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Protein

28S ribosomal protein S28, mitochondrial

Gene

MRPS28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S28, mitochondrial
Short name:
MRP-S28
Short name:
S28mt
Alternative name(s):
28S ribosomal protein S35, mitochondrial
Short name:
MRP-S35
Short name:
S35mt
Mitochondrial small ribosomal subunit protein bS1m1 Publication
Gene namesi
Name:MRPS28
Synonyms:MRPS35
ORF Names:HSPC007
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147586.9
HGNCiHGNC:14513 MRPS28
MIMi611990 gene
neXtProtiNX_Q9Y2Q9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi28957
PharmGKBiPA31016

Polymorphism and mutation databases

BioMutaiMRPS28
DMDMi22001973

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 71MitochondrionBy similarityAdd BLAST71
ChainiPRO_000008771472 – 18728S ribosomal protein S28, mitochondrialAdd BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73PhosphoserineBy similarity1
Modified residuei133N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2Q9
MaxQBiQ9Y2Q9
PaxDbiQ9Y2Q9
PeptideAtlasiQ9Y2Q9
PRIDEiQ9Y2Q9
ProteomicsDBi85872
TopDownProteomicsiQ9Y2Q9

PTM databases

iPTMnetiQ9Y2Q9
PhosphoSitePlusiQ9Y2Q9

Expressioni

Gene expression databases

BgeeiENSG00000147586 Expressed in 92 organ(s), highest expression level in adrenal tissue
CleanExiHS_MRPS28
HS_MRPS35
ExpressionAtlasiQ9Y2Q9 baseline and differential
GenevisibleiQ9Y2Q9 HS

Organism-specific databases

HPAiHPA027202

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi118784, 65 interactors
CORUMiQ9Y2Q9
IntActiQ9Y2Q9, 18 interactors
MINTiQ9Y2Q9
STRINGi9606.ENSP00000276585

Structurei

3D structure databases

ProteinModelPortaliQ9Y2Q9
SMRiQ9Y2Q9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4078 Eukaryota
ENOG4111RYH LUCA
GeneTreeiENSGT00390000001057
HOGENOMiHOG000230806
HOVERGENiHBG036126
InParanoidiQ9Y2Q9
KOiK17407
OMAiCRTRAVT
OrthoDBiEOG091G0VHY
PhylomeDBiQ9Y2Q9
TreeFamiTF315097

Family and domain databases

InterProiView protein in InterPro
IPR019375 Ribosomal_S28_mit
PANTHERiPTHR13447 PTHR13447, 1 hit
PfamiView protein in Pfam
PF10246 MRP-S35, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9Y2Q9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALCRTRAV AAESHFLRVF LFFRPFRGVG TESGSESGSS NAKEPKTRAG
60 70 80 90 100
GFASALERHS ELLQKVEPLQ KGSPKNVESF ASMLRHSPLT QMGPAKDKLV
110 120 130 140 150
IGRIFHIVEN DLYIDFGGKF HCVCRRPEVD GEKYQKGTRV RLRLLDLELT
160 170 180
SRFLGATTDT TVLEANAVLL GIQESKDSRS KEEHHEK
Length:187
Mass (Da):20,843
Last modified:November 1, 1999 - v1
Checksum:i2ED0EA43552B9B54
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAT2H0YAT2_HUMAN
28S ribosomal protein S28, mitochon...
MRPS28
143Annotation score:
E5RK86E5RK86_HUMAN
28S ribosomal protein S28, mitochon...
MRPS28
108Annotation score:
E5RFH3E5RFH3_HUMAN
28S ribosomal protein S28, mitochon...
MRPS28
125Annotation score:
E5RGC7E5RGC7_HUMAN
28S ribosomal protein S28, mitochon...
MRPS28
103Annotation score:
U3KQQ8U3KQQ8_HUMAN
28S ribosomal protein S28, mitochon...
MRPS28
83Annotation score:
H7C5V3H7C5V3_HUMAN
28S ribosomal protein S28, mitochon...
MRPS28
162Annotation score:
E5RFT8E5RFT8_HUMAN
28S ribosomal protein S28, mitochon...
MRPS28
86Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052047103R → W. Corresponds to variant dbSNP:rs16919579Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070663 mRNA Translation: AAD20969.1
AK315739 mRNA Translation: BAG38094.1
CH471068 Genomic DNA Translation: EAW87069.1
BC010150 mRNA Translation: AAH10150.1
AB061209 Genomic DNA Translation: BAB54959.1
CCDSiCCDS6226.1
RefSeqiNP_054737.1, NM_014018.2
UniGeneiHs.521124

Genome annotation databases

EnsembliENST00000276585; ENSP00000276585; ENSG00000147586
GeneIDi28957
KEGGihsa:28957
UCSCiuc003ybp.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070663 mRNA Translation: AAD20969.1
AK315739 mRNA Translation: BAG38094.1
CH471068 Genomic DNA Translation: EAW87069.1
BC010150 mRNA Translation: AAH10150.1
AB061209 Genomic DNA Translation: BAB54959.1
CCDSiCCDS6226.1
RefSeqiNP_054737.1, NM_014018.2
UniGeneiHs.521124

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AW1-187[»]
ProteinModelPortaliQ9Y2Q9
SMRiQ9Y2Q9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118784, 65 interactors
CORUMiQ9Y2Q9
IntActiQ9Y2Q9, 18 interactors
MINTiQ9Y2Q9
STRINGi9606.ENSP00000276585

PTM databases

iPTMnetiQ9Y2Q9
PhosphoSitePlusiQ9Y2Q9

Polymorphism and mutation databases

BioMutaiMRPS28
DMDMi22001973

Proteomic databases

EPDiQ9Y2Q9
MaxQBiQ9Y2Q9
PaxDbiQ9Y2Q9
PeptideAtlasiQ9Y2Q9
PRIDEiQ9Y2Q9
ProteomicsDBi85872
TopDownProteomicsiQ9Y2Q9

Protocols and materials databases

DNASUi28957
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276585; ENSP00000276585; ENSG00000147586
GeneIDi28957
KEGGihsa:28957
UCSCiuc003ybp.4 human

Organism-specific databases

CTDi28957
DisGeNETi28957
EuPathDBiHostDB:ENSG00000147586.9
GeneCardsiMRPS28
HGNCiHGNC:14513 MRPS28
HPAiHPA027202
MIMi611990 gene
neXtProtiNX_Q9Y2Q9
PharmGKBiPA31016
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4078 Eukaryota
ENOG4111RYH LUCA
GeneTreeiENSGT00390000001057
HOGENOMiHOG000230806
HOVERGENiHBG036126
InParanoidiQ9Y2Q9
KOiK17407
OMAiCRTRAVT
OrthoDBiEOG091G0VHY
PhylomeDBiQ9Y2Q9
TreeFamiTF315097

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPS28 human
GeneWikiiMRPS28
GenomeRNAii28957
PROiPR:Q9Y2Q9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147586 Expressed in 92 organ(s), highest expression level in adrenal tissue
CleanExiHS_MRPS28
HS_MRPS35
ExpressionAtlasiQ9Y2Q9 baseline and differential
GenevisibleiQ9Y2Q9 HS

Family and domain databases

InterProiView protein in InterPro
IPR019375 Ribosomal_S28_mit
PANTHERiPTHR13447 PTHR13447, 1 hit
PfamiView protein in Pfam
PF10246 MRP-S35, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRT28_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2Q9
Secondary accession number(s): B2RDZ7, Q96Q21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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