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UniProtKB - Q9Y2V2 (CHSP1_HUMAN)
Protein
Calcium-regulated heat-stable protein 1
Gene
CARHSP1
Organism
Homo sapiens (Human)
Status
Functioni
Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).
2 PublicationsGO - Molecular functioni
- mRNA 3'-UTR binding Source: UniProtKB
- phosphatase binding Source: UniProtKB
GO - Biological processi
- intracellular signal transduction Source: ProtInc
- regulation of mRNA stability Source: UniProtKB
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2V2 |
SignaLinki | Q9Y2V2 |
SIGNORi | Q9Y2V2 |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium-regulated heat-stable protein 1Alternative name(s): Calcium-regulated heat-stable protein of 24 kDa Short name: CRHSP-24 |
Gene namesi | Name:CARHSP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17150, CARHSP1 |
MIMi | 616885, gene |
neXtProti | NX_Q9Y2V2 |
VEuPathDBi | HostDB:ENSG00000153048 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- P-body 1 Publication
- Cytoplasmic granule 1 Publication
Note: Detected at cytoplasmic stress granules and P-bodies. Detected at exosome granules where mRNA is degraded (By similarity).By similarity
Cytosol
- cytosol Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
- cytoplasmic exosome (RNase complex) Source: Ensembl
- P granule Source: UniProtKB
- P-body Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 41 | S → D: Reduced affinity for single-stranded DNA. Abolishes location at cytoplasmic stress granules. 1 Publication | 1 | |
Mutagenesisi | 76 | H → Q: Reduced affinity for single-stranded DNA. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 23589 |
OpenTargetsi | ENSG00000153048 |
PharmGKBi | PA38440 |
Miscellaneous databases
Pharosi | Q9Y2V2, Tbio |
Genetic variation databases
BioMutai | CARHSP1 |
DMDMi | 41016932 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000100230 | 2 – 147 | Calcium-regulated heat-stable protein 1Add BLAST | 146 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 30 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 32 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 41 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 45 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 52 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 58 | PhosphoserineCombined sources | 1 | |
Modified residuei | 146 | PhosphoserineCombined sources | 1 | |
Modified residuei | 147 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Dephosphorylated by calcineurin in a Ca2+ dependent manner (By similarity). Can be phosphorylated by DYRK2 (in vitro).By similarity1 Publication
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9Y2V2 |
jPOSTi | Q9Y2V2 |
MassIVEi | Q9Y2V2 |
MaxQBi | Q9Y2V2 |
PaxDbi | Q9Y2V2 |
PeptideAtlasi | Q9Y2V2 |
PRIDEi | Q9Y2V2 |
ProteomicsDBi | 85909 |
TopDownProteomicsi | Q9Y2V2 |
PTM databases
GlyGeni | Q9Y2V2, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9Y2V2 |
PhosphoSitePlusi | Q9Y2V2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000153048, Expressed in right testis and 238 other tissues |
ExpressionAtlasi | Q9Y2V2, baseline and differential |
Genevisiblei | Q9Y2V2, HS |
Organism-specific databases
HPAi | ENSG00000153048, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Homodimer.
Interacts with STYX (By similarity).
By similarityBinary interactionsi
Q9Y2V2
GO - Molecular functioni
- phosphatase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 117124, 45 interactors |
IntActi | Q9Y2V2, 21 interactors |
MINTi | Q9Y2V2 |
STRINGi | 9606.ENSP00000379838 |
Miscellaneous databases
RNActi | Q9Y2V2, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q9Y2V2 |
SMRi | Q9Y2V2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 62 – 129 | CSDAdd BLAST | 68 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 52 | DisorderedSequence analysisAdd BLAST | 52 |
Phylogenomic databases
eggNOGi | KOG3070, Eukaryota |
GeneTreei | ENSGT00390000000022 |
HOGENOMi | CLU_139526_1_0_1 |
InParanoidi | Q9Y2V2 |
OMAi | THERWED |
OrthoDBi | 1560417at2759 |
PhylomeDBi | Q9Y2V2 |
TreeFami | TF324381 |
Family and domain databases
CDDi | cd04458, CSP_CDS, 1 hit |
Gene3Di | 2.40.50.140, 1 hit |
InterProi | View protein in InterPro IPR011129, CSD IPR019844, CSD_1 IPR002059, CSP_DNA-bd IPR012340, NA-bd_OB-fold |
Pfami | View protein in Pfam PF00313, CSD, 1 hit |
SMARTi | View protein in SMART SM00357, CSP, 1 hit |
SUPFAMi | SSF50249, SSF50249, 1 hit |
PROSITEi | View protein in PROSITE PS00352, CSD_1, 1 hit PS51857, CSD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q9Y2V2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSEPPPPPQ PPTHQASVGL LDTPRSRERS PSPLRGNVVP SPLPTRRTRT
60 70 80 90 100
FSATVRASQG PVYKGVCKCF CRSKGHGFIT PADGGPDIFL HISDVEGEYV
110 120 130 140
PVEGDEVTYK MCSIPPKNEK LQAVEVVITH LAPGTKHETW SGHVISS
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BNU9 | H3BNU9_HUMAN | Calcium-regulated heat-stable prote... | CARHSP1 | 131 | Annotation score: | ||
H3BUY4 | H3BUY4_HUMAN | Calcium-regulated heat-stable prote... | CARHSP1 | 124 | Annotation score: | ||
H3BSW7 | H3BSW7_HUMAN | Calcium-regulated heat-stable prote... | CARHSP1 | 112 | Annotation score: | ||
H3BPY5 | H3BPY5_HUMAN | Calcium-regulated heat-stable prote... | CARHSP1 | 125 | Annotation score: | ||
I3L3X8 | I3L3X8_HUMAN | Calcium-regulated heat-stable prote... | CARHSP1 | 94 | Annotation score: | ||
H3BTK3 | H3BTK3_HUMAN | Calcium-regulated heat-stable prote... | CARHSP1 | 71 | Annotation score: | ||
H3BQY0 | H3BQY0_HUMAN | Calcium-regulated heat-stable prote... | CARHSP1 | 114 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 60 | G → V in AAD25021 (PubMed:9712905).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF115345 mRNA Translation: AAD25021.1 AK311777 mRNA Translation: BAG34720.1 CH471112 Genomic DNA Translation: EAW85196.1 CH471112 Genomic DNA Translation: EAW85197.1 CH471112 Genomic DNA Translation: EAW85198.1 CH471112 Genomic DNA Translation: EAW85199.1 BC003366 mRNA Translation: AAH03366.1 BC108283 mRNA Translation: AAI08284.1 |
CCDSi | CCDS10537.1 |
RefSeqi | NP_001035941.1, NM_001042476.2 NP_001265189.1, NM_001278260.1 NP_001265190.1, NM_001278261.1 NP_001265191.1, NM_001278262.1 NP_001265192.1, NM_001278263.1 NP_001265193.1, NM_001278264.1 NP_001265194.1, NM_001278265.1 NP_001265195.1, NM_001278266.1 NP_055131.2, NM_014316.3 XP_005255286.1, XM_005255229.4 XP_011520746.1, XM_011522444.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF115345 mRNA Translation: AAD25021.1 AK311777 mRNA Translation: BAG34720.1 CH471112 Genomic DNA Translation: EAW85196.1 CH471112 Genomic DNA Translation: EAW85197.1 CH471112 Genomic DNA Translation: EAW85198.1 CH471112 Genomic DNA Translation: EAW85199.1 BC003366 mRNA Translation: AAH03366.1 BC108283 mRNA Translation: AAI08284.1 |
CCDSi | CCDS10537.1 |
RefSeqi | NP_001035941.1, NM_001042476.2 NP_001265189.1, NM_001278260.1 NP_001265190.1, NM_001278261.1 NP_001265191.1, NM_001278262.1 NP_001265192.1, NM_001278263.1 NP_001265193.1, NM_001278264.1 NP_001265194.1, NM_001278265.1 NP_001265195.1, NM_001278266.1 NP_055131.2, NM_014316.3 XP_005255286.1, XM_005255229.4 XP_011520746.1, XM_011522444.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3AQQ | X-ray | 2.80 | A/B/C/D | 1-147 | [»] | |
AlphaFoldDBi | Q9Y2V2 | |||||
SMRi | Q9Y2V2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117124, 45 interactors |
IntActi | Q9Y2V2, 21 interactors |
MINTi | Q9Y2V2 |
STRINGi | 9606.ENSP00000379838 |
PTM databases
GlyGeni | Q9Y2V2, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9Y2V2 |
PhosphoSitePlusi | Q9Y2V2 |
Genetic variation databases
BioMutai | CARHSP1 |
DMDMi | 41016932 |
Proteomic databases
EPDi | Q9Y2V2 |
jPOSTi | Q9Y2V2 |
MassIVEi | Q9Y2V2 |
MaxQBi | Q9Y2V2 |
PaxDbi | Q9Y2V2 |
PeptideAtlasi | Q9Y2V2 |
PRIDEi | Q9Y2V2 |
ProteomicsDBi | 85909 |
TopDownProteomicsi | Q9Y2V2 |
Protocols and materials databases
Antibodypediai | 24559, 78 antibodies from 21 providers |
DNASUi | 23589 |
Genome annotation databases
Organism-specific databases
CTDi | 23589 |
DisGeNETi | 23589 |
GeneCardsi | CARHSP1 |
HGNCi | HGNC:17150, CARHSP1 |
HPAi | ENSG00000153048, Tissue enhanced (testis) |
MIMi | 616885, gene |
neXtProti | NX_Q9Y2V2 |
OpenTargetsi | ENSG00000153048 |
PharmGKBi | PA38440 |
VEuPathDBi | HostDB:ENSG00000153048 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3070, Eukaryota |
GeneTreei | ENSGT00390000000022 |
HOGENOMi | CLU_139526_1_0_1 |
InParanoidi | Q9Y2V2 |
OMAi | THERWED |
OrthoDBi | 1560417at2759 |
PhylomeDBi | Q9Y2V2 |
TreeFami | TF324381 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2V2 |
SignaLinki | Q9Y2V2 |
SIGNORi | Q9Y2V2 |
Miscellaneous databases
BioGRID-ORCSi | 23589, 11 hits in 1096 CRISPR screens |
ChiTaRSi | CARHSP1, human |
GeneWikii | CARHSP1 |
GenomeRNAii | 23589 |
Pharosi | Q9Y2V2, Tbio |
PROi | PR:Q9Y2V2 |
RNActi | Q9Y2V2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153048, Expressed in right testis and 238 other tissues |
ExpressionAtlasi | Q9Y2V2, baseline and differential |
Genevisiblei | Q9Y2V2, HS |
Family and domain databases
CDDi | cd04458, CSP_CDS, 1 hit |
Gene3Di | 2.40.50.140, 1 hit |
InterProi | View protein in InterPro IPR011129, CSD IPR019844, CSD_1 IPR002059, CSP_DNA-bd IPR012340, NA-bd_OB-fold |
Pfami | View protein in Pfam PF00313, CSD, 1 hit |
SMARTi | View protein in SMART SM00357, CSP, 1 hit |
SUPFAMi | SSF50249, SSF50249, 1 hit |
PROSITEi | View protein in PROSITE PS00352, CSD_1, 1 hit PS51857, CSD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CHSP1_HUMAN | |
Accessioni | Q9Y2V2Primary (citable) accession number: Q9Y2V2 Secondary accession number(s): B2R4C3 Q9BQ53 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | January 16, 2004 | |
Last modified: | May 25, 2022 | |
This is version 173 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references