UniProtKB - Q9Y2M0 (FAN1_HUMAN)
Protein
Fanconi-associated nuclease 1
Gene
FAN1
Organism
Homo sapiens (Human)
Status
Functioni
Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).7 Publications
Catalytic activityi
- Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.2 Publications EC:3.1.4.1
Cofactori
Mn2+1 Publication, Mg2+1 PublicationNote: Binds 2 magnesium or manganese ions per subunit.By similarity1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 834 | Magnesium or manganese 2By similarity | 1 | |
Metal bindingi | 960 | Magnesium or manganese 11 Publication | 1 | |
Metal bindingi | 960 | Magnesium or manganese 21 Publication | 1 | |
Metal bindingi | 975 | Magnesium or manganese 11 Publication | 1 | |
Metal bindingi | 976 | Magnesium or manganese 1; via carbonyl oxygenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 41 – 69 | UBZ4-typePROSITE-ProRule annotationAdd BLAST | 29 |
GO - Molecular functioni
- 5'-3' exonuclease activity Source: UniProtKB
- 5'-flap endonuclease activity Source: UniProtKB
- flap-structured DNA binding Source: UniProtKB
- magnesium ion binding Source: UniProtKB
- phosphodiesterase I activity Source: UniProtKB-EC
- ubiquitin-dependent protein binding Source: UniProtKB
GO - Biological processi
- DNA repair Source: UniProtKB
- double-strand break repair via homologous recombination Source: UniProtKB
- interstrand cross-link repair Source: UniProtKB
- nucleotide-excision repair Source: UniProtKB
- nucleotide-excision repair, DNA incision Source: UniProtKB
Keywordsi
Molecular function | Endonuclease, Exonuclease, Hydrolase, Nuclease |
Biological process | DNA damage, DNA repair |
Ligand | Magnesium, Manganese, Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2M0 |
Reactomei | R-HSA-6783310, Fanconi Anemia Pathway |
Names & Taxonomyi
Protein namesi | |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29170, FAN1 |
MIMi | 613534, gene |
neXtProti | NX_Q9Y2M0 |
VEuPathDBi | HostDB:ENSG00000198690.9 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- intercellular bridge Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Interstitial nephritis, karyomegalic (KMIN)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare kidney disease characterized by chronic tubulointerstitial nephritis associated with massively enlarged tubular epithelial cell nuclei. The clinical picture is associated with recurrent upper respiratory tract infections in addition to chronic kidney disease beginning in the third decade of life.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068958 | 871 | C → R in KMIN; partially complement cell survival upon exposure to mitomycin C. 1 Publication | 1 | |
Natural variantiVAR_068959 | 929 | Q → P in KMIN. 1 Publication | 1 | |
Natural variantiVAR_068960 | 937 | G → D in KMIN. 1 PublicationCorresponds to variant dbSNP:rs1270571213Ensembl. | 1 | |
Natural variantiVAR_068961 | 960 | D → N in KMIN. 1 PublicationCorresponds to variant dbSNP:rs751703979Ensembl. | 1 |
Schizophrenia and autism. Schizophrenia is a severe psychiatric disorder characterized by positive, negative, and cognitive symptoms, and it is associated with increased mortality and severely reduced fecundity. Autim is a complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.Disease susceptibility may be associated with variants affecting the gene represented in this entry.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 44 | C → A: Abolishes interaction with monoubiquitinated FANCD2; when associated with A-47. 3 Publications | 1 | |
Mutagenesisi | 47 | C → A: Abolishes interaction with monoubiquitinated FANCD2; when associated with A-44. 2 Publications | 1 | |
Mutagenesisi | 477 | L → P: Still localized to sites of DNA damage but the strength of the signal is diminished. 1 Publication | 1 | |
Mutagenesisi | 706 | R → A: Strongly reduced affinity for sites that have a 5'-terminal phosphate anchor at a flap of 1 nucleotide; when associated with A-952. 1 Publication | 1 | |
Mutagenesisi | 864 | Q → A: Loss of nuclease activity; when associated with A-960; A-975 and A-977. 1 Publication | 1 | |
Mutagenesisi | 952 | R → A: Strongly reduced affinity for sites that have a 5'-terminal phosphate anchor at a flap of 1 nucleotide; when associated with A-706. 1 Publication | 1 | |
Mutagenesisi | 960 | D → A: Loss of nuclease activity. Loss of nuclease activity; when associated with A-864; A-975 and A-977. 3 Publications | 1 | |
Mutagenesisi | 975 | E → A: Loss of nuclease activity; when associated with A-864; A-960 and A-977. 1 Publication | 1 | |
Mutagenesisi | 977 | K → A: Loss of nuclease activity; when associated with A-864; A-960 and A-975. 2 Publications | 1 | |
Mutagenesisi | 981 – 982 | DR → AA: Loss of nuclease activity. 1 Publication | 2 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 22909 |
MalaCardsi | FAN1 |
MIMi | 614817, phenotype |
OpenTargetsi | ENSG00000198690 |
Orphaneti | 401996, Karyomegalic interstitial nephritis 144, Lynch syndrome |
PharmGKBi | PA165478601 |
Miscellaneous databases
Pharosi | Q9Y2M0, Tbio |
Genetic variation databases
BioMutai | FAN1 |
DMDMi | 160410012 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000311224 | 1 – 1017 | Fanconi-associated nuclease 1Add BLAST | 1017 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 180 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Ubiquitinated and degraded during mitotic exit by the APC/C-Cdh1 complex.1 Publication
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9Y2M0 |
jPOSTi | Q9Y2M0 |
MassIVEi | Q9Y2M0 |
PaxDbi | Q9Y2M0 |
PeptideAtlasi | Q9Y2M0 |
PRIDEi | Q9Y2M0 |
ProteomicsDBi | 85841 [Q9Y2M0-1] 85842 [Q9Y2M0-2] |
PTM databases
DEPODi | FAN1 |
iPTMneti | Q9Y2M0 |
PhosphoSitePlusi | Q9Y2M0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198690, Expressed in tibia and 227 other tissues |
ExpressionAtlasi | Q9Y2M0, baseline and differential |
Genevisiblei | Q9Y2M0, HS |
Organism-specific databases
HPAi | ENSG00000198690, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with FANCD2 (when monoubiquitinated).
Interacts with FANCI, MLH1, MLH3 and PMS2.
4 PublicationsGO - Molecular functioni
- ubiquitin-dependent protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116573, 53 interactors |
IntActi | Q9Y2M0, 24 interactors |
MINTi | Q9Y2M0 |
STRINGi | 9606.ENSP00000354497 |
Miscellaneous databases
RNActi | Q9Y2M0, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9Y2M0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 895 – 1007 | VRR-NUCAdd BLAST | 113 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 671 – 696 | Sequence analysisAdd BLAST | 26 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 14 – 22 | D-boxCurated | 9 | |
Motifi | 212 – 214 | KEN boxCurated | 3 |
Domaini
The UBZ4-type zinc finger specifically binds monoubiquitinated FANCD2.4 Publications
The KEN box and D-box are required for interaction with FZR1/CDH1 and essential for APC(CDH1)-mediated ubiquitination.1 Publication
Sequence similaritiesi
Belongs to the FAN1 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 41 – 69 | UBZ4-typePROSITE-ProRule annotationAdd BLAST | 29 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2143, Eukaryota |
GeneTreei | ENSGT00390000018637 |
HOGENOMi | CLU_005116_4_0_1 |
InParanoidi | Q9Y2M0 |
OMAi | FQTCPLD |
OrthoDBi | 1003565at2759 |
PhylomeDBi | Q9Y2M0 |
TreeFami | TF312870 |
Family and domain databases
Gene3Di | 3.40.1350.10, 1 hit |
InterProi | View protein in InterPro IPR033315, Fan1-like IPR006642, Rad18_UBZ4 IPR011856, tRNA_endonuc-like_dom_sf IPR014883, VRR_NUC |
PANTHERi | PTHR15749, PTHR15749, 1 hit |
Pfami | View protein in Pfam PF08774, VRR_NUC, 1 hit |
SMARTi | View protein in SMART SM00990, VRR_NUC, 1 hit SM00734, ZnF_Rad18, 1 hit |
PROSITEi | View protein in PROSITE PS51908, ZF_UBZ4, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y2M0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMSEGKPPDK KRPRRSLSIS KNKKKASNSI ISCFNNAPPA KLACPVCSKM
60 70 80 90 100
VPRYDLNRHL DEMCANNDFV QVDPGQVGLI NSNVSMVDLT SVTLEDVTPK
110 120 130 140 150
KSPPPKTNLT PGQSDSAKRE VKQKISPYFK SNDVVCKNQD ELRNRSVKVI
160 170 180 190 200
CLGSLASKLS RKYVKAKKSI DKDEEFAGSS PQSSKSTVVK SLIDNSSEIE
210 220 230 240 250
DEDQILENSS QKENVFKCDS LKEECIPEHM VRGSKIMEAE SQKATRECEK
260 270 280 290 300
SALTPGFSDN AIMLFSPDFT LRNTLKSTSE DSLVKQECIK EVVEKREACH
310 320 330 340 350
CEEVKMTVAS EAKIQLSDSE AKSHSSADDA SAWSNIQEAP LQDDSCLNND
360 370 380 390 400
IPHSIPLEQG SSCNGPGQTT GHPYYLRSFL VVLKTVLENE DDMLLFDEQE
410 420 430 440 450
KGIVTKFYQL SATGQKLYVR LFQRKLSWIK MTKLEYEEIA LDLTPVIEEL
460 470 480 490 500
TNAGFLQTES ELQELSEVLE LLSAPELKSL AKTFHLVNPN GQKQQLVDAF
510 520 530 540 550
LKLAKQRSVC TWGKNKPGIG AVILKRAKAL AGQSVRICKG PRAVFSRILL
560 570 580 590 600
LFSLTDSMED EDAACGGQGQ LSTVLLVNLG RMEFPSYTIN RKTHIFQDRD
610 620 630 640 650
DLIRYAAATH MLSDISSAMA NGNWEEAKEL AQCAKRDWNR LKNHPSLRCH
660 670 680 690 700
EDLPLFLRCF TVGWIYTRIL SRFVEILQRL HMYEEAVREL ESLLSQRIYC
710 720 730 740 750
PDSRGRWWDR LALNLHQHLK RLEPTIKCIT EGLADPEVRT GHRLSLYQRA
760 770 780 790 800
VRLRESPSCK KFKHLFQQLP EMAVQDVKHV TITGRLCPQR GMCKSVFVME
810 820 830 840 850
AGEAADPTTV LCSVEELALA HYRRSGFDQG IHGEGSTFST LYGLLLWDII
860 870 880 890 900
FMDGIPDVFR NACQAFPLDL CTDSFFTSRR PALEARLQLI HDAPEESLRA
910 920 930 940 950
WVAATWHEQE GRVASLVSWD RFTSLQQAQD LVSCLGGPVL SGVCRHLAAD
960 970 980 990 1000
FRHCRGGLPD LVVWNSQSRH FKLVEVKGPN DRLSHKQMIW LAELQKLGAE
1010
VEVCHVVAVG AKSQSLS
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BQ24 | H3BQ24_HUMAN | Fanconi-associated nuclease | FAN1 | 430 | Annotation score: | ||
A0A590UJL5 | A0A590UJL5_HUMAN | Fanconi-associated nuclease | FAN1 | 573 | Annotation score: | ||
A0A590UJF5 | A0A590UJF5_HUMAN | Fanconi-associated nuclease | FAN1 | 318 | Annotation score: | ||
A0A590UKC0 | A0A590UKC0_HUMAN | Fanconi-associated nuclease | FAN1 | 587 | Annotation score: | ||
H3BUK3 | H3BUK3_HUMAN | Fanconi-associated nuclease | FAN1 | 103 | Annotation score: | ||
A0A590UK78 | A0A590UK78_HUMAN | Fanconi-associated nuclease | FAN1 | 298 | Annotation score: | ||
A0A590UJ38 | A0A590UJ38_HUMAN | Fanconi-associated nuclease 1 | FAN1 | 237 | Annotation score: |
Sequence cautioni
The sequence AAH47882 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA76862 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 9 | D → DK in AAH47882 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 319 | S → P in BAF83676 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 487 | V → A in BAA76862 (PubMed:10231032).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037167 | 233 | G → E1 PublicationCorresponds to variant dbSNP:rs4779794EnsemblClinVar. | 1 | |
Natural variantiVAR_068958 | 871 | C → R in KMIN; partially complement cell survival upon exposure to mitomycin C. 1 Publication | 1 | |
Natural variantiVAR_068959 | 929 | Q → P in KMIN. 1 Publication | 1 | |
Natural variantiVAR_068960 | 937 | G → D in KMIN. 1 PublicationCorresponds to variant dbSNP:rs1270571213Ensembl. | 1 | |
Natural variantiVAR_068961 | 960 | D → N in KMIN. 1 PublicationCorresponds to variant dbSNP:rs751703979Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029429 | 527 – 533 | AKALAGQ → FCWLLLQ in isoform 2. 2 Publications | 7 | |
Alternative sequenceiVSP_029430 | 534 – 1017 | Missing in isoform 2. 2 PublicationsAdd BLAST | 484 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023235 mRNA Translation: BAA76862.3 Different initiation. AK290987 mRNA Translation: BAF83676.1 AC087481 Genomic DNA No translation available. BC047882 mRNA Translation: AAH47882.1 Different initiation. |
CCDSi | CCDS32186.1 [Q9Y2M0-1] CCDS58344.1 [Q9Y2M0-2] |
RefSeqi | NP_001139566.1, NM_001146094.1 [Q9Y2M0-2] NP_001139567.1, NM_001146095.1 [Q9Y2M0-2] NP_001139568.1, NM_001146096.1 [Q9Y2M0-2] NP_055782.3, NM_014967.4 [Q9Y2M0-1] XP_005254289.1, XM_005254232.4 [Q9Y2M0-1] XP_005254291.1, XM_005254234.4 [Q9Y2M0-1] XP_005254292.1, XM_005254235.3 [Q9Y2M0-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023235 mRNA Translation: BAA76862.3 Different initiation. AK290987 mRNA Translation: BAF83676.1 AC087481 Genomic DNA No translation available. BC047882 mRNA Translation: AAH47882.1 Different initiation. |
CCDSi | CCDS32186.1 [Q9Y2M0-1] CCDS58344.1 [Q9Y2M0-2] |
RefSeqi | NP_001139566.1, NM_001146094.1 [Q9Y2M0-2] NP_001139567.1, NM_001146095.1 [Q9Y2M0-2] NP_001139568.1, NM_001146096.1 [Q9Y2M0-2] NP_055782.3, NM_014967.4 [Q9Y2M0-1] XP_005254289.1, XM_005254232.4 [Q9Y2M0-1] XP_005254291.1, XM_005254234.4 [Q9Y2M0-1] XP_005254292.1, XM_005254235.3 [Q9Y2M0-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4REA | X-ray | 3.81 | A/B | 373-1017 | [»] | |
4REB | X-ray | 4.20 | A/H | 373-1017 | [»] | |
4REC | X-ray | 2.20 | A | 373-1017 | [»] | |
4RI8 | X-ray | 2.90 | A/B | 370-1017 | [»] | |
4RI9 | X-ray | 2.90 | A/B | 370-1017 | [»] | |
4RIA | X-ray | 3.00 | A/B | 370-1017 | [»] | |
4RIB | X-ray | 3.25 | A/B | 364-1017 | [»] | |
4RIC | X-ray | 2.80 | A/B | 370-1009 | [»] | |
4RID | X-ray | 3.30 | A/B | 370-1009 | [»] | |
4RY3 | X-ray | 2.80 | A | 371-1010 | [»] | |
SMRi | Q9Y2M0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116573, 53 interactors |
IntActi | Q9Y2M0, 24 interactors |
MINTi | Q9Y2M0 |
STRINGi | 9606.ENSP00000354497 |
PTM databases
DEPODi | FAN1 |
iPTMneti | Q9Y2M0 |
PhosphoSitePlusi | Q9Y2M0 |
Genetic variation databases
BioMutai | FAN1 |
DMDMi | 160410012 |
Proteomic databases
EPDi | Q9Y2M0 |
jPOSTi | Q9Y2M0 |
MassIVEi | Q9Y2M0 |
PaxDbi | Q9Y2M0 |
PeptideAtlasi | Q9Y2M0 |
PRIDEi | Q9Y2M0 |
ProteomicsDBi | 85841 [Q9Y2M0-1] 85842 [Q9Y2M0-2] |
Protocols and materials databases
Antibodypediai | 22515, 111 antibodies |
DNASUi | 22909 |
Genome annotation databases
Organism-specific databases
CTDi | 22909 |
DisGeNETi | 22909 |
GeneCardsi | FAN1 |
HGNCi | HGNC:29170, FAN1 |
HPAi | ENSG00000198690, Low tissue specificity |
MalaCardsi | FAN1 |
MIMi | 613534, gene 614817, phenotype |
neXtProti | NX_Q9Y2M0 |
OpenTargetsi | ENSG00000198690 |
Orphaneti | 401996, Karyomegalic interstitial nephritis 144, Lynch syndrome |
PharmGKBi | PA165478601 |
VEuPathDBi | HostDB:ENSG00000198690.9 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2143, Eukaryota |
GeneTreei | ENSGT00390000018637 |
HOGENOMi | CLU_005116_4_0_1 |
InParanoidi | Q9Y2M0 |
OMAi | FQTCPLD |
OrthoDBi | 1003565at2759 |
PhylomeDBi | Q9Y2M0 |
TreeFami | TF312870 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2M0 |
Reactomei | R-HSA-6783310, Fanconi Anemia Pathway |
Miscellaneous databases
BioGRID-ORCSi | 22909, 8 hits in 1000 CRISPR screens |
ChiTaRSi | FAN1, human |
GenomeRNAii | 22909 |
Pharosi | Q9Y2M0, Tbio |
PROi | PR:Q9Y2M0 |
RNActi | Q9Y2M0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198690, Expressed in tibia and 227 other tissues |
ExpressionAtlasi | Q9Y2M0, baseline and differential |
Genevisiblei | Q9Y2M0, HS |
Family and domain databases
Gene3Di | 3.40.1350.10, 1 hit |
InterProi | View protein in InterPro IPR033315, Fan1-like IPR006642, Rad18_UBZ4 IPR011856, tRNA_endonuc-like_dom_sf IPR014883, VRR_NUC |
PANTHERi | PTHR15749, PTHR15749, 1 hit |
Pfami | View protein in Pfam PF08774, VRR_NUC, 1 hit |
SMARTi | View protein in SMART SM00990, VRR_NUC, 1 hit SM00734, ZnF_Rad18, 1 hit |
PROSITEi | View protein in PROSITE PS51908, ZF_UBZ4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FAN1_HUMAN | |
Accessioni | Q9Y2M0Primary (citable) accession number: Q9Y2M0 Secondary accession number(s): A8K4M2, Q86WU8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | November 13, 2007 | |
Last modified: | April 7, 2021 | |
This is version 141 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families