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UniProtKB - Q9Y2P0 (ZN835_HUMAN)
Protein
Zinc finger protein 835
Gene
ZNF835
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 110 – 132 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 138 – 160 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 166 – 188 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 194 – 216 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 222 – 244 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 250 – 272 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 278 – 300 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 306 – 328 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 334 – 356 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 362 – 384 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 390 – 412 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 418 – 440 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 446 – 468 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 474 – 496 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2P0 |
SignaLinki | Q9Y2P0 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 835 |
Gene namesi | Name:ZNF835 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:34332, ZNF835 |
neXtProti | NX_Q9Y2P0 |
VEuPathDBi | HostDB:ENSG00000127903 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000127903 |
PharmGKBi | PA162410787 |
Miscellaneous databases
Pharosi | Q9Y2P0, Tdark |
Genetic variation databases
BioMutai | ZNF835 |
DMDMi | 403314387 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000319111 | 1 – 537 | Zinc finger protein 835Add BLAST | 537 |
Proteomic databases
jPOSTi | Q9Y2P0 |
MassIVEi | Q9Y2P0 |
PaxDbi | Q9Y2P0 |
PeptideAtlasi | Q9Y2P0 |
PRIDEi | Q9Y2P0 |
ProteomicsDBi | 32421 85852 |
PTM databases
iPTMneti | Q9Y2P0 |
PhosphoSitePlusi | Q9Y2P0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000127903, Expressed in buccal mucosa cell and 126 other tissues |
ExpressionAtlasi | Q9Y2P0, baseline and differential |
Genevisiblei | Q9Y2P0, HS |
Organism-specific databases
HPAi | ENSG00000127903, Low tissue specificity |
Interactioni
Binary interactionsi
Q9Y2P0
Protein-protein interaction databases
BioGRIDi | 124722, 68 interactors |
IntActi | Q9Y2P0, 67 interactors |
STRINGi | 9606.ENSP00000444747 |
Miscellaneous databases
RNActi | Q9Y2P0, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 12 – 109 | DisorderedSequence analysisAdd BLAST | 98 | |
Regioni | 497 – 537 | DisorderedSequence analysisAdd BLAST | 41 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 63 – 85 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 86 – 108 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 510 – 524 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 110 – 132 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 138 – 160 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 166 – 188 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 194 – 216 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 222 – 244 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 250 – 272 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 278 – 300 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 306 – 328 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 334 – 356 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 362 – 384 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 390 – 412 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 418 – 440 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 446 – 468 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 474 – 496 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000165608 |
HOGENOMi | CLU_002678_44_17_1 |
InParanoidi | Q9Y2P0 |
OMAi | PKKPWKC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9Y2P0 |
TreeFami | TF341817 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 14 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9Y2P0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGLLSVALQ GAELEGNWKH EGQVEDLQEN QESCPEPEAV ACKGDPAGDS
60 70 80 90 100
MQERDEFSRI PRTISSPAAT QASVPDDSSS RRCSAPGESP KERHPDSRQR
110 120 130 140 150
ERGGGPKKPW KCGDCGKAFS YCSAFILHQR IHTGEKPFAC PECGKAFSQS
160 170 180 190 200
VHLTLHQRTH TGEKPYACHE CGKAFSQGSY LASHWRTHTG EKPHRCADCG
210 220 230 240 250
KAFTRVTHLT QHRRVHTGER PYACAQCAKA FRNRSSLIEH QRIHTGEKPY
260 270 280 290 300
ECSACAKAFR FSSALIRHQR IHTEEKPYRC GQCAKAFAQI AHLTQHRRVH
310 320 330 340 350
TGEKPYTCQD CGALFSQSAS LAEHRRIHTG EKPYACGQCA KAFTQVSHLT
360 370 380 390 400
QHQRTHTGER PYPCHDCGKR FSNRSHLLQH RLVHTGERPY RCLQCGAAFS
410 420 430 440 450
HVSSLIEHQK IHTGERPYKC GECGKAFSQG SSLALHQRTH TGERPYTCPE
460 470 480 490 500
CGKAFSNRSY LIQHHIVHTG EKPYECSGCG KAFSFSSALI RHQRTHADSS
510 520 530
GRLCPAPTPD STPGLSQGGE TCQQGCPGRN PRGPAED
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0QYX0 | M0QYX0_HUMAN | Zinc finger protein 835 | ZNF835 | 92 | Annotation score: |
Sequence cautioni
The sequence AAD23609 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 156 | H → R in BAH13066 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061977 | 29 | E → K1 PublicationCorresponds to variant dbSNP:rs12462469Ensembl. | 1 | |
Natural variantiVAR_061978 | 88 | E → A1 PublicationCorresponds to variant dbSNP:rs12460400Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK023017 mRNA No translation available. AK299565 mRNA Translation: BAH13066.1 AC007228 Genomic DNA Translation: AAD23609.1 Sequence problems. CH471135 Genomic DNA Translation: EAW72470.1 |
CCDSi | CCDS56105.1 |
RefSeqi | NP_001005850.2, NM_001005850.2 XP_005259439.1, XM_005259382.2 XP_005259440.1, XM_005259383.3 |
Genome annotation databases
Ensembli | ENST00000537055; ENSP00000444747; ENSG00000127903 |
GeneIDi | 90485 |
KEGGi | hsa:90485 |
MANE-Selecti | ENST00000537055.4; ENSP00000444747.1; NM_001005850.3; NP_001005850.2 |
UCSCi | uc010ygn.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK023017 mRNA No translation available. AK299565 mRNA Translation: BAH13066.1 AC007228 Genomic DNA Translation: AAD23609.1 Sequence problems. CH471135 Genomic DNA Translation: EAW72470.1 |
CCDSi | CCDS56105.1 |
RefSeqi | NP_001005850.2, NM_001005850.2 XP_005259439.1, XM_005259382.2 XP_005259440.1, XM_005259383.3 |
3D structure databases
SMRi | Q9Y2P0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124722, 68 interactors |
IntActi | Q9Y2P0, 67 interactors |
STRINGi | 9606.ENSP00000444747 |
PTM databases
iPTMneti | Q9Y2P0 |
PhosphoSitePlusi | Q9Y2P0 |
Genetic variation databases
BioMutai | ZNF835 |
DMDMi | 403314387 |
Proteomic databases
jPOSTi | Q9Y2P0 |
MassIVEi | Q9Y2P0 |
PaxDbi | Q9Y2P0 |
PeptideAtlasi | Q9Y2P0 |
PRIDEi | Q9Y2P0 |
ProteomicsDBi | 32421 85852 |
Protocols and materials databases
Antibodypediai | 33227, 111 antibodies from 17 providers |
DNASUi | 90485 |
Genome annotation databases
Ensembli | ENST00000537055; ENSP00000444747; ENSG00000127903 |
GeneIDi | 90485 |
KEGGi | hsa:90485 |
MANE-Selecti | ENST00000537055.4; ENSP00000444747.1; NM_001005850.3; NP_001005850.2 |
UCSCi | uc010ygn.3, human |
Organism-specific databases
CTDi | 90485 |
GeneCardsi | ZNF835 |
HGNCi | HGNC:34332, ZNF835 |
HPAi | ENSG00000127903, Low tissue specificity |
neXtProti | NX_Q9Y2P0 |
OpenTargetsi | ENSG00000127903 |
PharmGKBi | PA162410787 |
VEuPathDBi | HostDB:ENSG00000127903 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000165608 |
HOGENOMi | CLU_002678_44_17_1 |
InParanoidi | Q9Y2P0 |
OMAi | PKKPWKC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9Y2P0 |
TreeFami | TF341817 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2P0 |
SignaLinki | Q9Y2P0 |
Miscellaneous databases
BioGRID-ORCSi | 90485, 10 hits in 1035 CRISPR screens |
ChiTaRSi | ZNF835, human |
GenomeRNAii | 90485 |
Pharosi | Q9Y2P0, Tdark |
PROi | PR:Q9Y2P0 |
RNActi | Q9Y2P0, protein |
Gene expression databases
Bgeei | ENSG00000127903, Expressed in buccal mucosa cell and 126 other tissues |
ExpressionAtlasi | Q9Y2P0, baseline and differential |
Genevisiblei | Q9Y2P0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 14 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN835_HUMAN | |
Accessioni | Q9Y2P0Primary (citable) accession number: Q9Y2P0 Secondary accession number(s): B7Z5Y0, G3V1S0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | September 5, 2012 | |
Last modified: | February 23, 2022 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families