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Entry version 164 (07 Apr 2021)
Sequence version 2 (18 May 2010)
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Protein

Trafficking protein particle complex subunit 8

Gene

TRAPPC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244). Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy (PubMed:26711178).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y2L5

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trafficking protein particle complex subunit 8
Alternative name(s):
Protein TRS85 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAPPC8
Synonyms:KIAA1012
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29169, TRAPPC8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614136, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2L5

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000153339.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22878

Open Targets

More...
OpenTargetsi
ENSG00000153339

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165429149

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y2L5, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRAPPC8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452850

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000656411 – 1435Trafficking protein particle complex subunit 8Add BLAST1435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei273PhosphoserineCombined sources1
Modified residuei279PhosphoserineCombined sources1
Modified residuei309PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y2L5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y2L5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y2L5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2L5

PeptideAtlas

More...
PeptideAtlasi
Q9Y2L5

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2L5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85834 [Q9Y2L5-1]
85835 [Q9Y2L5-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1829, 3 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9Y2L5, 1 site, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2L5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2L5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000153339, Expressed in hair follicle and 255 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2L5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2L5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000153339, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.

Interacts with TBC1D14 (PubMed:26711178).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116545, 40 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-4750, TRAPP III complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Y2L5

Database of interacting proteins

More...
DIPi
DIP-48280N

Protein interaction database and analysis system

More...
IntActi
Q9Y2L5, 20 interactors

Molecular INTeraction database

More...
MINTi
Q9Y2L5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000283351

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y2L5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y2L5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRS85 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1938, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000568

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004823_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2L5

Identification of Orthologs from Complete Genome Data

More...
OMAi
CHRNNLS

Database of Orthologous Groups

More...
OrthoDBi
625387at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2L5

TreeFam database of animal gene trees

More...
TreeFami
TF106128

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011990, TPR-like_helical_dom_sf
IPR024420, TRAPP_III_complex_Trs85

The PANTHER Classification System

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PANTHERi
PTHR12975, PTHR12975, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12739, TRAPPC-Trs85, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2L5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQCVQSVQE LIPDSFVPCV AALCSDEAER LTRLNHLSFA ELLKPFSRLT
60 70 80 90 100
SEVHMRDPNN QLHVIKNLKI AVSNIVTQPP QPGAIRKLLN DVVSGSQPAE
110 120 130 140 150
GLVANVITAG DYDLNISATT PWFESYRETF LQSMPALDHE FLNHYLACML
160 170 180 190 200
VASSSEAEPV EQFSKLSQEQ HRIQHNSDYS YPKWFIPNTL KYYVLLHDVS
210 220 230 240 250
AGDEQRAESI YEEMKQKYGT QGCYLLKINS RTSNRASDEQ IPDPWSQYLQ
260 270 280 290 300
KNSIQNQESY EDGPCTITSN KNSDNNLLSL DGLDNEVKDG LPNNFRAHPL
310 320 330 340 350
QLEQSSDPSN SIDGPDHLRS ASSLHETKKG NTGIIHGACL TLTDHDRIRQ
360 370 380 390 400
FIQEFTFRGL LPHIEKTIRQ LNDQLISRKG LSRSLFSATK KWFSGSKVPE
410 420 430 440 450
KSINDLKNTS GLLYPPEAPE LQIRKMADLC FLVQHYDLAY SCYHTAKKDF
460 470 480 490 500
LNDQAMLYAA GALEMAAVSA FLQPGAPRPY PAHYMDTAIQ TYRDICKNMV
510 520 530 540 550
LAERCVLLSA ELLKSQSKYS EAAALLIRLT SEDSDLRSAL LLEQAAHCFI
560 570 580 590 600
NMKSPMVRKY AFHMILAGHR FSKAGQKKHA LRCYCQAMQV YKGKGWSLAE
610 620 630 640 650
DHINFTIGRQ SYTLRQLDNA VSAFRHILIN ESKQSAAQQG AFLREYLYVY
660 670 680 690 700
KNVSQLSPDG PLPQLPLPYI NSSATRVFFG HDRRPADGEK QAATHVSLDQ
710 720 730 740 750
EYDSESSQQW RELEEQVVSV VNKGVIPSNF HPTQYCLNSY SDNSRFPLAV
760 770 780 790 800
VEEPITVEVA FRNPLKVLLL LTDLSLLWKF HPKDFSGKDN EEVKQLVTSE
810 820 830 840 850
PEMIGAEVIS EFLINGEESK VARLKLFPHH IGELHILGVV YNLGTIQGSM
860 870 880 890 900
TVDGIGALPG CHTGKYSLSM SVRGKQDLEI QGPRLNNTKE EKTSVKYGPD
910 920 930 940 950
RRLDPIITEE MPLLEVFFIH FPTGLLCGEI RKAYVEFVNV SKCPLTGLKV
960 970 980 990 1000
VSKRPEFFTF GGNTAVLTPL SPSASENCSA YKTVVTDATS VCTALISSAS
1010 1020 1030 1040 1050
SVDFGIGTGS QPEVIPVPLP DTVLLPGASV QLPMWLRGPD EEGVHEINFL
1060 1070 1080 1090 1100
FYYESVKKQP KIRHRILRHT AIICTSRSLN VRATVCRSNS LENEEGRGGN
1110 1120 1130 1140 1150
MLVFVDVENT NTSEAGVKEF HIVQVSSSSK HWKLQKSVNL SENKDTKLAS
1160 1170 1180 1190 1200
REKGKFCFKA IRCEKEEAAT QSSEKYTFAD IIFGNEQIIS SASPCADFFY
1210 1220 1230 1240 1250
RSLSSELKKP QAHLPVHTEK QSTEDAVRLI QKCSEVDLNI VILWKAYVVE
1260 1270 1280 1290 1300
DSKQLILEGQ HHVILRTIGK EAFSYPQKQE PPEMELLKFF RPENITVSSR
1310 1320 1330 1340 1350
PSVEQLSSLI KTSLHYPESF NHPFHQKSLC LVPVTLLLSN CSKADVDVIV
1360 1370 1380 1390 1400
DLRHKTTSPE ALEIHGSFTW LGQTQYKLQL KSQEIHSLQL KACFVHTGVY
1410 1420 1430
NLGTPRVFAK LSDQVTVFET SQQNSMPALI IISNV
Length:1,435
Mass (Da):160,997
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6D60A7C9E65F46D
GO
Isoform 2 (identifier: Q9Y2L5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     916-926: VFFIHFPTGLL → TLALAQEVNQR
     927-1002: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:1,359
Mass (Da):153,030
Checksum:i64D376D99DE70D11
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QQJ5J3QQJ5_HUMAN
Trafficking protein particle comple...
TRAPPC8
1,381Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSA1J3QSA1_HUMAN
Trafficking protein particle comple...
TRAPPC8
666Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSL8J3KSL8_HUMAN
Trafficking protein particle comple...
TRAPPC8
926Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR00J3QR00_HUMAN
Trafficking protein particle comple...
TRAPPC8
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQS5J3QQS5_HUMAN
Trafficking protein particle comple...
TRAPPC8
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI27110 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI27111 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA76856 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAG50957 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti251K → E in CAB66683 (PubMed:11230166).Curated1
Sequence conflicti631E → G in BAG50957 (PubMed:14702039).Curated1
Sequence conflicti1060P → T in BAG50957 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05781474N → S. Corresponds to variant dbSNP:rs34292533EnsemblClinVar.1
Natural variantiVAR_060250137L → S2 PublicationsCorresponds to variant dbSNP:rs6506948Ensembl.1
Natural variantiVAR_060251517S → G. Corresponds to variant dbSNP:rs17857486Ensembl.1
Natural variantiVAR_036270537R → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs754569032Ensembl.1
Natural variantiVAR_057815708Q → E. Corresponds to variant dbSNP:rs16962530Ensembl.1
Natural variantiVAR_060252954R → H. Corresponds to variant dbSNP:rs2170562Ensembl.1
Natural variantiVAR_0602531146T → A1 PublicationCorresponds to variant dbSNP:rs3737374Ensembl.1
Natural variantiVAR_0578161189I → V. Corresponds to variant dbSNP:rs36034613Ensembl.1
Natural variantiVAR_0602541298S → P. Corresponds to variant dbSNP:rs633500Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014454916 – 926VFFIHFPTGLL → TLALAQEVNQR in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_004000927 – 1002Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB023229 mRNA Translation: BAA76856.2 Different initiation.
AL136749 mRNA Translation: CAB66683.2
AC009831 Genomic DNA No translation available.
AC022960 Genomic DNA No translation available.
BC127109 mRNA Translation: AAI27110.1 Different initiation.
BC127110 mRNA Translation: AAI27111.1 Different initiation.
AK001662 mRNA Translation: BAG50957.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS11901.1 [Q9Y2L5-1]

NCBI Reference Sequences

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RefSeqi
NP_055754.2, NM_014939.3 [Q9Y2L5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000283351; ENSP00000283351; ENSG00000153339 [Q9Y2L5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22878

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22878

UCSC genome browser

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UCSCi
uc002kxc.5, human [Q9Y2L5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023229 mRNA Translation: BAA76856.2 Different initiation.
AL136749 mRNA Translation: CAB66683.2
AC009831 Genomic DNA No translation available.
AC022960 Genomic DNA No translation available.
BC127109 mRNA Translation: AAI27110.1 Different initiation.
BC127110 mRNA Translation: AAI27111.1 Different initiation.
AK001662 mRNA Translation: BAG50957.1 Different initiation.
CCDSiCCDS11901.1 [Q9Y2L5-1]
RefSeqiNP_055754.2, NM_014939.3 [Q9Y2L5-1]

3D structure databases

SMRiQ9Y2L5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116545, 40 interactors
ComplexPortaliCPX-4750, TRAPP III complex
CORUMiQ9Y2L5
DIPiDIP-48280N
IntActiQ9Y2L5, 20 interactors
MINTiQ9Y2L5
STRINGi9606.ENSP00000283351

PTM databases

GlyConnecti1829, 3 N-Linked glycans (1 site)
GlyGeniQ9Y2L5, 1 site, 1 N-linked glycan (1 site)
iPTMnetiQ9Y2L5
PhosphoSitePlusiQ9Y2L5

Genetic variation databases

BioMutaiTRAPPC8
DMDMi296452850

Proteomic databases

EPDiQ9Y2L5
jPOSTiQ9Y2L5
MassIVEiQ9Y2L5
PaxDbiQ9Y2L5
PeptideAtlasiQ9Y2L5
PRIDEiQ9Y2L5
ProteomicsDBi85834 [Q9Y2L5-1]
85835 [Q9Y2L5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
48760, 8 antibodies

The DNASU plasmid repository

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DNASUi
22878

Genome annotation databases

EnsembliENST00000283351; ENSP00000283351; ENSG00000153339 [Q9Y2L5-1]
GeneIDi22878
KEGGihsa:22878
UCSCiuc002kxc.5, human [Q9Y2L5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22878
DisGeNETi22878

GeneCards: human genes, protein and diseases

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GeneCardsi
TRAPPC8
HGNCiHGNC:29169, TRAPPC8
HPAiENSG00000153339, Low tissue specificity
MIMi614136, gene
neXtProtiNX_Q9Y2L5
OpenTargetsiENSG00000153339
PharmGKBiPA165429149
VEuPathDBiHostDB:ENSG00000153339.13

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1938, Eukaryota
GeneTreeiENSGT00390000000568
HOGENOMiCLU_004823_2_0_1
InParanoidiQ9Y2L5
OMAiCHRNNLS
OrthoDBi625387at2759
PhylomeDBiQ9Y2L5
TreeFamiTF106128

Enzyme and pathway databases

PathwayCommonsiQ9Y2L5
ReactomeiR-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
22878, 765 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRAPPC8, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KIAA1012

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22878
PharosiQ9Y2L5, Tdark

Protein Ontology

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PROi
PR:Q9Y2L5
RNActiQ9Y2L5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000153339, Expressed in hair follicle and 255 other tissues
ExpressionAtlasiQ9Y2L5, baseline and differential
GenevisibleiQ9Y2L5, HS

Family and domain databases

InterProiView protein in InterPro
IPR011990, TPR-like_helical_dom_sf
IPR024420, TRAPP_III_complex_Trs85
PANTHERiPTHR12975, PTHR12975, 1 hit
PfamiView protein in Pfam
PF12739, TRAPPC-Trs85, 1 hit
SUPFAMiSSF48452, SSF48452, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPPC8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2L5
Secondary accession number(s): A0JP15, B3KME5, Q9H0L2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 18, 2010
Last modified: April 7, 2021
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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