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Protein

Long-chain fatty acid transport protein 6

Gene

SLC27A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi221 – 232AMPSequence analysisAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • long-chain fatty acid transport Source: Reactome
  • very long-chain fatty acid metabolic process Source: ProtInc

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism, Lipid transport, Transport
LigandNucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-804914 Transport of fatty acids

Protein family/group databases

TCDBi4.C.1.1.11 the fatty acid transporter (fat) family

Chemistry databases

SwissLipidsiSLP:000001263

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain fatty acid transport protein 6
Short name:
FATP-6
Short name:
Fatty acid transport protein 6
Alternative name(s):
Fatty-acid-coenzyme A ligase, very long-chain 2
Solute carrier family 27 member 6
Very long-chain acyl-CoA synthetase homolog 1
Short name:
VLCSH1
Short name:
hVLCS-H1
Gene namesi
Name:SLC27A6
Synonyms:ACSVL2, FACVL2, FATP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113396.12
HGNCiHGNC:11000 SLC27A6
MIMi604196 gene
neXtProtiNX_Q9Y2P4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi28965
OpenTargetsiENSG00000113396
PharmGKBiPA35874

Polymorphism and mutation databases

BioMutaiSLC27A6
DMDMi74725713

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001932161 – 619Long-chain fatty acid transport protein 6Add BLAST619

Proteomic databases

EPDiQ9Y2P4
PaxDbiQ9Y2P4
PeptideAtlasiQ9Y2P4
PRIDEiQ9Y2P4
ProteomicsDBi85853

PTM databases

iPTMnetiQ9Y2P4
PhosphoSitePlusiQ9Y2P4

Expressioni

Tissue specificityi

Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus.1 Publication

Gene expression databases

BgeeiENSG00000113396 Expressed in 118 organ(s), highest expression level in heart
CleanExiHS_SLC27A6
ExpressionAtlasiQ9Y2P4 baseline and differential
GenevisibleiQ9Y2P4 HS

Organism-specific databases

HPAiHPA008987

Interactioni

Protein-protein interaction databases

BioGridi118790, 37 interactors
STRINGi9606.ENSP00000262462

Structurei

3D structure databases

ProteinModelPortaliQ9Y2P4
SMRiQ9Y2P4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1179 Eukaryota
ENOG410XQ8T LUCA
GeneTreeiENSGT00550000074420
HOGENOMiHOG000044189
HOVERGENiHBG005642
InParanoidiQ9Y2P4
KOiK08749
OMAiCFMNHTG
OrthoDBiEOG091G0B76
PhylomeDBiQ9Y2P4
TreeFamiTF313430

Family and domain databases

InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR030309 FATP6
PANTHERiPTHR43107:SF10 PTHR43107:SF10, 1 hit
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y2P4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLSWLTVLG AGMVVLHFLQ KLLFPYFWDD FWFVLKVVLI IIRLKKYEKR
60 70 80 90 100
GELVTVLDKF LSHAKRQPRK PFIIYEGDIY TYQDVDKRSS RVAHVFLNHS
110 120 130 140 150
SLKKGDTVAL LMSNEPDFVH VWFGLAKLGC VVAFLNTNIR SNSLLNCIRA
160 170 180 190 200
CGPRALVVGA DLLGTVEEIL PSLSENISVW GMKDSVPQGV ISLKEKLSTS
210 220 230 240 250
PDEPVPRSHH VVSLLKSTCL YIFTSGTTGL PKAAVISQLQ VLRGSAVLWA
260 270 280 290 300
FGCTAHDIVY ITLPLYHSSA AILGISGCVE LGATCVLKKK FSASQFWSDC
310 320 330 340 350
KKYDVTVFQY IGELCRYLCK QSKREGEKDH KVRLAIGNGI RSDVWREFLD
360 370 380 390 400
RFGNIKVCEL YAATESSISF MNYTGRIGAI GRTNLFYKLL STFDLIKYDF
410 420 430 440 450
QKDEPMRNEQ GWCIHVKKGE PGLLISRVNA KNPFFGYAGP YKHTKDKLLC
460 470 480 490 500
DVFKKGDVYL NTGDLIVQDQ DNFLYFWDRT GDTFRWKGEN VATTEVADVI
510 520 530 540 550
GMLDFIQEAN VYGVAISGYE GRAGMASIIL KPNTSLDLEK VYEQVVTFLP
560 570 580 590 600
AYACPRFLRI QEKMEATGTF KLLKHQLVED GFNPLKISEP LYFMDNLKKS
610
YVLLTRELYD QIMLGEIKL
Length:619
Mass (Da):70,112
Last modified:November 1, 1999 - v1
Checksum:i20264CE3FBB44FF5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RAJ2D6RAJ2_HUMAN
Long-chain fatty acid transport pro...
SLC27A6
162Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25P → T in AAH41945 (PubMed:15489334).Curated1
Sequence conflicti207R → H in CAD97625 (PubMed:17974005).Curated1
Sequence conflicti215L → I in AAH41945 (PubMed:15489334).Curated1
Sequence conflicti231P → S in CAG33410 (Ref. 3) Curated1
Sequence conflicti432N → S in CAD97625 (PubMed:17974005).Curated1
Sequence conflicti596N → D in CAD97625 (PubMed:17974005).Curated1
Sequence conflicti618K → N in CAG33410 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04824519L → V1 PublicationCorresponds to variant dbSNP:rs2526247Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064254 mRNA Translation: AAD29443.1
CR457129 mRNA Translation: CAG33410.1
BX537383 mRNA Translation: CAD97625.1
BC041945 mRNA Translation: AAH41945.1
CCDSiCCDS4145.1
RefSeqiNP_001017372.1, NM_001017372.2
NP_001304913.1, NM_001317984.1
NP_054750.1, NM_014031.4
UniGeneiHs.49765

Genome annotation databases

EnsembliENST00000262462; ENSP00000262462; ENSG00000113396
ENST00000395266; ENSP00000378684; ENSG00000113396
ENST00000506176; ENSP00000421024; ENSG00000113396
GeneIDi28965
KEGGihsa:28965
UCSCiuc003kuy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064254 mRNA Translation: AAD29443.1
CR457129 mRNA Translation: CAG33410.1
BX537383 mRNA Translation: CAD97625.1
BC041945 mRNA Translation: AAH41945.1
CCDSiCCDS4145.1
RefSeqiNP_001017372.1, NM_001017372.2
NP_001304913.1, NM_001317984.1
NP_054750.1, NM_014031.4
UniGeneiHs.49765

3D structure databases

ProteinModelPortaliQ9Y2P4
SMRiQ9Y2P4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118790, 37 interactors
STRINGi9606.ENSP00000262462

Chemistry databases

SwissLipidsiSLP:000001263

Protein family/group databases

TCDBi4.C.1.1.11 the fatty acid transporter (fat) family

PTM databases

iPTMnetiQ9Y2P4
PhosphoSitePlusiQ9Y2P4

Polymorphism and mutation databases

BioMutaiSLC27A6
DMDMi74725713

Proteomic databases

EPDiQ9Y2P4
PaxDbiQ9Y2P4
PeptideAtlasiQ9Y2P4
PRIDEiQ9Y2P4
ProteomicsDBi85853

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262462; ENSP00000262462; ENSG00000113396
ENST00000395266; ENSP00000378684; ENSG00000113396
ENST00000506176; ENSP00000421024; ENSG00000113396
GeneIDi28965
KEGGihsa:28965
UCSCiuc003kuy.3 human

Organism-specific databases

CTDi28965
DisGeNETi28965
EuPathDBiHostDB:ENSG00000113396.12
GeneCardsiSLC27A6
HGNCiHGNC:11000 SLC27A6
HPAiHPA008987
MIMi604196 gene
neXtProtiNX_Q9Y2P4
OpenTargetsiENSG00000113396
PharmGKBiPA35874
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1179 Eukaryota
ENOG410XQ8T LUCA
GeneTreeiENSGT00550000074420
HOGENOMiHOG000044189
HOVERGENiHBG005642
InParanoidiQ9Y2P4
KOiK08749
OMAiCFMNHTG
OrthoDBiEOG091G0B76
PhylomeDBiQ9Y2P4
TreeFamiTF313430

Enzyme and pathway databases

ReactomeiR-HSA-804914 Transport of fatty acids

Miscellaneous databases

ChiTaRSiSLC27A6 human
GeneWikiiSLC27A6
GenomeRNAii28965
PROiPR:Q9Y2P4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113396 Expressed in 118 organ(s), highest expression level in heart
CleanExiHS_SLC27A6
ExpressionAtlasiQ9Y2P4 baseline and differential
GenevisibleiQ9Y2P4 HS

Family and domain databases

InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR030309 FATP6
PANTHERiPTHR43107:SF10 PTHR43107:SF10, 1 hit
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS27A6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2P4
Secondary accession number(s): Q6IAM5, Q7Z6E6, Q86YF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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