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UniProtKB - Q9Y2Q5 (LTOR2_HUMAN)

Entry version 173 (07 Apr 2021)
Sequence version 1 (01 Nov 1999)
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Protein

Ragulator complex protein LAMTOR2

Gene

LAMTOR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y2Q5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1632852, Macroautophagy
R-HSA-165159, MTOR signalling
R-HSA-166208, mTORC1-mediated signalling
R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-5674135, MAP2K and MAPK activation
R-HSA-6798695, Neutrophil degranulation
R-HSA-8943724, Regulation of PTEN gene transcription
R-HSA-9639288, Amino acids regulate mTORC1

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9Y2Q5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ragulator complex protein LAMTOR2
Alternative name(s):
Endosomal adaptor protein p14
Late endosomal/lysosomal Mp1-interacting protein
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2
Mitogen-activated protein-binding protein-interacting protein
Short name:
MAPBP-interacting protein
Roadblock domain-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMTOR2
Synonyms:MAPBPIP, ROBLD3
ORF Names:HSPC003
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29796, LAMTOR2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610389, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y2Q5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000116586.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency due to defect in MAPBP-interacting protein (ID-MAPBPIP)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionThis form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		28956

MalaCards human disease database

More...MalaCardsi		LAMTOR2
MIMi610798, phenotype

Open Targets

More...OpenTargetsi		ENSG00000116586

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		90023, Primary immunodeficiency syndrome due to LAMTOR2 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164725527

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y2Q5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LAMTOR2

Domain mapping of disease mutations (DMDM)

More...DMDMi		12585246

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002209601 – 125Ragulator complex protein LAMTOR2Add BLAST125

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y2Q5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y2Q5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y2Q5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y2Q5

PeptideAtlas

More...PeptideAtlasi		Q9Y2Q5

PRoteomics IDEntifications database

More...PRIDEi		Q9Y2Q5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85869 [Q9Y2Q5-1]
85870 [Q9Y2Q5-2]
85871 [Q9Y2Q5-3]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q9Y2Q5-1 [Q9Y2Q5-1]
Q9Y2Q5-2 [Q9Y2Q5-2]
Q9Y2Q5-3 [Q9Y2Q5-3]

2D gel databases

USC-OGP 2-DE database

More...OGPi		Q9Y2Q5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y2Q5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y2Q5

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9Y2Q5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116586, Expressed in body of stomach and 226 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y2Q5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000116586, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5 (PubMed:20381137, PubMed:22980980). LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer (PubMed:20381137, PubMed:22980980).

Interacts with LAMTOR1 and LAMTOR3; the interaction is direct (PubMed:20381137, PubMed:22980980). The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability (PubMed:20381137, PubMed:22980980). The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906).

Interacts with MAPK1 and MAP2K1 (By similarity).

Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RRAGA/RagA or RRAGB/RagB GDP-bound, RRAGC/RagC or RRAGD/RagD GTP-bound, and Ragulator (PubMed:31704029, PubMed:31672913).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118783, 58 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4741, Ragulator complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9Y2Q5

Database of interacting proteins

More...DIPi		DIP-57000N

Protein interaction database and analysis system

More...IntActi		Q9Y2Q5, 18 interactors

Molecular INTeraction database

More...MINTi		Q9Y2Q5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357288

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y2Q5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1125
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9Y2Q5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y2Q5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni57 – 70Required for location at endosomesBy similarityAdd BLAST14

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GAMAD family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4107, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006100

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_141118_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y2Q5

Identification of Orthologs from Complete Genome Data

More...OMAi		CECGHVA

Database of Orthologous Groups

More...OrthoDBi		1515483at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y2Q5

TreeFam database of animal gene trees

More...TreeFami		TF313929

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037587, LAMTOR2-like
IPR004942, Roadblock/LAMTOR2_dom

The PANTHER Classification System

More...PANTHERi		PTHR13323, PTHR13323, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03259, Robl_LC7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00960, Robl_LC7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y2Q5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRPKALTQV LSQANTGGVQ STLLLNNEGS LLAYSGYGDT DARVTAAIAS 
        60         70         80         90        100
NIWAAYDRNG NQAFNEDNLK FILMDCMEGR VAITRVANLL LCMYAKETVG 
       110        120 
FGMLKAKAQA LVQYLEEPLT QVAAS
Length:125
Mass (Da):13,508
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69599211C2CBC03D
GO
Isoform 2 (identifier: Q9Y2Q5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-125: QALVQYLEEPLTQVAAS → VCGTDLCSPSAGPGFGAVPGGAPHPSGGILTALVEAGVRKEK

Show »
Length:150
Mass (Da):15,609
Checksum:iD45D4B887C721086
GO
Isoform 3 (identifier: Q9Y2Q5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-107: Missing.

Show »
Length:95
Mass (Da):10,242
Checksum:i13ADB9F75E3E9E8C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04098078 – 107Missing in isoform 3. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_036543109 – 125QALVQ…QVAAS → VCGTDLCSPSAGPGFGAVPG GAPHPSGGILTALVEAGVRK EK in isoform 2. CuratedAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF070659 mRNA Translation: AAD20965.1
AK307086 mRNA No translation available.
AL355388 Genomic DNA No translation available.
BC024190 mRNA Translation: AAH24190.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1128.1 [Q9Y2Q5-1]
CCDS44243.1 [Q9Y2Q5-3]

NCBI Reference Sequences

More...RefSeqi		NP_001138736.1, NM_001145264.1 [Q9Y2Q5-3]
NP_054736.1, NM_014017.3 [Q9Y2Q5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000368302; ENSP00000357285; ENSG00000116586 [Q9Y2Q5-2]
ENST00000368304; ENSP00000357287; ENSG00000116586 [Q9Y2Q5-3]
ENST00000368305; ENSP00000357288; ENSG00000116586 [Q9Y2Q5-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		28956

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:28956

UCSC genome browser

More...UCSCi		uc001fnb.4, human [Q9Y2Q5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

MAPBPIPbase

ROBLD3 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070659 mRNA Translation: AAD20965.1
AK307086 mRNA No translation available.
AL355388 Genomic DNA No translation available.
BC024190 mRNA Translation: AAH24190.1
CCDSiCCDS1128.1 [Q9Y2Q5-1]
CCDS44243.1 [Q9Y2Q5-3]
RefSeqiNP_001138736.1, NM_001145264.1 [Q9Y2Q5-3]
NP_054736.1, NM_014017.3 [Q9Y2Q5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5X6UX-ray2.40B1-125[»]
5X6VX-ray2.02B1-125[»]
5Y39X-ray2.65B/G1-125[»]
5Y3AX-ray2.90B/G1-125[»]
6B9XX-ray1.42B1-125[»]
6EHPX-ray2.30B2-125[»]
6EHRX-ray2.90B2-125[»]
6NZDelectron microscopy3.60B1-125[»]
6U62electron microscopy3.18E1-125[»]
6ULGelectron microscopy3.31B1-125[»]
6WJ2electron microscopy3.20B1-125[»]
6WJ3electron microscopy3.90B1-125[»]
BMRBiQ9Y2Q5
SMRiQ9Y2Q5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi118783, 58 interactors
ComplexPortaliCPX-4741, Ragulator complex
CORUMiQ9Y2Q5
DIPiDIP-57000N
IntActiQ9Y2Q5, 18 interactors
MINTiQ9Y2Q5
STRINGi9606.ENSP00000357288

PTM databases

iPTMnetiQ9Y2Q5
PhosphoSitePlusiQ9Y2Q5
SwissPalmiQ9Y2Q5

Genetic variation databases

BioMutaiLAMTOR2
DMDMi12585246

2D gel databases

OGPiQ9Y2Q5

Proteomic databases

EPDiQ9Y2Q5
jPOSTiQ9Y2Q5
MassIVEiQ9Y2Q5
PaxDbiQ9Y2Q5
PeptideAtlasiQ9Y2Q5
PRIDEiQ9Y2Q5
ProteomicsDBi85869 [Q9Y2Q5-1]
85870 [Q9Y2Q5-2]
85871 [Q9Y2Q5-3]
TopDownProteomicsiQ9Y2Q5-1 [Q9Y2Q5-1]
Q9Y2Q5-2 [Q9Y2Q5-2]
Q9Y2Q5-3 [Q9Y2Q5-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1218, 100 antibodies

The DNASU plasmid repository

More...DNASUi		28956

Genome annotation databases

EnsembliENST00000368302; ENSP00000357285; ENSG00000116586 [Q9Y2Q5-2]
ENST00000368304; ENSP00000357287; ENSG00000116586 [Q9Y2Q5-3]
ENST00000368305; ENSP00000357288; ENSG00000116586 [Q9Y2Q5-1]
GeneIDi28956
KEGGihsa:28956
UCSCiuc001fnb.4, human [Q9Y2Q5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		28956
DisGeNETi28956

GeneCards: human genes, protein and diseases

More...GeneCardsi		LAMTOR2
HGNCiHGNC:29796, LAMTOR2
HPAiENSG00000116586, Low tissue specificity
MalaCardsiLAMTOR2
MIMi610389, gene
610798, phenotype
neXtProtiNX_Q9Y2Q5
OpenTargetsiENSG00000116586
Orphaneti90023, Primary immunodeficiency syndrome due to LAMTOR2 deficiency
PharmGKBiPA164725527
VEuPathDBiHostDB:ENSG00000116586.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4107, Eukaryota
GeneTreeiENSGT00390000006100
HOGENOMiCLU_141118_0_0_1
InParanoidiQ9Y2Q5
OMAiCECGHVA
OrthoDBi1515483at2759
PhylomeDBiQ9Y2Q5
TreeFamiTF313929

Enzyme and pathway databases

PathwayCommonsiQ9Y2Q5
ReactomeiR-HSA-1632852, Macroautophagy
R-HSA-165159, MTOR signalling
R-HSA-166208, mTORC1-mediated signalling
R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-5674135, MAP2K and MAPK activation
R-HSA-6798695, Neutrophil degranulation
R-HSA-8943724, Regulation of PTEN gene transcription
R-HSA-9639288, Amino acids regulate mTORC1
SIGNORiQ9Y2Q5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		28956, 400 hits in 1006 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LAMTOR2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		28956
PharosiQ9Y2Q5, Tbio

Protein Ontology

More...PROi		PR:Q9Y2Q5
RNActiQ9Y2Q5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000116586, Expressed in body of stomach and 226 other tissues
GenevisibleiQ9Y2Q5, HS

Family and domain databases

InterProiView protein in InterPro
IPR037587, LAMTOR2-like
IPR004942, Roadblock/LAMTOR2_dom
PANTHERiPTHR13323, PTHR13323, 1 hit
PfamiView protein in Pfam
PF03259, Robl_LC7, 1 hit
SMARTiView protein in SMART
SM00960, Robl_LC7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLTOR2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2Q5
Secondary accession number(s): Q5VY97, Q5VY98, Q5VY99
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1999
Last modified: April 7, 2021
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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