UniProtKB - Q9Y2W6 (TDRKH_HUMAN)

BLAST

>sp|Q9Y2W6|TDRKH_HUMAN Tudor and KH domain-containing protein OS=Homo sapiens OX=9606 GN=TDRKH PE=1 SV=2
MSTERTSWTSLSTIQKIALGLGIPASATVAYILYRRYRESREERLTFVGEDDIEIEMRVP
QEAVKLIIGRQGANIKQLRKQTGARIDVDTEDVGDERVLLISGFPVQVCKAKAAIHQILT
ENTPVSEQLSVPQRSVGRIIGRGGETIRSICKASGAKITCDKESEGTLLLSRLIKISGTQ
KEVAAAKHLILEKVSEDEELRKRIAHSAETRVPRKQPISVRREDMTEPGGAGEPALWKNT
SSSMEPTAPLVTPPPKGGGDMAVVVSKEGSWEKPSDDSFQKSEAQAIPEMPMFEIPSPDF
SFHADEYLEVYVSASEHPNHFWIQIVGSRSLQLDKLVNEMTQHYENSVPEDLTVHVGDIV
AAPLPTNGSWYRARVLGTLENGNLDLYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECS
LARIAPSGDQWEEEALDEFDRLTHCADWKPLVAKISSYVQTGISTWPKIYLYDTSNGKKL
DIGLELVHKGYAIELPEDIEENRAVPDMLKDMATETDASLSTLLTETKKSSGEITHTLSC
LSLSEAASMSGDDNLEDDYLL

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History
Entry version 151 (07 Nov 2018)
Sequence version 2 (03 May 2011)
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Protein

Tudor and KH domain-containing protein

Gene

TDRKH

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.By similarity

GO - Molecular functionⁱ

RNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
DNA methylation involved in gamete generation Source: UniProtKB
fertilization Source: UniProtKB
gene silencing by RNA Source: UniProtKB-KW
male meiotic nuclear division Source: UniProtKB
piRNA metabolic process Source: UniProtKB
spermatogenesis Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	Differentiation, RNA-mediated gene silencing, Spermatogenesis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis

Reactomeⁱ

R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tudor and KH domain-containing protein Alternative name(s): Tudor domain-containing protein 2
Gene namesⁱ	Name:TDRKH Synonyms:TDRD2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000182134.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11713 TDRKH
MIMⁱ	609501 gene
neXtProtⁱ	NX_Q9Y2W6

Keywords - Cellular componentⁱ

Cytoplasm, Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11022
Open Targets More...OpenTargetsⁱ	ENSG00000182134
PharmGKBⁱ	PA36431

Polymorphism and mutation databases

BioMutaⁱ	TDRKH
DMDMⁱ	332278122

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050141	1 – 561	Tudor and KH domain-containing proteinAdd BLAST		561

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	65	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linkⁱ	76	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linkⁱ	110	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linkⁱ	112	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linkⁱ	152	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linkⁱ	175	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linkⁱ	181	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linkⁱ	187	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linkⁱ	193	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linkⁱ	256	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linkⁱ	267	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residueⁱ	278	PhosphoserineCombined sources	1
Cross-linkⁱ	479	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linkⁱ	510	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linkⁱ	529	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationⁱ

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9Y2W6
PaxDbⁱ	Q9Y2W6
PeptideAtlas More...PeptideAtlasⁱ	Q9Y2W6
PRIDEⁱ	Q9Y2W6
ProteomicsDBⁱ	85917 85918 [Q9Y2W6-3]

PTM databases

iPTMnetⁱ	Q9Y2W6
PhosphoSitePlusⁱ	Q9Y2W6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000182134 Expressed in 136 organ(s), highest expression level in testis
CleanExⁱ	HS_TDRKH
ExpressionAtlasⁱ	Q9Y2W6 baseline and differential
Genevisibleⁱ	Q9Y2W6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA016419 HPA019625

HPAⁱ

HPA016419
HPA019625

Interactionⁱ

Subunit structureⁱ

Interacts with (symmetrically methylated) PIWIL1, PIWIL2 and PIWIL4.By similarity

Protein-protein interaction databases

BioGridⁱ	116212, 23 interactors
Database of interacting proteins More...DIPⁱ	DIP-59459N
IntActⁱ	Q9Y2W6, 13 interactors
STRINGⁱ	9606.ENSP00000357812

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	309 – 317	Combined sources	9
Beta strandⁱ	320 – 325	Combined sources	6
Helixⁱ	332 – 344	Combined sources	13
Beta strandⁱ	359 – 363	Combined sources	5
Turnⁱ	365 – 367	Combined sources	3
Beta strandⁱ	370 – 378	Combined sources	9
Beta strandⁱ	380 – 382	Combined sources	3
Beta strandⁱ	384 – 388	Combined sources	5
Turnⁱ	389 – 391	Combined sources	3
Beta strandⁱ	394 – 397	Combined sources	4
Helixⁱ	399 – 401	Combined sources	3
Helixⁱ	407 – 410	Combined sources	4
Beta strandⁱ	417 – 421	Combined sources	5
Beta strandⁱ	424 – 430	Combined sources	7
Helixⁱ	433 – 442	Combined sources	10
Turnⁱ	444 – 448	Combined sources	5
Beta strandⁱ	451 – 455	Combined sources	5
Beta strandⁱ	468 – 473	Combined sources	6
Beta strandⁱ	475 – 477	Combined sources	3
Helixⁱ	482 – 488	Combined sources	7
Beta strandⁱ	491 – 494	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9Y2W6
SMRⁱ	Q9Y2W6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9Y2W6

EvolutionaryTraceⁱ

Q9Y2W6

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	52 – 115	KH 1PROSITE-ProRule annotationAdd BLAST	64
Domainⁱ	124 – 190	KH 2PROSITE-ProRule annotationAdd BLAST	67
Domainⁱ	353 – 412	TudorPROSITE-ProRule annotationAdd BLAST	60

Sequence similaritiesⁱ

Belongs to the Tdrkh family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG2279 Eukaryota ENOG410Z0DP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110295
HOGENOMⁱ	HOG000037932
HOVERGENⁱ	HBG055309
InParanoidⁱ	Q9Y2W6
KEGG Orthology (KO) More...KOⁱ	K18406
PhylomeDBⁱ	Q9Y2W6
TreeFamⁱ	TF318292

Family and domain databases

Gene3Dⁱ	2.40.50.90, 1 hit 3.30.1370.10, 2 hits
InterProⁱ	View protein in InterPro IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf IPR035437 SNase_OB-fold_sf IPR002999 Tudor
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00013 KH_1, 2 hits PF00567 TUDOR, 1 hit
SMARTⁱ	View protein in SMART SM00322 KH, 2 hits SM00333 TUDOR, 1 hit
SUPFAMⁱ	SSF54791 SSF54791, 2 hits
PROSITEⁱ	View protein in PROSITE PS50084 KH_TYPE_1, 2 hits PS50304 TUDOR, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y2W6-2) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTERTSWTS LSTIQKIALG LGIPASATVA YILYRRYRES REERLTFVGE 
        60         70         80         90        100
DDIEIEMRVP QEAVKLIIGR QGANIKQLRK QTGARIDVDT EDVGDERVLL 
       110        120        130        140        150
ISGFPVQVCK AKAAIHQILT ENTPVSEQLS VPQRSVGRII GRGGETIRSI 
       160        170        180        190        200
CKASGAKITC DKESEGTLLL SRLIKISGTQ KEVAAAKHLI LEKVSEDEEL 
       210        220        230        240        250
RKRIAHSAET RVPRKQPISV RREDMTEPGG AGEPALWKNT SSSMEPTAPL 
       260        270        280        290        300
VTPPPKGGGD MAVVVSKEGS WEKPSDDSFQ KSEAQAIPEM PMFEIPSPDF 
       310        320        330        340        350
SFHADEYLEV YVSASEHPNH FWIQIVGSRS LQLDKLVNEM TQHYENSVPE 
       360        370        380        390        400
DLTVHVGDIV AAPLPTNGSW YRARVLGTLE NGNLDLYFVD FGDNGDCPLK 
       410        420        430        440        450
DLRALRSDFL SLPFQAIECS LARIAPSGDQ WEEEALDEFD RLTHCADWKP 
       460        470        480        490        500
LVAKISSYVQ TGISTWPKIY LYDTSNGKKL DIGLELVHKG YAIELPEDIE 
       510        520        530        540        550
ENRAVPDMLK DMATETDASL STLLTETKKS SGEITHTLSC LSLSEAASMS 
       560 
GDDNLEDDYL L

Length:561

Mass (Da):62,046

Last modified:May 3, 2011 - v2

Checksum:ⁱF89EBBDC48A8D420

Isoform 2 (identifier: Q9Y2W6-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
108-152: Missing.

« Hide

        10         20         30         40         50
MSTERTSWTS LSTIQKIALG LGIPASATVA YILYRRYRES REERLTFVGE 
        60         70         80         90        100
DDIEIEMRVP QEAVKLIIGR QGANIKQLRK QTGARIDVDT EDVGDERVLL 
       110        120        130        140        150
ISGFPVQASG AKITCDKESE GTLLLSRLIK ISGTQKEVAA AKHLILEKVS 
       160        170        180        190        200
EDEELRKRIA HSAETRVPRK QPISVRREDM TEPGGAGEPA LWKNTSSSME 
       210        220        230        240        250
PTAPLVTPPP KGGGDMAVVV SKEGSWEKPS DDSFQKSEAQ AIPEMPMFEI 
       260        270        280        290        300
PSPDFSFHAD EYLEVYVSAS EHPNHFWIQI VGSRSLQLDK LVNEMTQHYE 
       310        320        330        340        350
NSVPEDLTVH VGDIVAAPLP TNGSWYRARV LGTLENGNLD LYFVDFGDNG 
       360        370        380        390        400
DCPLKDLRAL RSDFLSLPFQ AIECSLARIA PSGDQWEEEA LDEFDRLTHC 
       410        420        430        440        450
ADWKPLVAKI SSYVQTGIST WPKIYLYDTS NGKKLDIGLE LVHKGYAIEL 
       460        470        480        490        500
PEDIEENRAV PDMLKDMATE TDASLSTLLT ETKKSSGEIT HTLSCLSLSE 
       510 
AASMSGDDNL EDDYLL

Show »

Length:516

Mass (Da):57,218

Checksum:ⁱ5D5972E323EF12BC

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5SZR4	Q5SZR4_HUMAN	Tudor and KH domain containing, iso... Tudor and KH domain containing, isoform CRA_a (Tudor and KH domain-containing protein)	TDRKH hCG_16924	557	Annotation score:
F6TB26	F6TB26_HUMAN	Tudor and KH domain-containing prot... Tudor and KH domain-containing protein	TDRKH	605	Annotation score:
E9PKN8	E9PKN8_HUMAN	Tudor and KH domain-containing prot... Tudor and KH domain-containing protein	TDRKH	131	Annotation score:
B7ZAG4	B7ZAG4_HUMAN	cDNA, FLJ79178, highly similar to T... cDNA, FLJ79178, highly similar to Tudor and KH domain-containing protein	TDRKH	140	Annotation score:
E9PQX4	E9PQX4_HUMAN	Tudor and KH domain-containing prot... Tudor and KH domain-containing protein	TDRKH	58	Annotation score:

Sequence cautionⁱ

The sequence AAD30971 differs from that shown. Reason: Erroneous termination at position 562. Translated as stop.Curated

The sequence BC022467 differs from that shown. Reason: Erroneous termination at position 175. Translated as Lys.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	15	Q → H in AAF36701 (PubMed:10767542).Curated		1
Sequence conflictⁱ	321	F → S in AAF36701 (PubMed:10767542).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_055980	257	G → A. Corresponds to variant dbSNP:rs17853082Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_040981	108 – 152	Missing in isoform 2. CuratedAdd BLAST		45

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF119121 mRNA Translation: AAD30971.1 Sequence problems. AF227192 mRNA Translation: AAF36701.1 AL589765 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53411.1 CH471121 Genomic DNA Translation: EAW53409.1 CH471121 Genomic DNA Translation: EAW53410.1 BC022467 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41394.1 [Q9Y2W6-2] CCDS41395.1 [Q9Y2W6-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001077432.1, NM_001083963.1 [Q9Y2W6-2] NP_001077433.1, NM_001083964.1 [Q9Y2W6-3] NP_001077434.1, NM_001083965.1 [Q9Y2W6-2] NP_006853.2, NM_006862.3 [Q9Y2W6-2] XP_016855611.1, XM_017000122.1 [Q9Y2W6-2] XP_016855612.1, XM_017000123.1 [Q9Y2W6-2] XP_016855613.1, XM_017000124.1 [Q9Y2W6-2] XP_016855614.1, XM_017000125.1 [Q9Y2W6-2] XP_016855615.1, XM_017000126.1 [Q9Y2W6-2] XP_016855616.1, XM_017000127.1 [Q9Y2W6-2]
UniGeneⁱ	Hs.144439

Genome annotation databases

Ensemblⁱ	ENST00000368822; ENSP00000357812; ENSG00000182134 [Q9Y2W6-2] ENST00000368824; ENSP00000357815; ENSG00000182134 [Q9Y2W6-2] ENST00000368825; ENSP00000357817; ENSG00000182134 [Q9Y2W6-3] ENST00000368827; ENSP00000357819; ENSG00000182134 [Q9Y2W6-2] ENST00000458431; ENSP00000395718; ENSG00000182134 [Q9Y2W6-2]
GeneIDⁱ	11022
KEGGⁱ	hsa:11022
UCSC genome browser More...UCSCⁱ	uc001eza.6 human [Q9Y2W6-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2W6	Tudor and KH domain-containing protein		HUMAN		605	UniRef100_Q9Y2W6
Tudor and KH domain-containing protein (Fragment)		HUMAN		41
cDNA FLJ54003, highly similar to Tudor and KH domain-containing protein		HUMAN		337

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2W6	Tudor and KH domain-containing protein	)	MOUSE		560	UniRef90_Q80VL1
Tudor and KH domain containing		GORGO		605
Tudor and KH domain containing		PANTR		605
Uncharacterized protein		PANPA		605
Uncharacterized protein		PAPAN		596
+121
Q9Y2W6-3	TDRKH isoform 4		PONAB		516	UniRef90_Q9Y2W6-3
TDRKH isoform 4		PANTR		516
Tudor and KH domain-containing protein		MOUSE		515
UPI00027F22FF		THEGE		516
UPI0005F3781D		MANLE		516
+2

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2W6	Tudor and KH domain-containing protein	)	MOUSE		560	UniRef50_Q80VL1
Tudor and KH domain containing		PANTR		605
Uncharacterized protein		PANPA		605
Tudor and KH domain containing		GORGO		605
Uncharacterized protein		NOMLE		596
+181
Q9Y2W6-3	TDRKH isoform 4		PONAB		516	UniRef50_Q9Y2W6-3
TDRKH isoform 4		PANTR		516
Tudor and KH domain-containing protein		MOUSE		515
Uncharacterized protein		MYOLU		561
Uncharacterized protein		OTOGA		541
+61

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF119121 mRNA Translation: AAD30971.1 Sequence problems. AF227192 mRNA Translation: AAF36701.1 AL589765 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53411.1 CH471121 Genomic DNA Translation: EAW53409.1 CH471121 Genomic DNA Translation: EAW53410.1 BC022467 mRNA No translation available.
CCDSⁱ	CCDS41394.1 [Q9Y2W6-2] CCDS41395.1 [Q9Y2W6-3]
RefSeqⁱ	NP_001077432.1, NM_001083963.1 [Q9Y2W6-2] NP_001077433.1, NM_001083964.1 [Q9Y2W6-3] NP_001077434.1, NM_001083965.1 [Q9Y2W6-2] NP_006853.2, NM_006862.3 [Q9Y2W6-2] XP_016855611.1, XM_017000122.1 [Q9Y2W6-2] XP_016855612.1, XM_017000123.1 [Q9Y2W6-2] XP_016855613.1, XM_017000124.1 [Q9Y2W6-2] XP_016855614.1, XM_017000125.1 [Q9Y2W6-2] XP_016855615.1, XM_017000126.1 [Q9Y2W6-2] XP_016855616.1, XM_017000127.1 [Q9Y2W6-2]
UniGeneⁱ	Hs.144439

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DIQ	NMR	-	A	329-425	[»]
	3FDR	X-ray	1.75	A	327-420	[»]
	5J39	X-ray	1.95	A/B	309-498	[»]
	6B57	X-ray	1.93	A/B	309-497	[»]
ProteinModelPortalⁱ	Q9Y2W6
SMRⁱ	Q9Y2W6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116212, 23 interactors
DIPⁱ	DIP-59459N
IntActⁱ	Q9Y2W6, 13 interactors
STRINGⁱ	9606.ENSP00000357812

PTM databases

iPTMnetⁱ	Q9Y2W6
PhosphoSitePlusⁱ	Q9Y2W6

Polymorphism and mutation databases

BioMutaⁱ	TDRKH
DMDMⁱ	332278122

Proteomic databases

EPDⁱ	Q9Y2W6
PaxDbⁱ	Q9Y2W6
PeptideAtlasⁱ	Q9Y2W6
PRIDEⁱ	Q9Y2W6
ProteomicsDBⁱ	85917 85918 [Q9Y2W6-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11022
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368822; ENSP00000357812; ENSG00000182134 [Q9Y2W6-2] ENST00000368824; ENSP00000357815; ENSG00000182134 [Q9Y2W6-2] ENST00000368825; ENSP00000357817; ENSG00000182134 [Q9Y2W6-3] ENST00000368827; ENSP00000357819; ENSG00000182134 [Q9Y2W6-2] ENST00000458431; ENSP00000395718; ENSG00000182134 [Q9Y2W6-2]
GeneIDⁱ	11022
KEGGⁱ	hsa:11022
UCSCⁱ	uc001eza.6 human [Q9Y2W6-2]

Organism-specific databases

CTDⁱ	11022
DisGeNETⁱ	11022
EuPathDBⁱ	HostDB:ENSG00000182134.15
GeneCardsⁱ	TDRKH
HGNCⁱ	HGNC:11713 TDRKH
HPAⁱ	HPA016419 HPA019625
MIMⁱ	609501 gene
neXtProtⁱ	NX_Q9Y2W6
OpenTargetsⁱ	ENSG00000182134
PharmGKBⁱ	PA36431
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2279 Eukaryota ENOG410Z0DP LUCA
GeneTreeⁱ	ENSGT00730000110295
HOGENOMⁱ	HOG000037932
HOVERGENⁱ	HBG055309
InParanoidⁱ	Q9Y2W6
KOⁱ	K18406
PhylomeDBⁱ	Q9Y2W6
TreeFamⁱ	TF318292

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis

Reactomeⁱ

R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis

Miscellaneous databases

ChiTaRSⁱ	TDRKH human
EvolutionaryTraceⁱ	Q9Y2W6
GeneWikiⁱ	TDRKH
GenomeRNAiⁱ	11022
Protein Ontology More...PROⁱ	PR:Q9Y2W6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000182134 Expressed in 136 organ(s), highest expression level in testis
CleanExⁱ	HS_TDRKH
ExpressionAtlasⁱ	Q9Y2W6 baseline and differential
Genevisibleⁱ	Q9Y2W6 HS

Family and domain databases

Gene3Dⁱ	2.40.50.90, 1 hit 3.30.1370.10, 2 hits
InterProⁱ	View protein in InterPro IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf IPR035437 SNase_OB-fold_sf IPR002999 Tudor
Pfamⁱ	View protein in Pfam PF00013 KH_1, 2 hits PF00567 TUDOR, 1 hit
SMARTⁱ	View protein in SMART SM00322 KH, 2 hits SM00333 TUDOR, 1 hit
SUPFAMⁱ	SSF54791 SSF54791, 2 hits
PROSITEⁱ	View protein in PROSITE PS50084 KH_TYPE_1, 2 hits PS50304 TUDOR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TDRKH_HUMAN
Accessionⁱ	Q9Y2W6Primary (citable) accession number: Q9Y2W6 Secondary accession number(s): D3DV24 , Q5SZR3, Q5SZR5, Q8N582, Q9NYV5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
	Last sequence update:	May 3, 2011
	Last modified:	November 7, 2018
	This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q9Y2W6 (TDRKH_HUMAN)

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Tudor and KH domain-containing protein

TDRKH

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ