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Protein

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

Gene

PPP2R2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Caution

The EMBL entry for PubMed:10574460 is not complete, the paper shows the rest of the sequence (residues 1 to 23).Curated

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SIGNORiQ9Y2T4

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Alternative name(s):
IMYPNO1
PP2A subunit B isoform B55-gamma
PP2A subunit B isoform PR55-gamma
PP2A subunit B isoform R2-gamma
PP2A subunit B isoform gamma
Gene namesi
Name:PPP2R2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000074211.13
HGNCiHGNC:9306 PPP2R2C
MIMi605997 gene
neXtProtiNX_Q9Y2T4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi5522
OpenTargetsiENSG00000074211
PharmGKBiPA33670

Polymorphism and mutation databases

BioMutaiPPP2R2C
DMDMi145559437

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714281 – 447Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoformAdd BLAST447

Proteomic databases

PaxDbiQ9Y2T4
PeptideAtlasiQ9Y2T4
PRIDEiQ9Y2T4

PTM databases

iPTMnetiQ9Y2T4
PhosphoSitePlusiQ9Y2T4

Expressioni

Gene expression databases

BgeeiENSG00000074211
CleanExiHS_PPP2R2C
ExpressionAtlasiQ9Y2T4 baseline and differential
GenevisibleiQ9Y2T4 HS

Organism-specific databases

HPAiHPA042122
HPA042770

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with IER5 (PubMed:25816751).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP2CAP677753EBI-1774058,EBI-712311

Protein-protein interaction databases

BioGridi111514, 41 interactors
IntActiQ9Y2T4, 25 interactors
MINTiQ9Y2T4
STRINGi9606.ENSP00000335083

Structurei

3D structure databases

ProteinModelPortaliQ9Y2T4
SMRiQ9Y2T4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 61WD 1Add BLAST40
Repeati87 – 128WD 2Add BLAST42
Repeati171 – 209WD 3Add BLAST39
Repeati220 – 260WD 4Add BLAST41
Repeati279 – 317WD 5Add BLAST39
Repeati334 – 375WD 6Add BLAST42
Repeati410 – 446WD 7Add BLAST37

Sequence similaritiesi

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1354 Eukaryota
COG5170 LUCA
GeneTreeiENSGT00390000006311
HOGENOMiHOG000089745
HOVERGENiHBG000012
InParanoidiQ9Y2T4
KOiK04354
OMAiDLNMETK
OrthoDBiEOG091G09BB
PhylomeDBiQ9Y2T4
TreeFamiTF105553

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR000009 PP2A_PR55
IPR018067 PP2A_PR55_CS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11871 PTHR11871, 1 hit
PIRSFiPIRSF037309 PP2A_PR55, 1 hit
PRINTSiPR00600 PP2APR55
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS01024 PR55_1, 1 hit
PS01025 PR55_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2T4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEDTDTRKI NHSFLRDHSY VTEADIISTV EFNHTGELLA TGDKGGRVVI
60 70 80 90 100
FQREPESKNA PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ
110 120 130 140 150
QNAAHSLLST NDKTIKLWKI TERDKRPEGY NLKDEEGKLK DLSTVTSLQV
160 170 180 190 200
PVLKPMDLMV EVSPRRIFAN GHTYHINSIS VNSDCETYMS ADDLRINLWH
210 220 230 240 250
LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY SSSKGSLRLC
260 270 280 290 300
DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD
310 320 330 340 350
YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYENDCIFD KFECAWNGSD
360 370 380 390 400
SVIMTGAYNN FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR
410 420 430 440
RDDISVDSLD FTKKILHTAW HPAENIIAIA ATNNLYIFQD KVNSDMH
Length:447
Mass (Da):51,515
Last modified:April 17, 2007 - v4
Checksum:iDB002C2384686BBD
GO
Isoform 2 (identifier: Q9Y2T4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MGLSFFSKHLPIQEGQPWALKTP

Show »
Length:447
Mass (Da):51,376
Checksum:i3EEEDCCC0A023DCD
GO
Isoform 3 (identifier: Q9Y2T4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MGKRDT

Show »
Length:430
Mass (Da):49,470
Checksum:iFC27804D310C6D93
GO
Isoform 4 (identifier: Q9Y2T4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MREADTLRPPQLMEVS

Note: No experimental confirmation available.
Show »
Length:440
Mass (Da):50,636
Checksum:i05512449DDA70BCF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66E → D in AAG39636 (PubMed:10945473).Curated1
Sequence conflicti253R → P in AAG39636 (PubMed:10945473).Curated1
Sequence conflicti293G → D in AAG39636 (PubMed:10945473).Curated1
Sequence conflicti293G → D in AAP97279 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0364571 – 23MGEDT…SYVTE → MGLSFFSKHLPIQEGQPWAL KTP in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0364581 – 23MGEDT…SYVTE → MGKRDT in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0433801 – 23MGEDT…SYVTE → MREADTLRPPQLMEVS in isoform 4. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH007514 Genomic DNA Translation: AAD20987.1
AF086924 mRNA Translation: AAG39636.1
AF145027 mRNA Translation: AAP97279.1
AK093115 mRNA Translation: BAG52658.1
AK296474 mRNA Translation: BAH12367.1
AK316003 mRNA Translation: BAH14374.1
AC093323 Genomic DNA No translation available.
AC114815 Genomic DNA No translation available.
AC116317 Genomic DNA No translation available.
AC122939 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82393.1
CH471131 Genomic DNA Translation: EAW82394.1
CH471131 Genomic DNA Translation: EAW82395.1
BC032954 mRNA Translation: AAH32954.1
CCDSiCCDS3387.1 [Q9Y2T4-1]
CCDS3388.1 [Q9Y2T4-2]
CCDS56304.1 [Q9Y2T4-3]
CCDS56305.1 [Q9Y2T4-4]
PIRiJC7153
RefSeqiNP_001193923.1, NM_001206994.1 [Q9Y2T4-4]
NP_001193924.1, NM_001206995.1 [Q9Y2T4-4]
NP_001193925.1, NM_001206996.1 [Q9Y2T4-3]
NP_065149.2, NM_020416.3 [Q9Y2T4-1]
NP_870991.1, NM_181876.2 [Q9Y2T4-2]
UniGeneiHs.479069

Genome annotation databases

EnsembliENST00000335585; ENSP00000335083; ENSG00000074211 [Q9Y2T4-2]
ENST00000382599; ENSP00000372042; ENSG00000074211 [Q9Y2T4-1]
ENST00000506140; ENSP00000423649; ENSG00000074211 [Q9Y2T4-4]
ENST00000507294; ENSP00000425247; ENSG00000074211 [Q9Y2T4-4]
ENST00000515571; ENSP00000422374; ENSG00000074211 [Q9Y2T4-3]
GeneIDi5522
KEGGihsa:5522
UCSCiuc003gja.3 human [Q9Y2T4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry namei2ABG_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2T4
Secondary accession number(s): A8MSY7
, B7Z3Y1, Q7Z4V7, Q8NEC4, Q9H3G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 17, 2007
Last modified: June 20, 2018
This is version 156 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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