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Protein

Ragulator complex protein LAMTOR2

Gene

LAMTOR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.2 Publications

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: GO_Central
  • protein-containing complex scaffold activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
R-HSA-165159 mTOR signalling
R-HSA-166208 mTORC1-mediated signalling
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-6798695 Neutrophil degranulation
R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORiQ9Y2Q5

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR2
Alternative name(s):
Endosomal adaptor protein p14
Late endosomal/lysosomal Mp1-interacting protein
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2
Mitogen-activated protein-binding protein-interacting protein
Short name:
MAPBP-interacting protein
Roadblock domain-containing protein 3
Gene namesi
Name:LAMTOR2
Synonyms:MAPBPIP, ROBLD3
ORF Names:HSPC003
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116586.11
HGNCiHGNC:29796 LAMTOR2
MIMi610389 gene
neXtProtiNX_Q9Y2Q5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency due to defect in MAPBP-interacting protein (ID-MAPBPIP)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionThis form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency.
See also OMIM:610798

Organism-specific databases

DisGeNETi28956
MalaCardsiLAMTOR2
MIMi610798 phenotype
OpenTargetsiENSG00000116586
Orphaneti90023 Primary immunodeficiency syndrome due to p14 deficiency
PharmGKBiPA164725527

Polymorphism and mutation databases

BioMutaiLAMTOR2
DMDMi12585246

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002209601 – 125Ragulator complex protein LAMTOR2Add BLAST125

Proteomic databases

EPDiQ9Y2Q5
PaxDbiQ9Y2Q5
PeptideAtlasiQ9Y2Q5
PRIDEiQ9Y2Q5
ProteomicsDBi85869
85870 [Q9Y2Q5-2]
85871 [Q9Y2Q5-3]
TopDownProteomicsiQ9Y2Q5-1 [Q9Y2Q5-1]
Q9Y2Q5-2 [Q9Y2Q5-2]
Q9Y2Q5-3 [Q9Y2Q5-3]

2D gel databases

OGPiQ9Y2Q5

PTM databases

iPTMnetiQ9Y2Q5
PhosphoSitePlusiQ9Y2Q5

Expressioni

Gene expression databases

BgeeiENSG00000116586 Expressed in 210 organ(s), highest expression level in body of stomach
GenevisibleiQ9Y2Q5 HS

Organism-specific databases

HPAiHPA004126

Interactioni

Subunit structurei

Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer (PubMed:20381137, PubMed:22980980). The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability (PubMed:20381137, PubMed:22980980). The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts with LAMTOR1 and LAMTOR3; the interaction is direct. Interacts with MAPK1 and MAP2K1 (By similarity).By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118783, 24 interactors
CORUMiQ9Y2Q5
DIPiDIP-57000N
IntActiQ9Y2Q5, 18 interactors
MINTiQ9Y2Q5
STRINGi9606.ENSP00000357288

Structurei

Secondary structure

1125
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y2Q5
SMRiQ9Y2Q5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 70Required for location at endosomesBy similarityAdd BLAST14

Sequence similaritiesi

Belongs to the GAMAD family.Curated

Phylogenomic databases

eggNOGiKOG4107 Eukaryota
ENOG4111GWH LUCA
GeneTreeiENSGT00390000006100
HOGENOMiHOG000007645
HOVERGENiHBG004518
InParanoidiQ9Y2Q5
KOiK20398
OMAiCECGHVA
OrthoDBiEOG091G0W0V
PhylomeDBiQ9Y2Q5
TreeFamiTF313929

Family and domain databases

InterProiView protein in InterPro
IPR037587 LAMTOR2-like
IPR004942 Roadblock/LAMTOR2_dom
PANTHERiPTHR13323 PTHR13323, 1 hit
PfamiView protein in Pfam
PF03259 Robl_LC7, 1 hit
SMARTiView protein in SMART
SM00960 Robl_LC7, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y2Q5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRPKALTQV LSQANTGGVQ STLLLNNEGS LLAYSGYGDT DARVTAAIAS
60 70 80 90 100
NIWAAYDRNG NQAFNEDNLK FILMDCMEGR VAITRVANLL LCMYAKETVG
110 120
FGMLKAKAQA LVQYLEEPLT QVAAS
Length:125
Mass (Da):13,508
Last modified:November 1, 1999 - v1
Checksum:i69599211C2CBC03D
GO
Isoform 2 (identifier: Q9Y2Q5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-125: QALVQYLEEPLTQVAAS → VCGTDLCSPSAGPGFGAVPGGAPHPSGGILTALVEAGVRKEK

Note: No experimental confirmation available.
Show »
Length:150
Mass (Da):15,609
Checksum:iD45D4B887C721086
GO
Isoform 3 (identifier: Q9Y2Q5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-107: Missing.

Show »
Length:95
Mass (Da):10,242
Checksum:i13ADB9F75E3E9E8C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04098078 – 107Missing in isoform 3. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_036543109 – 125QALVQ…QVAAS → VCGTDLCSPSAGPGFGAVPG GAPHPSGGILTALVEAGVRK EK in isoform 2. CuratedAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070659 mRNA Translation: AAD20965.1
AK307086 mRNA No translation available.
AL355388 Genomic DNA No translation available.
BC024190 mRNA Translation: AAH24190.1
CCDSiCCDS1128.1 [Q9Y2Q5-1]
CCDS44243.1 [Q9Y2Q5-3]
RefSeqiNP_001138736.1, NM_001145264.1 [Q9Y2Q5-3]
NP_054736.1, NM_014017.3 [Q9Y2Q5-1]
UniGeneiHs.632483

Genome annotation databases

EnsembliENST00000368302; ENSP00000357285; ENSG00000116586 [Q9Y2Q5-2]
ENST00000368304; ENSP00000357287; ENSG00000116586 [Q9Y2Q5-3]
ENST00000368305; ENSP00000357288; ENSG00000116586 [Q9Y2Q5-1]
GeneIDi28956
KEGGihsa:28956
UCSCiuc001fnb.4 human [Q9Y2Q5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

MAPBPIPbase

ROBLD3 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070659 mRNA Translation: AAD20965.1
AK307086 mRNA No translation available.
AL355388 Genomic DNA No translation available.
BC024190 mRNA Translation: AAH24190.1
CCDSiCCDS1128.1 [Q9Y2Q5-1]
CCDS44243.1 [Q9Y2Q5-3]
RefSeqiNP_001138736.1, NM_001145264.1 [Q9Y2Q5-3]
NP_054736.1, NM_014017.3 [Q9Y2Q5-1]
UniGeneiHs.632483

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5X6UX-ray2.40B1-125[»]
5X6VX-ray2.02B1-125[»]
5Y39X-ray2.65B/G1-125[»]
5Y3AX-ray2.90B/G1-125[»]
6B9XX-ray1.42B1-125[»]
6EHPX-ray2.30B2-125[»]
6EHRX-ray2.90B2-125[»]
ProteinModelPortaliQ9Y2Q5
SMRiQ9Y2Q5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118783, 24 interactors
CORUMiQ9Y2Q5
DIPiDIP-57000N
IntActiQ9Y2Q5, 18 interactors
MINTiQ9Y2Q5
STRINGi9606.ENSP00000357288

PTM databases

iPTMnetiQ9Y2Q5
PhosphoSitePlusiQ9Y2Q5

Polymorphism and mutation databases

BioMutaiLAMTOR2
DMDMi12585246

2D gel databases

OGPiQ9Y2Q5

Proteomic databases

EPDiQ9Y2Q5
PaxDbiQ9Y2Q5
PeptideAtlasiQ9Y2Q5
PRIDEiQ9Y2Q5
ProteomicsDBi85869
85870 [Q9Y2Q5-2]
85871 [Q9Y2Q5-3]
TopDownProteomicsiQ9Y2Q5-1 [Q9Y2Q5-1]
Q9Y2Q5-2 [Q9Y2Q5-2]
Q9Y2Q5-3 [Q9Y2Q5-3]

Protocols and materials databases

DNASUi28956
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368302; ENSP00000357285; ENSG00000116586 [Q9Y2Q5-2]
ENST00000368304; ENSP00000357287; ENSG00000116586 [Q9Y2Q5-3]
ENST00000368305; ENSP00000357288; ENSG00000116586 [Q9Y2Q5-1]
GeneIDi28956
KEGGihsa:28956
UCSCiuc001fnb.4 human [Q9Y2Q5-1]

Organism-specific databases

CTDi28956
DisGeNETi28956
EuPathDBiHostDB:ENSG00000116586.11
GeneCardsiLAMTOR2
HGNCiHGNC:29796 LAMTOR2
HPAiHPA004126
MalaCardsiLAMTOR2
MIMi610389 gene
610798 phenotype
neXtProtiNX_Q9Y2Q5
OpenTargetsiENSG00000116586
Orphaneti90023 Primary immunodeficiency syndrome due to p14 deficiency
PharmGKBiPA164725527
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4107 Eukaryota
ENOG4111GWH LUCA
GeneTreeiENSGT00390000006100
HOGENOMiHOG000007645
HOVERGENiHBG004518
InParanoidiQ9Y2Q5
KOiK20398
OMAiCECGHVA
OrthoDBiEOG091G0W0V
PhylomeDBiQ9Y2Q5
TreeFamiTF313929

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
R-HSA-165159 mTOR signalling
R-HSA-166208 mTORC1-mediated signalling
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-6798695 Neutrophil degranulation
R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORiQ9Y2Q5

Miscellaneous databases

ChiTaRSiLAMTOR2 human
GenomeRNAii28956
PROiPR:Q9Y2Q5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116586 Expressed in 210 organ(s), highest expression level in body of stomach
GenevisibleiQ9Y2Q5 HS

Family and domain databases

InterProiView protein in InterPro
IPR037587 LAMTOR2-like
IPR004942 Roadblock/LAMTOR2_dom
PANTHERiPTHR13323 PTHR13323, 1 hit
PfamiView protein in Pfam
PF03259 Robl_LC7, 1 hit
SMARTiView protein in SMART
SM00960 Robl_LC7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLTOR2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2Q5
Secondary accession number(s): Q5VY97, Q5VY98, Q5VY99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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