CARHSP1

Protein namesⁱ	Recommended name: Calcium-regulated heat-stable protein 1 Alternative name(s): Calcium-regulated heat-stable protein of 24 kDa Short name: CRHSP-24
Gene namesⁱ	Name:CARHSP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000153048.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17150 CARHSP1
MIMⁱ	616885 gene
neXtProtⁱ	NX_Q9Y2V2

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	41	S → D: Reduced affinity for single-stranded DNA. Abolishes location at cytoplasmic stress granules. 1 Publication		1
Mutagenesisⁱ	76	H → Q: Reduced affinity for single-stranded DNA. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23589
Open Targets More...OpenTargetsⁱ	ENSG00000153048
PharmGKBⁱ	PA38440

Polymorphism and mutation databases

DMDMⁱ	41016932

DMDMⁱ

41016932

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000100230	2 – 147	Calcium-regulated heat-stable protein 1Add BLAST		146

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	30	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	32	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	41	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	45	PhosphothreonineCombined sources	1
Modified residueⁱ	52	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	58	PhosphoserineCombined sources	1
Modified residueⁱ	146	PhosphoserineCombined sources	1
Modified residueⁱ	147	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Dephosphorylated by calcineurin in a Ca²⁺ dependent manner (By similarity). Can be phosphorylated by DYRK2 (in vitro).By similarity1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y2V2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9Y2V2
PaxDbⁱ	Q9Y2V2
PeptideAtlas More...PeptideAtlasⁱ	Q9Y2V2
PRIDEⁱ	Q9Y2V2
ProteomicsDBⁱ	85909
TopDownProteomicsⁱ	Q9Y2V2

PTM databases

iPTMnetⁱ	Q9Y2V2
PhosphoSitePlusⁱ	Q9Y2V2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000153048 Expressed in 226 organ(s), highest expression level in right testis
CleanExⁱ	HS_CARHSP1
ExpressionAtlasⁱ	Q9Y2V2 baseline and differential
Genevisibleⁱ	Q9Y2V2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051911

HPAⁱ

HPA051911

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with STYX (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
DOCK8	Q8NF50	3	EBI-718719,EBI-2548605
DOCK8	Q8NF50-2	3	EBI-718719,EBI-10174653
KRTAP10-7	P60409	3	EBI-718719,EBI-10172290
KRTAP10-8	P60410	5	EBI-718719,EBI-10171774
NOTCH2NL	Q7Z3S9	5	EBI-718719,EBI-945833
PNMA1	Q8ND90	3	EBI-718719,EBI-302345
TRAF1	Q13077	3	EBI-718719,EBI-359224

GO - Molecular functionⁱ

phosphatase binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12801884

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117124, 28 interactors
IntActⁱ	Q9Y2V2, 19 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y2V2
STRINGⁱ	9606.ENSP00000311847

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	51 – 59	Combined sources	9
Beta strandⁱ	63 – 70	Combined sources	8
Turnⁱ	72 – 74	Combined sources	3
Beta strandⁱ	75 – 84	Combined sources	10
Beta strandⁱ	88 – 91	Combined sources	4
Helixⁱ	92 – 94	Combined sources	3
Beta strandⁱ	95 – 99	Combined sources	5
Beta strandⁱ	106 – 113	Combined sources	8
Beta strandⁱ	121 – 130	Combined sources	10
Beta strandⁱ	133 – 135	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9Y2V2
SMRⁱ	Q9Y2V2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	62 – 129	CSDAdd BLAST		68

Phylogenomic databases

eggNOGⁱ	KOG3070 Eukaryota COG1278 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000022
HOGENOMⁱ	HOG000059524
HOVERGENⁱ	HBG050947
InParanoidⁱ	Q9Y2V2
OMAⁱ	AVEVKII
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TYX
PhylomeDBⁱ	Q9Y2V2
TreeFamⁱ	TF324381

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04458 CSP_CDS, 1 hit
InterProⁱ	View protein in InterPro IPR019844 Cold-shock_CS IPR011129 CSD IPR002059 CSP_DNA-bd IPR012340 NA-bd_OB-fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00313 CSD, 1 hit
SMARTⁱ	View protein in SMART SM00357 CSP, 1 hit
SUPFAMⁱ	SSF50249 SSF50249, 1 hit
PROSITEⁱ	View protein in PROSITE PS00352 CSD_1, 1 hit PS51857 CSD_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show all Align All

Q9Y2V2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSEPPPPPQ PPTHQASVGL LDTPRSRERS PSPLRGNVVP SPLPTRRTRT 
        60         70         80         90        100
FSATVRASQG PVYKGVCKCF CRSKGHGFIT PADGGPDIFL HISDVEGEYV 
       110        120        130        140 
PVEGDEVTYK MCSIPPKNEK LQAVEVVITH LAPGTKHETW SGHVISS

Length:147

Mass (Da):15,892

Last modified:January 16, 2004 - v2

Checksum:ⁱ83D70DAE7B1FC573

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BNU9	H3BNU9_HUMAN	Calcium-regulated heat-stable prote... Calcium-regulated heat-stable protein 1	CARHSP1	131	Annotation score:
H3BSW7	H3BSW7_HUMAN	Calcium-regulated heat-stable prote... Calcium-regulated heat-stable protein 1	CARHSP1	112	Annotation score:
H3BUY4	H3BUY4_HUMAN	Calcium-regulated heat-stable prote... Calcium-regulated heat-stable protein 1	CARHSP1	124	Annotation score:
I3L3X8	I3L3X8_HUMAN	Calcium-regulated heat-stable prote... Calcium-regulated heat-stable protein 1	CARHSP1	94	Annotation score:
H3BPY5	H3BPY5_HUMAN	Calcium-regulated heat-stable prote... Calcium-regulated heat-stable protein 1	CARHSP1	125	Annotation score:
H3BTK3	H3BTK3_HUMAN	Calcium-regulated heat-stable prote... Calcium-regulated heat-stable protein 1	CARHSP1	71	Annotation score:
H3BQY0	H3BQY0_HUMAN	Calcium-regulated heat-stable prote... Calcium-regulated heat-stable protein 1	CARHSP1	114	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	60	G → V in AAD25021 (PubMed:9712905).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF115345 mRNA Translation: AAD25021.1 AK311777 mRNA Translation: BAG34720.1 CH471112 Genomic DNA Translation: EAW85196.1 CH471112 Genomic DNA Translation: EAW85197.1 CH471112 Genomic DNA Translation: EAW85198.1 CH471112 Genomic DNA Translation: EAW85199.1 BC003366 mRNA Translation: AAH03366.1 BC108283 mRNA Translation: AAI08284.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10537.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001035941.1, NM_001042476.2 NP_001265189.1, NM_001278260.1 NP_001265190.1, NM_001278261.1 NP_001265191.1, NM_001278262.1 NP_001265192.1, NM_001278263.1 NP_001265193.1, NM_001278264.1 NP_001265194.1, NM_001278265.1 NP_001265195.1, NM_001278266.1 NP_055131.2, NM_014316.3 XP_005255286.1, XM_005255229.4 XP_011520746.1, XM_011522444.2
UniGeneⁱ	Hs.632184

Genome annotation databases

Ensemblⁱ	ENST00000311052; ENSP00000311847; ENSG00000153048 ENST00000396593; ENSP00000379838; ENSG00000153048 ENST00000561530; ENSP00000455284; ENSG00000153048 ENST00000567554; ENSP00000455855; ENSG00000153048 ENST00000610831; ENSP00000478055; ENSG00000153048 ENST00000611932; ENSP00000481550; ENSG00000153048 ENST00000614449; ENSP00000480542; ENSG00000153048 ENST00000618335; ENSP00000483591; ENSG00000153048 ENST00000619881; ENSP00000480144; ENSG00000153048
GeneIDⁱ	23589
KEGGⁱ	hsa:23589
UCSC genome browser More...UCSCⁱ	uc002czh.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2V2	Calcium-regulated heat-stable protein 1 (Fragment)		HUMAN		131	UniRef100_Q9Y2V2
CARHSP1 isoform 13 (Fragment)		PANTR		112
Calcium regulated heat stable protein 1		GORGO		147
Uncharacterized protein		PANPA		147
Calcium-regulated heat-stable protein 1 (Fragment)		HUMAN		112
+10

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2V2	Calcium-regulated heat-stable protein 1 (Fragment)		HUMAN		131	UniRef90_Q9Y2V2
CARHSP1 isoform 13 (Fragment)		PANTR		112
Calcium regulated heat stable protein 1		GORGO		147
Uncharacterized protein		PANPA		147
Calcium-regulated heat-stable protein 1 (Fragment)		HUMAN		112
+10

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2V2	Calcium-regulated heat stable protein 1		RAT		147	UniRef50_Q9Y2V2
Calcium-regulated heat-stable protein 1 (Fragment)		HUMAN		131
CARHSP1 isoform 13 (Fragment)		PANTR		112
Calcium regulated heat stable protein 1		GORGO		147
Uncharacterized protein		PANPA		147
+50

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF115345 mRNA Translation: AAD25021.1 AK311777 mRNA Translation: BAG34720.1 CH471112 Genomic DNA Translation: EAW85196.1 CH471112 Genomic DNA Translation: EAW85197.1 CH471112 Genomic DNA Translation: EAW85198.1 CH471112 Genomic DNA Translation: EAW85199.1 BC003366 mRNA Translation: AAH03366.1 BC108283 mRNA Translation: AAI08284.1
CCDSⁱ	CCDS10537.1
RefSeqⁱ	NP_001035941.1, NM_001042476.2 NP_001265189.1, NM_001278260.1 NP_001265190.1, NM_001278261.1 NP_001265191.1, NM_001278262.1 NP_001265192.1, NM_001278263.1 NP_001265193.1, NM_001278264.1 NP_001265194.1, NM_001278265.1 NP_001265195.1, NM_001278266.1 NP_055131.2, NM_014316.3 XP_005255286.1, XM_005255229.4 XP_011520746.1, XM_011522444.2
UniGeneⁱ	Hs.632184

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3AQQ	X-ray	2.80	A/B/C/D	1-147	[»]
ProteinModelPortalⁱ	Q9Y2V2
SMRⁱ	Q9Y2V2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117124, 28 interactors
IntActⁱ	Q9Y2V2, 19 interactors
MINTⁱ	Q9Y2V2
STRINGⁱ	9606.ENSP00000311847

PTM databases

iPTMnetⁱ	Q9Y2V2
PhosphoSitePlusⁱ	Q9Y2V2

Polymorphism and mutation databases

DMDMⁱ	41016932

DMDMⁱ

41016932

Proteomic databases

EPDⁱ	Q9Y2V2
MaxQBⁱ	Q9Y2V2
PaxDbⁱ	Q9Y2V2
PeptideAtlasⁱ	Q9Y2V2
PRIDEⁱ	Q9Y2V2
ProteomicsDBⁱ	85909
TopDownProteomicsⁱ	Q9Y2V2

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23589
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000311052; ENSP00000311847; ENSG00000153048 ENST00000396593; ENSP00000379838; ENSG00000153048 ENST00000561530; ENSP00000455284; ENSG00000153048 ENST00000567554; ENSP00000455855; ENSG00000153048 ENST00000610831; ENSP00000478055; ENSG00000153048 ENST00000611932; ENSP00000481550; ENSG00000153048 ENST00000614449; ENSP00000480542; ENSG00000153048 ENST00000618335; ENSP00000483591; ENSG00000153048 ENST00000619881; ENSP00000480144; ENSG00000153048
GeneIDⁱ	23589
KEGGⁱ	hsa:23589
UCSCⁱ	uc002czh.2 human

Organism-specific databases

CTDⁱ	23589
DisGeNETⁱ	23589
EuPathDBⁱ	HostDB:ENSG00000153048.10
GeneCardsⁱ	CARHSP1
HGNCⁱ	HGNC:17150 CARHSP1
HPAⁱ	HPA051911
MIMⁱ	616885 gene
neXtProtⁱ	NX_Q9Y2V2
OpenTargetsⁱ	ENSG00000153048
PharmGKBⁱ	PA38440
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3070 Eukaryota COG1278 LUCA
GeneTreeⁱ	ENSGT00390000000022
HOGENOMⁱ	HOG000059524
HOVERGENⁱ	HBG050947
InParanoidⁱ	Q9Y2V2
OMAⁱ	AVEVKII
OrthoDBⁱ	EOG091G0TYX
PhylomeDBⁱ	Q9Y2V2
TreeFamⁱ	TF324381

Enzyme and pathway databases

SIGNORⁱ	Q9Y2V2

SIGNORⁱ

Q9Y2V2

Miscellaneous databases

ChiTaRSⁱ	CARHSP1 human
GeneWikiⁱ	CARHSP1
GenomeRNAiⁱ	23589
Protein Ontology More...PROⁱ	PR:Q9Y2V2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000153048 Expressed in 226 organ(s), highest expression level in right testis
CleanExⁱ	HS_CARHSP1
ExpressionAtlasⁱ	Q9Y2V2 baseline and differential
Genevisibleⁱ	Q9Y2V2 HS

Family and domain databases

CDDⁱ	cd04458 CSP_CDS, 1 hit
InterProⁱ	View protein in InterPro IPR019844 Cold-shock_CS IPR011129 CSD IPR002059 CSP_DNA-bd IPR012340 NA-bd_OB-fold
Pfamⁱ	View protein in Pfam PF00313 CSD, 1 hit
SMARTⁱ	View protein in SMART SM00357 CSP, 1 hit
SUPFAMⁱ	SSF50249 SSF50249, 1 hit
PROSITEⁱ	View protein in PROSITE PS00352 CSD_1, 1 hit PS51857 CSD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CHSP1_HUMAN
Accessionⁱ	Q9Y2V2Primary (citable) accession number: Q9Y2V2 Secondary accession number(s): B2R4C3 , D3DUF5, Q2YDX5, Q9BQ53
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
	Last sequence update:	January 16, 2004
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y2V2 (CHSP1_HUMAN)

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Calcium-regulated heat-stable protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ