LAMTOR2

Functionⁱ

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.2 Publications

GO - Molecular functionⁱ

guanyl-nucleotide exchange factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein-containing complex scaffold activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPKK activity Source: Ensembl
cell cycle arrest Source: Reactome
cellular protein localization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20381137
cellular response to amino acid stimulus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20381137
MAPK cascade Source: Reactome
neutrophil degranulation Source: Reactome
positive regulation of TOR signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20381137
regulation of cell growth
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20381137
regulation of macroautophagy Source: Reactome

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1632852 Macroautophagy R-HSA-165159 mTOR signalling R-HSA-166208 mTORC1-mediated signalling R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-5674135 MAP2K and MAPK activation R-HSA-6798695 Neutrophil degranulation R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORⁱ	Q9Y2Q5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ragulator complex protein LAMTOR2 Alternative name(s): Endosomal adaptor protein p14 Late endosomal/lysosomal Mp1-interacting protein Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2 Mitogen-activated protein-binding protein-interacting protein Short name: MAPBP-interacting protein Roadblock domain-containing protein 3
Gene namesⁱ	Name:LAMTOR2 Synonyms:MAPBPIP, ROBLD3 ORF Names:HSPC003
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000116586.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29796 LAMTOR2
MIMⁱ	610389 gene
neXtProtⁱ	NX_Q9Y2Q5

Keywords - Cellular componentⁱ

Endosome, Lysosome, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Immunodeficiency due to defect in MAPBP-interacting protein (ID-MAPBPIP)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionThis form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	28956
MalaCards human disease database More...MalaCardsⁱ	LAMTOR2
MIMⁱ	610798 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000116586
Orphanetⁱ	90023 Primary immunodeficiency syndrome due to p14 deficiency
PharmGKBⁱ	PA164725527

Polymorphism and mutation databases

BioMutaⁱ	LAMTOR2
DMDMⁱ	12585246

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000220960	1 – 125	Ragulator complex protein LAMTOR2Add BLAST		125

Proteomic databases

EPDⁱ	Q9Y2Q5
PaxDbⁱ	Q9Y2Q5
PeptideAtlas More...PeptideAtlasⁱ	Q9Y2Q5
PRIDEⁱ	Q9Y2Q5
ProteomicsDBⁱ	85869 85870 [Q9Y2Q5-2] 85871 [Q9Y2Q5-3]
TopDownProteomicsⁱ	Q9Y2Q5-1 [Q9Y2Q5-1] Q9Y2Q5-2 [Q9Y2Q5-2] Q9Y2Q5-3 [Q9Y2Q5-3]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	Q9Y2Q5

OGPⁱ

Q9Y2Q5

PTM databases

iPTMnetⁱ	Q9Y2Q5
PhosphoSitePlusⁱ	Q9Y2Q5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000116586 Expressed in 210 organ(s), highest expression level in body of stomach
Genevisibleⁱ	Q9Y2Q5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA004126

HPAⁱ

HPA004126

Interactionⁱ

Subunit structureⁱ

Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer (PubMed:20381137, PubMed:22980980). The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability (PubMed:20381137, PubMed:22980980). The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts with LAMTOR1 and LAMTOR3; the interaction is direct. Interacts with MAPK1 and MAP2K1 (By similarity).By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LAMTOR3	Q9UHA4	17	EBI-2643704,EBI-1038192
SLC38A9	Q8NBW4	3	EBI-2643704,EBI-9978316

GO - Molecular functionⁱ

guanyl-nucleotide exchange factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein-containing complex scaffold activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	118783, 24 interactors
CORUMⁱ	Q9Y2Q5
Database of interacting proteins More...DIPⁱ	DIP-57000N
IntActⁱ	Q9Y2Q5, 18 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y2Q5
STRINGⁱ	9606.ENSP00000357288

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 12	Combined sources	9
Beta strandⁱ	19 – 25	Combined sources	7
Beta strandⁱ	31 – 36	Combined sources	6
Beta strandⁱ	38 – 40	Combined sources	3
Helixⁱ	42 – 60	Combined sources	19
Turnⁱ	64 – 66	Combined sources	3
Beta strandⁱ	71 – 76	Combined sources	6
Beta strandⁱ	79 – 86	Combined sources	8
Beta strandⁱ	89 – 95	Combined sources	7
Helixⁱ	101 – 122	Combined sources	22

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9Y2Q5
SMRⁱ	Q9Y2Q5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	57 – 70	Required for location at endosomesBy similarityAdd BLAST		14

Sequence similaritiesⁱ

Belongs to the GAMAD family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4107 Eukaryota ENOG4111GWH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006100
HOGENOMⁱ	HOG000007645
HOVERGENⁱ	HBG004518
InParanoidⁱ	Q9Y2Q5
KEGG Orthology (KO) More...KOⁱ	K20398
OMAⁱ	CECGHVA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0W0V
PhylomeDBⁱ	Q9Y2Q5
TreeFamⁱ	TF313929

Family and domain databases

InterProⁱ	View protein in InterPro IPR037587 LAMTOR2-like IPR004942 Roadblock/LAMTOR2_dom
PANTHERⁱ	PTHR13323 PTHR13323, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03259 Robl_LC7, 1 hit
SMARTⁱ	View protein in SMART SM00960 Robl_LC7, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9Y2Q5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRPKALTQV LSQANTGGVQ STLLLNNEGS LLAYSGYGDT DARVTAAIAS 
        60         70         80         90        100
NIWAAYDRNG NQAFNEDNLK FILMDCMEGR VAITRVANLL LCMYAKETVG 
       110        120 
FGMLKAKAQA LVQYLEEPLT QVAAS

Length:125

Mass (Da):13,508

Last modified:November 1, 1999 - v1

Checksum:ⁱ69599211C2CBC03D

GO

Isoform 2 (identifier: Q9Y2Q5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
109-125: QALVQYLEEPLTQVAAS → VCGTDLCSPSAGPGFGAVPGGAPHPSGGILTALVEAGVRKEK

« Hide

        10         20         30         40         50
MLRPKALTQV LSQANTGGVQ STLLLNNEGS LLAYSGYGDT DARVTAAIAS 
        60         70         80         90        100
NIWAAYDRNG NQAFNEDNLK FILMDCMEGR VAITRVANLL LCMYAKETVG 
       110        120        130        140        150
FGMLKAKAVC GTDLCSPSAG PGFGAVPGGA PHPSGGILTA LVEAGVRKEK

Note: No experimental confirmation available.

Show »

Length:150

Mass (Da):15,609

Checksum:ⁱD45D4B887C721086

GO

Isoform 3 (identifier: Q9Y2Q5-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
78-107: Missing.

« Hide

        10         20         30         40         50
MLRPKALTQV LSQANTGGVQ STLLLNNEGS LLAYSGYGDT DARVTAAIAS 
        60         70         80         90 
NIWAAYDRNG NQAFNEDNLK FILMDCMAQA LVQYLEEPLT QVAAS

Show »

Length:95

Mass (Da):10,242

Checksum:ⁱ13ADB9F75E3E9E8C

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_040980	78 – 107	Missing in isoform 3. 1 PublicationAdd BLAST		30
Alternative sequenceⁱVSP_036543	109 – 125	QALVQ…QVAAS → VCGTDLCSPSAGPGFGAVPG GAPHPSGGILTALVEAGVRK EK in isoform 2. CuratedAdd BLAST		17

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF070659 mRNA Translation: AAD20965.1 AK307086 mRNA No translation available. AL355388 Genomic DNA No translation available. BC024190 mRNA Translation: AAH24190.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1128.1 [Q9Y2Q5-1] CCDS44243.1 [Q9Y2Q5-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001138736.1, NM_001145264.1 [Q9Y2Q5-3] NP_054736.1, NM_014017.3 [Q9Y2Q5-1]
UniGeneⁱ	Hs.632483

Genome annotation databases

Ensemblⁱ	ENST00000368302; ENSP00000357285; ENSG00000116586 [Q9Y2Q5-2] ENST00000368304; ENSP00000357287; ENSG00000116586 [Q9Y2Q5-3] ENST00000368305; ENSP00000357288; ENSG00000116586 [Q9Y2Q5-1]
GeneIDⁱ	28956
KEGGⁱ	hsa:28956
UCSC genome browser More...UCSCⁱ	uc001fnb.4 human [Q9Y2Q5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2Q5	Ragulator complex protein LAMTOR2		BOVIN		125	UniRef100_Q9Y2Q5
LAMTOR2 isoform 1		PANTR		125
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2		CALJA		125
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2		MACMU		125
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2		MACFA		125
+41
Q9Y2Q5-2	LAMTOR2 isoform 4		PANTR		150	UniRef100_A0A2J8K571
Q9Y2Q5-3	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2		CALJA		95	UniRef100_F7IE24
LAMTOR2 isoform 2		PANTR		95
Uncharacterized protein		PROCO		95
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2		SAIBB		95
Uncharacterized protein		MACMU		95
+16

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2Q5	Ragulator complex protein LAMTOR2		BOVIN		125	UniRef90_Q9Y2Q5
Ragulator complex protein LAMTOR2	)	MOUSE		125
Ragulator complex protein LAMTOR2		DANRE		125
Ragulator complex protein LAMTOR2		SALSA		125
Ragulator complex protein LAMTOR2		XENTR		125
+128
Q9Y2Q5-2	Uncharacterized protein		RABIT		147	UniRef90_G1TU32
Uncharacterized protein		COLAP		179
Uncharacterized protein		PAPAN		151
Uncharacterized protein		MANLE		177
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2		AILME		150
+6
Q9Y2Q5-3	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2		CALJA		95	UniRef90_F7IE24
LAMTOR2 isoform 2		PANTR		95
Uncharacterized protein		PROCO		95
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2		SAIBB		95
Uncharacterized protein		MACMU		95
+26

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2Q5	Ragulator complex protein LAMTOR2		BOVIN		125	UniRef50_Q9Y2Q5
Ragulator complex protein LAMTOR2		DANRE		125
Ragulator complex protein LAMTOR2-B		XENLA		125
Ragulator complex protein LAMTOR2		SALSA		125
Ragulator complex protein LAMTOR2		XENTR		125
+216
Q9Y2Q5-2	Ragulator complex protein LAMTOR2		TAEGU		125	UniRef50_B5FYY5
Ragulator complex protein LAMTOR2		ALLMI		173
Mitogen-activated protein-binding protein-interacting protein (Fragment)		ANAPL		108
ragulator complex protein LAMTOR2		ALLSI		134
Mitogen-activated protein-binding protein-interacting protein		Hypsiglena sp. JMG-2014		125
+53
Q9Y2Q5-3	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2		CALJA		95	UniRef50_F7IE24
LAMTOR2 isoform 2		PANTR		95
Uncharacterized protein		PROCO		95
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2		SAIBB		95
Uncharacterized protein		MACMU		95
+28

Cross-referencesⁱ

Web resourcesⁱ

MAPBPIPbase

ROBLD3 mutation db

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF070659 mRNA Translation: AAD20965.1 AK307086 mRNA No translation available. AL355388 Genomic DNA No translation available. BC024190 mRNA Translation: AAH24190.1
CCDSⁱ	CCDS1128.1 [Q9Y2Q5-1] CCDS44243.1 [Q9Y2Q5-3]
RefSeqⁱ	NP_001138736.1, NM_001145264.1 [Q9Y2Q5-3] NP_054736.1, NM_014017.3 [Q9Y2Q5-1]
UniGeneⁱ	Hs.632483

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5X6U	X-ray	2.40	B	1-125	[»]
	5X6V	X-ray	2.02	B	1-125	[»]
	5Y39	X-ray	2.65	B/G	1-125	[»]
	5Y3A	X-ray	2.90	B/G	1-125	[»]
	6B9X	X-ray	1.42	B	1-125	[»]
	6EHP	X-ray	2.30	B	2-125	[»]
	6EHR	X-ray	2.90	B	2-125	[»]
ProteinModelPortalⁱ	Q9Y2Q5
SMRⁱ	Q9Y2Q5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118783, 24 interactors
CORUMⁱ	Q9Y2Q5
DIPⁱ	DIP-57000N
IntActⁱ	Q9Y2Q5, 18 interactors
MINTⁱ	Q9Y2Q5
STRINGⁱ	9606.ENSP00000357288

PTM databases

iPTMnetⁱ	Q9Y2Q5
PhosphoSitePlusⁱ	Q9Y2Q5

Polymorphism and mutation databases

BioMutaⁱ	LAMTOR2
DMDMⁱ	12585246

2D gel databases

OGPⁱ	Q9Y2Q5

OGPⁱ

Q9Y2Q5

Proteomic databases

EPDⁱ	Q9Y2Q5
PaxDbⁱ	Q9Y2Q5
PeptideAtlasⁱ	Q9Y2Q5
PRIDEⁱ	Q9Y2Q5
ProteomicsDBⁱ	85869 85870 [Q9Y2Q5-2] 85871 [Q9Y2Q5-3]
TopDownProteomicsⁱ	Q9Y2Q5-1 [Q9Y2Q5-1] Q9Y2Q5-2 [Q9Y2Q5-2] Q9Y2Q5-3 [Q9Y2Q5-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	28956
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368302; ENSP00000357285; ENSG00000116586 [Q9Y2Q5-2] ENST00000368304; ENSP00000357287; ENSG00000116586 [Q9Y2Q5-3] ENST00000368305; ENSP00000357288; ENSG00000116586 [Q9Y2Q5-1]
GeneIDⁱ	28956
KEGGⁱ	hsa:28956
UCSCⁱ	uc001fnb.4 human [Q9Y2Q5-1]

Organism-specific databases

CTDⁱ	28956
DisGeNETⁱ	28956
EuPathDBⁱ	HostDB:ENSG00000116586.11
GeneCardsⁱ	LAMTOR2
HGNCⁱ	HGNC:29796 LAMTOR2
HPAⁱ	HPA004126
MalaCardsⁱ	LAMTOR2
MIMⁱ	610389 gene 610798 phenotype
neXtProtⁱ	NX_Q9Y2Q5
OpenTargetsⁱ	ENSG00000116586
Orphanetⁱ	90023 Primary immunodeficiency syndrome due to p14 deficiency
PharmGKBⁱ	PA164725527
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4107 Eukaryota ENOG4111GWH LUCA
GeneTreeⁱ	ENSGT00390000006100
HOGENOMⁱ	HOG000007645
HOVERGENⁱ	HBG004518
InParanoidⁱ	Q9Y2Q5
KOⁱ	K20398
OMAⁱ	CECGHVA
OrthoDBⁱ	EOG091G0W0V
PhylomeDBⁱ	Q9Y2Q5
TreeFamⁱ	TF313929

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1632852 Macroautophagy R-HSA-165159 mTOR signalling R-HSA-166208 mTORC1-mediated signalling R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-5674135 MAP2K and MAPK activation R-HSA-6798695 Neutrophil degranulation R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORⁱ	Q9Y2Q5

Miscellaneous databases

ChiTaRSⁱ	LAMTOR2 human
GenomeRNAiⁱ	28956
Protein Ontology More...PROⁱ	PR:Q9Y2Q5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000116586 Expressed in 210 organ(s), highest expression level in body of stomach
Genevisibleⁱ	Q9Y2Q5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR037587 LAMTOR2-like IPR004942 Roadblock/LAMTOR2_dom
PANTHERⁱ	PTHR13323 PTHR13323, 1 hit
Pfamⁱ	View protein in Pfam PF03259 Robl_LC7, 1 hit
SMARTⁱ	View protein in SMART SM00960 Robl_LC7, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LTOR2_HUMAN
Accessionⁱ	Q9Y2Q5Primary (citable) accession number: Q9Y2Q5 Secondary accession number(s): Q5VY97, Q5VY98, Q5VY99
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y2Q5 (LTOR2_HUMAN)

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Ragulator complex protein LAMTOR2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Lysosome

Endosome

Lysosome

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ