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Protein

Ubiquitin-conjugating enzyme E2 D4

Gene

UBE2D4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination.1 Publication

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ubiquitin conjugating enzyme activity Source: MGI
  • ubiquitin protein ligase binding Source: GO_Central
  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.3.2.B6 2681
ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ9Y2X8
UniPathwayi
UPA00143

Protein family/group databases

MoonDBiQ9Y2X8 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 D4 (EC:2.3.2.231 Publication)
Alternative name(s):
E2 ubiquitin-conjugating enzyme D4
HBUCE1
Ubiquitin carrier protein D4
Ubiquitin-protein ligase D4
Gene namesi
Name:UBE2D4
Synonyms:UBCH5D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000078967.12
HGNCiHGNC:21647 UBE2D4
neXtProtiNX_Q9Y2X8

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000078967
PharmGKBiPA134954568

Polymorphism and mutation databases

BioMutaiUBE2D4
DMDMi74753478

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002702021 – 147Ubiquitin-conjugating enzyme E2 D4Add BLAST147

Proteomic databases

EPDiQ9Y2X8
MaxQBiQ9Y2X8
PaxDbiQ9Y2X8
PeptideAtlasiQ9Y2X8
PRIDEiQ9Y2X8
ProteomicsDBi85931

PTM databases

iPTMnetiQ9Y2X8
PhosphoSitePlusiQ9Y2X8

Expressioni

Gene expression databases

BgeeiENSG00000078967 Expressed in 225 organ(s), highest expression level in muscle of leg
CleanExiHS_UBE2D4
ExpressionAtlasiQ9Y2X8 baseline and differential
GenevisibleiQ9Y2X8 HS

Organism-specific databases

HPAiHPA003920

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119641, 103 interactors
IntActiQ9Y2X8, 98 interactors
MINTiQ9Y2X8
STRINGi9606.ENSP00000222402

Structurei

3D structure databases

ProteinModelPortaliQ9Y2X8
SMRiQ9Y2X8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00910000143990
HOGENOMiHOG000233455
HOVERGENiHBG063308
InParanoidiQ9Y2X8
KOiK06689
OMAiTGEDMFH
OrthoDBiEOG091G0GF8
PhylomeDBiQ9Y2X8
TreeFamiTF101108

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9Y2X8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALKRIQKEL TDLQRDPPAQ CSAGPVGDDL FHWQATIMGP NDSPYQGGVF
60 70 80 90 100
FLTIHFPTDY PFKPPKVAFT TKIYHPNINS NGSICLDILR SQWSPALTVS
110 120 130 140
KVLLSICSLL CDPNPDDPLV PEIAHTYKAD REKYNRLARE WTQKYAM
Length:147
Mass (Da):16,649
Last modified:November 1, 1999 - v1
Checksum:i5F91A2C6BC667254
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J9H9C9J9H9_HUMAN
Ubiquitin-conjugating enzyme E2 D4
UBE2D4
122Annotation score:
F8WE07F8WE07_HUMAN
Ubiquitin-conjugating enzyme E2 D4
UBE2D4
74Annotation score:
F8WEH7F8WEH7_HUMAN
Ubiquitin-conjugating enzyme E2 D4
UBE2D4
39Annotation score:
H0YGA2H0YGA2_HUMAN
Ubiquitin-conjugating enzyme E2 D4
UBE2D4
31Annotation score:
F2Z3J6F2Z3J6_HUMAN
Ubiquitin-conjugating enzyme E2 D4
UBE2D4
42Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125044 mRNA Translation: AAD31180.1
AK001446 mRNA Translation: BAA91697.1
CH236951 Genomic DNA Translation: EAL24010.1
CH471073 Genomic DNA Translation: EAW94182.1
BC004104 mRNA Translation: AAH04104.1
CCDSiCCDS5474.1
RefSeqiNP_057067.1, NM_015983.3
UniGeneiHs.19196

Genome annotation databases

EnsembliENST00000222402; ENSP00000222402; ENSG00000078967
GeneIDi51619
KEGGihsa:51619
UCSCiuc003tja.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125044 mRNA Translation: AAD31180.1
AK001446 mRNA Translation: BAA91697.1
CH236951 Genomic DNA Translation: EAL24010.1
CH471073 Genomic DNA Translation: EAW94182.1
BC004104 mRNA Translation: AAH04104.1
CCDSiCCDS5474.1
RefSeqiNP_057067.1, NM_015983.3
UniGeneiHs.19196

3D structure databases

ProteinModelPortaliQ9Y2X8
SMRiQ9Y2X8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119641, 103 interactors
IntActiQ9Y2X8, 98 interactors
MINTiQ9Y2X8
STRINGi9606.ENSP00000222402

Protein family/group databases

MoonDBiQ9Y2X8 Predicted

PTM databases

iPTMnetiQ9Y2X8
PhosphoSitePlusiQ9Y2X8

Polymorphism and mutation databases

BioMutaiUBE2D4
DMDMi74753478

Proteomic databases

EPDiQ9Y2X8
MaxQBiQ9Y2X8
PaxDbiQ9Y2X8
PeptideAtlasiQ9Y2X8
PRIDEiQ9Y2X8
ProteomicsDBi85931

Protocols and materials databases

DNASUi51619
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222402; ENSP00000222402; ENSG00000078967
GeneIDi51619
KEGGihsa:51619
UCSCiuc003tja.3 human

Organism-specific databases

CTDi51619
EuPathDBiHostDB:ENSG00000078967.12
GeneCardsiUBE2D4
HGNCiHGNC:21647 UBE2D4
HPAiHPA003920
neXtProtiNX_Q9Y2X8
OpenTargetsiENSG00000078967
PharmGKBiPA134954568
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00910000143990
HOGENOMiHOG000233455
HOVERGENiHBG063308
InParanoidiQ9Y2X8
KOiK06689
OMAiTGEDMFH
OrthoDBiEOG091G0GF8
PhylomeDBiQ9Y2X8
TreeFamiTF101108

Enzyme and pathway databases

UniPathwayi
UPA00143

BRENDAi2.3.2.B6 2681
ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ9Y2X8

Miscellaneous databases

GenomeRNAii51619
PROiPR:Q9Y2X8

Gene expression databases

BgeeiENSG00000078967 Expressed in 225 organ(s), highest expression level in muscle of leg
CleanExiHS_UBE2D4
ExpressionAtlasiQ9Y2X8 baseline and differential
GenevisibleiQ9Y2X8 HS

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUB2D4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2X8
Secondary accession number(s): A4D1V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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