UniProtKB - Q9Y2P4 (S27A6_HUMAN)
Protein
Long-chain fatty acid transport protein 6
Gene
SLC27A6
Organism
Homo sapiens (Human)
Status
Functioni
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart (PubMed:12556534). Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs) (By similarity).By similarity1 Publication
Catalytic activityi
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphateBy similarityEC:6.2.1.15By similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 221 – 232 | AMPSequence analysisAdd BLAST | 12 |
GO - Molecular functioni
- arachidonate-CoA ligase activity Source: UniProtKB-EC
- long-chain fatty acid-CoA ligase activity Source: GO_Central
- long-chain fatty acid transporter activity Source: GO_Central
- nucleotide binding Source: UniProtKB-KW
- very long-chain fatty acid-CoA ligase activity Source: Ensembl
GO - Biological processi
- long-chain fatty acid transport Source: Reactome
- very long-chain fatty acid metabolic process Source: ProtInc
Keywordsi
Molecular function | Ligase |
Biological process | Fatty acid metabolism, Lipid metabolism, Lipid transport, Transport |
Ligand | Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2P4 |
Reactomei | R-HSA-804914, Transport of fatty acids |
Protein family/group databases
TCDBi | 4.C.1.1.11, the fatty acid transporter (fat) family |
Chemistry databases
SwissLipidsi | SLP:000001263 |
Names & Taxonomyi
Protein namesi | Recommended name: Long-chain fatty acid transport protein 6Short name: FATP-6 Short name: Fatty acid transport protein 6 Alternative name(s): |
Gene namesi | Name:SLC27A6 Synonyms:ACSVL2, FACVL2, FATP6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000113396.12 |
HGNCi | HGNC:11000, SLC27A6 |
MIMi | 604196, gene |
neXtProti | NX_Q9Y2P4 |
Subcellular locationi
Plasma membrane
- sarcolemma 1 Publication; Multi-pass membrane protein Sequence analysis
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Note: In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36.1 Publication
Plasma Membrane
- plasma membrane Source: Reactome
- sarcolemma Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 22 – 42 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 119 – 139 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 28965 |
OpenTargetsi | ENSG00000113396 |
PharmGKBi | PA35874 |
Miscellaneous databases
Pharosi | Q9Y2P4, Tbio |
Polymorphism and mutation databases
BioMutai | SLC27A6 |
DMDMi | 74725713 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193216 | 1 – 619 | Long-chain fatty acid transport protein 6Add BLAST | 619 |
Proteomic databases
EPDi | Q9Y2P4 |
jPOSTi | Q9Y2P4 |
MassIVEi | Q9Y2P4 |
PaxDbi | Q9Y2P4 |
PeptideAtlasi | Q9Y2P4 |
PRIDEi | Q9Y2P4 |
ProteomicsDBi | 85853 |
PTM databases
iPTMneti | Q9Y2P4 |
PhosphoSitePlusi | Q9Y2P4 |
Expressioni
Tissue specificityi
Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus.1 Publication
Gene expression databases
Bgeei | ENSG00000113396, Expressed in heart and 143 other tissues |
ExpressionAtlasi | Q9Y2P4, baseline and differential |
Genevisiblei | Q9Y2P4, HS |
Organism-specific databases
HPAi | ENSG00000113396, Tissue enhanced (adrenal) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 118790, 37 interactors |
IntActi | Q9Y2P4, 11 interactors |
STRINGi | 9606.ENSP00000262462 |
Miscellaneous databases
RNActi | Q9Y2P4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1179, Eukaryota |
GeneTreei | ENSGT00940000159700 |
HOGENOMi | CLU_000022_46_2_1 |
InParanoidi | Q9Y2P4 |
OMAi | FPYFWAD |
OrthoDBi | 386992at2759 |
PhylomeDBi | Q9Y2P4 |
TreeFami | TF313430 |
Family and domain databases
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf IPR030309, FATP6 |
PANTHERi | PTHR43107:SF10, PTHR43107:SF10, 1 hit |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9Y2P4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLSWLTVLG AGMVVLHFLQ KLLFPYFWDD FWFVLKVVLI IIRLKKYEKR
60 70 80 90 100
GELVTVLDKF LSHAKRQPRK PFIIYEGDIY TYQDVDKRSS RVAHVFLNHS
110 120 130 140 150
SLKKGDTVAL LMSNEPDFVH VWFGLAKLGC VVAFLNTNIR SNSLLNCIRA
160 170 180 190 200
CGPRALVVGA DLLGTVEEIL PSLSENISVW GMKDSVPQGV ISLKEKLSTS
210 220 230 240 250
PDEPVPRSHH VVSLLKSTCL YIFTSGTTGL PKAAVISQLQ VLRGSAVLWA
260 270 280 290 300
FGCTAHDIVY ITLPLYHSSA AILGISGCVE LGATCVLKKK FSASQFWSDC
310 320 330 340 350
KKYDVTVFQY IGELCRYLCK QSKREGEKDH KVRLAIGNGI RSDVWREFLD
360 370 380 390 400
RFGNIKVCEL YAATESSISF MNYTGRIGAI GRTNLFYKLL STFDLIKYDF
410 420 430 440 450
QKDEPMRNEQ GWCIHVKKGE PGLLISRVNA KNPFFGYAGP YKHTKDKLLC
460 470 480 490 500
DVFKKGDVYL NTGDLIVQDQ DNFLYFWDRT GDTFRWKGEN VATTEVADVI
510 520 530 540 550
GMLDFIQEAN VYGVAISGYE GRAGMASIIL KPNTSLDLEK VYEQVVTFLP
560 570 580 590 600
AYACPRFLRI QEKMEATGTF KLLKHQLVED GFNPLKISEP LYFMDNLKKS
610
YVLLTRELYD QIMLGEIKL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RAJ2 | D6RAJ2_HUMAN | Long-chain fatty acid transport pro... | SLC27A6 | 162 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 25 | P → T in AAH41945 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 207 | R → H in CAD97625 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 215 | L → I in AAH41945 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 231 | P → S in CAG33410 (Ref. 3) Curated | 1 | |
Sequence conflicti | 432 | N → S in CAD97625 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 596 | N → D in CAD97625 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 618 | K → N in CAG33410 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048245 | 19 | L → V1 PublicationCorresponds to variant dbSNP:rs2526247Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF064254 mRNA Translation: AAD29443.1 CR457129 mRNA Translation: CAG33410.1 BX537383 mRNA Translation: CAD97625.1 BC041945 mRNA Translation: AAH41945.1 |
CCDSi | CCDS4145.1 |
RefSeqi | NP_001017372.1, NM_001017372.2 NP_001304913.1, NM_001317984.1 NP_054750.1, NM_014031.4 |
Genome annotation databases
Ensembli | ENST00000262462; ENSP00000262462; ENSG00000113396 ENST00000395266; ENSP00000378684; ENSG00000113396 ENST00000506176; ENSP00000421024; ENSG00000113396 |
GeneIDi | 28965 |
KEGGi | hsa:28965 |
UCSCi | uc003kuy.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF064254 mRNA Translation: AAD29443.1 CR457129 mRNA Translation: CAG33410.1 BX537383 mRNA Translation: CAD97625.1 BC041945 mRNA Translation: AAH41945.1 |
CCDSi | CCDS4145.1 |
RefSeqi | NP_001017372.1, NM_001017372.2 NP_001304913.1, NM_001317984.1 NP_054750.1, NM_014031.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 118790, 37 interactors |
IntActi | Q9Y2P4, 11 interactors |
STRINGi | 9606.ENSP00000262462 |
Chemistry databases
SwissLipidsi | SLP:000001263 |
Protein family/group databases
TCDBi | 4.C.1.1.11, the fatty acid transporter (fat) family |
PTM databases
iPTMneti | Q9Y2P4 |
PhosphoSitePlusi | Q9Y2P4 |
Polymorphism and mutation databases
BioMutai | SLC27A6 |
DMDMi | 74725713 |
Proteomic databases
EPDi | Q9Y2P4 |
jPOSTi | Q9Y2P4 |
MassIVEi | Q9Y2P4 |
PaxDbi | Q9Y2P4 |
PeptideAtlasi | Q9Y2P4 |
PRIDEi | Q9Y2P4 |
ProteomicsDBi | 85853 |
Protocols and materials databases
Antibodypediai | 1944, 83 antibodies |
Genome annotation databases
Ensembli | ENST00000262462; ENSP00000262462; ENSG00000113396 ENST00000395266; ENSP00000378684; ENSG00000113396 ENST00000506176; ENSP00000421024; ENSG00000113396 |
GeneIDi | 28965 |
KEGGi | hsa:28965 |
UCSCi | uc003kuy.3, human |
Organism-specific databases
CTDi | 28965 |
DisGeNETi | 28965 |
EuPathDBi | HostDB:ENSG00000113396.12 |
GeneCardsi | SLC27A6 |
HGNCi | HGNC:11000, SLC27A6 |
HPAi | ENSG00000113396, Tissue enhanced (adrenal) |
MIMi | 604196, gene |
neXtProti | NX_Q9Y2P4 |
OpenTargetsi | ENSG00000113396 |
PharmGKBi | PA35874 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1179, Eukaryota |
GeneTreei | ENSGT00940000159700 |
HOGENOMi | CLU_000022_46_2_1 |
InParanoidi | Q9Y2P4 |
OMAi | FPYFWAD |
OrthoDBi | 386992at2759 |
PhylomeDBi | Q9Y2P4 |
TreeFami | TF313430 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2P4 |
Reactomei | R-HSA-804914, Transport of fatty acids |
Miscellaneous databases
BioGRID-ORCSi | 28965, 6 hits in 845 CRISPR screens |
ChiTaRSi | SLC27A6, human |
GeneWikii | SLC27A6 |
GenomeRNAii | 28965 |
Pharosi | Q9Y2P4, Tbio |
PROi | PR:Q9Y2P4 |
RNActi | Q9Y2P4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000113396, Expressed in heart and 143 other tissues |
ExpressionAtlasi | Q9Y2P4, baseline and differential |
Genevisiblei | Q9Y2P4, HS |
Family and domain databases
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf IPR030309, FATP6 |
PANTHERi | PTHR43107:SF10, PTHR43107:SF10, 1 hit |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S27A6_HUMAN | |
Accessioni | Q9Y2P4Primary (citable) accession number: Q9Y2P4 Secondary accession number(s): Q6IAM5, Q7Z6E6, Q86YF6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations