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1 to 25 of 122  Show
  1. 1
    "Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24."
    Mai M., Qian C., Yokomizo A., Smith D.I., Liu W.
    Genomics 55:341-344(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 5 other entries.

  2. 2
    "Properties of mouse Axin2 and human AXIN2: chromosomal location, expression pattern, interaction with Axin and effects on embryonic axis formation."
    Zhang T., Fagotto F., Hsu W., Zeng L., Gilbert D., Copeland N.G., Jenkins N.A., Warburton D., Costantini F.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Category: Sequences.
    Tissue: Brain and Lymphoblast.
    Source: UniProtKB/Swiss-Prot (reviewed).
  3. 3
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 4665 other entries.

  4. 4
    "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Category: Sequences.
    Tissue: Brain.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 50448 other entries.

  5. 5
    "Identification of 3' UTR of Axin2."
    Takahashi M., Furukawa Y.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 697-843.
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  6. 6
    "Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling."
    Liu W., Dong X., Mai M., Seelan R.S., Taniguchi K., Krishnadath K.K., Halling K.C., Cunningham J.M., Qian C., Christensen E., Roches P.C., Smith D.I., Thibodeau S.N.
    Nat. Genet. 26:146-147(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN COLORECTAL CANCER.
    Category: Pathology & Biotech.
    Source: UniProtKB/Swiss-Prot (reviewed).
  7. 7
    "Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer."
    Lammi L., Arte S., Somer M., Jarvinen H., Lahermo P., Thesleff I., Pirinen S., Nieminen P.
    Am. J. Hum. Genet. 74:1043-1050(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN ODCRCS.
    Category: Pathology & Biotech.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 17 other entries.

  8. 8
    "Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia."
    Liu W., Rui H., Wang J., Lin S., He Y., Chen M., Li Q., Ye Z., Zhang S., Chan S.C., Chen Y.-G., Han J., Lin S.-C.
    EMBO J. 25:1646-1658(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SMAD7 AND RNF111.
    Category: Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 4 and mapped to 42 other entries.

  9. 9
    Category: Function, PTM / Processing, Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 3 and mapped to 72 other entries.

  10. 10
    "The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling."
    Lui T.T., Lacroix C., Ahmed S.M., Goldenberg S.J., Leach C.A., Daulat A.M., Angers S.
    Mol. Cell. Biol. 31:2053-2065(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, DEUBIQUITINATION BY USP34.
    Category: PTM / Processing.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2 and mapped to 18 other entries.

  11. 11
    "RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling."
    Zhang Y., Liu S., Mickanin C., Feng Y., Charlat O., Michaud G.A., Schirle M., Shi X., Hild M., Bauer A., Myer V.E., Finan P.M., Porter J.A., Huang S.M., Cong F.
    Nat. Cell Biol. 13:623-629(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ADP-RIBOSYLATION, UBIQUITINATION, INTERACTION WITH RNF146; TNKS AND TNKS2.
    Category: Function, PTM / Processing, Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 6 and mapped to 60 other entries.

  12. 12
    "Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population."
    Kanzaki H., Ouchida M., Hanafusa H., Yano M., Suzuki H., Aoe M., Imai K., Shimizu N., Nakachi K., Shimizu K.
    Int. J. Mol. Med. 18:279-284(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PRO-50.
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 5 other entries.

  13. 13
    "GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin."
    Ikeda S., Kishida M., Matsuura Y., Usui H., Kikuchi A.
    Oncogene 19:537-545(2000) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Source: IntAct:Q9Y2T1.

    This publication is mapped to 15 other entries.

  14. 14
    "Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway."
    Jho E.H., Zhang T., Domon C., Joo C.K., Freund J.N., Costantini F.
    Mol. Cell. Biol. 22:1172-1183(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-3640821.

    This publication is mapped to 11 other entries.

  15. 15
    "Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors."
    Lustig B., Jerchow B., Sachs M., Weiler S., Pietsch T., Karsten U., van de Wetering M., Clevers H., Schlag P.M., Birchmeier W., Behrens J.
    Mol. Cell. Biol. 22:1184-1193(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-3640821.

    This publication is mapped to 23 other entries.

  16. 16
    "Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling."
    Leung J.Y., Kolligs F.T., Wu R., Zhai Y., Kuick R., Hanash S., Cho K.R., Fearon E.R.
    J. Biol. Chem. 277:21657-21665(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Expression, Sequences.
    Annotation: Activation of AXIN2 expression by beta-catenin-T cell factor. [GeneRIF:8313]. Pathway. [Reactome:R-HSA-3640821].
    Source: GeneRIF:8313, Reactome:R-HSA-3640821.

    This publication is mapped to 44 other entries.

  17. 17
    "Expression of axin2 is regulated by the alternative 5'-untranslated regions of its mRNA."
    Hughes T.A., Brady H.J.
    J. Biol. Chem. 280:8581-8588(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Expression, Sequences.
    Annotation: axin2 expression is regulated by its alternative 5'UTR mRNA.
    Source: GeneRIF:8313.

    This publication is mapped to 6 other entries.

  18. 18
    "E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation."
    Hughes T.A., Brady H.J.
    Biochem. Biophys. Res. Commun. 329:1267-1274(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: E2F1 induces stabilisation of axin2 mRNAs.
    Source: GeneRIF:8313.

    This publication is mapped to 6 other entries.

  19. 19
    "Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability."
    Koinuma K., Yamashita Y., Liu W., Hatanaka H., Kurashina K., Wada T., Takada S., Kaneda R., Choi Y.L., Fujiwara S.I., Miyakura Y., Nagai H., Mano H.
    Oncogene 25:139-146(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: epigenetic silencing of AXIN2 is specifically associated with carcinogenesis in colorectal carcinoma with microsatellite instability.
    Source: GeneRIF:8313.

    This publication is mapped to 6 other entries.

  20. 20
    "Axis inhibition protein 2 (AXIN2) polymorphisms may be a risk factor for selective tooth agenesis."
    Mostowska A., Biedziak B., Jagodzinski P.P.
    J. Hum. Genet. 51:262-266(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Observational study of gene-disease association. (HuGE Navigator).
    Source: GeneRIF:8313.

    This publication is mapped to 6 other entries.

  21. 21
    "Tankyrase recruitment to the lateral membrane in polarized epithelial cells: regulation by cell-cell contact and protein poly(ADP-ribosyl)ation."
    Yeh T.Y., Meyer T.N., Schwesinger C., Tsun Z.Y., Lee R.M., Chi N.W.
    Biochem. J. 399:415-425(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-3640821, Reactome:R-HSA-3640842.

    This publication is mapped to 8 other entries.

  22. 22
    "Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis."
    PAFNORD Group
    Lejeune S., Guillemot F., Triboulet J.P., Cattan S., Mouton C., Porchet N., Manouvrier S., Buisine M.P.
    Hum. Mutat. 27:1064-1064(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Results show Low frequency of AXIN2 mutations in patients with multiple polyposis.
    Source: GeneRIF:8313.

    This publication is mapped to 22 other entries.

  23. 23
    "A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells."
    Yook J.I., Li X.Y., Ota I., Hu C., Kim H.S., Kim N.H., Cha S.Y., Ryu J.K., Choi Y.J., Kim J., Fearon E.R., Weiss S.J.
    Nat. Cell Biol. 8:1398-1406(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: The identification of a beta-catenin-T-cell factor-regulated Axin2-GSK3beta-Snail1 axis provides new mechanistic insights into cancer-associated epithelial-mesenchymal transition programmes.
    Source: GeneRIF:8313.

    This publication is mapped to 12 other entries.

  24. 24
    "Colorectal cancer and genetic alterations in the Wnt pathway."
    Segditsas S., Tomlinson I.
    Oncogene 25:7531-7537(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: AXIN1 AXIN2 and TCF7L2 may have roles in development of colorectal carcinomas (review).
    Source: GeneRIF:8313.

    This publication is mapped to 38 other entries.

  25. 25
    "Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas."
    Koch A., Hrychyk A., Hartmann W., Waha A., Mikeska T., Waha A., Schuller U., Sorensen N., Berthold F., Goodyer C.G., Wiestler O.D., Birchmeier W., Behrens J., Pietsch T.
    Int. J. Cancer 121:284-291(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech, Sequences.
    Annotation: Findings indicate that mutations of AXIN2 can lead to an oncogenic activation of the Wnt pathway in medulloblastomas.
    Source: GeneRIF:8313.

    This publication is mapped to 6 other entries.

1 to 25 of 122  Show
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