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Protein

Trafficking protein particle complex subunit 8

Gene

TRAPPC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.1 Publication

GO - Molecular functioni

GO - Biological processi

  • autophagosome assembly Source: GO_Central
  • autophagy of peroxisome Source: GO_Central
  • ER to Golgi vesicle-mediated transport Source: GO_Central
  • Golgi organization Source: UniProtKB
  • protein localization by the Cvt pathway Source: GO_Central
  • protein localization to phagophore assembly site Source: GO_Central

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 8
Alternative name(s):
Protein TRS85 homolog
Gene namesi
Name:TRAPPC8
Synonyms:KIAA1012
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000153339.13
HGNCiHGNC:29169 TRAPPC8
MIMi614136 gene
neXtProtiNX_Q9Y2L5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000153339
PharmGKBiPA165429149

Polymorphism and mutation databases

BioMutaiTRAPPC8
DMDMi296452850

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000656411 – 1435Trafficking protein particle complex subunit 8Add BLAST1435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273PhosphoserineCombined sources1
Modified residuei279PhosphoserineCombined sources1
Modified residuei309PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y2L5
PaxDbiQ9Y2L5
PeptideAtlasiQ9Y2L5
PRIDEiQ9Y2L5
ProteomicsDBi85834
85835 [Q9Y2L5-2]

PTM databases

GlyConnecti1829
iPTMnetiQ9Y2L5
PhosphoSitePlusiQ9Y2L5

Miscellaneous databases

PMAP-CutDBiQ9Y2L5

Expressioni

Gene expression databases

BgeeiENSG00000153339 Expressed in 244 organ(s), highest expression level in hair follicle
CleanExiHS_KIAA1012
ExpressionAtlasiQ9Y2L5 baseline and differential
GenevisibleiQ9Y2L5 HS

Organism-specific databases

HPAiHPA041107

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116545, 26 interactors
CORUMiQ9Y2L5
DIPiDIP-48280N
IntActiQ9Y2L5, 10 interactors
STRINGi9606.ENSP00000283351

Structurei

3D structure databases

ProteinModelPortaliQ9Y2L5
SMRiQ9Y2L5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRS85 family.Curated

Phylogenomic databases

eggNOGiKOG1938 Eukaryota
ENOG410XPCJ LUCA
GeneTreeiENSGT00390000000568
HOGENOMiHOG000046881
HOVERGENiHBG036226
InParanoidiQ9Y2L5
KOiK20305
OMAiCHRNNLS
OrthoDBiEOG091G062Q
PhylomeDBiQ9Y2L5
TreeFamiTF106128

Family and domain databases

InterProiView protein in InterPro
IPR011990 TPR-like_helical_dom_sf
IPR024420 TRAPP_III_complex_Trs85
PANTHERiPTHR12975 PTHR12975, 1 hit
PfamiView protein in Pfam
PF12739 TRAPPC-Trs85, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2L5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQCVQSVQE LIPDSFVPCV AALCSDEAER LTRLNHLSFA ELLKPFSRLT
60 70 80 90 100
SEVHMRDPNN QLHVIKNLKI AVSNIVTQPP QPGAIRKLLN DVVSGSQPAE
110 120 130 140 150
GLVANVITAG DYDLNISATT PWFESYRETF LQSMPALDHE FLNHYLACML
160 170 180 190 200
VASSSEAEPV EQFSKLSQEQ HRIQHNSDYS YPKWFIPNTL KYYVLLHDVS
210 220 230 240 250
AGDEQRAESI YEEMKQKYGT QGCYLLKINS RTSNRASDEQ IPDPWSQYLQ
260 270 280 290 300
KNSIQNQESY EDGPCTITSN KNSDNNLLSL DGLDNEVKDG LPNNFRAHPL
310 320 330 340 350
QLEQSSDPSN SIDGPDHLRS ASSLHETKKG NTGIIHGACL TLTDHDRIRQ
360 370 380 390 400
FIQEFTFRGL LPHIEKTIRQ LNDQLISRKG LSRSLFSATK KWFSGSKVPE
410 420 430 440 450
KSINDLKNTS GLLYPPEAPE LQIRKMADLC FLVQHYDLAY SCYHTAKKDF
460 470 480 490 500
LNDQAMLYAA GALEMAAVSA FLQPGAPRPY PAHYMDTAIQ TYRDICKNMV
510 520 530 540 550
LAERCVLLSA ELLKSQSKYS EAAALLIRLT SEDSDLRSAL LLEQAAHCFI
560 570 580 590 600
NMKSPMVRKY AFHMILAGHR FSKAGQKKHA LRCYCQAMQV YKGKGWSLAE
610 620 630 640 650
DHINFTIGRQ SYTLRQLDNA VSAFRHILIN ESKQSAAQQG AFLREYLYVY
660 670 680 690 700
KNVSQLSPDG PLPQLPLPYI NSSATRVFFG HDRRPADGEK QAATHVSLDQ
710 720 730 740 750
EYDSESSQQW RELEEQVVSV VNKGVIPSNF HPTQYCLNSY SDNSRFPLAV
760 770 780 790 800
VEEPITVEVA FRNPLKVLLL LTDLSLLWKF HPKDFSGKDN EEVKQLVTSE
810 820 830 840 850
PEMIGAEVIS EFLINGEESK VARLKLFPHH IGELHILGVV YNLGTIQGSM
860 870 880 890 900
TVDGIGALPG CHTGKYSLSM SVRGKQDLEI QGPRLNNTKE EKTSVKYGPD
910 920 930 940 950
RRLDPIITEE MPLLEVFFIH FPTGLLCGEI RKAYVEFVNV SKCPLTGLKV
960 970 980 990 1000
VSKRPEFFTF GGNTAVLTPL SPSASENCSA YKTVVTDATS VCTALISSAS
1010 1020 1030 1040 1050
SVDFGIGTGS QPEVIPVPLP DTVLLPGASV QLPMWLRGPD EEGVHEINFL
1060 1070 1080 1090 1100
FYYESVKKQP KIRHRILRHT AIICTSRSLN VRATVCRSNS LENEEGRGGN
1110 1120 1130 1140 1150
MLVFVDVENT NTSEAGVKEF HIVQVSSSSK HWKLQKSVNL SENKDTKLAS
1160 1170 1180 1190 1200
REKGKFCFKA IRCEKEEAAT QSSEKYTFAD IIFGNEQIIS SASPCADFFY
1210 1220 1230 1240 1250
RSLSSELKKP QAHLPVHTEK QSTEDAVRLI QKCSEVDLNI VILWKAYVVE
1260 1270 1280 1290 1300
DSKQLILEGQ HHVILRTIGK EAFSYPQKQE PPEMELLKFF RPENITVSSR
1310 1320 1330 1340 1350
PSVEQLSSLI KTSLHYPESF NHPFHQKSLC LVPVTLLLSN CSKADVDVIV
1360 1370 1380 1390 1400
DLRHKTTSPE ALEIHGSFTW LGQTQYKLQL KSQEIHSLQL KACFVHTGVY
1410 1420 1430
NLGTPRVFAK LSDQVTVFET SQQNSMPALI IISNV
Length:1,435
Mass (Da):160,997
Last modified:May 18, 2010 - v2
Checksum:iA6D60A7C9E65F46D
GO
Isoform 2 (identifier: Q9Y2L5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     916-926: VFFIHFPTGLL → TLALAQEVNQR
     927-1002: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:1,359
Mass (Da):153,030
Checksum:i64D376D99DE70D11
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QSA1J3QSA1_HUMAN
Trafficking protein particle comple...
TRAPPC8
666Annotation score:
J3KSL8J3KSL8_HUMAN
Trafficking protein particle comple...
TRAPPC8
926Annotation score:
J3QQJ5J3QQJ5_HUMAN
Trafficking protein particle comple...
TRAPPC8
1,381Annotation score:
J3QR00J3QR00_HUMAN
Trafficking protein particle comple...
TRAPPC8
187Annotation score:
J3QQS5J3QQS5_HUMAN
Trafficking protein particle comple...
TRAPPC8
95Annotation score:

Sequence cautioni

The sequence AAI27110 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI27111 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA76856 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAG50957 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251K → E in CAB66683 (PubMed:11230166).Curated1
Sequence conflicti631E → G in BAG50957 (PubMed:14702039).Curated1
Sequence conflicti1060P → T in BAG50957 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05781474N → S. Corresponds to variant dbSNP:rs34292533Ensembl.1
Natural variantiVAR_060250137L → S2 PublicationsCorresponds to variant dbSNP:rs6506948Ensembl.1
Natural variantiVAR_060251517S → G. Corresponds to variant dbSNP:rs17857486Ensembl.1
Natural variantiVAR_036270537R → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs754569032Ensembl.1
Natural variantiVAR_057815708Q → E. Corresponds to variant dbSNP:rs16962530Ensembl.1
Natural variantiVAR_060252954R → H. Corresponds to variant dbSNP:rs2170562Ensembl.1
Natural variantiVAR_0602531146T → A1 PublicationCorresponds to variant dbSNP:rs3737374Ensembl.1
Natural variantiVAR_0578161189I → V. Corresponds to variant dbSNP:rs36034613Ensembl.1
Natural variantiVAR_0602541298S → P. Corresponds to variant dbSNP:rs633500Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014454916 – 926VFFIHFPTGLL → TLALAQEVNQR in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_004000927 – 1002Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023229 mRNA Translation: BAA76856.2 Different initiation.
AL136749 mRNA Translation: CAB66683.2
AC009831 Genomic DNA No translation available.
AC022960 Genomic DNA No translation available.
BC127109 mRNA Translation: AAI27110.1 Different initiation.
BC127110 mRNA Translation: AAI27111.1 Different initiation.
AK001662 mRNA Translation: BAG50957.1 Different initiation.
CCDSiCCDS11901.1 [Q9Y2L5-1]
RefSeqiNP_055754.2, NM_014939.3
UniGeneiHs.202001

Genome annotation databases

EnsembliENST00000283351; ENSP00000283351; ENSG00000153339 [Q9Y2L5-1]
GeneIDi22878
KEGGihsa:22878
UCSCiuc002kxc.5 human [Q9Y2L5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023229 mRNA Translation: BAA76856.2 Different initiation.
AL136749 mRNA Translation: CAB66683.2
AC009831 Genomic DNA No translation available.
AC022960 Genomic DNA No translation available.
BC127109 mRNA Translation: AAI27110.1 Different initiation.
BC127110 mRNA Translation: AAI27111.1 Different initiation.
AK001662 mRNA Translation: BAG50957.1 Different initiation.
CCDSiCCDS11901.1 [Q9Y2L5-1]
RefSeqiNP_055754.2, NM_014939.3
UniGeneiHs.202001

3D structure databases

ProteinModelPortaliQ9Y2L5
SMRiQ9Y2L5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116545, 26 interactors
CORUMiQ9Y2L5
DIPiDIP-48280N
IntActiQ9Y2L5, 10 interactors
STRINGi9606.ENSP00000283351

PTM databases

GlyConnecti1829
iPTMnetiQ9Y2L5
PhosphoSitePlusiQ9Y2L5

Polymorphism and mutation databases

BioMutaiTRAPPC8
DMDMi296452850

Proteomic databases

EPDiQ9Y2L5
PaxDbiQ9Y2L5
PeptideAtlasiQ9Y2L5
PRIDEiQ9Y2L5
ProteomicsDBi85834
85835 [Q9Y2L5-2]

Protocols and materials databases

DNASUi22878
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283351; ENSP00000283351; ENSG00000153339 [Q9Y2L5-1]
GeneIDi22878
KEGGihsa:22878
UCSCiuc002kxc.5 human [Q9Y2L5-1]

Organism-specific databases

CTDi22878
EuPathDBiHostDB:ENSG00000153339.13
GeneCardsiTRAPPC8
H-InvDBiHIX0014382
HIX0039822
HGNCiHGNC:29169 TRAPPC8
HPAiHPA041107
MIMi614136 gene
neXtProtiNX_Q9Y2L5
OpenTargetsiENSG00000153339
PharmGKBiPA165429149
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1938 Eukaryota
ENOG410XPCJ LUCA
GeneTreeiENSGT00390000000568
HOGENOMiHOG000046881
HOVERGENiHBG036226
InParanoidiQ9Y2L5
KOiK20305
OMAiCHRNNLS
OrthoDBiEOG091G062Q
PhylomeDBiQ9Y2L5
TreeFamiTF106128

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiTRAPPC8 human
GeneWikiiKIAA1012
GenomeRNAii22878
PMAP-CutDBiQ9Y2L5
PROiPR:Q9Y2L5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153339 Expressed in 244 organ(s), highest expression level in hair follicle
CleanExiHS_KIAA1012
ExpressionAtlasiQ9Y2L5 baseline and differential
GenevisibleiQ9Y2L5 HS

Family and domain databases

InterProiView protein in InterPro
IPR011990 TPR-like_helical_dom_sf
IPR024420 TRAPP_III_complex_Trs85
PANTHERiPTHR12975 PTHR12975, 1 hit
PfamiView protein in Pfam
PF12739 TRAPPC-Trs85, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPPC8_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2L5
Secondary accession number(s): A0JP15, B3KME5, Q9H0L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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