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Entry version 179 (17 Jun 2020)
Sequence version 1 (01 Nov 1999)
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Protein

Zinc finger protein with KRAB and SCAN domains 5

Gene

ZKSCAN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri346 – 368C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri717 – 739C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri745 – 763C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST19
Zinc fingeri773 – 795C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri801 – 823C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 5
Alternative name(s):
Zinc finger protein 95 homolog
Short name:
Zfp-95
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZKSCAN5
Synonyms:KIAA1015, ZFP95
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000196652.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12867 ZKSCAN5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611272 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2L8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23660

Open Targets

More...
OpenTargetsi
ENSG00000196652

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162409785

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y2L8 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZKSCAN5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
11136143

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473151 – 839Zinc finger protein with KRAB and SCAN domains 5Add BLAST839

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki216Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki248Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki270Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki303Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei335PhosphoserineCombined sources1
Cross-linki509Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki513Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki709Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y2L8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9Y2L8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y2L8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2L8

PeptideAtlas

More...
PeptideAtlasi
Q9Y2L8

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2L8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85838

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2L8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2L8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000196652 Expressed in amniotic fluid and 188 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2L8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2L8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000196652 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
117182, 10 interactors

Protein interaction database and analysis system

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IntActi
Q9Y2L8, 6 interactors

Molecular INTeraction database

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MINTi
Q9Y2L8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377725

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y2L8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1839
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y2L8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y2L8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 132SCAN boxPROSITE-ProRule annotationAdd BLAST82
Domaini218 – 291KRABPROSITE-ProRule annotationAdd BLAST74

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri346 – 368C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri717 – 739C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri745 – 763C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST19
Zinc fingeri773 – 795C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri801 – 823C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162299

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_23_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2L8

KEGG Orthology (KO)

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KOi
K09229

Identification of Orthologs from Complete Genome Data

More...
OMAi
KSHQCRE

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2L8

TreeFam database of animal gene trees

More...
TreeFami
TF338146

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y2L8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIMTESREVI DLDPPAETSQ EQEDLFIVKV EEEDCTWMQE YNPPTFETFY
60 70 80 90 100
QRFRHFQYHE ASGPREALSQ LRVLCCEWLR PELHTKEQIL ELLVLEQFLT
110 120 130 140 150
ILPEEFQPWV REHHPESGEE AVAVIENIQR ELEERRQQIV ACPDVLPRKM
160 170 180 190 200
ATPGAVQESC SPHPLTVDTQ PEQAPQKPRL LEENALPVLQ VPSLPLKDSQ
210 220 230 240 250
ELTASLLSTG SQKLVKIEEV ADVAVSFILE EWGHLDQSQK SLYRDDRKEN
260 270 280 290 300
YGSITSMGYE SRDNMELIVK QISDDSESHW VAPEHTERSV PQDPDFAEVS
310 320 330 340 350
DLKGMVQRWQ VNPTVGKSRQ NPSQKRDLDA ITDISPKQST HGERGHRCSD
360 370 380 390 400
CGKFFLQASN FIQHRRIHTG EKPFKCGECG KSYNQRVHLT QHQRVHTGEK
410 420 430 440 450
PYKCQVCGKA FRVSSHLVQH HSVHSGERPY GCNECGKNFG RHSHLIEHLK
460 470 480 490 500
RHFREKSQRC SDKRSKNTKL SVKKKISEYS EADMELSGKT QRNVSQVQDF
510 520 530 540 550
GEGCEFQGKL DRKQGIPMKE ILGQPSSKRM NYSEVPYVHK KSSTGERPHK
560 570 580 590 600
CNECGKSFIQ SAHLIQHQRI HTGEKPFRCE ECGKSYNQRV HLTQHQRVHT
610 620 630 640 650
GEKPYTCPLC GKAFRVRSHL VQHQSVHSGE RPFKCNECGK GFGRRSHLAG
660 670 680 690 700
HLRLHSREKS HQCRECGEIF FQYVSLIEHQ VLHMGQKNEK NGICEEAYSW
710 720 730 740 750
NLTVIEDKKI ELQEQPYQCD ICGKAFGYSS DLIQHYRTHT AEKPYQCDIC
760 770 780 790 800
RENVGQCSHT KQHQKIYSST KSHQCHECGR GFTLKSHLNQ HQRIHTGEKP
810 820 830
FQCKECGMNF SWSCSLFKHL RSHERTDPIN TLSVEGSLL
Length:839
Mass (Da):96,903
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2E082CF6610806D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WBD4F8WBD4_HUMAN
Zinc finger protein with KRAB and S...
ZKSCAN5
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76859 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF170025 mRNA Translation: AAF24219.1
AB023232 mRNA Translation: BAA76859.2 Different initiation.
CH236956 Genomic DNA Translation: EAL23873.1
CH471091 Genomic DNA Translation: EAW76654.1
CH471091 Genomic DNA Translation: EAW76655.1
CH471091 Genomic DNA Translation: EAW76656.1
CH471091 Genomic DNA Translation: EAW76657.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5667.1

NCBI Reference Sequences

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RefSeqi
NP_001305011.1, NM_001318082.1
NP_001305012.1, NM_001318083.1
NP_001305013.1, NM_001318084.1
NP_055384.1, NM_014569.3
NP_659570.1, NM_145102.3
XP_016867407.1, XM_017011918.1
XP_016867408.1, XM_017011919.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000326775; ENSP00000322872; ENSG00000196652
ENST00000394170; ENSP00000377725; ENSG00000196652
ENST00000451158; ENSP00000392104; ENSG00000196652

Database of genes from NCBI RefSeq genomes

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GeneIDi
23660

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23660

UCSC genome browser

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UCSCi
uc003uqv.4 human

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170025 mRNA Translation: AAF24219.1
AB023232 mRNA Translation: BAA76859.2 Different initiation.
CH236956 Genomic DNA Translation: EAL23873.1
CH471091 Genomic DNA Translation: EAW76654.1
CH471091 Genomic DNA Translation: EAW76655.1
CH471091 Genomic DNA Translation: EAW76656.1
CH471091 Genomic DNA Translation: EAW76657.1
CCDSiCCDS5667.1
RefSeqiNP_001305011.1, NM_001318082.1
NP_001305012.1, NM_001318083.1
NP_001305013.1, NM_001318084.1
NP_055384.1, NM_014569.3
NP_659570.1, NM_145102.3
XP_016867407.1, XM_017011918.1
XP_016867408.1, XM_017011919.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EM5NMR-A768-800[»]
2EMMNMR-A544-576[»]
2EMZNMR-A628-660[»]
2EN3NMR-A796-828[»]
2EOMNMR-A341-373[»]
2EONNMR-A397-429[»]
2EOONMR-A425-457[»]
2YSONMR-A656-688[»]
2YTGNMR-A369-401[»]
SMRiQ9Y2L8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117182, 10 interactors
IntActiQ9Y2L8, 6 interactors
MINTiQ9Y2L8
STRINGi9606.ENSP00000377725

PTM databases

iPTMnetiQ9Y2L8
PhosphoSitePlusiQ9Y2L8

Polymorphism and mutation databases

BioMutaiZKSCAN5
DMDMi11136143

Proteomic databases

jPOSTiQ9Y2L8
MassIVEiQ9Y2L8
MaxQBiQ9Y2L8
PaxDbiQ9Y2L8
PeptideAtlasiQ9Y2L8
PRIDEiQ9Y2L8
ProteomicsDBi85838

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q9Y2L8 4 sequenced antibodies

Antibodypedia a portal for validated antibodies

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Antibodypediai
30392 106 antibodies

The DNASU plasmid repository

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DNASUi
23660

Genome annotation databases

EnsembliENST00000326775; ENSP00000322872; ENSG00000196652
ENST00000394170; ENSP00000377725; ENSG00000196652
ENST00000451158; ENSP00000392104; ENSG00000196652
GeneIDi23660
KEGGihsa:23660
UCSCiuc003uqv.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23660
DisGeNETi23660
EuPathDBiHostDB:ENSG00000196652.11

GeneCards: human genes, protein and diseases

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GeneCardsi
ZKSCAN5
HGNCiHGNC:12867 ZKSCAN5
HPAiENSG00000196652 Low tissue specificity
MIMi611272 gene
neXtProtiNX_Q9Y2L8
OpenTargetsiENSG00000196652
PharmGKBiPA162409785

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162299
HOGENOMiCLU_002678_23_3_1
InParanoidiQ9Y2L8
KOiK09229
OMAiKSHQCRE
OrthoDBi1318335at2759
PhylomeDBiQ9Y2L8
TreeFamiTF338146

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
23660 10 hits in 810 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZKSCAN5 human
EvolutionaryTraceiQ9Y2L8

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZKSCAN5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23660
PharosiQ9Y2L8 Tbio

Protein Ontology

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PROi
PR:Q9Y2L8
RNActiQ9Y2L8 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196652 Expressed in amniotic fluid and 188 other tissues
ExpressionAtlasiQ9Y2L8 baseline and differential
GenevisibleiQ9Y2L8 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZKSC5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2L8
Secondary accession number(s): A4D280, D6W5S9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: June 17, 2020
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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