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Protein

Nucleolar protein 58

Gene

NOP58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs.By similarity3 Publications

GO - Molecular functioni

  • ATPase binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • snoRNA binding Source: BHF-UCL
  • TFIID-class transcription factor complex binding Source: UniProtKB

GO - Biological processi

  • rRNA processing Source: UniProtKB
  • snoRNA localization Source: UniProtKB

Keywordsi

Molecular functionRibonucleoprotein
Biological processRibosome biogenesis

Enzyme and pathway databases

ReactomeiR-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 58
Alternative name(s):
Nucleolar protein 5
Gene namesi
Name:NOP58
Synonyms:NOL5, NOP5
ORF Names:HSPC120
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000055044.10
HGNCiHGNC:29926 NOP58
MIMi616742 gene
neXtProtiNX_Q9Y2X3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000055044
PharmGKBiPA164724092

Polymorphism and mutation databases

BioMutaiNOP58
DMDMi17380155

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190231 – 529Nucleolar protein 58Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphothreonineCombined sources1
Modified residuei109PhosphoserineCombined sources1
Cross-linki157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei304PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Cross-linki353Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki411Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki415Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki422Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki426Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki441Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki444Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki465Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki467Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linki467Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki467Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei483PhosphoserineCombined sources1
Cross-linki485Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki497Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linki497Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei502PhosphoserineCombined sources1
Modified residuei514PhosphoserineCombined sources1

Post-translational modificationi

Sumoylation is essential for high-affinity binding to snoRNAs.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y2X3
MaxQBiQ9Y2X3
PaxDbiQ9Y2X3
PeptideAtlasiQ9Y2X3
PRIDEiQ9Y2X3
ProteomicsDBi85927

2D gel databases

SWISS-2DPAGEiQ9Y2X3

PTM databases

iPTMnetiQ9Y2X3
PhosphoSitePlusiQ9Y2X3
SwissPalmiQ9Y2X3

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000055044 Expressed in 197 organ(s), highest expression level in epithelium of mammary gland
ExpressionAtlasiQ9Y2X3 baseline and differential
GenevisibleiQ9Y2X3 HS

Organism-specific databases

HPAiHPA018472
HPA021062

Interactioni

Subunit structurei

Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins SNU13, NOP56, NOP58 and FBL assemble stepwise onto the snoRNA. Interacts with NOLC1/Nopp140. Interacts with NUFIP1, RUVBL1 AND RUVBL2; RUVBL1:RUVBL2 seem to bridge the association of NOP58 with NUFIP1. Interacts with PIH1D1 (PubMed:17636026).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TGS1Q96RS02EBI-395469,EBI-949244

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119631, 134 interactors
CORUMiQ9Y2X3
DIPiDIP-32926N
IntActiQ9Y2X3, 66 interactors
MINTiQ9Y2X3
STRINGi9606.ENSP00000264279

Structurei

3D structure databases

ProteinModelPortaliQ9Y2X3
SMRiQ9Y2X3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini282 – 400NopPROSITE-ProRule annotationAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi441 – 524Lys-richAdd BLAST84

Sequence similaritiesi

Belongs to the NOP5/NOP56 family.Curated

Phylogenomic databases

eggNOGiKOG2572 Eukaryota
COG1498 LUCA
GeneTreeiENSGT00550000074998
HOGENOMiHOG000196310
InParanoidiQ9Y2X3
KOiK14565
OMAiHSLCDQV
OrthoDBiEOG091G07GD
PhylomeDBiQ9Y2X3
TreeFamiTF105688

Family and domain databases

Gene3Di1.10.287.660, 1 hit
InterProiView protein in InterPro
IPR029012 Helix_hairpin_bin_sf
IPR012974 NOP5_N
IPR002687 Nop_dom
IPR036070 Nop_dom_sf
IPR012976 NOSIC
PfamiView protein in Pfam
PF01798 Nop, 1 hit
PF08156 NOP5NT, 1 hit
SMARTiView protein in SMART
SM00931 NOSIC, 1 hit
SUPFAMiSSF89124 SSF89124, 1 hit
PROSITEiView protein in PROSITE
PS51358 NOP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9Y2X3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVLFETSVG YAIFKVLNEK KLQEVDSLWK EFETPEKANK IVKLKHFEKF
60 70 80 90 100
QDTAEALAAF TALMEGKINK QLKKVLKKIV KEAHEPLAVA DAKLGGVIKE
110 120 130 140 150
KLNLSCIHSP VVNELMRGIR SQMDGLIPGV EPREMAAMCL GLAHSLSRYR
160 170 180 190 200
LKFSADKVDT MIVQAISLLD DLDKELNNYI MRCREWYGWH FPELGKIISD
210 220 230 240 250
NLTYCKCLQK VGDRKNYASA KLSELLPEEV EAEVKAAAEI SMGTEVSEED
260 270 280 290 300
ICNILHLCTQ VIEISEYRTQ LYEYLQNRMM AIAPNVTVMV GELVGARLIA
310 320 330 340 350
HAGSLLNLAK HAASTVQILG AEKALFRALK SRRDTPKYGL IYHASLVGQT
360 370 380 390 400
SPKHKGKISR MLAAKTVLAI RYDAFGEDSS SAMGVENRAK LEARLRTLED
410 420 430 440 450
RGIRKISGTG KALAKTEKYE HKSEVKTYDP SGDSTLPTCS KKRKIEQVDK
460 470 480 490 500
EDEITEKKAK KAKIKVKVEE EEEEKVAEEE ETSVKKKKKR GKKKHIKEEP
510 520
LSEEEPCTST AIASPEKKKK KKKKRENED
Length:529
Mass (Da):59,578
Last modified:November 1, 1999 - v1
Checksum:i27CD73CFF5B9A556
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZ72H7BZ72_HUMAN
Nucleolar protein 58
NOP58
187Annotation score:
F8WED0F8WED0_HUMAN
Nucleolar protein 58
NOP58
68Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2L → M in CAB55989 (PubMed:17974005).Curated1
Sequence conflicti129G → V in CAB55989 (PubMed:17974005).Curated1
Sequence conflicti202 – 221LTYCK…YASAK → YHTASVYRKLAIGRLCLCQ in AAF29084 (PubMed:11042152).CuratedAdd BLAST20
Sequence conflicti235 – 260KAAAE…HLCTQ → EGSCRDIHGNRGFRRRYLQY SASLHP in AAF29084 (PubMed:11042152).CuratedAdd BLAST26
Sequence conflicti280M → V in CAB55989 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059461387N → T. Corresponds to variant dbSNP:rs34748654Ensembl.1
Natural variantiVAR_059462389A → P. Corresponds to variant dbSNP:rs34458926Ensembl.1
Natural variantiVAR_059463400D → A. Corresponds to variant dbSNP:rs35900977Ensembl.1
Natural variantiVAR_059464508T → P. Corresponds to variant dbSNP:rs34523815Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123534 mRNA Translation: AAD27610.1
AF263608 mRNA Translation: AAF91394.1
AC064836 Genomic DNA Translation: AAY24145.1
BC032592 mRNA Translation: AAH32592.1
BC009306 mRNA Translation: AAH09306.1
AL117554 mRNA Translation: CAB55989.2
AF161469 mRNA Translation: AAF29084.1
CCDSiCCDS2353.1
PIRiT17299
RefSeqiNP_057018.1, NM_015934.4
UniGeneiHs.471104

Genome annotation databases

EnsembliENST00000264279; ENSP00000264279; ENSG00000055044
GeneIDi51602
KEGGihsa:51602
UCSCiuc002uzb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123534 mRNA Translation: AAD27610.1
AF263608 mRNA Translation: AAF91394.1
AC064836 Genomic DNA Translation: AAY24145.1
BC032592 mRNA Translation: AAH32592.1
BC009306 mRNA Translation: AAH09306.1
AL117554 mRNA Translation: CAB55989.2
AF161469 mRNA Translation: AAF29084.1
CCDSiCCDS2353.1
PIRiT17299
RefSeqiNP_057018.1, NM_015934.4
UniGeneiHs.471104

3D structure databases

ProteinModelPortaliQ9Y2X3
SMRiQ9Y2X3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119631, 134 interactors
CORUMiQ9Y2X3
DIPiDIP-32926N
IntActiQ9Y2X3, 66 interactors
MINTiQ9Y2X3
STRINGi9606.ENSP00000264279

PTM databases

iPTMnetiQ9Y2X3
PhosphoSitePlusiQ9Y2X3
SwissPalmiQ9Y2X3

Polymorphism and mutation databases

BioMutaiNOP58
DMDMi17380155

2D gel databases

SWISS-2DPAGEiQ9Y2X3

Proteomic databases

EPDiQ9Y2X3
MaxQBiQ9Y2X3
PaxDbiQ9Y2X3
PeptideAtlasiQ9Y2X3
PRIDEiQ9Y2X3
ProteomicsDBi85927

Protocols and materials databases

DNASUi51602
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264279; ENSP00000264279; ENSG00000055044
GeneIDi51602
KEGGihsa:51602
UCSCiuc002uzb.4 human

Organism-specific databases

CTDi51602
EuPathDBiHostDB:ENSG00000055044.10
GeneCardsiNOP58
HGNCiHGNC:29926 NOP58
HPAiHPA018472
HPA021062
MIMi616742 gene
neXtProtiNX_Q9Y2X3
OpenTargetsiENSG00000055044
PharmGKBiPA164724092
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2572 Eukaryota
COG1498 LUCA
GeneTreeiENSGT00550000074998
HOGENOMiHOG000196310
InParanoidiQ9Y2X3
KOiK14565
OMAiHSLCDQV
OrthoDBiEOG091G07GD
PhylomeDBiQ9Y2X3
TreeFamiTF105688

Enzyme and pathway databases

ReactomeiR-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiNOP58 human
GeneWikiiNOP5/NOP58
GenomeRNAii51602
PROiPR:Q9Y2X3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000055044 Expressed in 197 organ(s), highest expression level in epithelium of mammary gland
ExpressionAtlasiQ9Y2X3 baseline and differential
GenevisibleiQ9Y2X3 HS

Family and domain databases

Gene3Di1.10.287.660, 1 hit
InterProiView protein in InterPro
IPR029012 Helix_hairpin_bin_sf
IPR012974 NOP5_N
IPR002687 Nop_dom
IPR036070 Nop_dom_sf
IPR012976 NOSIC
PfamiView protein in Pfam
PF01798 Nop, 1 hit
PF08156 NOP5NT, 1 hit
SMARTiView protein in SMART
SM00931 NOSIC, 1 hit
SUPFAMiSSF89124 SSF89124, 1 hit
PROSITEiView protein in PROSITE
PS51358 NOP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOP58_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2X3
Secondary accession number(s): Q53SA4
, Q6PK08, Q9P036, Q9UFN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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