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Entry version 173 (08 May 2019)
Sequence version 3 (07 Mar 2006)
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Protein

RNA 3'-terminal phosphate cyclase-like protein

Gene

RCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • endoribonuclease activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA 3'-terminal phosphate cyclase-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RCL1
Synonyms:RNAC, RPC2, RPCL1, RTC2
ORF Names:HSPC338
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17687 RCL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611405 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2P8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10171

Open Targets

More...
OpenTargetsi
ENSG00000120158

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134894364

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RCL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90103518

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001564381 – 373RNA 3'-terminal phosphate cyclase-like proteinAdd BLAST373

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y2P8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y2P8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2P8

PeptideAtlas

More...
PeptideAtlasi
Q9Y2P8

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2P8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85857

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2P8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2P8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Y2P8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120158 Expressed in 199 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2P8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2P8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA071308

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115473, 32 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y2P8, 14 interactors

Molecular INTeraction database

More...
MINTi
Q9Y2P8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371169

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y2P8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3980 Eukaryota
COG0430 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063404

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000157670

KEGG Orthology (KO)

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KOi
K11108

Identification of Orthologs from Complete Genome Data

More...
OMAi
GEVFFSC

Database of Orthologous Groups

More...
OrthoDBi
1423847at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2P8

TreeFam database of animal gene trees

More...
TreeFami
TF300831

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00875 RNA_Cyclase_Class_I, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.360.20, 1 hit
3.65.10.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013791 RNA3'-term_phos_cycl_insert
IPR023797 RNA3'_phos_cyclase_dom
IPR037136 RNA3'_phos_cyclase_dom_sf
IPR000228 RNA3'_term_phos_cyc
IPR016443 RNA3'_term_phos_cyc_type_2
IPR020719 RNA3'_term_phos_cycl-like_CS
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
IPR036553 RPTC_insert

The PANTHER Classification System

More...
PANTHERi
PTHR11096 PTHR11096, 1 hit
PTHR11096:SF1 PTHR11096:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01137 RTC, 1 hit
PF05189 RTC_insert, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005378 RNA3'_term_phos_cycl_euk, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55205 SSF55205, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03400 18S_RNA_Rcl1p, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01287 RTC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2P8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATQAHSLSY AGCNFLRQRL VLSTLSGRPV KIRKIRARDD NPGLRDFEAS
60 70 80 90 100
FIRLLDKITN GSRIEINQTG TTLYYQPGLL YGGSVEHDCS VLRGIGYYLE
110 120 130 140 150
SLLCLAPFMK HPLKIVLRGV TNDQVDPSVD VLKATALPLL KQFGIDGESF
160 170 180 190 200
ELKIVRRGMP PGGGGEVVFS CPVRKVLKPI QLTDPGKIKR IRGMAYSVRV
210 220 230 240 250
SPQMANRIVD SARSILNKFI PDIYIYTDHM KGVNSGKSPG FGLSLVAETT
260 270 280 290 300
SGTFLSAELA SNPQGQGAAV LPEDLGRNCA RLLLEEIYRG GCVDSTNQSL
310 320 330 340 350
ALLLMTLGQQ DVSKVLLGPL SPYTIEFLRH LKSFFQIMFK IETKPCGEEL
360 370
KGGDKVLMTC VGIGFSNLSK TLK
Length:373
Mass (Da):40,843
Last modified:March 7, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i533FAE8420AF93CB
GO
Isoform 2 (identifier: Q9Y2P8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MATQAHSLS → MTSLTPGCR
     10-195: Missing.

Note: No experimental confirmation available.
Show »
Length:187
Mass (Da):20,284
Checksum:iA9BF3D695E5E6A1B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VZU3Q5VZU3_HUMAN
RNA 3'-terminal phosphate cyclase-l...
RCL1
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VYW8Q5VYW8_HUMAN
RNA 3'-terminal phosphate cyclase-l...
RCL1
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VZU2Q5VZU2_HUMAN
RNA 3'-terminal phosphate cyclase-l...
RCL1
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD32456 differs from that shown. Reason: Frameshift at positions 13 and 58.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6H → Y in BAB14300 (PubMed:14702039).Curated1
Sequence conflicti46D → S in AAF29016 (Ref. 8) Curated1
Sequence conflicti49A → S in AAF29016 (Ref. 8) Curated1
Sequence conflicti153K → N in BAB14300 (PubMed:14702039).Curated1
Sequence conflicti310Q → R in CAB89811 (PubMed:10790377).Curated1
Sequence conflicti310Q → R in AAD32456 (PubMed:11042152).Curated1
Sequence conflicti310Q → R in AAF29016 (Ref. 8) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0564521 – 9MATQAHSLS → MTSLTPGCR in isoform 2. 1 Publication9
Alternative sequenceiVSP_05645310 – 195Missing in isoform 2. 1 PublicationAdd BLAST186

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ276894 mRNA Translation: CAB89811.1
AK022904 mRNA Translation: BAB14300.1
EF553527 mRNA Translation: ABQ66271.1
AL158147 Genomic DNA No translation available.
AL353151 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58776.1
CH471071 Genomic DNA Translation: EAW58777.1
BC001025 mRNA Translation: AAH01025.1
AF067172 mRNA Translation: AAD32456.1 Frameshift.
AF161456 mRNA Translation: AAF29016.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6456.1 [Q9Y2P8-1]
CCDS69565.1 [Q9Y2P8-2]

NCBI Reference Sequences

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RefSeqi
NP_001273628.1, NM_001286699.1
NP_001273629.1, NM_001286700.1
NP_001273630.1, NM_001286701.1 [Q9Y2P8-2]
NP_005763.3, NM_005772.4 [Q9Y2P8-1]
XP_011515975.1, XM_011517673.2 [Q9Y2P8-2]
XP_016869665.1, XM_017014176.1 [Q9Y2P8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000381728; ENSP00000371147; ENSG00000120158 [Q9Y2P8-2]
ENST00000381730; ENSP00000371149; ENSG00000120158 [Q9Y2P8-2]
ENST00000381750; ENSP00000371169; ENSG00000120158 [Q9Y2P8-1]
ENST00000448872; ENSP00000388096; ENSG00000120158 [Q9Y2P8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10171

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10171

UCSC genome browser

More...
UCSCi
uc003zis.4 human [Q9Y2P8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276894 mRNA Translation: CAB89811.1
AK022904 mRNA Translation: BAB14300.1
EF553527 mRNA Translation: ABQ66271.1
AL158147 Genomic DNA No translation available.
AL353151 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58776.1
CH471071 Genomic DNA Translation: EAW58777.1
BC001025 mRNA Translation: AAH01025.1
AF067172 mRNA Translation: AAD32456.1 Frameshift.
AF161456 mRNA Translation: AAF29016.1
CCDSiCCDS6456.1 [Q9Y2P8-1]
CCDS69565.1 [Q9Y2P8-2]
RefSeqiNP_001273628.1, NM_001286699.1
NP_001273629.1, NM_001286700.1
NP_001273630.1, NM_001286701.1 [Q9Y2P8-2]
NP_005763.3, NM_005772.4 [Q9Y2P8-1]
XP_011515975.1, XM_011517673.2 [Q9Y2P8-2]
XP_016869665.1, XM_017014176.1 [Q9Y2P8-2]

3D structure databases

SMRiQ9Y2P8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115473, 32 interactors
IntActiQ9Y2P8, 14 interactors
MINTiQ9Y2P8
STRINGi9606.ENSP00000371169

PTM databases

iPTMnetiQ9Y2P8
PhosphoSitePlusiQ9Y2P8
SwissPalmiQ9Y2P8

Polymorphism and mutation databases

BioMutaiRCL1
DMDMi90103518

Proteomic databases

EPDiQ9Y2P8
jPOSTiQ9Y2P8
PaxDbiQ9Y2P8
PeptideAtlasiQ9Y2P8
PRIDEiQ9Y2P8
ProteomicsDBi85857

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10171
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381728; ENSP00000371147; ENSG00000120158 [Q9Y2P8-2]
ENST00000381730; ENSP00000371149; ENSG00000120158 [Q9Y2P8-2]
ENST00000381750; ENSP00000371169; ENSG00000120158 [Q9Y2P8-1]
ENST00000448872; ENSP00000388096; ENSG00000120158 [Q9Y2P8-2]
GeneIDi10171
KEGGihsa:10171
UCSCiuc003zis.4 human [Q9Y2P8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10171
DisGeNETi10171

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RCL1
HGNCiHGNC:17687 RCL1
HPAiHPA071308
MIMi611405 gene
neXtProtiNX_Q9Y2P8
OpenTargetsiENSG00000120158
PharmGKBiPA134894364

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3980 Eukaryota
COG0430 LUCA
GeneTreeiENSGT00530000063404
HOGENOMiHOG000157670
KOiK11108
OMAiGEVFFSC
OrthoDBi1423847at2759
PhylomeDBiQ9Y2P8
TreeFamiTF300831

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RCL1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RCL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10171

Protein Ontology

More...
PROi
PR:Q9Y2P8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000120158 Expressed in 199 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiQ9Y2P8 baseline and differential
GenevisibleiQ9Y2P8 HS

Family and domain databases

CDDicd00875 RNA_Cyclase_Class_I, 1 hit
Gene3Di3.30.360.20, 1 hit
3.65.10.20, 1 hit
InterProiView protein in InterPro
IPR013791 RNA3'-term_phos_cycl_insert
IPR023797 RNA3'_phos_cyclase_dom
IPR037136 RNA3'_phos_cyclase_dom_sf
IPR000228 RNA3'_term_phos_cyc
IPR016443 RNA3'_term_phos_cyc_type_2
IPR020719 RNA3'_term_phos_cycl-like_CS
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
IPR036553 RPTC_insert
PANTHERiPTHR11096 PTHR11096, 1 hit
PTHR11096:SF1 PTHR11096:SF1, 1 hit
PfamiView protein in Pfam
PF01137 RTC, 1 hit
PF05189 RTC_insert, 1 hit
PIRSFiPIRSF005378 RNA3'_term_phos_cycl_euk, 1 hit
SUPFAMiSSF55205 SSF55205, 1 hit
TIGRFAMsiTIGR03400 18S_RNA_Rcl1p, 1 hit
PROSITEiView protein in PROSITE
PS01287 RTC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRCL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2P8
Secondary accession number(s): D3DRI2
, Q5VYW9, Q5VZU1, Q9H9D0, Q9NY00, Q9P044
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 7, 2006
Last modified: May 8, 2019
This is version 173 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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