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Protein

Calcium-regulated heat-stable protein 1

Gene

CARHSP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).2 Publications

GO - Molecular functioni

  • DNA binding Source: InterPro
  • mRNA 3'-UTR binding Source: UniProtKB
  • phosphatase binding Source: UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • intracellular signal transduction Source: ProtInc
  • regulation of mRNA stability Source: UniProtKB

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

SIGNORiQ9Y2V2

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-regulated heat-stable protein 1
Alternative name(s):
Calcium-regulated heat-stable protein of 24 kDa
Short name:
CRHSP-24
Gene namesi
Name:CARHSP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000153048.10
HGNCiHGNC:17150 CARHSP1
MIMi616885 gene
neXtProtiNX_Q9Y2V2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi41S → D: Reduced affinity for single-stranded DNA. Abolishes location at cytoplasmic stress granules. 1 Publication1
Mutagenesisi76H → Q: Reduced affinity for single-stranded DNA. 1 Publication1

Organism-specific databases

DisGeNETi23589
OpenTargetsiENSG00000153048
PharmGKBiPA38440

Polymorphism and mutation databases

DMDMi41016932

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001002302 – 147Calcium-regulated heat-stable protein 1Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei30PhosphoserineCombined sources1 Publication1
Modified residuei32PhosphoserineCombined sources1 Publication1
Modified residuei41PhosphoserineCombined sources1 Publication1
Modified residuei45PhosphothreonineCombined sources1
Modified residuei52PhosphoserineCombined sources1 Publication1
Modified residuei58PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1

Post-translational modificationi

Dephosphorylated by calcineurin in a Ca2+ dependent manner (By similarity). Can be phosphorylated by DYRK2 (in vitro).By similarity1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2V2
MaxQBiQ9Y2V2
PaxDbiQ9Y2V2
PeptideAtlasiQ9Y2V2
PRIDEiQ9Y2V2
ProteomicsDBi85909
TopDownProteomicsiQ9Y2V2

PTM databases

iPTMnetiQ9Y2V2
PhosphoSitePlusiQ9Y2V2

Expressioni

Gene expression databases

BgeeiENSG00000153048
CleanExiHS_CARHSP1
ExpressionAtlasiQ9Y2V2 baseline and differential
GenevisibleiQ9Y2V2 HS

Organism-specific databases

HPAiHPA051911

Interactioni

Subunit structurei

Homodimer. Interacts with STYX (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117124, 28 interactors
IntActiQ9Y2V2, 18 interactors
MINTiQ9Y2V2
STRINGi9606.ENSP00000311847

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi51 – 59Combined sources9
Beta strandi63 – 70Combined sources8
Turni72 – 74Combined sources3
Beta strandi75 – 84Combined sources10
Beta strandi88 – 91Combined sources4
Helixi92 – 94Combined sources3
Beta strandi95 – 99Combined sources5
Beta strandi106 – 113Combined sources8
Beta strandi121 – 130Combined sources10
Beta strandi133 – 135Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AQQX-ray2.80A/B/C/D1-147[»]
ProteinModelPortaliQ9Y2V2
SMRiQ9Y2V2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 129CSDAdd BLAST68

Phylogenomic databases

eggNOGiKOG3070 Eukaryota
COG1278 LUCA
GeneTreeiENSGT00390000000022
HOGENOMiHOG000059524
HOVERGENiHBG050947
InParanoidiQ9Y2V2
OMAiCTIPPKN
OrthoDBiEOG091G0TYX
PhylomeDBiQ9Y2V2
TreeFamiTF324381

Family and domain databases

CDDicd04458 CSP_CDS, 1 hit
InterProiView protein in InterPro
IPR019844 Cold-shock_CS
IPR011129 CSD
IPR002059 CSP_DNA-bd
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF00313 CSD, 1 hit
SMARTiView protein in SMART
SM00357 CSP, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS00352 CSD_1, 1 hit
PS51857 CSD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y2V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEPPPPPQ PPTHQASVGL LDTPRSRERS PSPLRGNVVP SPLPTRRTRT
60 70 80 90 100
FSATVRASQG PVYKGVCKCF CRSKGHGFIT PADGGPDIFL HISDVEGEYV
110 120 130 140
PVEGDEVTYK MCSIPPKNEK LQAVEVVITH LAPGTKHETW SGHVISS
Length:147
Mass (Da):15,892
Last modified:January 16, 2004 - v2
Checksum:i83D70DAE7B1FC573
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60G → V in AAD25021 (PubMed:9712905).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115345 mRNA Translation: AAD25021.1
AK311777 mRNA Translation: BAG34720.1
CH471112 Genomic DNA Translation: EAW85196.1
CH471112 Genomic DNA Translation: EAW85197.1
CH471112 Genomic DNA Translation: EAW85198.1
CH471112 Genomic DNA Translation: EAW85199.1
BC003366 mRNA Translation: AAH03366.1
BC108283 mRNA Translation: AAI08284.1
CCDSiCCDS10537.1
RefSeqiNP_001035941.1, NM_001042476.2
NP_001265189.1, NM_001278260.1
NP_001265190.1, NM_001278261.1
NP_001265191.1, NM_001278262.1
NP_001265192.1, NM_001278263.1
NP_001265193.1, NM_001278264.1
NP_001265194.1, NM_001278265.1
NP_001265195.1, NM_001278266.1
NP_055131.2, NM_014316.3
XP_005255286.1, XM_005255229.4
XP_011520746.1, XM_011522444.2
UniGeneiHs.632184

Genome annotation databases

EnsembliENST00000311052; ENSP00000311847; ENSG00000153048
ENST00000396593; ENSP00000379838; ENSG00000153048
ENST00000561530; ENSP00000455284; ENSG00000153048
ENST00000567554; ENSP00000455855; ENSG00000153048
ENST00000610831; ENSP00000478055; ENSG00000153048
ENST00000611932; ENSP00000481550; ENSG00000153048
ENST00000614449; ENSP00000480542; ENSG00000153048
ENST00000618335; ENSP00000483591; ENSG00000153048
ENST00000619881; ENSP00000480144; ENSG00000153048
GeneIDi23589
KEGGihsa:23589
UCSCiuc002czh.2 human

Similar proteinsi

Entry informationi

Entry nameiCHSP1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2V2
Secondary accession number(s): B2R4C3
, D3DUF5, Q2YDX5, Q9BQ53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: June 20, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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