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Protein

Translation machinery-associated protein 7

Gene

TMA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cytoplasmic translation Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Translation machinery-associated protein 7
Alternative name(s):
Coiled-coil domain-containing protein 72
Gene namesi
Name:TMA7
Synonyms:CCDC72
ORF Names:HSPC016, HSPC330
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000232112.3
HGNCiHGNC:26932 TMA7
MIMi615808 gene
neXtProtiNX_Q9Y2S6

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000232112
PharmGKBiPA143485423

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002356811 – 64Translation machinery-associated protein 7Add BLAST64

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61ADP-ribosylserine1 Publication1

Keywords - PTMi

ADP-ribosylation

Proteomic databases

EPDiQ9Y2S6
MaxQBiQ9Y2S6
PaxDbiQ9Y2S6
PeptideAtlasiQ9Y2S6
PRIDEiQ9Y2S6
ProteomicsDBi85886
TopDownProteomicsiQ9Y2S6

PTM databases

iPTMnetiQ9Y2S6
PhosphoSitePlusiQ9Y2S6

Expressioni

Tissue specificityi

Expressed in dermal papilla cells with aggregative behavior.1 Publication

Gene expression databases

BgeeiENSG00000232112 Expressed in 88 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_CCDC72
ExpressionAtlasiQ9Y2S6 baseline and differential
GenevisibleiQ9Y2S6 HS

Organism-specific databases

HPAiHPA047397

Interactioni

Protein-protein interaction databases

BioGridi119505, 5 interactors
IntActiQ9Y2S6, 4 interactors
STRINGi9606.ENSP00000397843

Structurei

3D structure databases

ProteinModelPortaliQ9Y2S6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili21 – 50Sequence analysisAdd BLAST30

Sequence similaritiesi

Belongs to the TMA7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410JP6Z Eukaryota
ENOG410ZJ3Y LUCA
GeneTreeiENSGT00390000003710
HOGENOMiHOG000197071
HOVERGENiHBG081046
InParanoidiQ9Y2S6
OMAiKKGPLNT
TreeFamiTF300250

Family and domain databases

InterProiView protein in InterPro
IPR015157 TMA7
PANTHERiPTHR28632 PTHR28632, 1 hit
PfamiView protein in Pfam
PF09072 TMA7, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y2S6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGREGGKKK PLKQPKKQAK EMDEEDKAFK QKQKEEQKKL EELKAKAAGK
60
GPLATGGIKK SGKK
Length:64
Mass (Da):7,066
Last modified:November 1, 1999 - v1
Checksum:iE79BA054EC176B74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077202 mRNA Translation: AAD26997.1
AY508979 mRNA Translation: AAR87665.1
AY794023 mRNA Translation: AAV40981.1
BC080531 mRNA Translation: AAH80531.1
AF161448 mRNA Translation: AAF29008.1
CCDSiCCDS46823.1
RefSeqiNP_057017.1, NM_015933.5
UniGeneiHs.356440

Genome annotation databases

EnsembliENST00000438607; ENSP00000397843; ENSG00000232112
GeneIDi51372
KEGGihsa:51372
UCSCiuc003cte.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077202 mRNA Translation: AAD26997.1
AY508979 mRNA Translation: AAR87665.1
AY794023 mRNA Translation: AAV40981.1
BC080531 mRNA Translation: AAH80531.1
AF161448 mRNA Translation: AAF29008.1
CCDSiCCDS46823.1
RefSeqiNP_057017.1, NM_015933.5
UniGeneiHs.356440

3D structure databases

ProteinModelPortaliQ9Y2S6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119505, 5 interactors
IntActiQ9Y2S6, 4 interactors
STRINGi9606.ENSP00000397843

PTM databases

iPTMnetiQ9Y2S6
PhosphoSitePlusiQ9Y2S6

Proteomic databases

EPDiQ9Y2S6
MaxQBiQ9Y2S6
PaxDbiQ9Y2S6
PeptideAtlasiQ9Y2S6
PRIDEiQ9Y2S6
ProteomicsDBi85886
TopDownProteomicsiQ9Y2S6

Protocols and materials databases

DNASUi51372
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000438607; ENSP00000397843; ENSG00000232112
GeneIDi51372
KEGGihsa:51372
UCSCiuc003cte.2 human

Organism-specific databases

CTDi51372
EuPathDBiHostDB:ENSG00000232112.3
GeneCardsiTMA7
H-InvDBiHIX0123438
HIX0203214
HGNCiHGNC:26932 TMA7
HPAiHPA047397
MIMi615808 gene
neXtProtiNX_Q9Y2S6
OpenTargetsiENSG00000232112
PharmGKBiPA143485423
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JP6Z Eukaryota
ENOG410ZJ3Y LUCA
GeneTreeiENSGT00390000003710
HOGENOMiHOG000197071
HOVERGENiHBG081046
InParanoidiQ9Y2S6
OMAiKKGPLNT
TreeFamiTF300250

Miscellaneous databases

ChiTaRSiTMA7 human
GenomeRNAii51372
PROiPR:Q9Y2S6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000232112 Expressed in 88 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_CCDC72
ExpressionAtlasiQ9Y2S6 baseline and differential
GenevisibleiQ9Y2S6 HS

Family and domain databases

InterProiView protein in InterPro
IPR015157 TMA7
PANTHERiPTHR28632 PTHR28632, 1 hit
PfamiView protein in Pfam
PF09072 TMA7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMA7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2S6
Secondary accession number(s): Q9P052
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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