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Entry version 163 (11 Dec 2019)
Sequence version 2 (05 Apr 2011)
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Protein

Zinc finger protein 257

Gene

ZNF257

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri173 – 195C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 310C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 425C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri431 – 453C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 257
Alternative name(s):
Bone marrow zinc finger 4
Short name:
BMZF-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF257
Synonyms:BMZF4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197134.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13498 ZNF257

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606957 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2Q1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
113835

Open Targets

More...
OpenTargetsi
ENSG00000197134

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37786

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y2Q1 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF257

Domain mapping of disease mutations (DMDM)

More...
DMDMi
327478547

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474901 – 563Zinc finger protein 257Add BLAST563

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y2Q1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y2Q1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y2Q1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2Q1

PeptideAtlas

More...
PeptideAtlasi
Q9Y2Q1

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2Q1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85861 [Q9Y2Q1-1]
85862 [Q9Y2Q1-2]
85863 [Q9Y2Q1-3]
85864 [Q9Y2Q1-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2Q1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2Q1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197134 Expressed in 101 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2Q1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2Q1 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125264, 1 interactor

Protein interaction database and analysis system

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IntActi
Q9Y2Q1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000470209

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y2Q1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y2Q1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 310C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 425C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri431 – 453C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00970000193359

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2Q1

KEGG Orthology (KO)

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KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
GKPFNRF

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2Q1

TreeFam database of animal gene trees

More...
TreeFami
TF342117

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2Q1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPLTIRDVT VEFSLEEWHC LDTAQQNLYR DVMLENYRNL VFLGIAVSKP
60 70 80 90 100
DLITCLEQGK EPCNMKRHEM VAKPPVMCSH IAEDLCPERD IKYFFQKVIL
110 120 130 140 150
RRYDKCEHEN LQLRKGCKSV DECKVCKGGY NGLNQCLITT QSKMYQCDKY
160 170 180 190 200
VKVFYKFSNS DRHKIRHTEK KTCKCKECGK SFCMLSQLTR HKRIHIRENS
210 220 230 240 250
HKCEECGKAF NQSSALTRHK MTHTGEKPYK CEECGKAFNR SSHLTQHKVI
260 270 280 290 300
HTREKPYKCE ECGKAFNRSS HITQHKRIHN REKPFKYDEC CKAFKWSSAL
310 320 330 340 350
TTLTQHKRIH TGEKPYKCEE CGKAFNQSSA LTRHKMIHTG EKPFQCEECG
360 370 380 390 400
KAFNRSSHLT QHKIIHTKEK PYKCEECGKA FNRSSHLTKH KRIHTREKAY
410 420 430 440 450
KCDEYCKAFN WSSALTTLTQ HKIIHTGEKP YKCEECGKAF NRSSYLIRHK
460 470 480 490 500
IIHTGEKPYK CEECGKAFNQ SSHLTQHKII HTGEKPYKCE ECGKAFNRSS
510 520 530 540 550
HLSQHKIIHT GEKPYKCEEC GKPFNRFSYL TVHKRIHAGE NPNKYEECGK
560
ACNHSSNLTK HNS
Length:563
Mass (Da):65,779
Last modified:April 5, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19440275324E119B
GO
Isoform 2 (identifier: Q9Y2Q1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-204: Missing.

Show »
Length:535
Mass (Da):62,426
Checksum:i28C39BD95F13431D
GO
Isoform 3 (identifier: Q9Y2Q1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Show »
Length:531
Mass (Da):62,017
Checksum:iCB9C3942B06AA3A4
GO
Isoform 4 (identifier: Q9Y2Q1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-83: Missing.

Show »
Length:530
Mass (Da):62,058
Checksum:iBC4FAEE8D2905E21
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QXX9M0QXX9_HUMAN
Zinc finger protein 257
ZNF257
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYA6M0QYA6_HUMAN
Zinc finger protein 257
ZNF257
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0E0A0A494C0E0_HUMAN
Zinc finger protein 257
ZNF257
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0N1M0R0N1_HUMAN
Zinc finger protein 257
ZNF257
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R321M0R321_HUMAN
Zinc finger protein 257
ZNF257
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti355R → G in AAH36446 (PubMed:15489334).Curated1
Sequence conflicti450K → E in AAD20957 (PubMed:10585455).Curated1
Sequence conflicti501 – 502HL → QP in AAD20957 (PubMed:10585455).Curated2
Sequence conflicti506K → R in AAD20957 (PubMed:10585455).Curated1
Sequence conflicti523P → A in AAD20957 (PubMed:10585455).Curated1
Sequence conflicti526R → T in AAD20957 (PubMed:10585455).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0408581 – 32Missing in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_04085951 – 83Missing in isoform 4. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_040860177 – 204Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF070651 mRNA Translation: AAD20957.1
AK056694 mRNA Translation: BAG51786.1
AC003973 Genomic DNA No translation available.
AC011482 Genomic DNA No translation available.
BC036446 mRNA Translation: AAH36446.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46030.1 [Q9Y2Q1-1]

NCBI Reference Sequences

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RefSeqi
NP_001303925.1, NM_001316996.1 [Q9Y2Q1-3]
NP_001303926.1, NM_001316997.1
NP_001303927.1, NM_001316998.1
NP_258429.2, NM_033468.3 [Q9Y2Q1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000594947; ENSP00000470209; ENSG00000197134 [Q9Y2Q1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
113835

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:113835

UCSC genome browser

More...
UCSCi
uc010ecx.4 human [Q9Y2Q1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070651 mRNA Translation: AAD20957.1
AK056694 mRNA Translation: BAG51786.1
AC003973 Genomic DNA No translation available.
AC011482 Genomic DNA No translation available.
BC036446 mRNA Translation: AAH36446.1
CCDSiCCDS46030.1 [Q9Y2Q1-1]
RefSeqiNP_001303925.1, NM_001316996.1 [Q9Y2Q1-3]
NP_001303926.1, NM_001316997.1
NP_001303927.1, NM_001316998.1
NP_258429.2, NM_033468.3 [Q9Y2Q1-1]

3D structure databases

SMRiQ9Y2Q1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125264, 1 interactor
IntActiQ9Y2Q1, 1 interactor
STRINGi9606.ENSP00000470209

PTM databases

iPTMnetiQ9Y2Q1
PhosphoSitePlusiQ9Y2Q1

Polymorphism and mutation databases

BioMutaiZNF257
DMDMi327478547

Proteomic databases

EPDiQ9Y2Q1
jPOSTiQ9Y2Q1
MassIVEiQ9Y2Q1
PaxDbiQ9Y2Q1
PeptideAtlasiQ9Y2Q1
PRIDEiQ9Y2Q1
ProteomicsDBi85861 [Q9Y2Q1-1]
85862 [Q9Y2Q1-2]
85863 [Q9Y2Q1-3]
85864 [Q9Y2Q1-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
113835

Genome annotation databases

EnsembliENST00000594947; ENSP00000470209; ENSG00000197134 [Q9Y2Q1-1]
GeneIDi113835
KEGGihsa:113835
UCSCiuc010ecx.4 human [Q9Y2Q1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
113835
DisGeNETi113835
EuPathDBiHostDB:ENSG00000197134.11

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF257
HGNCiHGNC:13498 ZNF257
MIMi606957 gene
neXtProtiNX_Q9Y2Q1
OpenTargetsiENSG00000197134
PharmGKBiPA37786

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00970000193359
HOGENOMiHOG000234617
InParanoidiQ9Y2Q1
KOiK09228
OMAiGKPFNRF
OrthoDBi1318335at2759
PhylomeDBiQ9Y2Q1
TreeFamiTF342117

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
113835
PharosiQ9Y2Q1 Tdark

Protein Ontology

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PROi
PR:Q9Y2Q1
RNActiQ9Y2Q1 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000197134 Expressed in 101 organ(s), highest expression level in testis
ExpressionAtlasiQ9Y2Q1 baseline and differential
GenevisibleiQ9Y2Q1 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN257_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2Q1
Secondary accession number(s): B3KPS4, E9PG34, Q8NE34
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: April 5, 2011
Last modified: December 11, 2019
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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