Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 170 (22 Apr 2020)
Sequence version 4 (17 Apr 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

Gene

PPP2R2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Caution

The EMBL entry for PubMed:10574460 is not complete, the paper shows the rest of the sequence (residues 1 to 23).Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9Y2T4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Alternative name(s):
IMYPNO1
PP2A subunit B isoform B55-gamma
PP2A subunit B isoform PR55-gamma
PP2A subunit B isoform R2-gamma
PP2A subunit B isoform gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP2R2C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9306 PPP2R2C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605997 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2T4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5522

Open Targets

More...
OpenTargetsi
ENSG00000074211

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33670

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y2T4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP2R2C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145559437

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000714281 – 447Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoformAdd BLAST447

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y2T4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y2T4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2T4

PeptideAtlas

More...
PeptideAtlasi
Q9Y2T4

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2T4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85893
85894 [Q9Y2T4-2]
85895 [Q9Y2T4-3]
85896 [Q9Y2T4-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2T4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2T4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000074211 Expressed in putamen and 152 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2T4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2T4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000074211 Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity).

Interacts with IER5 (PubMed:25816751).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111514, 53 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y2T4, 39 interactors

Molecular INTeraction database

More...
MINTi
Q9Y2T4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000335083

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y2T4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y2T4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati22 – 61WD 1Add BLAST40
Repeati87 – 128WD 2Add BLAST42
Repeati171 – 209WD 3Add BLAST39
Repeati220 – 260WD 4Add BLAST41
Repeati279 – 317WD 5Add BLAST39
Repeati334 – 375WD 6Add BLAST42
Repeati410 – 446WD 7Add BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1354 Eukaryota
COG5170 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182864

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021713_3_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2T4

KEGG Orthology (KO)

More...
KOi
K04354

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFLPDHN

Database of Orthologous Groups

More...
OrthoDBi
810409at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2T4

TreeFam database of animal gene trees

More...
TreeFami
TF105553

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000009 PP2A_PR55
IPR018067 PP2A_PR55_CS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11871 PTHR11871, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037309 PP2A_PR55, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00600 PP2APR55

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01024 PR55_1, 1 hit
PS01025 PR55_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2T4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGEDTDTRKI NHSFLRDHSY VTEADIISTV EFNHTGELLA TGDKGGRVVI
60 70 80 90 100
FQREPESKNA PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ
110 120 130 140 150
QNAAHSLLST NDKTIKLWKI TERDKRPEGY NLKDEEGKLK DLSTVTSLQV
160 170 180 190 200
PVLKPMDLMV EVSPRRIFAN GHTYHINSIS VNSDCETYMS ADDLRINLWH
210 220 230 240 250
LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY SSSKGSLRLC
260 270 280 290 300
DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD
310 320 330 340 350
YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYENDCIFD KFECAWNGSD
360 370 380 390 400
SVIMTGAYNN FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR
410 420 430 440
RDDISVDSLD FTKKILHTAW HPAENIIAIA ATNNLYIFQD KVNSDMH
Length:447
Mass (Da):51,515
Last modified:April 17, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB002C2384686BBD
GO
Isoform 2 (identifier: Q9Y2T4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MGLSFFSKHLPIQEGQPWALKTP

Show »
Length:447
Mass (Da):51,376
Checksum:i3EEEDCCC0A023DCD
GO
Isoform 3 (identifier: Q9Y2T4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MGKRDT

Show »
Length:430
Mass (Da):49,470
Checksum:iFC27804D310C6D93
GO
Isoform 4 (identifier: Q9Y2T4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MREADTLRPPQLMEVS

Show »
Length:440
Mass (Da):50,636
Checksum:i05512449DDA70BCF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R943D6R943_HUMAN
Serine/threonine-protein phosphatas...
PPP2R2C
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti66E → D in AAG39636 (PubMed:10945473).Curated1
Sequence conflicti253R → P in AAG39636 (PubMed:10945473).Curated1
Sequence conflicti293G → D in AAG39636 (PubMed:10945473).Curated1
Sequence conflicti293G → D in AAP97279 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0364571 – 23MGEDT…SYVTE → MGLSFFSKHLPIQEGQPWAL KTP in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0364581 – 23MGEDT…SYVTE → MGKRDT in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0433801 – 23MGEDT…SYVTE → MREADTLRPPQLMEVS in isoform 4. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AH007514 Genomic DNA Translation: AAD20987.1
AF086924 mRNA Translation: AAG39636.1
AF145027 mRNA Translation: AAP97279.1
AK093115 mRNA Translation: BAG52658.1
AK296474 mRNA Translation: BAH12367.1
AK316003 mRNA Translation: BAH14374.1
AC093323 Genomic DNA No translation available.
AC114815 Genomic DNA No translation available.
AC116317 Genomic DNA No translation available.
AC122939 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82393.1
CH471131 Genomic DNA Translation: EAW82394.1
CH471131 Genomic DNA Translation: EAW82395.1
BC032954 mRNA Translation: AAH32954.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3387.1 [Q9Y2T4-1]
CCDS3388.1 [Q9Y2T4-2]
CCDS56304.1 [Q9Y2T4-3]
CCDS56305.1 [Q9Y2T4-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7153

NCBI Reference Sequences

More...
RefSeqi
NP_001193923.1, NM_001206994.1 [Q9Y2T4-4]
NP_001193924.1, NM_001206995.1 [Q9Y2T4-4]
NP_001193925.1, NM_001206996.1 [Q9Y2T4-3]
NP_065149.2, NM_020416.3 [Q9Y2T4-1]
NP_870991.1, NM_181876.2 [Q9Y2T4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000335585; ENSP00000335083; ENSG00000074211 [Q9Y2T4-2]
ENST00000382599; ENSP00000372042; ENSG00000074211 [Q9Y2T4-1]
ENST00000506140; ENSP00000423649; ENSG00000074211 [Q9Y2T4-4]
ENST00000507294; ENSP00000425247; ENSG00000074211 [Q9Y2T4-4]
ENST00000515571; ENSP00000422374; ENSG00000074211 [Q9Y2T4-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5522

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5522

UCSC genome browser

More...
UCSCi
uc003gja.3 human [Q9Y2T4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH007514 Genomic DNA Translation: AAD20987.1
AF086924 mRNA Translation: AAG39636.1
AF145027 mRNA Translation: AAP97279.1
AK093115 mRNA Translation: BAG52658.1
AK296474 mRNA Translation: BAH12367.1
AK316003 mRNA Translation: BAH14374.1
AC093323 Genomic DNA No translation available.
AC114815 Genomic DNA No translation available.
AC116317 Genomic DNA No translation available.
AC122939 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82393.1
CH471131 Genomic DNA Translation: EAW82394.1
CH471131 Genomic DNA Translation: EAW82395.1
BC032954 mRNA Translation: AAH32954.1
CCDSiCCDS3387.1 [Q9Y2T4-1]
CCDS3388.1 [Q9Y2T4-2]
CCDS56304.1 [Q9Y2T4-3]
CCDS56305.1 [Q9Y2T4-4]
PIRiJC7153
RefSeqiNP_001193923.1, NM_001206994.1 [Q9Y2T4-4]
NP_001193924.1, NM_001206995.1 [Q9Y2T4-4]
NP_001193925.1, NM_001206996.1 [Q9Y2T4-3]
NP_065149.2, NM_020416.3 [Q9Y2T4-1]
NP_870991.1, NM_181876.2 [Q9Y2T4-2]

3D structure databases

SMRiQ9Y2T4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111514, 53 interactors
IntActiQ9Y2T4, 39 interactors
MINTiQ9Y2T4
STRINGi9606.ENSP00000335083

PTM databases

iPTMnetiQ9Y2T4
PhosphoSitePlusiQ9Y2T4

Polymorphism and mutation databases

BioMutaiPPP2R2C
DMDMi145559437

Proteomic databases

jPOSTiQ9Y2T4
MassIVEiQ9Y2T4
PaxDbiQ9Y2T4
PeptideAtlasiQ9Y2T4
PRIDEiQ9Y2T4
ProteomicsDBi85893
85894 [Q9Y2T4-2]
85895 [Q9Y2T4-3]
85896 [Q9Y2T4-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22656 101 antibodies

The DNASU plasmid repository

More...
DNASUi
5522

Genome annotation databases

EnsembliENST00000335585; ENSP00000335083; ENSG00000074211 [Q9Y2T4-2]
ENST00000382599; ENSP00000372042; ENSG00000074211 [Q9Y2T4-1]
ENST00000506140; ENSP00000423649; ENSG00000074211 [Q9Y2T4-4]
ENST00000507294; ENSP00000425247; ENSG00000074211 [Q9Y2T4-4]
ENST00000515571; ENSP00000422374; ENSG00000074211 [Q9Y2T4-3]
GeneIDi5522
KEGGihsa:5522
UCSCiuc003gja.3 human [Q9Y2T4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5522
DisGeNETi5522

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPP2R2C
HGNCiHGNC:9306 PPP2R2C
HPAiENSG00000074211 Tissue enhanced (brain)
MIMi605997 gene
neXtProtiNX_Q9Y2T4
OpenTargetsiENSG00000074211
PharmGKBiPA33670

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1354 Eukaryota
COG5170 LUCA
GeneTreeiENSGT00950000182864
HOGENOMiCLU_021713_3_3_1
InParanoidiQ9Y2T4
KOiK04354
OMAiGFLPDHN
OrthoDBi810409at2759
PhylomeDBiQ9Y2T4
TreeFamiTF105553

Enzyme and pathway databases

SIGNORiQ9Y2T4

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPP2R2C human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PPP2R2C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5522
PharosiQ9Y2T4 Tbio

Protein Ontology

More...
PROi
PR:Q9Y2T4
RNActiQ9Y2T4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000074211 Expressed in putamen and 152 other tissues
ExpressionAtlasiQ9Y2T4 baseline and differential
GenevisibleiQ9Y2T4 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR000009 PP2A_PR55
IPR018067 PP2A_PR55_CS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11871 PTHR11871, 1 hit
PIRSFiPIRSF037309 PP2A_PR55, 1 hit
PRINTSiPR00600 PP2APR55
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS01024 PR55_1, 1 hit
PS01025 PR55_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei2ABG_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2T4
Secondary accession number(s): A8MSY7
, B7Z3Y1, Q7Z4V7, Q8NEC4, Q9H3G7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 17, 2007
Last modified: April 22, 2020
This is version 170 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again