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UniProtKB - Q9Y2R2 (PTN22_HUMAN)

Entry version 182 (02 Jun 2021)
Sequence version 2 (27 Mar 2002)
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Protein

Tyrosine-protein phosphatase non-receptor type 22

Gene

PTPN22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643).

Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704).

Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343).

Dephosphorylates the immune system activator SKAP2 (PubMed:21719704).

Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208).

Promotes host antiviral responses mediated by type 1 interferon (By similarity).

Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).

Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity).

By similarity6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Down-regulated by phosphorylation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei195SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei227Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei274Substrate1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processAutophagy, Immunity

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.3.48, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y2R2

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430, Translocation of ZAP-70 to Immunological synapse

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y2R2

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9Y2R2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 22 (EC:3.1.3.481 Publication)
Alternative name(s):
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
Lymphoid phosphatase
Short name:
LyP
PEST-domain phosphatase
Short name:
PEP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPN22
Synonyms:PTPN8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9652, PTPN22

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600716, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y2R2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000134242.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Systemic lupus erythematosus (SLE)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Related information in OMIM
Diabetes mellitus, insulin-dependent (IDDM)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022605620R → W in IDDM, RA, SLE and VTLG; also found in patients with Graves disease, Hashimoto thyroiditis and Addison disease; associated with reduced risk of Crohn disease but not of ulcerative colitis; affects CSK kinase binding; alters B cell receptor signaling and memory B cell proliferation. 12 PublicationsCorresponds to variant dbSNP:rs2476601EnsemblClinVar.1
Rheumatoid arthritis (RA)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionAn inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Related information in OMIM
Vitiligo (VTLG)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA pigmentary disorder of the skin and mucous membranes. It is characterized by circumscribed depigmented macules and patches, commonly on extensor aspects of extremities, on the face or neck and in skin folds. Vitiligo is a progressive disorder in which some or all of the melanocytes in the affected skin are selectively destroyed. It is a multifactorial disorder with a complex etiology probably including autoimmune mechanisms, and is associated with an elevated risk of other autoimmune diseases.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022605620R → W in IDDM, RA, SLE and VTLG; also found in patients with Graves disease, Hashimoto thyroiditis and Addison disease; associated with reduced risk of Crohn disease but not of ulcerative colitis; affects CSK kinase binding; alters B cell receptor signaling and memory B cell proliferation. 12 PublicationsCorresponds to variant dbSNP:rs2476601EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi35S → E: Loss of phosphorylation by PKC/PRKCD. 1 Publication1
Mutagenesisi36T → E: No effect on phosphorylation by PKC/PRKCD. 1 Publication1
Mutagenesisi129C → S: Decreases activity 2 fold. 1 Publication1
Mutagenesisi231C → S: Decreases activity 7 fold. 1 Publication1

Keywords - Diseasei

Diabetes mellitus, Disease variant, Systemic lupus erythematosus

Organism-specific databases

DisGeNET

More...DisGeNETi		26191

MalaCards human disease database

More...MalaCardsi		PTPN22
MIMi152700, phenotype
180300, phenotype
193200, phenotype
222100, phenotype

Open Targets

More...OpenTargetsi		ENSG00000134242

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		397, Giant cell arteritis
900, Granulomatosis with polyangiitis
85410, Oligoarticular juvenile idiopathic arthritis
85408, Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis
536, Systemic lupus erythematosus
3437, Vogt-Koyanagi-Harada disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33995

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y2R2, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2889

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		3084

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PTPN22

Domain mapping of disease mutations (DMDM)

More...DMDMi		20139861

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000947751 – 807Tyrosine-protein phosphatase non-receptor type 22Add BLAST807

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei35Phosphoserine; by PKC/PRKCD1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi129 ↔ 2271 Publication
Modified residuei449PhosphoserineCombined sources1
Modified residuei635PhosphoserineBy similarity1
Modified residuei684PhosphoserineBy similarity1
Modified residuei692PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y2R2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y2R2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y2R2

PeptideAtlas

More...PeptideAtlasi		Q9Y2R2

PRoteomics IDEntifications database

More...PRIDEi		Q9Y2R2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		21761
22726
85874 [Q9Y2R2-1]
85875 [Q9Y2R2-2]
85876 [Q9Y2R2-3]
85877 [Q9Y2R2-4]
85878 [Q9Y2R2-5]

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		PTPN22

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y2R2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y2R2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in bone marrow, B and T-cells, PBMCs, natural killer cells, monocytes, dendritic cells and neutrophils (PubMed:15208781). Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By muramyl-dipeptide and lipopolysaccharide.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134242, Expressed in bone marrow and 155 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y2R2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y2R2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134242, Tissue enhanced (bone marrow, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CSK (PubMed:15208781).

Interacts with LPXN (By similarity).

Interacts with CBL (PubMed:10068674).

Interacts with TRAF3 (via MATH domain); the interaction promotes TRAF3 polyubiquitination (PubMed:23871208).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117604, 47 interactors

Database of interacting proteins

More...DIPi		DIP-29953N

Protein interaction database and analysis system

More...IntActi		Q9Y2R2, 24 interactors

Molecular INTeraction database

More...MINTi		Q9Y2R2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000352833

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9Y2R2

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y2R2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1807
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y2R2

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Y2R2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 289Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST266

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni227 – 233Substrate binding7
Regioni676 – 700DisorderedSequence analysisAdd BLAST25
Regioni724 – 746DisorderedSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0789, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160958

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y2R2

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y2R2

TreeFam database of animal gene trees

More...TreeFami		TF351977

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR016276, PTPN22
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00102, Y_phosphatase, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000930, PTPN8_PTPN22, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00700, PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00194, PTPc, 1 hit
SM00404, PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52799, SSF52799, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50055, TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2R2-1) [UniParc]FASTAAdd to basket
Also known as: LyP1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDQREILQKF LDEAQSKKIT KEEFANEFLK LKRQSTKYKA DKTYPTTVAE 
        60         70         80         90        100
KPKNIKKNRY KDILPYDYSR VELSLITSDE DSSYINANFI KGVYGPKAYI 
       110        120        130        140        150
ATQGPLSTTL LDFWRMIWEY SVLIIVMACM EYEMGKKKCE RYWAEPGEMQ 
       160        170        180        190        200
LEFGPFSVSC EAEKRKSDYI IRTLKVKFNS ETRTIYQFHY KNWPDHDVPS 
       210        220        230        240        250
SIDPILELIW DVRCYQEDDS VPICIHCSAG CGRTGVICAI DYTWMLLKDG 
       260        270        280        290        300
IIPENFSVFS LIREMRTQRP SLVQTQEQYE LVYNAVLELF KRQMDVIRDK 
       310        320        330        340        350
HSGTESQAKH CIPEKNHTLQ ADSYSPNLPK STTKAAKMMN QQRTKMEIKE 
       360        370        380        390        400
SSSFDFRTSE ISAKEELVLH PAKSSTSFDF LELNYSFDKN ADTTMKWQTK 
       410        420        430        440        450
AFPIVGEPLQ KHQSLDLGSL LFEGCSNSKP VNAAGRYFNS KVPITRTKST 
       460        470        480        490        500
PFELIQQRET KEVDSKENFS YLESQPHDSC FVEMQAQKVM HVSSAELNYS 
       510        520        530        540        550
LPYDSKHQIR NASNVKHHDS SALGVYSYIP LVENPYFSSW PPSGTSSKMS 
       560        570        580        590        600
LDLPEKQDGT VFPSSLLPTS STSLFSYYNS HDSLSLNSPT NISSLLNQES 
       610        620        630        640        650
AVLATAPRID DEIPPPLPVR TPESFIVVEE AGEFSPNVPK SLSSAVKVKI 
       660        670        680        690        700
GTSLEWGGTS EPKKFDDSVI LRPSKSVKLR SPKSELHQDR SSPPPPLPER 
       710        720        730        740        750
TLESFFLADE DCMQAQSIET YSTSYPDTME NSTSSKQTLK TPGKSFTRSK 
       760        770        780        790        800
SLKILRNMKK SICNSCPPNK PAESVQSNNS SSFLNFGFAN RFSKPKGPRN 

PPPTWNI
Length:807
Mass (Da):91,705
Last modified:March 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1ABE8AE89C9D9FBF
GO
Isoform 2 (identifier: Q9Y2R2-2) [UniParc]FASTAAdd to basket
Also known as: LyP2

The sequence of this isoform differs from the canonical sequence as follows:
     685-807: ELHQDRSSPP...PRNPPPTWNI → GKNFSWL

Note: Due to intron retention.Curated
Show »
Length:691
Mass (Da):78,769
Checksum:iA85EF69FDFDE9D58
GO
Isoform 3 (identifier: Q9Y2R2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-305: Missing.

Show »
Length:752
Mass (Da):85,138
Checksum:i826CAD31B7C20983
GO
Isoform 4 (identifier: Q9Y2R2-4) [UniParc]FASTAAdd to basket
Also known as: LYP3

The sequence of this isoform differs from the canonical sequence as follows:
     647-674: Missing.

Show »
Length:779
Mass (Da):88,647
Checksum:iAEA60DFC0BB05C11
GO
Isoform 5 (identifier: Q9Y2R2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-160: Missing.
     181-203: ETRTIYQFHYKNWPDHDVPSSID → VSVILAHQTSLQNLFSQITPAHF
     204-807: Missing.

Show »
Length:179
Mass (Da):20,932
Checksum:iE5F9FFCC426C6E2C
GO
Isoform 6 (identifier: Q9Y2R2-6) [UniParc]FASTAAdd to basket
Also known as: PTPN22.6

The sequence of this isoform differs from the canonical sequence as follows:
     124-250: Missing.
     788-807: FANRFSKPKGPRNPPPTWNI → MCVILLKS

Note: Lacks most of the phosphatase domain and functions as a dominant negative isoform of the full length PTPN22.Curated
Show »
Length:668
Mass (Da):75,488
Checksum:i93025ACF91033DAA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J1S7A0A0B4J1S7_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN22
807Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMT0E9PMT0_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN22
795Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H2S8F5H2S8_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN22
783Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTE6A0A0A0MTE6_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN22
752Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTD9A0A0A0MTD9_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN22
668Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PM87E9PM87_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN22
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMK2E9PMK2_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN22
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51 – 52KP → NA in AAD00904 (PubMed:10068674).Curated2
Sequence conflicti51 – 52KP → NA in AAD00905 (PubMed:10068674).Curated2
Sequence conflicti126V → G in AAD27764 (PubMed:21044313).Curated1
Sequence conflicti147G → V in AAD27764 (PubMed:21044313).Curated1
Sequence conflicti240I → IV in AAD00905 (PubMed:10068674).Curated1
Sequence conflicti372A → V in AK310570 (PubMed:14702039).Curated1
Sequence conflicti420L → P in AAD27764 (PubMed:21044313).Curated1
Sequence conflicti742P → S in AAD27764 (PubMed:21044313).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_072629201S → F Moderately reduces phosphatase activity. 1 PublicationCorresponds to variant dbSNP:rs7416347Ensembl.1
Natural variantiVAR_072630263R → Q Reduces risk of SLE and RA but not IDDM; associated with reduced risk of ulcerative colitis but not of Crohn disease; severely reduces phosphatase activity. 3 PublicationsCorresponds to variant dbSNP:rs33996649Ensembl.1
Natural variantiVAR_072631266R → W Severely reduces phosphatase activity. 1 PublicationCorresponds to variant dbSNP:rs72650670Ensembl.1
Natural variantiVAR_022605620R → W in IDDM, RA, SLE and VTLG; also found in patients with Graves disease, Hashimoto thyroiditis and Addison disease; associated with reduced risk of Crohn disease but not of ulcerative colitis; affects CSK kinase binding; alters B cell receptor signaling and memory B cell proliferation. 12 PublicationsCorresponds to variant dbSNP:rs2476601EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044428124 – 250Missing in isoform 6. 1 PublicationAdd BLAST127
Alternative sequenceiVSP_039725137 – 160Missing in isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_039726181 – 203ETRTI…PSSID → VSVILAHQTSLQNLFSQITP AHF in isoform 5. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_039727204 – 807Missing in isoform 5. 1 PublicationAdd BLAST604
Alternative sequenceiVSP_039728251 – 305Missing in isoform 3. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_039729647 – 674Missing in isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_005134685 – 807ELHQD…PTWNI → GKNFSWL in isoform 2. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_044429788 – 807FANRF…PTWNI → MCVILLKS in isoform 6. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF001846 mRNA Translation: AAD00904.1
AF001847 mRNA Translation: AAD00905.1
GU479452 mRNA Translation: ADD59979.1
AF077031 mRNA Translation: AAD27764.1
AK310570 mRNA No translation available.
EF064714 Genomic DNA Translation: ABK41897.1
AL137856 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56575.1
CH471122 Genomic DNA Translation: EAW56576.1
BC017785 mRNA Translation: AAH17785.1
BC071670 mRNA Translation: AAH71670.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS863.1 [Q9Y2R2-1]
CCDS864.2 [Q9Y2R2-3]

NCBI Reference Sequences

More...RefSeqi		NP_001180360.1, NM_001193431.2 [Q9Y2R2-4]
NP_001295226.1, NM_001308297.1
NP_036543.4, NM_012411.5 [Q9Y2R2-3]
NP_057051.3, NM_015967.6 [Q9Y2R2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000460620; ENSP00000433141; ENSG00000134242 [Q9Y2R2-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26191

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26191

UCSC genome browser

More...UCSCi		uc001edt.4, human [Q9Y2R2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001846 mRNA Translation: AAD00904.1
AF001847 mRNA Translation: AAD00905.1
GU479452 mRNA Translation: ADD59979.1
AF077031 mRNA Translation: AAD27764.1
AK310570 mRNA No translation available.
EF064714 Genomic DNA Translation: ABK41897.1
AL137856 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56575.1
CH471122 Genomic DNA Translation: EAW56576.1
BC017785 mRNA Translation: AAH17785.1
BC071670 mRNA Translation: AAH71670.1
CCDSiCCDS863.1 [Q9Y2R2-1]
CCDS864.2 [Q9Y2R2-3]
RefSeqiNP_001180360.1, NM_001193431.2 [Q9Y2R2-4]
NP_001295226.1, NM_001308297.1
NP_036543.4, NM_012411.5 [Q9Y2R2-3]
NP_057051.3, NM_015967.6 [Q9Y2R2-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P6XX-ray1.90A/B1-302[»]
2QCJX-ray3.00A/B1-294[»]
2QCTX-ray2.80A/B1-294[»]
3BRHX-ray2.20A/B1-310[»]
3H2XX-ray2.20A1-302[»]
3OLRX-ray2.50A/B/C/D1-294[»]
3OMHX-ray2.90A/B/C/D1-294[»]
4J51X-ray2.30A/B1-303[»]
SMRiQ9Y2R2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117604, 47 interactors
DIPiDIP-29953N
IntActiQ9Y2R2, 24 interactors
MINTiQ9Y2R2
STRINGi9606.ENSP00000352833

Chemistry databases

BindingDBiQ9Y2R2
ChEMBLiCHEMBL2889
GuidetoPHARMACOLOGYi3084

PTM databases

DEPODiPTPN22
iPTMnetiQ9Y2R2
PhosphoSitePlusiQ9Y2R2

Genetic variation databases

BioMutaiPTPN22
DMDMi20139861

Proteomic databases

jPOSTiQ9Y2R2
MassIVEiQ9Y2R2
PaxDbiQ9Y2R2
PeptideAtlasiQ9Y2R2
PRIDEiQ9Y2R2
ProteomicsDBi21761
22726
85874 [Q9Y2R2-1]
85875 [Q9Y2R2-2]
85876 [Q9Y2R2-3]
85877 [Q9Y2R2-4]
85878 [Q9Y2R2-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33846, 299 antibodies

The DNASU plasmid repository

More...DNASUi		26191

Genome annotation databases

EnsembliENST00000460620; ENSP00000433141; ENSG00000134242 [Q9Y2R2-5]
GeneIDi26191
KEGGihsa:26191
UCSCiuc001edt.4, human [Q9Y2R2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26191
DisGeNETi26191

GeneCards: human genes, protein and diseases

More...GeneCardsi		PTPN22
HGNCiHGNC:9652, PTPN22
HPAiENSG00000134242, Tissue enhanced (bone marrow, lymphoid tissue)
MalaCardsiPTPN22
MIMi152700, phenotype
180300, phenotype
193200, phenotype
222100, phenotype
600716, gene
neXtProtiNX_Q9Y2R2
OpenTargetsiENSG00000134242
Orphaneti397, Giant cell arteritis
900, Granulomatosis with polyangiitis
85410, Oligoarticular juvenile idiopathic arthritis
85408, Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis
536, Systemic lupus erythematosus
3437, Vogt-Koyanagi-Harada disease
PharmGKBiPA33995
VEuPathDBiHostDB:ENSG00000134242.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0789, Eukaryota
GeneTreeiENSGT00940000160958
InParanoidiQ9Y2R2
PhylomeDBiQ9Y2R2
TreeFamiTF351977

Enzyme and pathway databases

BRENDAi3.1.3.48, 2681
PathwayCommonsiQ9Y2R2
ReactomeiR-HSA-202427, Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430, Translocation of ZAP-70 to Immunological synapse
SignaLinkiQ9Y2R2
SIGNORiQ9Y2R2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		26191, 9 hits in 999 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PTPN22, human
EvolutionaryTraceiQ9Y2R2

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PTPN22

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26191
PharosiQ9Y2R2, Tchem

Protein Ontology

More...PROi		PR:Q9Y2R2
RNActiQ9Y2R2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134242, Expressed in bone marrow and 155 other tissues
ExpressionAtlasiQ9Y2R2, baseline and differential
GenevisibleiQ9Y2R2, HS

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR016276, PTPN22
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102, Y_phosphatase, 1 hit
PIRSFiPIRSF000930, PTPN8_PTPN22, 1 hit
PRINTSiPR00700, PRTYPHPHTASE
SMARTiView protein in SMART
SM00194, PTPc, 1 hit
SM00404, PTPc_motif, 1 hit
SUPFAMiSSF52799, SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50055, TYR_PHOSPHATASE_PTP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTN22_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2R2
Secondary accession number(s): A0N0K6
, B1ALC8, D4NZ71, E9PLD8, E9PPI1, O95063, O95064, Q6IPX8, Q8WVM1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: June 2, 2021
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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