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UniProtKB - Q9Y2M5 (KLH20_HUMAN)

Entry version 173 (07 Apr 2021)
Sequence version 4 (01 Sep 2009)
Previous versions | rss
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Protein

Kelch-like protein 20

Gene

KLHL20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression (PubMed:21840486).6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processProtein transport, Transport, Ubl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y2M5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8951664, Neddylation
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kelch-like protein 20
Alternative name(s):
Kelch-like ECT2-interacting protein
Kelch-like protein X
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLHL20
Synonyms:KLEIP, KLHLX
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25056, KLHL20

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617679, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y2M5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000076321.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm, Golgi apparatus, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi109V → A in KLHL20m6; abolishes interaction with CUL3; when associated with A-111; A-113; A-146; A-148 and A-150. 4 Publications1
Mutagenesisi111I → A in KLHL20m6; abolishes interaction with CUL3; when associated with A-109; A-113; A-146; A-148 and A-150. 4 Publications1
Mutagenesisi113D → A in KLHL20m6; abolishes interaction with CUL3; when associated with A-109; A-111; A-146; A-148 and A-150. 4 Publications1
Mutagenesisi146C → A in KLHL20m6; abolishes interaction with CUL3; when associated with A-109; A-111; A-113; A-148 and A-150. 4 Publications1
Mutagenesisi148L → A in KLHL20m6; abolishes interaction with CUL3; when associated with A-109; A-111; A-113; A-146 and A-150. 4 Publications1
Mutagenesisi150L → A in KLHL20m6; abolishes interaction with CUL3; when associated with A-109; A-111; A-113; A-146 and A-148. 4 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		27252

Open Targets

More...OpenTargetsi		ENSG00000076321

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134982126

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y2M5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KLHL20

Domain mapping of disease mutations (DMDM)

More...DMDMi		257051084

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001191231 – 609Kelch-like protein 20Add BLAST609

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y2M5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y2M5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y2M5

PeptideAtlas

More...PeptideAtlasi		Q9Y2M5

PRoteomics IDEntifications database

More...PRIDEi		Q9Y2M5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5204
85844 [Q9Y2M5-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y2M5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y2M5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By hypoxia.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000076321, Expressed in secondary oocyte and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y2M5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y2M5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000076321, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the BCR(KLHL20) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL20 and RBX1.

Interacts with PDZ-RhoGEF/ARHGEF11, DAPK1, PML and CORO7.

Interacts with F-actin.

Interacts with IFN-gamma (IFNG).

Interacts (via kelch repeats) with IVNS1ABP (via kelch repeats); this interaction blocks the assembly of CUL3-KLHL20 complex (PubMed:25619834).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9Y2M5
With#Exp.IntAct
ATN1 [Q86V38]3EBI-714379,EBI-11954292
ATXN1 [P54253]6EBI-714379,EBI-930964
ATXN3 [P54252]3EBI-714379,EBI-946046
BAG6 - isoform 2 [P46379-2]3EBI-714379,EBI-10988864
CRYAA2 [A0A140G945]3EBI-714379,EBI-25838900
CUL3 [Q13618]6EBI-714379,EBI-456129
DAPK1 [P53355]11EBI-714379,EBI-358616
DBH [P09172]3EBI-714379,EBI-8589586
DCTN1 - isoform 5 [Q14203-5]3EBI-714379,EBI-25840379
DMWD [G5E9A7]3EBI-714379,EBI-10976677
F13A1 [P00488]3EBI-714379,EBI-2565863
FGFR3 [P22607]3EBI-714379,EBI-348399
GFAP [P14136]3EBI-714379,EBI-744302
GIPC1 - isoform 2 [O14908-2]3EBI-714379,EBI-25913156
GLE1 [Q53GS7]3EBI-714379,EBI-1955541
GRN [P28799]3EBI-714379,EBI-747754
GSN [P06396]3EBI-714379,EBI-351506
HSPB1 [P04792]3EBI-714379,EBI-352682
HTRA2 [O43464]3EBI-714379,EBI-517086
HTT [P42858]9EBI-714379,EBI-466029
KIF1B - isoform 2 [O60333-2]3EBI-714379,EBI-10975473
KLF11 [O14901]3EBI-714379,EBI-948266
KLK6 [Q92876]3EBI-714379,EBI-2432309
MECP2 [P51608]3EBI-714379,EBI-1189067
NDUFV2 [P19404]3EBI-714379,EBI-713665
NOS3 [P29474]3EBI-714379,EBI-1391623
PAK1 [Q13153]3EBI-714379,EBI-1307
PHYH [O14832]3EBI-714379,EBI-721853
PML [P29590]9EBI-714379,EBI-295890
PMP22 [D3DTS7]3EBI-714379,EBI-25882629
PRKN - isoform 5 [O60260-5]3EBI-714379,EBI-21251460
PRMT6 [Q96LA8]2EBI-714379,EBI-912440
PRPS1 [P60891]3EBI-714379,EBI-749195
RNF11 [Q9Y3C5]3EBI-714379,EBI-396669
SNCA [P37840]3EBI-714379,EBI-985879
SPRED1 [Q7Z699]3EBI-714379,EBI-5235340
TARDBP [Q13148]3EBI-714379,EBI-372899
TSC1 [Q86WV8]3EBI-714379,EBI-12806590
TTR [P02766]3EBI-714379,EBI-711909
WFS1 [O76024]3EBI-714379,EBI-720609

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118100, 107 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9Y2M5

Protein interaction database and analysis system

More...IntActi		Q9Y2M5, 99 interactors

Molecular INTeraction database

More...MINTi		Q9Y2M5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000209884

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y2M5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1609
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y2M5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini68 – 135BTBPROSITE-ProRule annotationAdd BLAST68
Domaini170 – 272BACKAdd BLAST103
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati319 – 365Kelch 1Add BLAST47
Repeati367 – 413Kelch 2Add BLAST47
Repeati414 – 460Kelch 3Add BLAST47
Repeati462 – 507Kelch 4Add BLAST46
Repeati509 – 554Kelch 5Add BLAST46
Repeati556 – 601Kelch 6Add BLAST46

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4441, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155161

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004253_14_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y2M5

Identification of Orthologs from Complete Genome Data

More...OMAi		NSWSPIV

Database of Orthologous Groups

More...OrthoDBi		731760at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y2M5

TreeFam database of animal gene trees

More...TreeFami		TF329218

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.120.10.80, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011705, BACK
IPR017096, BTB-kelch_protein
IPR000210, BTB/POZ_dom
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1
IPR030594, KLHL17/KLHL20
IPR011333, SKP1/BTB/POZ_sf

The PANTHER Classification System

More...PANTHERi		PTHR24412:SF454, PTHR24412:SF454, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07707, BACK, 1 hit
PF00651, BTB, 1 hit
PF01344, Kelch_1, 6 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037037, Kelch-like_protein_gigaxonin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00875, BACK, 1 hit
SM00225, BTB, 1 hit
SM00612, Kelch, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF117281, SSF117281, 1 hit
SSF54695, SSF54695, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50097, BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y2M5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGKPMRRCT NIRPGETGMD VTSRCTLGDP NKLPEGVPQP ARMPYISDKH 
        60         70         80         90        100
PRQTLEVINL LRKHRELCDV VLVVGAKKIY AHRVILSACS PYFRAMFTGE 
       110        120        130        140        150
LAESRQTEVV IRDIDERAME LLIDFAYTSQ ITVEEGNVQT LLPAACLLQL 
       160        170        180        190        200
AEIQEACCEF LKRQLDPSNC LGIRAFADTH SCRELLRIAD KFTQHNFQEV 
       210        220        230        240        250
MESEEFMLLP ANQLIDIISS DELNVRSEEQ VFNAVMAWVK YSIQERRPQL 
       260        270        280        290        300
PQVLQHVRLP LLSPKFLVGT VGSDPLIKSD EECRDLVDEA KNYLLLPQER 
       310        320        330        340        350
PLMQGPRTRP RKPIRCGEVL FAVGGWCSGD AISSVERYDP QTNEWRMVAS 
       360        370        380        390        400
MSKRRCGVGV SVLDDLLYAV GGHDGSSYLN SVERYDPKTN QWSSDVAPTS 
       410        420        430        440        450
TCRTSVGVAV LGGFLYAVGG QDGVSCLNIV ERYDPKENKW TRVASMSTRR 
       460        470        480        490        500
LGVAVAVLGG FLYAVGGSDG TSPLNTVERY NPQENRWHTI APMGTRRKHL 
       510        520        530        540        550
GCAVYQDMIY AVGGRDDTTE LSSAERYNPR TNQWSPVVAM TSRRSGVGLA 
       560        570        580        590        600
VVNGQLMAVG GFDGTTYLKT IEVFDPDANT WRLYGGMNYR RLGGGVGVIK 

MTHCESHIW
Length:609
Mass (Da):67,955
Last modified:September 1, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA05E3FE8341B422
GO
Isoform 2 (identifier: Q9Y2M5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MEGKPMRRCT → MVHGRKANAQ
     11-199: Missing.

Show »
Length:420
Mass (Da):46,490
Checksum:i87CFCA63FAB1F719
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti171L → Q in BAG50912 (PubMed:14702039).Curated1
Sequence conflicti321F → S in BAG50912 (PubMed:14702039).Curated1
Sequence conflicti334S → N in BAG50912 (PubMed:14702039).Curated1
Sequence conflicti396V → M in BAG50912 (PubMed:14702039).Curated1
Sequence conflicti593G → W in BAA77027 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0570261 – 10MEGKPMRRCT → MVHGRKANAQ in isoform 2. 1 Publication10
Alternative sequenceiVSP_05702711 – 199Missing in isoform 2. 1 PublicationAdd BLAST189

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ844466 mRNA Translation: CAH59617.1
AB026190 mRNA Translation: BAA77027.1
AK001430 mRNA Translation: BAG50912.1
AK300755 mRNA Translation: BAG62422.1
AL109921 Genomic DNA No translation available.
BX248409 Genomic DNA No translation available.
BC063418 mRNA Translation: AAH63418.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1310.1 [Q9Y2M5-1]

NCBI Reference Sequences

More...RefSeqi		NP_055273.2, NM_014458.3 [Q9Y2M5-1]
XP_005245150.1, XM_005245093.3 [Q9Y2M5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000209884; ENSP00000209884; ENSG00000076321 [Q9Y2M5-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27252

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27252

UCSC genome browser

More...UCSCi		uc001gjc.5, human [Q9Y2M5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ844466 mRNA Translation: CAH59617.1
AB026190 mRNA Translation: BAA77027.1
AK001430 mRNA Translation: BAG50912.1
AK300755 mRNA Translation: BAG62422.1
AL109921 Genomic DNA No translation available.
BX248409 Genomic DNA No translation available.
BC063418 mRNA Translation: AAH63418.1
CCDSiCCDS1310.1 [Q9Y2M5-1]
RefSeqiNP_055273.2, NM_014458.3 [Q9Y2M5-1]
XP_005245150.1, XM_005245093.3 [Q9Y2M5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YQ4X-ray1.58A303-600[»]
6GY5X-ray1.09A303-605[»]
SMRiQ9Y2M5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi118100, 107 interactors
CORUMiQ9Y2M5
IntActiQ9Y2M5, 99 interactors
MINTiQ9Y2M5
STRINGi9606.ENSP00000209884

PTM databases

iPTMnetiQ9Y2M5
PhosphoSitePlusiQ9Y2M5

Genetic variation databases

BioMutaiKLHL20
DMDMi257051084

Proteomic databases

EPDiQ9Y2M5
MassIVEiQ9Y2M5
PaxDbiQ9Y2M5
PeptideAtlasiQ9Y2M5
PRIDEiQ9Y2M5
ProteomicsDBi5204
85844 [Q9Y2M5-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20562, 103 antibodies

Genome annotation databases

EnsembliENST00000209884; ENSP00000209884; ENSG00000076321 [Q9Y2M5-1]
GeneIDi27252
KEGGihsa:27252
UCSCiuc001gjc.5, human [Q9Y2M5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27252
DisGeNETi27252

GeneCards: human genes, protein and diseases

More...GeneCardsi		KLHL20
HGNCiHGNC:25056, KLHL20
HPAiENSG00000076321, Low tissue specificity
MIMi617679, gene
neXtProtiNX_Q9Y2M5
OpenTargetsiENSG00000076321
PharmGKBiPA134982126
VEuPathDBiHostDB:ENSG00000076321.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4441, Eukaryota
GeneTreeiENSGT00940000155161
HOGENOMiCLU_004253_14_2_1
InParanoidiQ9Y2M5
OMAiNSWSPIV
OrthoDBi731760at2759
PhylomeDBiQ9Y2M5
TreeFamiTF329218

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ9Y2M5
ReactomeiR-HSA-8951664, Neddylation
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27252, 7 hits in 1008 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KLHL20, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KLHL20

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27252
PharosiQ9Y2M5, Tbio

Protein Ontology

More...PROi		PR:Q9Y2M5
RNActiQ9Y2M5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000076321, Expressed in secondary oocyte and 235 other tissues
ExpressionAtlasiQ9Y2M5, baseline and differential
GenevisibleiQ9Y2M5, HS

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705, BACK
IPR017096, BTB-kelch_protein
IPR000210, BTB/POZ_dom
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1
IPR030594, KLHL17/KLHL20
IPR011333, SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF454, PTHR24412:SF454, 2 hits
PfamiView protein in Pfam
PF07707, BACK, 1 hit
PF00651, BTB, 1 hit
PF01344, Kelch_1, 6 hits
PIRSFiPIRSF037037, Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875, BACK, 1 hit
SM00225, BTB, 1 hit
SM00612, Kelch, 6 hits
SUPFAMiSSF117281, SSF117281, 1 hit
SSF54695, SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097, BTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLH20_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2M5
Secondary accession number(s): B3KMA0
, B4DUR0, Q5TZF2, Q5ZF45, Q9H457
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: September 1, 2009
Last modified: April 7, 2021
This is version 173 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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