SLC27A6

Functionⁱ

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	221 – 232	AMPSequence analysisAdd BLAST		12

GO - Molecular functionⁱ

fatty acid transmembrane transporter activity Source: Reactome
long-chain fatty acid-CoA ligase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
long-chain fatty acid transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nucleotide binding Source: UniProtKB-KW
very long-chain fatty acid-CoA ligase activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

long-chain fatty acid transport Source: Reactome
very long-chain fatty acid metabolic process
Source: ProtInc
Traceable author statementⁱ
- 10471116

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ligase
Biological process	Fatty acid metabolism, Lipid metabolism, Lipid transport, Transport
Ligand	Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-804914 Transport of fatty acids

Reactomeⁱ

R-HSA-804914 Transport of fatty acids

Protein family/group databases

TCDBⁱ	4.C.1.1.11 the fatty acid transporter (fat) family

TCDBⁱ

4.C.1.1.11 the fatty acid transporter (fat) family

Chemistry databases

SwissLipidsⁱ	SLP:000001263

SwissLipidsⁱ

SLP:000001263

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Long-chain fatty acid transport protein 6 Short name: FATP-6 Short name: Fatty acid transport protein 6 Alternative name(s): Fatty-acid-coenzyme A ligase, very long-chain 2 Solute carrier family 27 member 6 Very long-chain acyl-CoA synthetase homolog 1 Short name: VLCSH1 Short name: hVLCS-H1
Gene namesⁱ	Name:SLC27A6 Synonyms:ACSVL2, FACVL2, FATP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000113396.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11000 SLC27A6
MIMⁱ	604196 gene
neXtProtⁱ	NX_Q9Y2P4

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	22 – 42	HelicalSequence analysisAdd BLAST		21
Transmembraneⁱ	119 – 139	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	28965
Open Targets More...OpenTargetsⁱ	ENSG00000113396
PharmGKBⁱ	PA35874

Polymorphism and mutation databases

BioMutaⁱ	SLC27A6
DMDMⁱ	74725713

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000193216	1 – 619	Long-chain fatty acid transport protein 6Add BLAST		619

Proteomic databases

EPDⁱ	Q9Y2P4
PaxDbⁱ	Q9Y2P4
PeptideAtlas More...PeptideAtlasⁱ	Q9Y2P4
PRIDEⁱ	Q9Y2P4
ProteomicsDBⁱ	85853

PTM databases

iPTMnetⁱ	Q9Y2P4
PhosphoSitePlusⁱ	Q9Y2P4

Expressionⁱ

Tissue specificityⁱ

Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000113396 Expressed in 118 organ(s), highest expression level in heart
CleanExⁱ	HS_SLC27A6
ExpressionAtlasⁱ	Q9Y2P4 baseline and differential
Genevisibleⁱ	Q9Y2P4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA008987

HPAⁱ

HPA008987

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	118790, 37 interactors
STRINGⁱ	9606.ENSP00000262462

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y2P4
SMRⁱ	Q9Y2P4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ATP-dependent AMP-binding enzyme family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1179 Eukaryota ENOG410XQ8T LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074420
HOGENOMⁱ	HOG000044189
HOVERGENⁱ	HBG005642
InParanoidⁱ	Q9Y2P4
KEGG Orthology (KO) More...KOⁱ	K08749
OMAⁱ	CFMNHTG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B76
PhylomeDBⁱ	Q9Y2P4
TreeFamⁱ	TF313430

Family and domain databases

InterProⁱ	View protein in InterPro IPR025110 AMP-bd_C IPR020845 AMP-binding_CS IPR000873 AMP-dep_Synth/Lig IPR030309 FATP6
PANTHERⁱ	PTHR43107:SF10 PTHR43107:SF10, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00501 AMP-binding, 1 hit PF13193 AMP-binding_C, 1 hit
PROSITEⁱ	View protein in PROSITE PS00455 AMP_BINDING, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9Y2P4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLSWLTVLG AGMVVLHFLQ KLLFPYFWDD FWFVLKVVLI IIRLKKYEKR 
        60         70         80         90        100
GELVTVLDKF LSHAKRQPRK PFIIYEGDIY TYQDVDKRSS RVAHVFLNHS 
       110        120        130        140        150
SLKKGDTVAL LMSNEPDFVH VWFGLAKLGC VVAFLNTNIR SNSLLNCIRA 
       160        170        180        190        200
CGPRALVVGA DLLGTVEEIL PSLSENISVW GMKDSVPQGV ISLKEKLSTS 
       210        220        230        240        250
PDEPVPRSHH VVSLLKSTCL YIFTSGTTGL PKAAVISQLQ VLRGSAVLWA 
       260        270        280        290        300
FGCTAHDIVY ITLPLYHSSA AILGISGCVE LGATCVLKKK FSASQFWSDC 
       310        320        330        340        350
KKYDVTVFQY IGELCRYLCK QSKREGEKDH KVRLAIGNGI RSDVWREFLD 
       360        370        380        390        400
RFGNIKVCEL YAATESSISF MNYTGRIGAI GRTNLFYKLL STFDLIKYDF 
       410        420        430        440        450
QKDEPMRNEQ GWCIHVKKGE PGLLISRVNA KNPFFGYAGP YKHTKDKLLC 
       460        470        480        490        500
DVFKKGDVYL NTGDLIVQDQ DNFLYFWDRT GDTFRWKGEN VATTEVADVI 
       510        520        530        540        550
GMLDFIQEAN VYGVAISGYE GRAGMASIIL KPNTSLDLEK VYEQVVTFLP 
       560        570        580        590        600
AYACPRFLRI QEKMEATGTF KLLKHQLVED GFNPLKISEP LYFMDNLKKS 
       610 
YVLLTRELYD QIMLGEIKL

Length:619

Mass (Da):70,112

Last modified:November 1, 1999 - v1

Checksum:ⁱ20264CE3FBB44FF5

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D6RAJ2	D6RAJ2_HUMAN		Long-chain fatty acid transport pro... Long-chain fatty acid transport protein 6	SLC27A6	162	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	25	P → T in AAH41945 (PubMed:15489334).Curated	1
Sequence conflictⁱ	207	R → H in CAD97625 (PubMed:17974005).Curated	1
Sequence conflictⁱ	215	L → I in AAH41945 (PubMed:15489334).Curated	1
Sequence conflictⁱ	231	P → S in CAG33410 (Ref. 3) Curated	1
Sequence conflictⁱ	432	N → S in CAD97625 (PubMed:17974005).Curated	1
Sequence conflictⁱ	596	N → D in CAD97625 (PubMed:17974005).Curated	1
Sequence conflictⁱ	618	K → N in CAG33410 (Ref. 3) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048245	19	L → V1 PublicationCorresponds to variant dbSNP:rs2526247Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF064254 mRNA Translation: AAD29443.1 CR457129 mRNA Translation: CAG33410.1 BX537383 mRNA Translation: CAD97625.1 BC041945 mRNA Translation: AAH41945.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4145.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001017372.1, NM_001017372.2 NP_001304913.1, NM_001317984.1 NP_054750.1, NM_014031.4
UniGeneⁱ	Hs.49765

Genome annotation databases

Ensemblⁱ	ENST00000262462; ENSP00000262462; ENSG00000113396 ENST00000395266; ENSP00000378684; ENSG00000113396 ENST00000506176; ENSP00000421024; ENSG00000113396
GeneIDⁱ	28965
KEGGⁱ	hsa:28965
UCSC genome browser More...UCSCⁱ	uc003kuy.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2P4	Long-chain fatty acid transport protein 6 (Fragment)		HUMAN		162	UniRef100_Q9Y2P4

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2P4	Long-chain fatty acid transport protein 6 (Fragment)		HUMAN		162	UniRef90_Q9Y2P4
Solute carrier family 27 member 6		PONAB		621
Uncharacterized protein		MACMU		620
Uncharacterized protein		MACFA		620
SLC27A6 isoform 1		PANTR		619
+25

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2P4	Very long-chain acyl-CoA synthetase		HUMAN		620	UniRef50_O14975
Very long-chain acyl-CoA synthetase		RAT		620
Very long-chain acyl-CoA synthetase		MOUSE		620
Solute carrier family 27 member 2		SAIBB		754
Solute carrier family 27 member 2		PONAB		620
+714

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF064254 mRNA Translation: AAD29443.1 CR457129 mRNA Translation: CAG33410.1 BX537383 mRNA Translation: CAD97625.1 BC041945 mRNA Translation: AAH41945.1
CCDSⁱ	CCDS4145.1
RefSeqⁱ	NP_001017372.1, NM_001017372.2 NP_001304913.1, NM_001317984.1 NP_054750.1, NM_014031.4
UniGeneⁱ	Hs.49765

3D structure databases

ProteinModelPortalⁱ	Q9Y2P4
SMRⁱ	Q9Y2P4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118790, 37 interactors
STRINGⁱ	9606.ENSP00000262462

Chemistry databases

SwissLipidsⁱ	SLP:000001263

SwissLipidsⁱ

SLP:000001263

Protein family/group databases

TCDBⁱ	4.C.1.1.11 the fatty acid transporter (fat) family

TCDBⁱ

4.C.1.1.11 the fatty acid transporter (fat) family

PTM databases

iPTMnetⁱ	Q9Y2P4
PhosphoSitePlusⁱ	Q9Y2P4

Polymorphism and mutation databases

BioMutaⁱ	SLC27A6
DMDMⁱ	74725713

Proteomic databases

EPDⁱ	Q9Y2P4
PaxDbⁱ	Q9Y2P4
PeptideAtlasⁱ	Q9Y2P4
PRIDEⁱ	Q9Y2P4
ProteomicsDBⁱ	85853

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000262462; ENSP00000262462; ENSG00000113396 ENST00000395266; ENSP00000378684; ENSG00000113396 ENST00000506176; ENSP00000421024; ENSG00000113396
GeneIDⁱ	28965
KEGGⁱ	hsa:28965
UCSCⁱ	uc003kuy.3 human

Organism-specific databases

CTDⁱ	28965
DisGeNETⁱ	28965
EuPathDBⁱ	HostDB:ENSG00000113396.12
GeneCardsⁱ	SLC27A6
HGNCⁱ	HGNC:11000 SLC27A6
HPAⁱ	HPA008987
MIMⁱ	604196 gene
neXtProtⁱ	NX_Q9Y2P4
OpenTargetsⁱ	ENSG00000113396
PharmGKBⁱ	PA35874
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1179 Eukaryota ENOG410XQ8T LUCA
GeneTreeⁱ	ENSGT00550000074420
HOGENOMⁱ	HOG000044189
HOVERGENⁱ	HBG005642
InParanoidⁱ	Q9Y2P4
KOⁱ	K08749
OMAⁱ	CFMNHTG
OrthoDBⁱ	EOG091G0B76
PhylomeDBⁱ	Q9Y2P4
TreeFamⁱ	TF313430

Enzyme and pathway databases

Reactomeⁱ	R-HSA-804914 Transport of fatty acids

Reactomeⁱ

R-HSA-804914 Transport of fatty acids

Miscellaneous databases

ChiTaRSⁱ	SLC27A6 human
GeneWikiⁱ	SLC27A6
GenomeRNAiⁱ	28965
Protein Ontology More...PROⁱ	PR:Q9Y2P4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000113396 Expressed in 118 organ(s), highest expression level in heart
CleanExⁱ	HS_SLC27A6
ExpressionAtlasⁱ	Q9Y2P4 baseline and differential
Genevisibleⁱ	Q9Y2P4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR025110 AMP-bd_C IPR020845 AMP-binding_CS IPR000873 AMP-dep_Synth/Lig IPR030309 FATP6
PANTHERⁱ	PTHR43107:SF10 PTHR43107:SF10, 1 hit
Pfamⁱ	View protein in Pfam PF00501 AMP-binding, 1 hit PF13193 AMP-binding_C, 1 hit
PROSITEⁱ	View protein in PROSITE PS00455 AMP_BINDING, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S27A6_HUMAN
Accessionⁱ	Q9Y2P4Primary (citable) accession number: Q9Y2P4 Secondary accession number(s): Q6IAM5, Q7Z6E6, Q86YF6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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UniProtKB - Q9Y2P4 (S27A6_HUMAN)

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Long-chain fatty acid transport protein 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ