UniProtKB - Q9Y2R2 (PTN22_HUMAN)
Protein
Tyrosine-protein phosphatase non-receptor type 22
Gene
PTPN22
Organism
Homo sapiens (Human)
Status
Functioni
Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity).By similarity6 Publications
Catalytic activityi
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphatePROSITE-ProRule annotation1 PublicationEC:3.1.3.48PROSITE-ProRule annotation1 Publication
- H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphateBy similarityThis reaction proceeds in the forwardBy similarity direction.
Activity regulationi
Down-regulated by phosphorylation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 195 | SubstrateBy similarity | 1 | |
Active sitei | 227 | Phosphocysteine intermediatePROSITE-ProRule annotation | 1 | |
Binding sitei | 274 | Substrate1 Publication | 1 |
GO - Molecular functioni
- kinase binding Source: BHF-UCL
- non-membrane spanning protein tyrosine phosphatase activity Source: GO_Central
- phosphatase activity Source: UniProtKB
- protein tyrosine phosphatase activity Source: UniProtKB
- SH3 domain binding Source: BHF-UCL
- ubiquitin protein ligase binding Source: UniProtKB
GO - Biological processi
- autophagy Source: UniProtKB-KW
- cellular response to muramyl dipeptide Source: UniProtKB
- lipopolysaccharide-mediated signaling pathway Source: UniProtKB
- negative regulation of autophagy Source: UniProtKB
- negative regulation of gene expression Source: UniProtKB
- negative regulation of interleukin-6 production Source: UniProtKB
- negative regulation of interleukin-8 production Source: UniProtKB
- negative regulation of JUN kinase activity Source: UniProtKB
- negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway Source: UniProtKB
- negative regulation of p38MAPK cascade Source: UniProtKB
- negative regulation of T cell activation Source: BHF-UCL
- negative regulation of T cell receptor signaling pathway Source: UniProtKB
- negative regulation of tumor necrosis factor production Source: UniProtKB
- peptidyl-tyrosine dephosphorylation Source: GO_Central
- phosphoanandamide dephosphorylation Source: BHF-UCL
- positive regulation of CD8-positive, alpha-beta T cell proliferation Source: GO_Central
- positive regulation of defense response to virus by host Source: GO_Central
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of granzyme B production Source: GO_Central
- positive regulation of interferon-gamma production Source: UniProtKB
- positive regulation of protein K63-linked ubiquitination Source: UniProtKB
- positive regulation of toll-like receptor 3 signaling pathway Source: UniProtKB
- positive regulation of toll-like receptor 4 signaling pathway Source: UniProtKB
- positive regulation of toll-like receptor 7 signaling pathway Source: GO_Central
- positive regulation of toll-like receptor 9 signaling pathway Source: GO_Central
- positive regulation of type I interferon production Source: UniProtKB
- protein dephosphorylation Source: BHF-UCL
- regulation of B cell receptor signaling pathway Source: BHF-UCL
- regulation of innate immune response Source: BHF-UCL
- regulation of natural killer cell proliferation Source: BHF-UCL
- regulation of NIK/NF-kappaB signaling Source: UniProtKB
- response to lipopolysaccharide Source: UniProtKB
- T cell differentiation Source: BHF-UCL
- T cell receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Biological process | Autophagy, Immunity |
Enzyme and pathway databases
BRENDAi | 3.1.3.48, 2681 |
PathwayCommonsi | Q9Y2R2 |
Reactomei | R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains R-HSA-202430, Translocation of ZAP-70 to Immunological synapse |
SignaLinki | Q9Y2R2 |
SIGNORi | Q9Y2R2 |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein phosphatase non-receptor type 22 (EC:3.1.3.481 Publication)Alternative name(s): Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP Lymphoid phosphatase Short name: LyP PEST-domain phosphatase Short name: PEP |
Gene namesi | Name:PTPN22 Synonyms:PTPN8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9652, PTPN22 |
MIMi | 600716, gene |
neXtProti | NX_Q9Y2R2 |
VEuPathDBi | HostDB:ENSG00000134242.15 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- cytoplasmic side of plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- perinuclear region of cytoplasm Source: BHF-UCL
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Systemic lupus erythematosus (SLE)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Related information in OMIMDiabetes mellitus, insulin-dependent (IDDM)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022605 | 620 | R → W in IDDM, RA, SLE and VTLG; also found in patients with Graves disease, Hashimoto thyroiditis and Addison disease; associated with reduced risk of Crohn disease but not of ulcerative colitis; affects CSK kinase binding; alters B cell receptor signaling and memory B cell proliferation. 12 PublicationsCorresponds to variant dbSNP:rs2476601EnsemblClinVar. | 1 |
Rheumatoid arthritis (RA)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionAn inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Related information in OMIMVitiligo (VTLG)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA pigmentary disorder of the skin and mucous membranes. It is characterized by circumscribed depigmented macules and patches, commonly on extensor aspects of extremities, on the face or neck and in skin folds. Vitiligo is a progressive disorder in which some or all of the melanocytes in the affected skin are selectively destroyed. It is a multifactorial disorder with a complex etiology probably including autoimmune mechanisms, and is associated with an elevated risk of other autoimmune diseases.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022605 | 620 | R → W in IDDM, RA, SLE and VTLG; also found in patients with Graves disease, Hashimoto thyroiditis and Addison disease; associated with reduced risk of Crohn disease but not of ulcerative colitis; affects CSK kinase binding; alters B cell receptor signaling and memory B cell proliferation. 12 PublicationsCorresponds to variant dbSNP:rs2476601EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 35 | S → E: Loss of phosphorylation by PKC/PRKCD. 1 Publication | 1 | |
Mutagenesisi | 36 | T → E: No effect on phosphorylation by PKC/PRKCD. 1 Publication | 1 | |
Mutagenesisi | 129 | C → S: Decreases activity 2 fold. 1 Publication | 1 | |
Mutagenesisi | 231 | C → S: Decreases activity 7 fold. 1 Publication | 1 |
Keywords - Diseasei
Diabetes mellitus, Disease variant, Systemic lupus erythematosusOrganism-specific databases
DisGeNETi | 26191 |
MalaCardsi | PTPN22 |
MIMi | 152700, phenotype 180300, phenotype 193200, phenotype 222100, phenotype |
OpenTargetsi | ENSG00000134242 |
Orphaneti | 397, Giant cell arteritis 900, Granulomatosis with polyangiitis 85410, Oligoarticular juvenile idiopathic arthritis 85408, Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis 536, Systemic lupus erythematosus 3437, Vogt-Koyanagi-Harada disease |
PharmGKBi | PA33995 |
Miscellaneous databases
Pharosi | Q9Y2R2, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2889 |
GuidetoPHARMACOLOGYi | 3084 |
Genetic variation databases
BioMutai | PTPN22 |
DMDMi | 20139861 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094775 | 1 – 807 | Tyrosine-protein phosphatase non-receptor type 22Add BLAST | 807 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 35 | Phosphoserine; by PKC/PRKCD1 Publication | 1 | |
Disulfide bondi | 129 ↔ 227 | 1 Publication | ||
Modified residuei | 449 | PhosphoserineCombined sources | 1 | |
Modified residuei | 635 | PhosphoserineBy similarity | 1 | |
Modified residuei | 684 | PhosphoserineBy similarity | 1 | |
Modified residuei | 692 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases.1 Publication
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
jPOSTi | Q9Y2R2 |
MassIVEi | Q9Y2R2 |
PaxDbi | Q9Y2R2 |
PeptideAtlasi | Q9Y2R2 |
PRIDEi | Q9Y2R2 |
ProteomicsDBi | 21761 22726 85874 [Q9Y2R2-1] 85875 [Q9Y2R2-2] 85876 [Q9Y2R2-3] 85877 [Q9Y2R2-4] 85878 [Q9Y2R2-5] |
PTM databases
DEPODi | PTPN22 |
iPTMneti | Q9Y2R2 |
PhosphoSitePlusi | Q9Y2R2 |
Expressioni
Tissue specificityi
Expressed in bone marrow, B and T-cells, PBMCs, natural killer cells, monocytes, dendritic cells and neutrophils (PubMed:15208781). Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells.1 Publication
Inductioni
By muramyl-dipeptide and lipopolysaccharide.1 Publication
Gene expression databases
Bgeei | ENSG00000134242, Expressed in bone marrow and 154 other tissues |
ExpressionAtlasi | Q9Y2R2, baseline and differential |
Genevisiblei | Q9Y2R2, HS |
Organism-specific databases
HPAi | ENSG00000134242, Tissue enhanced (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsQ9Y2R2
GO - Molecular functioni
- kinase binding Source: BHF-UCL
- SH3 domain binding Source: BHF-UCL
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 117604, 47 interactors |
DIPi | DIP-29953N |
IntActi | Q9Y2R2, 24 interactors |
MINTi | Q9Y2R2 |
STRINGi | 9606.ENSP00000352833 |
Chemistry databases
BindingDBi | Q9Y2R2 |
Miscellaneous databases
RNActi | Q9Y2R2, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9Y2R2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y2R2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 289 | Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST | 266 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 227 – 233 | Substrate binding | 7 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0789, Eukaryota |
GeneTreei | ENSGT00940000160958 |
InParanoidi | Q9Y2R2 |
PhylomeDBi | Q9Y2R2 |
TreeFami | TF351977 |
Family and domain databases
Gene3Di | 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR016276, PTPN22 IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00102, Y_phosphatase, 1 hit |
PIRSFi | PIRSF000930, PTPN8_PTPN22, 1 hit |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194, PTPc, 1 hit SM00404, PTPc_motif, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50055, TYR_PHOSPHATASE_PTP, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y2R2-1) [UniParc]FASTAAdd to basket
Also known as: LyP1
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDQREILQKF LDEAQSKKIT KEEFANEFLK LKRQSTKYKA DKTYPTTVAE
60 70 80 90 100
KPKNIKKNRY KDILPYDYSR VELSLITSDE DSSYINANFI KGVYGPKAYI
110 120 130 140 150
ATQGPLSTTL LDFWRMIWEY SVLIIVMACM EYEMGKKKCE RYWAEPGEMQ
160 170 180 190 200
LEFGPFSVSC EAEKRKSDYI IRTLKVKFNS ETRTIYQFHY KNWPDHDVPS
210 220 230 240 250
SIDPILELIW DVRCYQEDDS VPICIHCSAG CGRTGVICAI DYTWMLLKDG
260 270 280 290 300
IIPENFSVFS LIREMRTQRP SLVQTQEQYE LVYNAVLELF KRQMDVIRDK
310 320 330 340 350
HSGTESQAKH CIPEKNHTLQ ADSYSPNLPK STTKAAKMMN QQRTKMEIKE
360 370 380 390 400
SSSFDFRTSE ISAKEELVLH PAKSSTSFDF LELNYSFDKN ADTTMKWQTK
410 420 430 440 450
AFPIVGEPLQ KHQSLDLGSL LFEGCSNSKP VNAAGRYFNS KVPITRTKST
460 470 480 490 500
PFELIQQRET KEVDSKENFS YLESQPHDSC FVEMQAQKVM HVSSAELNYS
510 520 530 540 550
LPYDSKHQIR NASNVKHHDS SALGVYSYIP LVENPYFSSW PPSGTSSKMS
560 570 580 590 600
LDLPEKQDGT VFPSSLLPTS STSLFSYYNS HDSLSLNSPT NISSLLNQES
610 620 630 640 650
AVLATAPRID DEIPPPLPVR TPESFIVVEE AGEFSPNVPK SLSSAVKVKI
660 670 680 690 700
GTSLEWGGTS EPKKFDDSVI LRPSKSVKLR SPKSELHQDR SSPPPPLPER
710 720 730 740 750
TLESFFLADE DCMQAQSIET YSTSYPDTME NSTSSKQTLK TPGKSFTRSK
760 770 780 790 800
SLKILRNMKK SICNSCPPNK PAESVQSNNS SSFLNFGFAN RFSKPKGPRN
PPPTWNI
Isoform 6 (identifier: Q9Y2R2-6) [UniParc]FASTAAdd to basket
Also known as: PTPN22.6
The sequence of this isoform differs from the canonical sequence as follows:
124-250: Missing.
788-807: FANRFSKPKGPRNPPPTWNI → MCVILLKS
Note: Lacks most of the phosphatase domain and functions as a dominant negative isoform of the full length PTPN22.Curated
Show »Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4J1S7 | A0A0B4J1S7_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN22 | 807 | Annotation score: | ||
E9PMT0 | E9PMT0_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN22 | 795 | Annotation score: | ||
F5H2S8 | F5H2S8_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN22 | 783 | Annotation score: | ||
A0A0A0MTE6 | A0A0A0MTE6_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN22 | 752 | Annotation score: | ||
A0A0A0MTD9 | A0A0A0MTD9_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN22 | 668 | Annotation score: | ||
E9PM87 | E9PM87_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN22 | 135 | Annotation score: | ||
E9PMK2 | E9PMK2_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN22 | 92 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 51 – 52 | KP → NA in AAD00904 (PubMed:10068674).Curated | 2 | |
Sequence conflicti | 51 – 52 | KP → NA in AAD00905 (PubMed:10068674).Curated | 2 | |
Sequence conflicti | 126 | V → G in AAD27764 (PubMed:21044313).Curated | 1 | |
Sequence conflicti | 147 | G → V in AAD27764 (PubMed:21044313).Curated | 1 | |
Sequence conflicti | 240 | I → IV in AAD00905 (PubMed:10068674).Curated | 1 | |
Sequence conflicti | 372 | A → V in AK310570 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 420 | L → P in AAD27764 (PubMed:21044313).Curated | 1 | |
Sequence conflicti | 742 | P → S in AAD27764 (PubMed:21044313).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072629 | 201 | S → F Moderately reduces phosphatase activity. 1 PublicationCorresponds to variant dbSNP:rs7416347Ensembl. | 1 | |
Natural variantiVAR_072630 | 263 | R → Q Reduces risk of SLE and RA but not IDDM; associated with reduced risk of ulcerative colitis but not of Crohn disease; severely reduces phosphatase activity. 3 PublicationsCorresponds to variant dbSNP:rs33996649Ensembl. | 1 | |
Natural variantiVAR_072631 | 266 | R → W Severely reduces phosphatase activity. 1 PublicationCorresponds to variant dbSNP:rs72650670Ensembl. | 1 | |
Natural variantiVAR_022605 | 620 | R → W in IDDM, RA, SLE and VTLG; also found in patients with Graves disease, Hashimoto thyroiditis and Addison disease; associated with reduced risk of Crohn disease but not of ulcerative colitis; affects CSK kinase binding; alters B cell receptor signaling and memory B cell proliferation. 12 PublicationsCorresponds to variant dbSNP:rs2476601EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044428 | 124 – 250 | Missing in isoform 6. 1 PublicationAdd BLAST | 127 | |
Alternative sequenceiVSP_039725 | 137 – 160 | Missing in isoform 5. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_039726 | 181 – 203 | ETRTI…PSSID → VSVILAHQTSLQNLFSQITP AHF in isoform 5. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_039727 | 204 – 807 | Missing in isoform 5. 1 PublicationAdd BLAST | 604 | |
Alternative sequenceiVSP_039728 | 251 – 305 | Missing in isoform 3. 1 PublicationAdd BLAST | 55 | |
Alternative sequenceiVSP_039729 | 647 – 674 | Missing in isoform 4. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_005134 | 685 – 807 | ELHQD…PTWNI → GKNFSWL in isoform 2. 1 PublicationAdd BLAST | 123 | |
Alternative sequenceiVSP_044429 | 788 – 807 | FANRF…PTWNI → MCVILLKS in isoform 6. 1 PublicationAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF001846 mRNA Translation: AAD00904.1 AF001847 mRNA Translation: AAD00905.1 GU479452 mRNA Translation: ADD59979.1 AF077031 mRNA Translation: AAD27764.1 AK310570 mRNA No translation available. EF064714 Genomic DNA Translation: ABK41897.1 AL137856 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56575.1 CH471122 Genomic DNA Translation: EAW56576.1 BC017785 mRNA Translation: AAH17785.1 BC071670 mRNA Translation: AAH71670.1 |
CCDSi | CCDS863.1 [Q9Y2R2-1] CCDS864.2 [Q9Y2R2-3] |
RefSeqi | NP_001180360.1, NM_001193431.2 [Q9Y2R2-4] NP_001295226.1, NM_001308297.1 NP_036543.4, NM_012411.5 [Q9Y2R2-3] NP_057051.3, NM_015967.6 [Q9Y2R2-1] |
Genome annotation databases
Ensembli | ENST00000460620; ENSP00000433141; ENSG00000134242 [Q9Y2R2-5] |
GeneIDi | 26191 |
KEGGi | hsa:26191 |
UCSCi | uc001edt.4, human [Q9Y2R2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF001846 mRNA Translation: AAD00904.1 AF001847 mRNA Translation: AAD00905.1 GU479452 mRNA Translation: ADD59979.1 AF077031 mRNA Translation: AAD27764.1 AK310570 mRNA No translation available. EF064714 Genomic DNA Translation: ABK41897.1 AL137856 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56575.1 CH471122 Genomic DNA Translation: EAW56576.1 BC017785 mRNA Translation: AAH17785.1 BC071670 mRNA Translation: AAH71670.1 |
CCDSi | CCDS863.1 [Q9Y2R2-1] CCDS864.2 [Q9Y2R2-3] |
RefSeqi | NP_001180360.1, NM_001193431.2 [Q9Y2R2-4] NP_001295226.1, NM_001308297.1 NP_036543.4, NM_012411.5 [Q9Y2R2-3] NP_057051.3, NM_015967.6 [Q9Y2R2-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2P6X | X-ray | 1.90 | A/B | 1-302 | [»] | |
2QCJ | X-ray | 3.00 | A/B | 1-294 | [»] | |
2QCT | X-ray | 2.80 | A/B | 1-294 | [»] | |
3BRH | X-ray | 2.20 | A/B | 1-310 | [»] | |
3H2X | X-ray | 2.20 | A | 1-302 | [»] | |
3OLR | X-ray | 2.50 | A/B/C/D | 1-294 | [»] | |
3OMH | X-ray | 2.90 | A/B/C/D | 1-294 | [»] | |
4J51 | X-ray | 2.30 | A/B | 1-303 | [»] | |
SMRi | Q9Y2R2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117604, 47 interactors |
DIPi | DIP-29953N |
IntActi | Q9Y2R2, 24 interactors |
MINTi | Q9Y2R2 |
STRINGi | 9606.ENSP00000352833 |
Chemistry databases
BindingDBi | Q9Y2R2 |
ChEMBLi | CHEMBL2889 |
GuidetoPHARMACOLOGYi | 3084 |
PTM databases
DEPODi | PTPN22 |
iPTMneti | Q9Y2R2 |
PhosphoSitePlusi | Q9Y2R2 |
Genetic variation databases
BioMutai | PTPN22 |
DMDMi | 20139861 |
Proteomic databases
jPOSTi | Q9Y2R2 |
MassIVEi | Q9Y2R2 |
PaxDbi | Q9Y2R2 |
PeptideAtlasi | Q9Y2R2 |
PRIDEi | Q9Y2R2 |
ProteomicsDBi | 21761 22726 85874 [Q9Y2R2-1] 85875 [Q9Y2R2-2] 85876 [Q9Y2R2-3] 85877 [Q9Y2R2-4] 85878 [Q9Y2R2-5] |
Protocols and materials databases
Antibodypediai | 33846, 300 antibodies |
DNASUi | 26191 |
Genome annotation databases
Ensembli | ENST00000460620; ENSP00000433141; ENSG00000134242 [Q9Y2R2-5] |
GeneIDi | 26191 |
KEGGi | hsa:26191 |
UCSCi | uc001edt.4, human [Q9Y2R2-1] |
Organism-specific databases
CTDi | 26191 |
DisGeNETi | 26191 |
GeneCardsi | PTPN22 |
HGNCi | HGNC:9652, PTPN22 |
HPAi | ENSG00000134242, Tissue enhanced (bone marrow, lymphoid tissue) |
MalaCardsi | PTPN22 |
MIMi | 152700, phenotype 180300, phenotype 193200, phenotype 222100, phenotype 600716, gene |
neXtProti | NX_Q9Y2R2 |
OpenTargetsi | ENSG00000134242 |
Orphaneti | 397, Giant cell arteritis 900, Granulomatosis with polyangiitis 85410, Oligoarticular juvenile idiopathic arthritis 85408, Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis 536, Systemic lupus erythematosus 3437, Vogt-Koyanagi-Harada disease |
PharmGKBi | PA33995 |
VEuPathDBi | HostDB:ENSG00000134242.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0789, Eukaryota |
GeneTreei | ENSGT00940000160958 |
InParanoidi | Q9Y2R2 |
PhylomeDBi | Q9Y2R2 |
TreeFami | TF351977 |
Enzyme and pathway databases
BRENDAi | 3.1.3.48, 2681 |
PathwayCommonsi | Q9Y2R2 |
Reactomei | R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains R-HSA-202430, Translocation of ZAP-70 to Immunological synapse |
SignaLinki | Q9Y2R2 |
SIGNORi | Q9Y2R2 |
Miscellaneous databases
BioGRID-ORCSi | 26191, 9 hits in 999 CRISPR screens |
ChiTaRSi | PTPN22, human |
EvolutionaryTracei | Q9Y2R2 |
GeneWikii | PTPN22 |
GenomeRNAii | 26191 |
Pharosi | Q9Y2R2, Tchem |
PROi | PR:Q9Y2R2 |
RNActi | Q9Y2R2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134242, Expressed in bone marrow and 154 other tissues |
ExpressionAtlasi | Q9Y2R2, baseline and differential |
Genevisiblei | Q9Y2R2, HS |
Family and domain databases
Gene3Di | 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR016276, PTPN22 IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00102, Y_phosphatase, 1 hit |
PIRSFi | PIRSF000930, PTPN8_PTPN22, 1 hit |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194, PTPc, 1 hit SM00404, PTPc_motif, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50055, TYR_PHOSPHATASE_PTP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTN22_HUMAN | |
Accessioni | Q9Y2R2Primary (citable) accession number: Q9Y2R2 Secondary accession number(s): A0N0K6 Q8WVM1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | March 27, 2002 | |
Last modified: | April 7, 2021 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families