UniProtKB - Q9Y2Q5 (LTOR2_HUMAN)
Ragulator complex protein LAMTOR2
LAMTOR2
Functioni
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: InterPro
- molecular adaptor activity Source: InterPro
GO - Biological processi
- activation of MAPKK activity Source: Ensembl
- cell cycle arrest Source: Reactome
- cellular protein localization Source: UniProtKB
- cellular response to amino acid stimulus Source: UniProtKB
- fibroblast migration Source: Ensembl
- MAPK cascade Source: Reactome
- neutrophil degranulation Source: Reactome
- positive regulation of TOR signaling Source: UniProtKB
- protein localization to cell junction Source: Ensembl
- regulation of cell growth Source: UniProtKB
- regulation of cell-substrate junction organization Source: MGI
- regulation of macroautophagy Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | Q9Y2Q5 |
Reactomei | R-HSA-1632852, Macroautophagy R-HSA-165159, MTOR signalling R-HSA-166208, mTORC1-mediated signalling R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-5674135, MAP2K and MAPK activation R-HSA-6798695, Neutrophil degranulation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9639288, Amino acids regulate mTORC1 |
SIGNORi | Q9Y2Q5 |
Names & Taxonomyi
Protein namesi | Recommended name: Ragulator complex protein LAMTOR2Alternative name(s): Endosomal adaptor protein p14 Late endosomal/lysosomal Mp1-interacting protein Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2 Mitogen-activated protein-binding protein-interacting protein Short name: MAPBP-interacting protein Roadblock domain-containing protein 3 |
Gene namesi | Name:LAMTOR2 Synonyms:MAPBPIP, ROBLD3 ORF Names:HSPC003 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29796, LAMTOR2 |
MIMi | 610389, gene |
neXtProti | NX_Q9Y2Q5 |
VEuPathDBi | HostDB:ENSG00000116586.11 |
Subcellular locationi
Endosome
- Late endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Lysosome
- Lysosome membrane 1 Publication; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Endosome
- endosome membrane Source: Reactome
- late endosome Source: UniProtKB
- Ragulator complex Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- specific granule membrane Source: Reactome
- tertiary granule membrane Source: Reactome
Keywords - Cellular componenti
Endosome, Lysosome, MembranePathology & Biotechi
Involvement in diseasei
Immunodeficiency due to defect in MAPBP-interacting protein (ID-MAPBPIP)1 Publication
Organism-specific databases
DisGeNETi | 28956 |
MalaCardsi | LAMTOR2 |
MIMi | 610798, phenotype |
OpenTargetsi | ENSG00000116586 |
Orphaneti | 90023, Primary immunodeficiency syndrome due to LAMTOR2 deficiency |
PharmGKBi | PA164725527 |
Miscellaneous databases
Pharosi | Q9Y2Q5, Tbio |
Genetic variation databases
BioMutai | LAMTOR2 |
DMDMi | 12585246 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220960 | 1 – 125 | Ragulator complex protein LAMTOR2Add BLAST | 125 |
Proteomic databases
EPDi | Q9Y2Q5 |
jPOSTi | Q9Y2Q5 |
MassIVEi | Q9Y2Q5 |
PaxDbi | Q9Y2Q5 |
PeptideAtlasi | Q9Y2Q5 |
PRIDEi | Q9Y2Q5 |
ProteomicsDBi | 85869 [Q9Y2Q5-1] 85870 [Q9Y2Q5-2] 85871 [Q9Y2Q5-3] |
TopDownProteomicsi | Q9Y2Q5-1 [Q9Y2Q5-1] Q9Y2Q5-2 [Q9Y2Q5-2] Q9Y2Q5-3 [Q9Y2Q5-3] |
2D gel databases
OGPi | Q9Y2Q5 |
PTM databases
iPTMneti | Q9Y2Q5 |
PhosphoSitePlusi | Q9Y2Q5 |
SwissPalmi | Q9Y2Q5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000116586, Expressed in body of stomach and 226 other tissues |
Genevisiblei | Q9Y2Q5, HS |
Organism-specific databases
HPAi | ENSG00000116586, Low tissue specificity |
Interactioni
Subunit structurei
Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5 (PubMed:20381137, PubMed:22980980). LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer (PubMed:20381137, PubMed:22980980).
Interacts with LAMTOR1 and LAMTOR3; the interaction is direct (PubMed:20381137, PubMed:22980980). The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability (PubMed:20381137, PubMed:22980980). The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906).
Interacts with MAPK1 and MAP2K1 (By similarity).
Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RRAGA/RagA or RRAGB/RagB GDP-bound, RRAGC/RagC or RRAGD/RagD GTP-bound, and Ragulator (PubMed:31704029, PubMed:31672913).
By similarity6 PublicationsBinary interactionsi
Hide detailsQ9Y2Q5
With | #Exp. | IntAct |
---|---|---|
BORCS6 [Q96GS4] | 4 | EBI-2643704,EBI-10193358 |
LAMTOR1 [Q6IAA8] | 14 | EBI-2643704,EBI-715385 |
LAMTOR3 [Q9UHA4] | 18 | EBI-2643704,EBI-1038192 |
SLC38A9 [Q8NBW4] | 3 | EBI-2643704,EBI-9978316 |
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 118783, 55 interactors |
ComplexPortali | CPX-4741, Ragulator complex |
CORUMi | Q9Y2Q5 |
DIPi | DIP-57000N |
IntActi | Q9Y2Q5, 18 interactors |
MINTi | Q9Y2Q5 |
STRINGi | 9606.ENSP00000357288 |
Miscellaneous databases
RNActi | Q9Y2Q5, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9Y2Q5 |
SMRi | Q9Y2Q5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 57 – 70 | Required for location at endosomesBy similarityAdd BLAST | 14 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4107, Eukaryota |
GeneTreei | ENSGT00390000006100 |
HOGENOMi | CLU_141118_0_0_1 |
InParanoidi | Q9Y2Q5 |
OMAi | CECGHVA |
OrthoDBi | 1515483at2759 |
PhylomeDBi | Q9Y2Q5 |
TreeFami | TF313929 |
Family and domain databases
InterProi | View protein in InterPro IPR037587, LAMTOR2-like IPR004942, Roadblock/LAMTOR2_dom |
PANTHERi | PTHR13323, PTHR13323, 1 hit |
Pfami | View protein in Pfam PF03259, Robl_LC7, 1 hit |
SMARTi | View protein in SMART SM00960, Robl_LC7, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLRPKALTQV LSQANTGGVQ STLLLNNEGS LLAYSGYGDT DARVTAAIAS
60 70 80 90 100
NIWAAYDRNG NQAFNEDNLK FILMDCMEGR VAITRVANLL LCMYAKETVG
110 120
FGMLKAKAQA LVQYLEEPLT QVAAS
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040980 | 78 – 107 | Missing in isoform 3. 1 PublicationAdd BLAST | 30 | |
Alternative sequenceiVSP_036543 | 109 – 125 | QALVQ…QVAAS → VCGTDLCSPSAGPGFGAVPG GAPHPSGGILTALVEAGVRK EK in isoform 2. CuratedAdd BLAST | 17 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF070659 mRNA Translation: AAD20965.1 AK307086 mRNA No translation available. AL355388 Genomic DNA No translation available. BC024190 mRNA Translation: AAH24190.1 |
CCDSi | CCDS1128.1 [Q9Y2Q5-1] CCDS44243.1 [Q9Y2Q5-3] |
RefSeqi | NP_001138736.1, NM_001145264.1 [Q9Y2Q5-3] NP_054736.1, NM_014017.3 [Q9Y2Q5-1] |
Genome annotation databases
Ensembli | ENST00000368302; ENSP00000357285; ENSG00000116586 [Q9Y2Q5-2] ENST00000368304; ENSP00000357287; ENSG00000116586 [Q9Y2Q5-3] ENST00000368305; ENSP00000357288; ENSG00000116586 [Q9Y2Q5-1] |
GeneIDi | 28956 |
KEGGi | hsa:28956 |
UCSCi | uc001fnb.4, human [Q9Y2Q5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
MAPBPIPbase ROBLD3 mutation db |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF070659 mRNA Translation: AAD20965.1 AK307086 mRNA No translation available. AL355388 Genomic DNA No translation available. BC024190 mRNA Translation: AAH24190.1 |
CCDSi | CCDS1128.1 [Q9Y2Q5-1] CCDS44243.1 [Q9Y2Q5-3] |
RefSeqi | NP_001138736.1, NM_001145264.1 [Q9Y2Q5-3] NP_054736.1, NM_014017.3 [Q9Y2Q5-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5X6U | X-ray | 2.40 | B | 1-125 | [»] | |
5X6V | X-ray | 2.02 | B | 1-125 | [»] | |
5Y39 | X-ray | 2.65 | B/G | 1-125 | [»] | |
5Y3A | X-ray | 2.90 | B/G | 1-125 | [»] | |
6B9X | X-ray | 1.42 | B | 1-125 | [»] | |
6EHP | X-ray | 2.30 | B | 2-125 | [»] | |
6EHR | X-ray | 2.90 | B | 2-125 | [»] | |
6NZD | electron microscopy | 3.60 | B | 1-125 | [»] | |
6U62 | electron microscopy | 3.18 | E | 1-125 | [»] | |
6ULG | electron microscopy | 3.31 | B | 1-125 | [»] | |
6WJ2 | electron microscopy | 3.20 | B | 1-125 | [»] | |
6WJ3 | electron microscopy | 3.90 | B | 1-125 | [»] | |
BMRBi | Q9Y2Q5 | |||||
SMRi | Q9Y2Q5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118783, 55 interactors |
ComplexPortali | CPX-4741, Ragulator complex |
CORUMi | Q9Y2Q5 |
DIPi | DIP-57000N |
IntActi | Q9Y2Q5, 18 interactors |
MINTi | Q9Y2Q5 |
STRINGi | 9606.ENSP00000357288 |
PTM databases
iPTMneti | Q9Y2Q5 |
PhosphoSitePlusi | Q9Y2Q5 |
SwissPalmi | Q9Y2Q5 |
Genetic variation databases
BioMutai | LAMTOR2 |
DMDMi | 12585246 |
2D gel databases
OGPi | Q9Y2Q5 |
Proteomic databases
EPDi | Q9Y2Q5 |
jPOSTi | Q9Y2Q5 |
MassIVEi | Q9Y2Q5 |
PaxDbi | Q9Y2Q5 |
PeptideAtlasi | Q9Y2Q5 |
PRIDEi | Q9Y2Q5 |
ProteomicsDBi | 85869 [Q9Y2Q5-1] 85870 [Q9Y2Q5-2] 85871 [Q9Y2Q5-3] |
TopDownProteomicsi | Q9Y2Q5-1 [Q9Y2Q5-1] Q9Y2Q5-2 [Q9Y2Q5-2] Q9Y2Q5-3 [Q9Y2Q5-3] |
Protocols and materials databases
Antibodypediai | 1218, 97 antibodies |
DNASUi | 28956 |
Genome annotation databases
Ensembli | ENST00000368302; ENSP00000357285; ENSG00000116586 [Q9Y2Q5-2] ENST00000368304; ENSP00000357287; ENSG00000116586 [Q9Y2Q5-3] ENST00000368305; ENSP00000357288; ENSG00000116586 [Q9Y2Q5-1] |
GeneIDi | 28956 |
KEGGi | hsa:28956 |
UCSCi | uc001fnb.4, human [Q9Y2Q5-1] |
Organism-specific databases
CTDi | 28956 |
DisGeNETi | 28956 |
GeneCardsi | LAMTOR2 |
HGNCi | HGNC:29796, LAMTOR2 |
HPAi | ENSG00000116586, Low tissue specificity |
MalaCardsi | LAMTOR2 |
MIMi | 610389, gene 610798, phenotype |
neXtProti | NX_Q9Y2Q5 |
OpenTargetsi | ENSG00000116586 |
Orphaneti | 90023, Primary immunodeficiency syndrome due to LAMTOR2 deficiency |
PharmGKBi | PA164725527 |
VEuPathDBi | HostDB:ENSG00000116586.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4107, Eukaryota |
GeneTreei | ENSGT00390000006100 |
HOGENOMi | CLU_141118_0_0_1 |
InParanoidi | Q9Y2Q5 |
OMAi | CECGHVA |
OrthoDBi | 1515483at2759 |
PhylomeDBi | Q9Y2Q5 |
TreeFami | TF313929 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2Q5 |
Reactomei | R-HSA-1632852, Macroautophagy R-HSA-165159, MTOR signalling R-HSA-166208, mTORC1-mediated signalling R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-5674135, MAP2K and MAPK activation R-HSA-6798695, Neutrophil degranulation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9639288, Amino acids regulate mTORC1 |
SIGNORi | Q9Y2Q5 |
Miscellaneous databases
BioGRID-ORCSi | 28956, 377 hits in 884 CRISPR screens |
ChiTaRSi | LAMTOR2, human |
GenomeRNAii | 28956 |
Pharosi | Q9Y2Q5, Tbio |
PROi | PR:Q9Y2Q5 |
RNActi | Q9Y2Q5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116586, Expressed in body of stomach and 226 other tissues |
Genevisiblei | Q9Y2Q5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR037587, LAMTOR2-like IPR004942, Roadblock/LAMTOR2_dom |
PANTHERi | PTHR13323, PTHR13323, 1 hit |
Pfami | View protein in Pfam PF03259, Robl_LC7, 1 hit |
SMARTi | View protein in SMART SM00960, Robl_LC7, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LTOR2_HUMAN | |
Accessioni | Q9Y2Q5Primary (citable) accession number: Q9Y2Q5 Secondary accession number(s): Q5VY97, Q5VY98, Q5VY99 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 172 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM