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UniProtKB - Q9Y2P0 (ZN835_HUMAN)

Entry version 162 (23 Feb 2022)
Sequence version 2 (05 Sep 2012)
Previous versions | rss
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Protein

Zinc finger protein 835

Gene

ZNF835

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri110 – 132C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri138 – 160C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri166 – 188C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri194 – 216C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y2P0

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y2P0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 835
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF835
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:34332, ZNF835

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y2P0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000127903

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000127903

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162410787

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y2P0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF835

Domain mapping of disease mutations (DMDM)

More...DMDMi		403314387

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003191111 – 537Zinc finger protein 835Add BLAST537

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y2P0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y2P0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y2P0

PeptideAtlas

More...PeptideAtlasi		Q9Y2P0

PRoteomics IDEntifications database

More...PRIDEi		Q9Y2P0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		32421
85852

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y2P0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y2P0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000127903, Expressed in buccal mucosa cell and 126 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y2P0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y2P0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000127903, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9Y2P0
With#Exp.IntAct
BEGAIN [Q9BUH8]3EBI-5667516,EBI-742722
BYSL [Q13895]3EBI-5667516,EBI-358049
CABP5 [Q9NP86]3EBI-5667516,EBI-10311131
CCDC130 [P13994]3EBI-5667516,EBI-716093
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-5667516,EBI-10961624
CCDC6 [Q16204]3EBI-5667516,EBI-1045350
CCNDBP1 [O95273]3EBI-5667516,EBI-748961
CDR2L [Q86X02]3EBI-5667516,EBI-11063830
CEP70 [Q8NHQ1]3EBI-5667516,EBI-739624
CIB3 [Q96Q77]3EBI-5667516,EBI-10292696
CLK3 [P49761]5EBI-5667516,EBI-745579
CYSRT1 [A8MQ03]3EBI-5667516,EBI-3867333
DEUP1 [Q05D60]3EBI-5667516,EBI-748597
FSD2 [A1L4K1]3EBI-5667516,EBI-5661036
GOLGA2 [Q08379]3EBI-5667516,EBI-618309
GOLGA6L9 [A6NEM1]3EBI-5667516,EBI-5916454
GOPC - isoform 2 [Q9HD26-2]3EBI-5667516,EBI-11102276
GRIPAP1 [Q4V328]3EBI-5667516,EBI-717919
GUCD1 - isoform 2 [Q96NT3-2]3EBI-5667516,EBI-11978177
HAP1 [P54257]3EBI-5667516,EBI-712814
HOOK2 - isoform 2 [Q96ED9-2]3EBI-5667516,EBI-10961706
HOXB1 [Q4VB01]3EBI-5667516,EBI-17494170
HSF2BP [O75031]3EBI-5667516,EBI-7116203
IKBKG [Q9Y6K9]3EBI-5667516,EBI-81279
IL16 - isoform 2 [Q14005-2]3EBI-5667516,EBI-17178971
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-5667516,EBI-14069005
KRT31 [Q15323]3EBI-5667516,EBI-948001
KRTAP12-3 [P60328]3EBI-5667516,EBI-11953334
KRTAP4-5 [Q9BYR2]3EBI-5667516,EBI-11993254
LDOC1 [O95751]3EBI-5667516,EBI-740738
MAGOHB [Q96A72]3EBI-5667516,EBI-746778
MKRN3 [Q13064]3EBI-5667516,EBI-2340269
MYF5 [P13349]3EBI-5667516,EBI-17491620
OSBPL3 [Q9H4L5]3EBI-5667516,EBI-1051317
POLR1C [O15160]3EBI-5667516,EBI-1055079
PRDM14 [Q9GZV8]3EBI-5667516,EBI-3957793
RINT1 [Q6NUQ1]3EBI-5667516,EBI-726876
RNF187 [Q5TA31]3EBI-5667516,EBI-6868977
RUNDC3A - isoform 3 [Q59EK9-3]3EBI-5667516,EBI-11957366
SHCBP1L [Q9BZQ2]3EBI-5667516,EBI-10818532
SHFL - isoform 4 [Q9NUL5-4]3EBI-5667516,EBI-11955083
SPATA2 [Q9UM82]3EBI-5667516,EBI-744066
STAMBPL1 [Q96FJ0]3EBI-5667516,EBI-745021
STX1A [Q16623]3EBI-5667516,EBI-712466
TEX12 [Q9BXU0]3EBI-5667516,EBI-12090309
TLE5 - isoform 2 [Q08117-2]3EBI-5667516,EBI-11741437
TRAF4 [Q9BUZ4]3EBI-5667516,EBI-3650647
TRIM23 [P36406]3EBI-5667516,EBI-740098
TRIM41 [Q8WV44]6EBI-5667516,EBI-725997
TSPYL2 [Q9H2G4]3EBI-5667516,EBI-947459
TXK [P42681]3EBI-5667516,EBI-7877438
U2AF2 - isoform 2 [P26368-2]3EBI-5667516,EBI-11097439
ZNF121 [P58317]3EBI-5667516,EBI-1228269
ZNF202 [O95125]3EBI-5667516,EBI-751960
ZNF343 [Q6P1L6]3EBI-5667516,EBI-10252492
ZNF497 [Q6ZNH5]3EBI-5667516,EBI-10486136
ZNF524 [Q96C55]3EBI-5667516,EBI-10283126
ZNF526 [Q8TF50]3EBI-5667516,EBI-11035148
ZNF552 [Q9H707]3EBI-5667516,EBI-2555731
ZNF572 [Q7Z3I7]3EBI-5667516,EBI-10172590
ZNF629 [Q9UEG4]3EBI-5667516,EBI-9977294
ZNF71 [Q9NQZ8]3EBI-5667516,EBI-7138235
ZNF768 [Q9H5H4]3EBI-5667516,EBI-1210580
ZNF792 [Q3KQV3]3EBI-5667516,EBI-10240849
ZNF837 [Q96EG3]3EBI-5667516,EBI-11962574

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124722, 68 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y2P0, 67 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000444747

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y2P0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y2P0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni12 – 109DisorderedSequence analysisAdd BLAST98
Regioni497 – 537DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi63 – 85Polar residuesSequence analysisAdd BLAST23
Compositional biasi86 – 108Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi510 – 524Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri110 – 132C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri138 – 160C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri166 – 188C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri194 – 216C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000165608

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_44_17_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y2P0

Identification of Orthologs from Complete Genome Data

More...OMAi		PKKPWKC

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y2P0

TreeFam database of animal gene trees

More...TreeFami		TF341817

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 14 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 14 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 9 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 14 hits
PS50157, ZINC_FINGER_C2H2_2, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y2P0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGLLSVALQ GAELEGNWKH EGQVEDLQEN QESCPEPEAV ACKGDPAGDS 
        60         70         80         90        100
MQERDEFSRI PRTISSPAAT QASVPDDSSS RRCSAPGESP KERHPDSRQR 
       110        120        130        140        150
ERGGGPKKPW KCGDCGKAFS YCSAFILHQR IHTGEKPFAC PECGKAFSQS 
       160        170        180        190        200
VHLTLHQRTH TGEKPYACHE CGKAFSQGSY LASHWRTHTG EKPHRCADCG 
       210        220        230        240        250
KAFTRVTHLT QHRRVHTGER PYACAQCAKA FRNRSSLIEH QRIHTGEKPY 
       260        270        280        290        300
ECSACAKAFR FSSALIRHQR IHTEEKPYRC GQCAKAFAQI AHLTQHRRVH 
       310        320        330        340        350
TGEKPYTCQD CGALFSQSAS LAEHRRIHTG EKPYACGQCA KAFTQVSHLT 
       360        370        380        390        400
QHQRTHTGER PYPCHDCGKR FSNRSHLLQH RLVHTGERPY RCLQCGAAFS 
       410        420        430        440        450
HVSSLIEHQK IHTGERPYKC GECGKAFSQG SSLALHQRTH TGERPYTCPE 
       460        470        480        490        500
CGKAFSNRSY LIQHHIVHTG EKPYECSGCG KAFSFSSALI RHQRTHADSS 
       510        520        530 
GRLCPAPTPD STPGLSQGGE TCQQGCPGRN PRGPAED
Length:537
Mass (Da):59,631
Last modified:September 5, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99746C9E4D456DAB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYX0M0QYX0_HUMAN
Zinc finger protein 835
ZNF835
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD23609 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti156H → R in BAH13066 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06197729E → K1 PublicationCorresponds to variant dbSNP:rs12462469Ensembl.1
Natural variantiVAR_06197888E → A1 PublicationCorresponds to variant dbSNP:rs12460400Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK023017 mRNA No translation available.
AK299565 mRNA Translation: BAH13066.1
AC007228 Genomic DNA Translation: AAD23609.1 Sequence problems.
CH471135 Genomic DNA Translation: EAW72470.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS56105.1

NCBI Reference Sequences

More...RefSeqi		NP_001005850.2, NM_001005850.2
XP_005259439.1, XM_005259382.2
XP_005259440.1, XM_005259383.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000537055; ENSP00000444747; ENSG00000127903

Database of genes from NCBI RefSeq genomes

More...GeneIDi		90485

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:90485

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000537055.4; ENSP00000444747.1; NM_001005850.3; NP_001005850.2

UCSC genome browser

More...UCSCi		uc010ygn.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023017 mRNA No translation available.
AK299565 mRNA Translation: BAH13066.1
AC007228 Genomic DNA Translation: AAD23609.1 Sequence problems.
CH471135 Genomic DNA Translation: EAW72470.1
CCDSiCCDS56105.1
RefSeqiNP_001005850.2, NM_001005850.2
XP_005259439.1, XM_005259382.2
XP_005259440.1, XM_005259383.3

3D structure databases

SMRiQ9Y2P0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124722, 68 interactors
IntActiQ9Y2P0, 67 interactors
STRINGi9606.ENSP00000444747

PTM databases

iPTMnetiQ9Y2P0
PhosphoSitePlusiQ9Y2P0

Genetic variation databases

BioMutaiZNF835
DMDMi403314387

Proteomic databases

jPOSTiQ9Y2P0
MassIVEiQ9Y2P0
PaxDbiQ9Y2P0
PeptideAtlasiQ9Y2P0
PRIDEiQ9Y2P0
ProteomicsDBi32421
85852

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33227, 111 antibodies from 17 providers

The DNASU plasmid repository

More...DNASUi		90485

Genome annotation databases

EnsembliENST00000537055; ENSP00000444747; ENSG00000127903
GeneIDi90485
KEGGihsa:90485
MANE-SelectiENST00000537055.4; ENSP00000444747.1; NM_001005850.3; NP_001005850.2
UCSCiuc010ygn.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		90485

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF835
HGNCiHGNC:34332, ZNF835
HPAiENSG00000127903, Low tissue specificity
neXtProtiNX_Q9Y2P0
OpenTargetsiENSG00000127903
PharmGKBiPA162410787
VEuPathDBiHostDB:ENSG00000127903

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000165608
HOGENOMiCLU_002678_44_17_1
InParanoidiQ9Y2P0
OMAiPKKPWKC
OrthoDBi1318335at2759
PhylomeDBiQ9Y2P0
TreeFamiTF341817

Enzyme and pathway databases

PathwayCommonsiQ9Y2P0
SignaLinkiQ9Y2P0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		90485, 10 hits in 1035 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF835, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		90485
PharosiQ9Y2P0, Tdark

Protein Ontology

More...PROi		PR:Q9Y2P0
RNActiQ9Y2P0, protein

Gene expression databases

BgeeiENSG00000127903, Expressed in buccal mucosa cell and 126 other tissues
ExpressionAtlasiQ9Y2P0, baseline and differential
GenevisibleiQ9Y2P0, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 14 hits
SUPFAMiSSF57667, SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 14 hits
PS50157, ZINC_FINGER_C2H2_2, 14 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN835_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2P0
Secondary accession number(s): B7Z5Y0, G3V1S0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 5, 2012
Last modified: February 23, 2022
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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