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Entry version 180 (02 Jun 2021)
Sequence version 2 (28 Jul 2009)
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Protein

Zinc finger protein 256

Gene

ZNF256

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri90 – 112C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri239 – 261C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri519 – 541C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri547 – 569C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 597C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri603 – 625C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y2P7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 256
Alternative name(s):
Bone marrow zinc finger 3
Short name:
BMZF-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF256
Synonyms:BMZF3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13049, ZNF256

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606956, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2P7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000152454.3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000152454

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37627

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y2P7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF256

Domain mapping of disease mutations (DMDM)

More...
DMDMi
254763378

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474891 – 627Zinc finger protein 256Add BLAST627

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y2P7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2P7

PeptideAtlas

More...
PeptideAtlasi
Q9Y2P7

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2P7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85855 [Q9Y2P7-1]
85856 [Q9Y2P7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2P7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2P7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By GDNF/glial cell line-derived neurotrophic factor.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152454, Expressed in oocyte and 162 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2P7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2P7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000152454, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRIM28.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115474, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y2P7, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000282308

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y2P7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y2P7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 96KRABPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni55 – 76DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi62 – 76Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The KRAB domain mediates interaction with TRIM28 and is required for transcriptional repressor activity.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri90 – 112C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri239 – 261C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri519 – 541C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri547 – 569C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 597C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri603 – 625C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154734

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_55_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2P7

Identification of Orthologs from Complete Genome Data

More...
OMAi
QAAHTRK

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2P7

TreeFam database of animal gene trees

More...
TreeFami
TF339848

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 14 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 15 hits
PS50157, ZINC_FINGER_C2H2_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2P7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAELTAPA QGIVTFEDVA VYFSWKEWGL LDEAQKCLYH DVMLENLTLT
60 70 80 90 100
TSLGGSGAGD EEAPYQQSTS PQRVSQVRIP KALPSPQKTN PCEICGPVLR
110 120 130 140 150
QILHLVEHQG THHGQKLYTD GACRKQLQFT AYLHQHQKQH VGQKHFRSNG
160 170 180 190 200
GRDMFLSSCT FEVSGKPFTC KEVGKDFLVR SRFLQQQAAH TRKKSNRTKS
210 220 230 240 250
AVAFHSVKNH YNWGECVKAF SYKHVRVQHQ GDLIRERSYM CSECGKSFST
260 270 280 290 300
SCSLSDHLRV HTSEKPYTCG ECGKSYRQSS SLITHRRIHT GVRPHQCDEC
310 320 330 340 350
GKLFNRKYDL LIHQRVHTGE RPYKCSECGK SFSHSSSLIT HQRIHTGMRP
360 370 380 390 400
YECSECGKSF IHSSSLITHQ RVHTGTRPYM CSECGKSFSQ SCHLIKHRRL
410 420 430 440 450
HIGEGPYECS ECGKLFTYRS RFFQHQRVHT GVRSHECHEC GKLFSRKFDL
460 470 480 490 500
IVHERVHTGE RPYECSECGK SFTCKSYLIS HWKVHTGARP YECGECGKSF
510 520 530 540 550
THSSTLLQHQ RVHTGERPYE CNECGKFFSQ SSSLIRHRRS HTGERPYECS
560 570 580 590 600
ECWKSFSNHS SLVKHRRVHT GERPYECSEC GKSFSQSSNL TNHQRIHSGE
610 620
RPYECSDCGK FFTFNSNLLK HQNVHKG
Length:627
Mass (Da):71,871
Last modified:July 28, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF03506B03E4A6E86
GO
Isoform 2 (identifier: Q9Y2P7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Show »
Length:474
Mass (Da):54,856
Checksum:i304E4C25742FD014
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R2X0M0R2X0_HUMAN
Zinc finger protein 256
ZNF256
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti254L → P in BAG36789 (PubMed:14702039).Curated1
Sequence conflicti552C → F in BAG36789 (PubMed:14702039).Curated1
Sequence conflicti574P → L in AAD32449 (PubMed:10585455).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_058326304F → I. Corresponds to variant dbSNP:rs953619Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0377211 – 153Missing in isoform 2. 3 PublicationsAdd BLAST153

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF067165 mRNA Translation: AAD32449.1
BT006853 mRNA Translation: AAP35499.1
AK314094 mRNA Translation: BAG36789.1
AC008969 Genomic DNA No translation available.
AC010326 Genomic DNA No translation available.
BC001438 mRNA Translation: AAH01438.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12966.1 [Q9Y2P7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_005764.2, NM_005773.2 [Q9Y2P7-1]
XP_016881627.1, XM_017026138.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000282308; ENSP00000282308; ENSG00000152454 [Q9Y2P7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10172

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10172

UCSC genome browser

More...
UCSCi
uc002qqu.4, human [Q9Y2P7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067165 mRNA Translation: AAD32449.1
BT006853 mRNA Translation: AAP35499.1
AK314094 mRNA Translation: BAG36789.1
AC008969 Genomic DNA No translation available.
AC010326 Genomic DNA No translation available.
BC001438 mRNA Translation: AAH01438.2
CCDSiCCDS12966.1 [Q9Y2P7-1]
RefSeqiNP_005764.2, NM_005773.2 [Q9Y2P7-1]
XP_016881627.1, XM_017026138.1

3D structure databases

SMRiQ9Y2P7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115474, 2 interactors
IntActiQ9Y2P7, 2 interactors
STRINGi9606.ENSP00000282308

PTM databases

iPTMnetiQ9Y2P7
PhosphoSitePlusiQ9Y2P7

Genetic variation databases

BioMutaiZNF256
DMDMi254763378

Proteomic databases

MassIVEiQ9Y2P7
PaxDbiQ9Y2P7
PeptideAtlasiQ9Y2P7
PRIDEiQ9Y2P7
ProteomicsDBi85855 [Q9Y2P7-1]
85856 [Q9Y2P7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
33319, 124 antibodies

The DNASU plasmid repository

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DNASUi
10172

Genome annotation databases

EnsembliENST00000282308; ENSP00000282308; ENSG00000152454 [Q9Y2P7-1]
GeneIDi10172
KEGGihsa:10172
UCSCiuc002qqu.4, human [Q9Y2P7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10172

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF256
HGNCiHGNC:13049, ZNF256
HPAiENSG00000152454, Low tissue specificity
MIMi606956, gene
neXtProtiNX_Q9Y2P7
OpenTargetsiENSG00000152454
PharmGKBiPA37627
VEuPathDBiHostDB:ENSG00000152454.3

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000154734
HOGENOMiCLU_002678_55_2_1
InParanoidiQ9Y2P7
OMAiQAAHTRK
OrthoDBi1318335at2759
PhylomeDBiQ9Y2P7
TreeFamiTF339848

Enzyme and pathway databases

PathwayCommonsiQ9Y2P7
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
10172, 9 hits in 1006 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10172
PharosiQ9Y2P7, Tdark

Protein Ontology

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PROi
PR:Q9Y2P7
RNActiQ9Y2P7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152454, Expressed in oocyte and 162 other tissues
ExpressionAtlasiQ9Y2P7, baseline and differential
GenevisibleiQ9Y2P7, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 15 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 15 hits
PS50157, ZINC_FINGER_C2H2_2, 15 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN256_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2P7
Secondary accession number(s): B2RA92, Q53Y85, Q9BV71
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 28, 2009
Last modified: June 2, 2021
This is version 180 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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