13
DMDMⁱ	17369913

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047184	1 – 288	Krueppel-like factor 13Add BLAST		288

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	268	PhosphoserineCombined sources	1
Modified residueⁱ	270	PhosphoserineCombined sources	1
Modified residueⁱ	279	PhosphoserineBy similarity	1
Modified residueⁱ	283	PhosphoserineBy similarity	1
Modified residueⁱ	287	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated.

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y2Y9
PaxDbⁱ	Q9Y2Y9
PeptideAtlas More...PeptideAtlasⁱ	Q9Y2Y9
PRIDEⁱ	Q9Y2Y9
ProteomicsDBⁱ	85939

PTM databases

iPTMnetⁱ	Q9Y2Y9
PhosphoSitePlusⁱ	Q9Y2Y9

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000169926 Expressed in 212 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_KLF13
ExpressionAtlasⁱ	Q9Y2Y9 baseline and differential
Genevisibleⁱ	Q9Y2Y9 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GATA4	P43694	3	EBI-1255893,EBI-7049352
PRPF4B	Q13523	5	EBI-1255893,EBI-395940

Protein-protein interaction databases

BioGridⁱ	119642, 11 interactors
ELMⁱ	Q9Y2Y9
IntActⁱ	Q9Y2Y9, 4 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y2Y9
STRINGⁱ	9606.ENSP00000302456

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y2Y9
SMRⁱ	Q9Y2Y9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	2 – 145	Ala/Pro-richAdd BLAST	144
Compositional biasⁱ	2 – 5	Poly-Ala	4
Compositional biasⁱ	113 – 116	Poly-Ala	4
Compositional biasⁱ	148 – 168	Arg/Lys-rich (basic)Add BLAST	21
Compositional biasⁱ	264 – 287	Ser-richAdd BLAST	24

Domainⁱ

The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.

Sequence similaritiesⁱ

Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	167 – 191	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	197 – 221	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	227 – 249	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118984
HOGENOMⁱ	HOG000233575
HOVERGENⁱ	HBG050746
InParanoidⁱ	Q9Y2Y9
KEGG Orthology (KO) More...KOⁱ	K09208
OMAⁱ	FNQQTPN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1BN0
PhylomeDBⁱ	Q9Y2Y9
TreeFamⁱ	TF351003

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q9Y2Y9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAAAYVDHF AAECLVSMSS RAVVHGPREG PESRPEGAAV AATPTLPRVE 
        60         70         80         90        100
ERRDGKDSAS LFVVARILAD LNQQAPAPAP AERREGAAAR KARTPCRLPP 
       110        120        130        140        150
PAPEPTSPGA EGAAAAPPSP AWSEPEPEAG LEPEREPGPA GSGEPGLRQR 
       160        170        180        190        200
VRRGRSRADL ESPQRKHKCH YAGCEKVYGK SSHLKAHLRT HTGERPFACS 
       210        220        230        240        250
WQDCNKKFAR SDELARHYRT HTGEKKFSCP ICEKRFMRSD HLTKHARRHA 
       260        270        280 
NFHPGMLQRR GGGSRTGSLS DYSRSDASSP TISPASSP

Length:288

Mass (Da):31,180

Last modified:November 1, 1999 - v1

Checksum:ⁱDD2765EE00E9C049

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YK05	H0YK05_HUMAN	Krueppel-like factor 13 Krueppel-like factor 13	KLF13	100	Annotation score:
A0A087X1K6	A0A087X1K6_HUMAN	Krueppel-like factor 13 Krueppel-like factor 13	KLF13	286	Annotation score:
H0YKM8	H0YKM8_HUMAN	Krueppel-like factor 13 Krueppel-like factor 13	KLF13	14	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	39	A → S in AAD34020 (PubMed:10415854).Curated		1
Sequence conflictⁱ	104 – 114	EPTSPGAEGAA → MSPPPPALKARR in AAD34020 (PubMed:10415854).CuratedAdd BLAST		11

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF132599 mRNA Translation: AAD26864.1 AF150628 mRNA Translation: AAD34020.1 BC013946 mRNA Translation: AAH13946.1 BC010438 mRNA Translation: AAH10438.1 BC012741 mRNA Translation: AAH12741.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10025.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001289390.1, NM_001302461.1 NP_057079.2, NM_015995.3
UniGeneⁱ	Hs.376443 Hs.525752 Hs.585100

Genome annotation databases

Ensemblⁱ	ENST00000307145; ENSP00000302456; ENSG00000169926 ENST00000621843; ENSP00000484904; ENSG00000275746
GeneIDⁱ	51621
KEGGⁱ	hsa:51621

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2Y9	Kruppel-like factor 13 (Fragment)		HUMAN		288	UniRef100_Q9Y2Y9

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2Y9	Krueppel-like factor 13		MOUSE		289	UniRef90_Q9JJZ6
KLF13 protein		BOVIN		296
Krueppel-like factor 13		ODORO		293
Kruppel-like factor 13 (Fragment)		MUSPF		94
Krueppel-like factor 13		Enhydra lutris kenyoni		293
+49

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2Y9	Krueppel-like factor 13		MOUSE		289	UniRef50_Q9JJZ6
KLF13 protein		BOVIN		296
Uncharacterized protein		FELCA		293
Krueppel-like factor 13		NEOSC		293
Krueppel-like factor 13		Enhydra lutris kenyoni		293
+158

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF132599 mRNA Translation: AAD26864.1 AF150628 mRNA Translation: AAD34020.1 BC013946 mRNA Translation: AAH13946.1 BC010438 mRNA Translation: AAH10438.1 BC012741 mRNA Translation: AAH12741.1
CCDSⁱ	CCDS10025.1
RefSeqⁱ	NP_001289390.1, NM_001302461.1 NP_057079.2, NM_015995.3
UniGeneⁱ	Hs.376443 Hs.525752 Hs.585100

3D structure databases

ProteinModelPortalⁱ	Q9Y2Y9
SMRⁱ	Q9Y2Y9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119642, 11 interactors
ELMⁱ	Q9Y2Y9
IntActⁱ	Q9Y2Y9, 4 interactors
MINTⁱ	Q9Y2Y9
STRINGⁱ	9606.ENSP00000302456

PTM databases

iPTMnetⁱ	Q9Y2Y9
PhosphoSitePlusⁱ	Q9Y2Y9

Polymorphism and mutation databases

BioMutaⁱ	KLF13
DMDMⁱ	17369913

Proteomic databases

EPDⁱ	Q9Y2Y9
PaxDbⁱ	Q9Y2Y9
PeptideAtlasⁱ	Q9Y2Y9
PRIDEⁱ	Q9Y2Y9
ProteomicsDBⁱ	85939

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000307145; ENSP00000302456; ENSG00000169926 ENST00000621843; ENSP00000484904; ENSG00000275746
GeneIDⁱ	51621
KEGGⁱ	hsa:51621

Organism-specific databases

CTDⁱ	51621
DisGeNETⁱ	51621
EuPathDBⁱ	HostDB:ENSG00000169926.9
GeneCardsⁱ	KLF13
HGNCⁱ	HGNC:13672 KLF13
MalaCardsⁱ	KLF13
MIMⁱ	605328 gene
neXtProtⁱ	NX_Q9Y2Y9
OpenTargetsⁱ	ENSG00000169926
PharmGKBⁱ	PA30133
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000118984
HOGENOMⁱ	HOG000233575
HOVERGENⁱ	HBG050746
InParanoidⁱ	Q9Y2Y9
KOⁱ	K09208
OMAⁱ	FNQQTPN
OrthoDBⁱ	EOG091G1BN0
PhylomeDBⁱ	Q9Y2Y9
TreeFamⁱ	TF351003

Enzyme and pathway databases

SIGNORⁱ	Q9Y2Y9

SIGNORⁱ

Q9Y2Y9

Miscellaneous databases

ChiTaRSⁱ	KLF13 human
GeneWikiⁱ	KLF13
GenomeRNAiⁱ	51621
Protein Ontology More...PROⁱ	PR:Q9Y2Y9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000169926 Expressed in 212 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_KLF13
ExpressionAtlasⁱ	Q9Y2Y9 baseline and differential
Genevisibleⁱ	Q9Y2Y9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KLF13_HUMAN
Accessionⁱ	Q9Y2Y9Primary (citable) accession number: Q9Y2Y9 Secondary accession number(s): Q9Y356
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - Q9Y2Y9 (KLF13_HUMAN)

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Krueppel-like factor 13

KLF13

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ