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Protein

Transmembrane protein 98

Gene

TMEM98

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 98
Alternative name(s):
Protein TADA1
Gene namesi
Name:TMEM98
ORF Names:UNQ536/PRO1079
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000006042.11
HGNCiHGNC:24529 TMEM98
MIMi615949 gene
neXtProtiNX_Q9Y2Y6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Nanophthalmos 4 (NNO4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder of eye development characterized by extreme hyperopia (farsightedness) and small functional eyes. The cornea and lens are normal in size and shape. Hyperopia occurs because insufficient growth along the visual axis places these lensing components too close to the retina. Nanophthalmic eyes show considerable thickening of both the choroidal vascular bed and scleral coat, which provide nutritive and structural support for the retina.
See also OMIM:615972
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071807193A → P in NNO4. 1 PublicationCorresponds to variant dbSNP:rs587777690EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi26022
MalaCardsiTMEM98
MIMi615972 phenotype
OpenTargetsiENSG00000006042
Orphaneti35612 Nanophthalmia
PharmGKBiPA142670747

Polymorphism and mutation databases

BioMutaiTMEM98
DMDMi74735246

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002517111 – 226Transmembrane protein 98Add BLAST226

Proteomic databases

EPDiQ9Y2Y6
PaxDbiQ9Y2Y6
PeptideAtlasiQ9Y2Y6
PRIDEiQ9Y2Y6
ProteomicsDBi85937

PTM databases

iPTMnetiQ9Y2Y6
PhosphoSitePlusiQ9Y2Y6
SwissPalmiQ9Y2Y6

Expressioni

Tissue specificityi

Expressed in the eye, particularly in corneal endothelium, iris, ciliary body, sclera, optic nerve, optic nerve head, and retina.1 Publication

Gene expression databases

BgeeiENSG00000006042 Expressed in 169 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_TMEM98
ExpressionAtlasiQ9Y2Y6 baseline and differential
GenevisibleiQ9Y2Y6 HS

Organism-specific databases

HPAiHPA040473
HPA053385

Interactioni

Protein-protein interaction databases

BioGridi117492, 16 interactors
IntActiQ9Y2Y6, 9 interactors
MINTiQ9Y2Y6
STRINGi9606.ENSP00000378138

Structurei

3D structure databases

ProteinModelPortaliQ9Y2Y6
SMRiQ9Y2Y6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM98 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIT4 Eukaryota
ENOG410ZMUV LUCA
GeneTreeiENSGT00390000012062
HOGENOMiHOG000220854
HOVERGENiHBG079813
InParanoidiQ9Y2Y6
OMAiLVVVCRH
OrthoDBiEOG091G0QX1
PhylomeDBiQ9Y2Y6
TreeFamiTF336444

Family and domain databases

InterProiView protein in InterPro
IPR029668 TMEM98
PANTHERiPTHR32510 PTHR32510, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.iShow all

Q9Y2Y6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METVVIVAIG VLATIFLASF AALVLVCRQR YCRPRDLLQR YDSKPIVDLI
60 70 80 90 100
GAMETQSEPS ELELDDVVIT NPHIEAILEN EDWIEDASGL MSHCIAILKI
110 120 130 140 150
CHTLTEKLVA MTMGSGAKMK TSASVSDIIV VAKRISPRVD DVVKSMYPPL
160 170 180 190 200
DPKLLDARTT ALLLSVSHLV LVTRNACHLT GGLDWIDQSL SAAEEHLEVL
210 220
REAALASEPD KGLPGPEGFL QEQSAI
Length:226
Mass (Da):24,611
Last modified:November 1, 1999 - v1
Checksum:i4F9997AD8FD3DD0F
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J6Q8C9J6Q8_HUMAN
Transmembrane protein 98
TMEM98
222Annotation score:
C9J3Y0C9J3Y0_HUMAN
Transmembrane protein 98
TMEM98
137Annotation score:
J3QS57J3QS57_HUMAN
Transmembrane protein 98
TMEM98
138Annotation score:
J9JIC8J9JIC8_HUMAN
Transmembrane protein 98
TMEM98
201Annotation score:
J3QLG7J3QLG7_HUMAN
Transmembrane protein 98
TMEM98
93Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104L → P in CAB56018 (PubMed:11230166).Curated1
Sequence conflicti196H → R in CAB56018 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05145183W → R. Corresponds to variant dbSNP:rs35124349Ensembl.1
Natural variantiVAR_071807193A → P in NNO4. 1 PublicationCorresponds to variant dbSNP:rs587777690EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132000 mRNA Translation: AAD22105.1
AL117619 mRNA Translation: CAB56018.1
AY358573 mRNA Translation: AAQ88936.1
CR457125 mRNA Translation: CAG33406.1
CH471147 Genomic DNA Translation: EAW80219.1
CH471147 Genomic DNA Translation: EAW80220.1
BC000526 mRNA Translation: AAH00526.1
CCDSiCCDS11274.1
PIRiT17328
RefSeqiNP_001028676.1, NM_001033504.1
NP_001288675.1, NM_001301746.1
NP_056359.2, NM_015544.2
UniGeneiHs.3447

Genome annotation databases

EnsembliENST00000394642; ENSP00000378138; ENSG00000006042
ENST00000579849; ENSP00000463245; ENSG00000006042
GeneIDi26022
KEGGihsa:26022
UCSCiuc002hhq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTMM98_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2Y6
Secondary accession number(s): E1P631, Q9UFK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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