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Protein

Polymerase delta-interacting protein 2

Gene

POLDIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Polymerase delta-interacting protein 2
Alternative name(s):
38 kDa DNA polymerase delta interaction protein
Short name:
p38
Gene namesi
Name:POLDIP2
Synonyms:PDIP38, POLD4
ORF Names:HSPC017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000004142.11
HGNCiHGNC:23781 POLDIP2
MIMi611519 gene
neXtProtiNX_Q9Y2S7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26073
OpenTargetsiENSG00000004142
PharmGKBiPA134866227

Polymorphism and mutation databases

BioMutaiPOLDIP2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001979751 – 368Polymerase delta-interacting protein 2Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei292PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y2S7
MaxQBiQ9Y2S7
PeptideAtlasiQ9Y2S7
PRIDEiQ9Y2S7
ProteomicsDBi85887

PTM databases

iPTMnetiQ9Y2S7
PhosphoSitePlusiQ9Y2S7

Expressioni

Gene expression databases

BgeeiENSG00000004142 Expressed in 222 organ(s), highest expression level in muscle of leg
CleanExiHS_POLD4
HS_POLDIP2
ExpressionAtlasiQ9Y2S7 baseline and differential
GenevisibleiQ9Y2S7 HS

Organism-specific databases

HPAiHPA007700

Interactioni

Subunit structurei

Interacts with PCNA and POLD2.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi117531, 68 interactors
IntActiQ9Y2S7, 63 interactors
MINTiQ9Y2S7

Structurei

3D structure databases

ProteinModelPortaliQ9Y2S7
SMRiQ9Y2S7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini235 – 360ApaGPROSITE-ProRule annotationAdd BLAST126

Phylogenomic databases

GeneTreeiENSGT00390000010198
HOVERGENiHBG053549
InParanoidiQ9Y2S7
KOiK17809
OMAiRAWQKKN
OrthoDBiEOG091G0BNI
PhylomeDBiQ9Y2S7

Family and domain databases

Gene3Di2.60.40.1470, 1 hit
InterProiView protein in InterPro
IPR007474 ApaG_domain
IPR036767 ApaG_sf
IPR011722 Hemimethylated_DNA-bd_dom
IPR036623 Hemimethylated_DNA-bd_sf
PfamiView protein in Pfam
PF04379 DUF525, 1 hit
PF08755 YccV-like, 1 hit
SMARTiView protein in SMART
SM00992 YccV-like, 1 hit
SUPFAMiSSF110069 SSF110069, 1 hit
SSF141255 SSF141255, 1 hit
PROSITEiView protein in PROSITE
PS51087 APAG, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y2S7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAACTARRAL AVGSRWWSRS LTGARWPRPL CAAAGAGAFS PASTTTTRRH
60 70 80 90 100
LSSRNRPEGK VLETVGVFEV PKQNGKYETG QLFLHSIFGY RGVVLFPWQA
110 120 130 140 150
RLYDRDVASA APEKAENPAG HGSKEVKGKT HTYYQVLIDA RDCPHISQRS
160 170 180 190 200
QTEAVTFLAN HDDSRALYAI PGLDYVSHED ILPYTSTDQV PIQHELFERF
210 220 230 240 250
LLYDQTKAPP FVARETLRAW QEKNHPWLEL SDVHRETTEN IRVTVIPFYM
260 270 280 290 300
GMREAQNSHV YWWRYCIRLE NLDSDVVQLR ERHWRIFSLS GTLETVRGRG
310 320 330 340 350
VVGREPVLSK EQPAFQYSSH VSLQASSGHM WGTFRFERPD GSHFDVRIPP
360
FSLESNKDEK TPPSGLHW
Length:368
Mass (Da):42,033
Last modified:November 1, 1999 - v1
Checksum:i1882F93273542CCF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DEM9B4DEM9_HUMAN
cDNA FLJ52257, highly similar to Po...
POLDIP2
350Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9A → P in AAK92018 (PubMed:12522211).Curated1
Sequence conflicti28R → K in AAK92018 (PubMed:12522211).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179891 mRNA Translation: AAK92018.1
AF077203 mRNA Translation: AAD26998.1
AK313232 mRNA Translation: BAG36043.1
BC000655 mRNA Translation: AAH00655.1
BC009265 mRNA Translation: AAH09265.1
CCDSiCCDS74018.1
RefSeqiNP_001277074.1, NM_001290145.1
NP_056399.1, NM_015584.4
UniGeneiHs.241543

Genome annotation databases

EnsembliENST00000540200; ENSP00000475924; ENSG00000004142
GeneIDi26073
KEGGihsa:26073
UCSCiuc032ezc.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179891 mRNA Translation: AAK92018.1
AF077203 mRNA Translation: AAD26998.1
AK313232 mRNA Translation: BAG36043.1
BC000655 mRNA Translation: AAH00655.1
BC009265 mRNA Translation: AAH09265.1
CCDSiCCDS74018.1
RefSeqiNP_001277074.1, NM_001290145.1
NP_056399.1, NM_015584.4
UniGeneiHs.241543

3D structure databases

ProteinModelPortaliQ9Y2S7
SMRiQ9Y2S7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117531, 68 interactors
IntActiQ9Y2S7, 63 interactors
MINTiQ9Y2S7

PTM databases

iPTMnetiQ9Y2S7
PhosphoSitePlusiQ9Y2S7

Polymorphism and mutation databases

BioMutaiPOLDIP2

Proteomic databases

EPDiQ9Y2S7
MaxQBiQ9Y2S7
PeptideAtlasiQ9Y2S7
PRIDEiQ9Y2S7
ProteomicsDBi85887

Protocols and materials databases

DNASUi26073
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000540200; ENSP00000475924; ENSG00000004142
GeneIDi26073
KEGGihsa:26073
UCSCiuc032ezc.2 human

Organism-specific databases

CTDi26073
DisGeNETi26073
EuPathDBiHostDB:ENSG00000004142.11
GeneCardsiPOLDIP2
HGNCiHGNC:23781 POLDIP2
HPAiHPA007700
MIMi611519 gene
neXtProtiNX_Q9Y2S7
OpenTargetsiENSG00000004142
PharmGKBiPA134866227
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000010198
HOVERGENiHBG053549
InParanoidiQ9Y2S7
KOiK17809
OMAiRAWQKKN
OrthoDBiEOG091G0BNI
PhylomeDBiQ9Y2S7

Miscellaneous databases

ChiTaRSiPOLDIP2 human
GeneWikiiPOLDIP2
GenomeRNAii26073
PROiPR:Q9Y2S7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000004142 Expressed in 222 organ(s), highest expression level in muscle of leg
CleanExiHS_POLD4
HS_POLDIP2
ExpressionAtlasiQ9Y2S7 baseline and differential
GenevisibleiQ9Y2S7 HS

Family and domain databases

Gene3Di2.60.40.1470, 1 hit
InterProiView protein in InterPro
IPR007474 ApaG_domain
IPR036767 ApaG_sf
IPR011722 Hemimethylated_DNA-bd_dom
IPR036623 Hemimethylated_DNA-bd_sf
PfamiView protein in Pfam
PF04379 DUF525, 1 hit
PF08755 YccV-like, 1 hit
SMARTiView protein in SMART
SM00992 YccV-like, 1 hit
SUPFAMiSSF110069 SSF110069, 1 hit
SSF141255 SSF141255, 1 hit
PROSITEiView protein in PROSITE
PS51087 APAG, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDIP2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2S7
Secondary accession number(s): B2R846, Q96JE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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