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Protein

Potassium channel subfamily K member 7

Gene

KCNK7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • potassium channel activity Source: Reactome
  • potassium ion leak channel activity Source: GO_Central
  • voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
R-HSA-5576886 Phase 4 - resting membrane potential

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium channel subfamily K member 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNK7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000173338.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6282 KCNK7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603940 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2U2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 10CytoplasmicSequence analysis10
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei92 – 119Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST28
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 170CytoplasmicSequence analysisAdd BLAST30
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Intramembranei199 – 227Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST29
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 307CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10089

Open Targets

More...
OpenTargetsi
ENSG00000173338

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30064

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNK7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13124109

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001017511 – 307Potassium channel subfamily K member 7Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2U2

PeptideAtlas

More...
PeptideAtlasi
Q9Y2U2

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2U2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85900
85901 [Q9Y2U2-2]
85902 [Q9Y2U2-3]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173338 Expressed in 98 organ(s), highest expression level in skin of abdomen

CleanEx database of gene expression profiles

More...
CleanExi
HS_KCNK7

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2U2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2U2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA077577

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000344820

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Y2U2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y2U2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1418 Eukaryota
COG1226 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161992

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000286014

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052237

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2U2

KEGG Orthology (KO)

More...
KOi
K04918

Identification of Orthologs from Complete Genome Data

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OMAi
LWGLQGD

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0DIX

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2U2

TreeFam database of animal gene trees

More...
TreeFami
TF313947

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR005408 2pore_dom_K_chnl_TWIK
IPR013099 K_chnl_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07885 Ion_trans_2, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038061 K_channel_subfamily_K_type, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01333 2POREKCHANEL
PR01586 TWIKCHANNEL

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q9Y2U2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGGLRPWSRY GLLVVAHLLA LGLGAVVFQA LEGPPACRLQ AELRAELAAF
60 70 80 90 100
QAEHRACLPP GALEELLGTA LATQAHGVST LGNSSEGRTW DLPSALLFAA
110 120 130 140 150
SILTTTGYGH MAPLSPGGKA FCMVYAALGL PASLALVATL RHCLLPVLSR
160 170 180 190 200
PRAWVAVHWQ LSPARAALLQ AVALGLLVAS SFVLLPALVL WGLQGDCSLL
210 220 230 240 250
GAVYFCFSSL STIGLEDLLP GRGRSLHPVI YHLGQLALLG YLLLGLLAML
260 270 280 290 300
LAVETFSELP QVRAMGKFFR PSGPVTAEDQ GGILGQDELA LSTLPPAAPA

SGQAPAC
Length:307
Mass (Da):31,947
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD4A36DD9591ADAC
GO
Isoform B (identifier: Q9Y2U2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-252: YLLLGLLAMLLA → GGTSLQGTAWEG
     253-307: Missing.

Show »
Length:252
Mass (Da):26,212
Checksum:iA0C93A5D690C3295
GO
Isoform C (identifier: Q9Y2U2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-257: YLLLGLLAMLLAVETFS → KSSHLTACGGRGKRSLD
     258-307: Missing.

Show »
Length:257
Mass (Da):26,822
Checksum:i73FBC250F69D67FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCM4H0YCM4_HUMAN
Potassium channel subfamily K membe...
KCNK7
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEB9H0YEB9_HUMAN
Potassium channel subfamily K membe...
KCNK7
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006695241 – 257YLLLG…VETFS → KSSHLTACGGRGKRSLD in isoform C. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_006693241 – 252YLLLG…AMLLA → GGTSLQGTAWEG in isoform B. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_006694253 – 307Missing in isoform B. 2 PublicationsAdd BLAST55
Alternative sequenceiVSP_006696258 – 307Missing in isoform C. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF110522 mRNA Translation: AAD29578.1
AF110524 mRNA Translation: AAD29580.1
AF110523 mRNA Translation: AAD29579.1
CH471076 Genomic DNA Translation: EAW74413.1
BC103809 mRNA Translation: AAI03810.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31608.1 [Q9Y2U2-1]
CCDS41673.1 [Q9Y2U2-3]
CCDS8106.1 [Q9Y2U2-2]

NCBI Reference Sequences

More...
RefSeqi
NP_005705.1, NM_005714.1 [Q9Y2U2-3]
NP_203133.1, NM_033347.1 [Q9Y2U2-1]
NP_203134.1, NM_033348.1 [Q9Y2U2-2]
NP_258416.1, NM_033455.1 [Q9Y2U2-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.175218

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340313; ENSP00000344820; ENSG00000173338 [Q9Y2U2-1]
ENST00000342202; ENSP00000343923; ENSG00000173338 [Q9Y2U2-2]
ENST00000394216; ENSP00000377764; ENSG00000173338 [Q9Y2U2-3]
ENST00000394217; ENSP00000377765; ENSG00000173338 [Q9Y2U2-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10089

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10089

UCSC genome browser

More...
UCSCi
uc001oeq.3 human [Q9Y2U2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110522 mRNA Translation: AAD29578.1
AF110524 mRNA Translation: AAD29580.1
AF110523 mRNA Translation: AAD29579.1
CH471076 Genomic DNA Translation: EAW74413.1
BC103809 mRNA Translation: AAI03810.1
CCDSiCCDS31608.1 [Q9Y2U2-1]
CCDS41673.1 [Q9Y2U2-3]
CCDS8106.1 [Q9Y2U2-2]
RefSeqiNP_005705.1, NM_005714.1 [Q9Y2U2-3]
NP_203133.1, NM_033347.1 [Q9Y2U2-1]
NP_203134.1, NM_033348.1 [Q9Y2U2-2]
NP_258416.1, NM_033455.1 [Q9Y2U2-2]
UniGeneiHs.175218

3D structure databases

ProteinModelPortaliQ9Y2U2
SMRiQ9Y2U2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000344820

Polymorphism and mutation databases

BioMutaiKCNK7
DMDMi13124109

Proteomic databases

PaxDbiQ9Y2U2
PeptideAtlasiQ9Y2U2
PRIDEiQ9Y2U2
ProteomicsDBi85900
85901 [Q9Y2U2-2]
85902 [Q9Y2U2-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340313; ENSP00000344820; ENSG00000173338 [Q9Y2U2-1]
ENST00000342202; ENSP00000343923; ENSG00000173338 [Q9Y2U2-2]
ENST00000394216; ENSP00000377764; ENSG00000173338 [Q9Y2U2-3]
ENST00000394217; ENSP00000377765; ENSG00000173338 [Q9Y2U2-2]
GeneIDi10089
KEGGihsa:10089
UCSCiuc001oeq.3 human [Q9Y2U2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10089
DisGeNETi10089
EuPathDBiHostDB:ENSG00000173338.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KCNK7
HGNCiHGNC:6282 KCNK7
HPAiHPA077577
MIMi603940 gene
neXtProtiNX_Q9Y2U2
OpenTargetsiENSG00000173338
PharmGKBiPA30064

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1418 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00940000161992
HOGENOMiHOG000286014
HOVERGENiHBG052237
InParanoidiQ9Y2U2
KOiK04918
OMAiLWGLQGD
OrthoDBiEOG091G0DIX
PhylomeDBiQ9Y2U2
TreeFamiTF313947

Enzyme and pathway databases

ReactomeiR-HSA-1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
R-HSA-5576886 Phase 4 - resting membrane potential

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KCNK7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10089

Protein Ontology

More...
PROi
PR:Q9Y2U2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000173338 Expressed in 98 organ(s), highest expression level in skin of abdomen
CleanExiHS_KCNK7
ExpressionAtlasiQ9Y2U2 baseline and differential
GenevisibleiQ9Y2U2 HS

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR005408 2pore_dom_K_chnl_TWIK
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PIRSFiPIRSF038061 K_channel_subfamily_K_type, 1 hit
PRINTSiPR01333 2POREKCHANEL
PR01586 TWIKCHANNEL

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNK7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2U2
Secondary accession number(s): Q3SYI2, Q9Y2U3, Q9Y2U4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: December 5, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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