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Entry version 168 (13 Feb 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Guanine deaminase

Gene

GDA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+Note: Binds 1 zinc ion per subunit.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: guanine degradation

This protein is involved in step 1 of the subpathway that synthesizes xanthine from guanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Guanine deaminase (GDA), Guanine deaminase (GDA)
This subpathway is part of the pathway guanine degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes xanthine from guanine, the pathway guanine degradation and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi82Zinc; via tele nitrogenCombined sources1 Publication1
Metal bindingi84Zinc; via tele nitrogenCombined sources1 Publication1
Metal bindingi240Zinc; via tele nitrogenCombined sources1 Publication1
Metal bindingi330ZincCombined sources1 Publication1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei330SubstrateCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS04276-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.4.3 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-74259 Purine catabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9Y2T3

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00603;UER00660

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M38.981

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanine deaminase (EC:3.5.4.3)
Short name:
Guanase
Short name:
Guanine aminase
Alternative name(s):
Guanine aminohydrolase
Short name:
GAH
p51-nedasin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GDA
Synonyms:KIAA1258
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000119125.16

Human Gene Nomenclature Database

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HGNCi
HGNC:4212 GDA

Online Mendelian Inheritance in Man (OMIM)

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MIMi
139260 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2T3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
9615

Open Targets

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OpenTargetsi
ENSG00000119125

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28625

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3129

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GDA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
9910736

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001222981 – 454Guanine deaminaseAdd BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei453PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y2T3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y2T3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y2T3

PeptideAtlas

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PeptideAtlasi
Q9Y2T3

PRoteomics IDEntifications database

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PRIDEi
Q9Y2T3

ProteomicsDB human proteome resource

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ProteomicsDBi
85890
85891 [Q9Y2T3-2]
85892 [Q9Y2T3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y2T3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2T3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000119125 Expressed in 137 organ(s), highest expression level in jejunal mucosa

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y2T3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y2T3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019352
HPA024099
HPA030387

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114976, 45 interactors

Molecular INTeraction database

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MINTi
Q9Y2T3

STRING: functional protein association networks

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STRINGi
9606.ENSP00000238018

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9Y2T3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1454
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2UZ9X-ray2.30A1-454[»]
3E0LX-ray2.37A/B1-454[»]
4AQLX-ray1.99A1-454[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y2T3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y2T3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9Y2T3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni84 – 87Substrate bindingCombined sources1 Publication4
Regioni213 – 214Substrate bindingCombined sources1 Publication2
Regioni240 – 243Substrate bindingCombined sources1 Publication4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3968 Eukaryota
COG0402 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000017130

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000257692

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG005930

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y2T3

KEGG Orthology (KO)

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KOi
K01487

Identification of Orthologs from Complete Genome Data

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OMAi
ASYFATN

Database of Orthologous Groups

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OrthoDBi
612054at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y2T3

TreeFam database of animal gene trees

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TreeFami
TF324539

Family and domain databases

Conserved Domains Database

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CDDi
cd01303 GDEase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006680 Amidohydro-rel
IPR014311 Guanine_deaminase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase

The PANTHER Classification System

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PANTHERi
PTHR11271:SF6 PTHR11271:SF6, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01979 Amidohydro_1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF51556 SSF51556, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR02967 guan_deamin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2T3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCAAQMPPLA HIFRGTFVHS TWTCPMEVLR DHLLGVSDSG KIVFLEEASQ
60 70 80 90 100
QEKLAKEWCF KPCEIRELSH HEFFMPGLVD THIHASQYSF AGSSIDLPLL
110 120 130 140 150
EWLTKYTFPA EHRFQNIDFA EEVYTRVVRR TLKNGTTTAC YFATIHTDSS
160 170 180 190 200
LLLADITDKF GQRAFVGKVC MDLNDTFPEY KETTEESIKE TERFVSEMLQ
210 220 230 240 250
KNYSRVKPIV TPRFSLSCSE TLMGELGNIA KTRDLHIQSH ISENRDEVEA
260 270 280 290 300
VKNLYPSYKN YTSVYDKNNL LTNKTVMAHG CYLSAEELNV FHERGASIAH
310 320 330 340 350
CPNSNLSLSS GFLNVLEVLK HEVKIGLGTD VAGGYSYSML DAIRRAVMVS
360 370 380 390 400
NILLINKVNE KSLTLKEVFR LATLGGSQAL GLDGEIGNFE VGKEFDAILI
410 420 430 440 450
NPKASDSPID LFYGDFFGDI SEAVIQKFLY LGDDRNIEEV YVGGKQVVPF

SSSV
Length:454
Mass (Da):51,003
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA45C868E6EEA7380
GO
Isoform 2 (identifier: Q9Y2T3-2) [UniParc]FASTAAdd to basket
Also known as: c

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.

Show »
Length:380
Mass (Da):42,445
Checksum:i6AD0F99117A467CE
GO
Isoform 3 (identifier: Q9Y2T3-3) [UniParc]FASTAAdd to basket
Also known as: a

The sequence of this isoform differs from the canonical sequence as follows:
     454-454: V → VKETIHLPASSPHPPPFP

Show »
Length:471
Mass (Da):52,837
Checksum:i5B9BF9B0E1111F88
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SZC5Q5SZC5_HUMAN
Guanine deaminase
GDA
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SZC3Q5SZC3_HUMAN
Guanine deaminase
GDA
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SZC6Q5SZC6_HUMAN
Guanine deaminase
GDA
393Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDZ7H0YDZ7_HUMAN
Guanine deaminase
GDA
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86572 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti316 – 318LEV → ARI in AAG40469 (Ref. 3) Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0420751 – 74Missing in isoform 2. 2 PublicationsAdd BLAST74
Alternative sequenceiVSP_042076454V → VKETIHLPASSPHPPPFP in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF095286 mRNA Translation: AAD25978.1
AF019638 mRNA Translation: AAF13301.1
AF144745 mRNA Translation: AAG40469.1
AB033084 mRNA Translation: BAA86572.1 Different initiation.
AK300418 mRNA Translation: BAG62147.1
AK315988 mRNA Translation: BAH14359.1
AL583829 Genomic DNA No translation available.
AL590311 Genomic DNA No translation available.
AL135924 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62529.1
BC053584 mRNA Translation: AAH53584.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS56576.1 [Q9Y2T3-3]
CCDS56577.1 [Q9Y2T3-2]
CCDS6641.1 [Q9Y2T3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001229434.1, NM_001242505.2 [Q9Y2T3-3]
NP_001229435.1, NM_001242506.2 [Q9Y2T3-2]
NP_001229436.1, NM_001242507.2 [Q9Y2T3-2]
NP_004284.1, NM_004293.4 [Q9Y2T3-1]
XP_005252374.1, XM_005252317.1 [Q9Y2T3-3]
XP_016870825.1, XM_017015336.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.494163

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000238018; ENSP00000238018; ENSG00000119125 [Q9Y2T3-3]
ENST00000358399; ENSP00000351170; ENSG00000119125 [Q9Y2T3-1]
ENST00000475764; ENSP00000436619; ENSG00000119125 [Q9Y2T3-1]
ENST00000545168; ENSP00000437972; ENSG00000119125 [Q9Y2T3-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9615

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9615

UCSC genome browser

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UCSCi
uc004aiq.4 human [Q9Y2T3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095286 mRNA Translation: AAD25978.1
AF019638 mRNA Translation: AAF13301.1
AF144745 mRNA Translation: AAG40469.1
AB033084 mRNA Translation: BAA86572.1 Different initiation.
AK300418 mRNA Translation: BAG62147.1
AK315988 mRNA Translation: BAH14359.1
AL583829 Genomic DNA No translation available.
AL590311 Genomic DNA No translation available.
AL135924 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62529.1
BC053584 mRNA Translation: AAH53584.1
CCDSiCCDS56576.1 [Q9Y2T3-3]
CCDS56577.1 [Q9Y2T3-2]
CCDS6641.1 [Q9Y2T3-1]
RefSeqiNP_001229434.1, NM_001242505.2 [Q9Y2T3-3]
NP_001229435.1, NM_001242506.2 [Q9Y2T3-2]
NP_001229436.1, NM_001242507.2 [Q9Y2T3-2]
NP_004284.1, NM_004293.4 [Q9Y2T3-1]
XP_005252374.1, XM_005252317.1 [Q9Y2T3-3]
XP_016870825.1, XM_017015336.1
UniGeneiHs.494163

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2UZ9X-ray2.30A1-454[»]
3E0LX-ray2.37A/B1-454[»]
4AQLX-ray1.99A1-454[»]
ProteinModelPortaliQ9Y2T3
SMRiQ9Y2T3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114976, 45 interactors
MINTiQ9Y2T3
STRINGi9606.ENSP00000238018

Chemistry databases

BindingDBiQ9Y2T3
ChEMBLiCHEMBL3129

Protein family/group databases

MEROPSiM38.981

PTM databases

iPTMnetiQ9Y2T3
PhosphoSitePlusiQ9Y2T3

Polymorphism and mutation databases

BioMutaiGDA
DMDMi9910736

Proteomic databases

EPDiQ9Y2T3
jPOSTiQ9Y2T3
PaxDbiQ9Y2T3
PeptideAtlasiQ9Y2T3
PRIDEiQ9Y2T3
ProteomicsDBi85890
85891 [Q9Y2T3-2]
85892 [Q9Y2T3-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9615
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238018; ENSP00000238018; ENSG00000119125 [Q9Y2T3-3]
ENST00000358399; ENSP00000351170; ENSG00000119125 [Q9Y2T3-1]
ENST00000475764; ENSP00000436619; ENSG00000119125 [Q9Y2T3-1]
ENST00000545168; ENSP00000437972; ENSG00000119125 [Q9Y2T3-2]
GeneIDi9615
KEGGihsa:9615
UCSCiuc004aiq.4 human [Q9Y2T3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9615
DisGeNETi9615
EuPathDBiHostDB:ENSG00000119125.16

GeneCards: human genes, protein and diseases

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GeneCardsi
GDA
HGNCiHGNC:4212 GDA
HPAiHPA019352
HPA024099
HPA030387
MIMi139260 gene
neXtProtiNX_Q9Y2T3
OpenTargetsiENSG00000119125
PharmGKBiPA28625

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3968 Eukaryota
COG0402 LUCA
GeneTreeiENSGT00390000017130
HOGENOMiHOG000257692
HOVERGENiHBG005930
InParanoidiQ9Y2T3
KOiK01487
OMAiASYFATN
OrthoDBi612054at2759
PhylomeDBiQ9Y2T3
TreeFamiTF324539

Enzyme and pathway databases

UniPathwayi
UPA00603;UER00660

BioCyciMetaCyc:HS04276-MONOMER
BRENDAi3.5.4.3 2681
ReactomeiR-HSA-74259 Purine catabolism
SABIO-RKiQ9Y2T3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GDA human
EvolutionaryTraceiQ9Y2T3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9615

Protein Ontology

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PROi
PR:Q9Y2T3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119125 Expressed in 137 organ(s), highest expression level in jejunal mucosa
ExpressionAtlasiQ9Y2T3 baseline and differential
GenevisibleiQ9Y2T3 HS

Family and domain databases

CDDicd01303 GDEase, 1 hit
Gene3Di2.30.40.10, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR014311 Guanine_deaminase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR11271:SF6 PTHR11271:SF6, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR02967 guan_deamin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGUAD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2T3
Secondary accession number(s): B4DTY5
, Q5SZC7, Q9H335, Q9ULG2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: February 13, 2019
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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