UniProtKB - Q9Y2Y4 (ZBT32_HUMAN)
Zinc finger and BTB domain-containing protein 32
ZBTB32
Functioni
DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).
By similarity1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 373 – 395 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 401 – 423 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 428 – 450 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- zinc ion binding Source: UniProtKB
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2Y4 |
SignaLinki | Q9Y2Y4 |
SIGNORi | Q9Y2Y4 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and BTB domain-containing protein 32Alternative name(s): FANCC-interacting protein Fanconi anemia zinc finger protein Testis zinc finger protein Zinc finger protein 538 |
Gene namesi | Name:ZBTB32 Synonyms:FAZF, TZFP, ZNF538 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16763, ZBTB32 |
MIMi | 605859, gene |
neXtProti | NX_Q9Y2Y4 |
VEuPathDBi | HostDB:ENSG00000011590 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Note: Located in nuclear speckles.
Nucleus
- nucleoplasm Source: GO_Central
- nucleus Source: GO_Central
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 27033 |
OpenTargetsi | ENSG00000011590 |
PharmGKBi | PA142670541 |
Miscellaneous databases
Pharosi | Q9Y2Y4, Tbio |
Genetic variation databases
BioMutai | ZBTB32 |
DMDMi | 74762048 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000273417 | 1 – 487 | Zinc finger and BTB domain-containing protein 32Add BLAST | 487 |
Proteomic databases
MassIVEi | Q9Y2Y4 |
PaxDbi | Q9Y2Y4 |
PeptideAtlasi | Q9Y2Y4 |
PRIDEi | Q9Y2Y4 |
ProteomicsDBi | 85936 |
PTM databases
iPTMneti | Q9Y2Y4 |
PhosphoSitePlusi | Q9Y2Y4 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000011590, Expressed in right testis and 115 other tissues |
ExpressionAtlasi | Q9Y2Y4, baseline and differential |
Genevisiblei | Q9Y2Y4, HS |
Organism-specific databases
HPAi | ENSG00000011590, Tissue enriched (testis) |
Interactioni
Subunit structurei
Homodimer (via PTB domain).
Interacts with the N-terminal of FANCC.
Interacts with ZBTB16.
Interacts with GATA3 (By similarity).
By similarityBinary interactionsi
Q9Y2Y4
With | #Exp. | IntAct |
---|---|---|
RHOXF2 [Q9BQY4] | 3 | EBI-954098,EBI-372094 |
Hoxa1 [P09022] from Mus musculus. | 3 | EBI-954098,EBI-3957603 |
Protein-protein interaction databases
BioGRIDi | 117964, 66 interactors |
IntActi | Q9Y2Y4, 8 interactors |
MINTi | Q9Y2Y4 |
STRINGi | 9606.ENSP00000376035 |
Miscellaneous databases
RNActi | Q9Y2Y4, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9Y2Y4 |
BMRBi | Q9Y2Y4 |
SMRi | Q9Y2Y4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y2Y4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 87 | BTBPROSITE-ProRule annotationAdd BLAST | 59 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 112 – 244 | DisorderedSequence analysisAdd BLAST | 133 | |
Regioni | 308 – 371 | DisorderedSequence analysisAdd BLAST | 64 | |
Regioni | 468 – 487 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 112 – 173 | Basic and acidic residuesSequence analysisAdd BLAST | 62 | |
Compositional biasi | 308 – 324 | Polar residuesSequence analysisAdd BLAST | 17 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 373 – 395 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 401 – 423 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 428 – 450 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162716 |
HOGENOMi | CLU_600733_0_0_1 |
InParanoidi | Q9Y2Y4 |
OMAi | VWRDQRI |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9Y2Y4 |
TreeFami | TF350825 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSLPPIRLPS PYGSDRLVQL AARLRPALCD TLITVGSQEF PAHSLVLAGV
60 70 80 90 100
SQQLGRRGQW ALGEGISPST FAQLLNFVYG ESVELQPGEL RPLQEAARAL
110 120 130 140 150
GVQSLEEACW RARGDRAKKP DPGLKKHQEE PEKPSRNPER ELGDPGEKQK
160 170 180 190 200
PEQVSRTGGR EQEMLHKHSP PRGRPEMAGA TQEAQQEQTR SKEKRLQAPV
210 220 230 240 250
GQRGADGKHG VLTWLRENPG GSEESLRKLP GPLPPAGSLQ TSVTPRPSWA
260 270 280 290 300
EAPWLVGGQP ALWSILLMPP RYGIPFYHST PTTGAWQEVW REQRIPLSLN
310 320 330 340 350
APKGLWSQNQ LASSSPTPGS LPQGPAQLSP GEMEESDQGH TGALATCAGH
360 370 380 390 400
EDKAGCPPRP HPPPAPPARS RPYACSVCGK RFSLKHQMET HYRVHTGEKP
410 420 430 440 450
FSCSLCPQRS RDFSAMTKHL RTHGAAPYRC SLCGAGCPSL ASMQAHMRGH
460 470 480
SPSQLPPGWT IRSTFLYSSS RPSRPSTSPC CPSSSTT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DGF1 | A0A0C4DGF1_HUMAN | Zinc finger and BTB domain-containi... | ZBTB32 | 302 | Annotation score: | ||
K7EMJ1 | K7EMJ1_HUMAN | Zinc finger and BTB domain-containi... | ZBTB32 | 71 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030145 | 174 | R → S. Corresponds to variant dbSNP:rs2227278Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF130255 mRNA Translation: AAD27708.1 AF165097 mRNA Translation: AAD48448.1 BC017700 mRNA Translation: AAH17700.1 Different termination. |
CCDSi | CCDS12471.1 |
PIRi | JC7126 |
RefSeqi | NP_001303831.1, NM_001316902.1 NP_001303832.1, NM_001316903.1 NP_055198.1, NM_014383.2 XP_011525020.1, XM_011526718.2 XP_016882078.1, XM_017026589.1 |
Genome annotation databases
Ensembli | ENST00000262630.7; ENSP00000262630.3; ENSG00000011590.14 ENST00000392197.7; ENSP00000376035.1; ENSG00000011590.14 |
GeneIDi | 27033 |
KEGGi | hsa:27033 |
MANE-Selecti | ENST00000392197.7; ENSP00000376035.1; NM_014383.3; NP_055198.1 |
UCSCi | uc002oay.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF130255 mRNA Translation: AAD27708.1 AF165097 mRNA Translation: AAD48448.1 BC017700 mRNA Translation: AAH17700.1 Different termination. |
CCDSi | CCDS12471.1 |
PIRi | JC7126 |
RefSeqi | NP_001303831.1, NM_001316902.1 NP_001303832.1, NM_001316903.1 NP_055198.1, NM_014383.2 XP_011525020.1, XM_011526718.2 XP_016882078.1, XM_017026589.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3M5B | X-ray | 2.00 | A/B | 1-117 | [»] | |
AlphaFoldDBi | Q9Y2Y4 | |||||
BMRBi | Q9Y2Y4 | |||||
SMRi | Q9Y2Y4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117964, 66 interactors |
IntActi | Q9Y2Y4, 8 interactors |
MINTi | Q9Y2Y4 |
STRINGi | 9606.ENSP00000376035 |
PTM databases
iPTMneti | Q9Y2Y4 |
PhosphoSitePlusi | Q9Y2Y4 |
Genetic variation databases
BioMutai | ZBTB32 |
DMDMi | 74762048 |
Proteomic databases
MassIVEi | Q9Y2Y4 |
PaxDbi | Q9Y2Y4 |
PeptideAtlasi | Q9Y2Y4 |
PRIDEi | Q9Y2Y4 |
ProteomicsDBi | 85936 |
Protocols and materials databases
Antibodypediai | 35117, 181 antibodies from 24 providers |
DNASUi | 27033 |
Genome annotation databases
Ensembli | ENST00000262630.7; ENSP00000262630.3; ENSG00000011590.14 ENST00000392197.7; ENSP00000376035.1; ENSG00000011590.14 |
GeneIDi | 27033 |
KEGGi | hsa:27033 |
MANE-Selecti | ENST00000392197.7; ENSP00000376035.1; NM_014383.3; NP_055198.1 |
UCSCi | uc002oay.3, human |
Organism-specific databases
CTDi | 27033 |
DisGeNETi | 27033 |
GeneCardsi | ZBTB32 |
HGNCi | HGNC:16763, ZBTB32 |
HPAi | ENSG00000011590, Tissue enriched (testis) |
MIMi | 605859, gene |
neXtProti | NX_Q9Y2Y4 |
OpenTargetsi | ENSG00000011590 |
PharmGKBi | PA142670541 |
VEuPathDBi | HostDB:ENSG00000011590 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162716 |
HOGENOMi | CLU_600733_0_0_1 |
InParanoidi | Q9Y2Y4 |
OMAi | VWRDQRI |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9Y2Y4 |
TreeFami | TF350825 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2Y4 |
SignaLinki | Q9Y2Y4 |
SIGNORi | Q9Y2Y4 |
Miscellaneous databases
BioGRID-ORCSi | 27033, 11 hits in 1131 CRISPR screens |
ChiTaRSi | ZBTB32, human |
EvolutionaryTracei | Q9Y2Y4 |
GeneWikii | ZBTB32 |
GenomeRNAii | 27033 |
Pharosi | Q9Y2Y4, Tbio |
PROi | PR:Q9Y2Y4 |
RNActi | Q9Y2Y4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000011590, Expressed in right testis and 115 other tissues |
ExpressionAtlasi | Q9Y2Y4, baseline and differential |
Genevisiblei | Q9Y2Y4, HS |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBT32_HUMAN | |
Accessioni | Q9Y2Y4Primary (citable) accession number: Q9Y2Y4 Secondary accession number(s): Q8WVP2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2007 |
Last sequence update: | November 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families