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Protein

Lysine-specific demethylase 2A

Gene

KDM2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+1 PublicationNote: Binds 1 Fe2+ ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei209SubstrateBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi212Iron; catalytic1 Publication1
Metal bindingi214Iron; catalyticPROSITE-ProRule annotation1
Binding sitei229SubstrateBy similarity1
Metal bindingi284Iron; catalyticPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri564 – 610CXXC-typePROSITE-ProRule annotationAdd BLAST47
Zinc fingeri617 – 678PHD-typePROSITE-ProRule annotationAdd BLAST62

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Dioxygenase, DNA-binding, Oxidoreductase, Repressor
Biological processTranscription, Transcription regulation, Ubl conjugation pathway
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3214842 HDMs demethylate histones

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9Y2K7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysine-specific demethylase 2A (EC:1.14.11.271 Publication)
Alternative name(s):
CXXC-type zinc finger protein 8
F-box and leucine-rich repeat protein 11
F-box protein FBL7
F-box protein Lilina
F-box/LRR-repeat protein 11
JmjC domain-containing histone demethylation protein 1A
[Histone-H3]-lysine-36 demethylase 1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KDM2A
Synonyms:CXXC8, FBL7, FBXL11, JHDM1A, KIAA1004
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000173120.14

Human Gene Nomenclature Database

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HGNCi
HGNC:13606 KDM2A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605657 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2K7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi212 – 214HVD → AVA: Abolishes lysine-specific histone demethylase activity. 1 Publication3
Mutagenesisi212H → A: Abolishes histone demethylase activity. 1 Publication1
Mutagenesisi571C → A: Abolishes association with centromeric heterochromatin; when associated with A-574 and A-577. 1 Publication1
Mutagenesisi574C → A: Abolishes association with centromeric heterochromatin; when associated with A-571 and A-577. 1 Publication1
Mutagenesisi577C → A: Abolishes association with centromeric heterochromatin; when associated with A-571 and A-574. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
22992

Open Targets

More...
OpenTargetsi
ENSG00000173120

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164721195

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1938210

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2671

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KDM2A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38257795

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001198551 – 1162Lysine-specific demethylase 2AAdd BLAST1162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei28PhosphoserineCombined sources1
Modified residuei390PhosphoserineCombined sources1
Modified residuei394PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki505Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei550PhosphothreonineCombined sources1
Modified residuei558PhosphoserineCombined sources1
Modified residuei632PhosphothreonineCombined sources1
Modified residuei692PhosphoserineCombined sources1
Modified residuei713PhosphothreonineCombined sources1
Modified residuei718PhosphoserineBy similarity1
Modified residuei731PhosphoserineCombined sources1
Modified residuei825PhosphoserineCombined sources1
Modified residuei832PhosphoserineCombined sources1
Modified residuei869PhosphoserineCombined sources1
Modified residuei883PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y2K7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y2K7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y2K7

PeptideAtlas

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PeptideAtlasi
Q9Y2K7

PRoteomics IDEntifications database

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PRIDEi
Q9Y2K7

ProteomicsDB human proteome resource

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ProteomicsDBi
85827
85828 [Q9Y2K7-2]
85829 [Q9Y2K7-3]

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
Q9Y2K7

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y2K7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Y2K7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in brain, testis and ovary, followed by lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000173120 Expressed in 240 organ(s), highest expression level in vagina

CleanEx database of gene expression profiles

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CleanExi
HS_FBXL11

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y2K7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y2K7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB012272
HPA044251

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). Interacts with CBX5/HP1A; the interaction promotes CBX5 localization to chromatin.By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116639, 38 interactors

Database of interacting proteins

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DIPi
DIP-34596N

Protein interaction database and analysis system

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IntActi
Q9Y2K7, 21 interactors

Molecular INTeraction database

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MINTi
Q9Y2K7

STRING: functional protein association networks

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STRINGi
9606.ENSP00000432786

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9Y2K7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11162
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YU1X-ray2.70A1-517[»]
2YU2X-ray2.70A1-517[»]
4BBQX-ray2.24A/B567-681[»]
6BYHX-ray2.61E/F/I888-932[»]
6C16X-ray3.27C/F888-932[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y2K7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y2K7

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y2K7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini148 – 316JmjCPROSITE-ProRule annotationAdd BLAST169
Domaini889 – 936F-boxAdd BLAST48
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati961 – 982LRR 1Add BLAST22
Repeati984 – 1010LRR 2Add BLAST27
Repeati1048 – 1073LRR 3Add BLAST26
Repeati1074 – 1103LRR 4Add BLAST30
Repeati1104 – 1128LRR 5Add BLAST25
Repeati1129 – 1156LRR 6Add BLAST28

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The JmjC domain mediates demethylation activity and is required for satellite silencing.
The CXXC zinc finger preferentially recognizes nonmethylated CpG DNA, and binding is blocked when the CpG DNA is methylated.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JHDM1 histone demethylase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri564 – 610CXXC-typePROSITE-ProRule annotationAdd BLAST47
Zinc fingeri617 – 678PHD-typePROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Leucine-rich repeat, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1633 Eukaryota
KOG1947 Eukaryota
ENOG410XQXU LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155484

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007396

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y2K7

KEGG Orthology (KO)

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KOi
K10276

Identification of Orthologs from Complete Genome Data

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OMAi
RNMIDFR

Database of Orthologous Groups

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OrthoDBi
1537996at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y2K7

TreeFam database of animal gene trees

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TreeFami
TF106480

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001810 F-box_dom
IPR003347 JmjC_dom
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

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Pfami
View protein in Pfam
PF00646 F-box, 1 hit
PF16866 PHD_4, 1 hit
PF02008 zf-CXXC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00558 JmjC, 1 hit
SM00367 LRR_CC, 3 hits
SM00249 PHD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51184 JMJC, 1 hit
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2K7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPEEERIRY SQRLRGTMRR RYEDDGISDD EIEGKRTFDL EEKLHTNKYN
60 70 80 90 100
ANFVTFMEGK DFNVEYIQRG GLRDPLIFKN SDGLGIKMPD PDFTVNDVKM
110 120 130 140 150
CVGSRRMVDV MDVNTQKGIE MTMAQWTRYY ETPEEEREKL YNVISLEFSH
160 170 180 190 200
TRLENMVQRP STVDFIDWVD NMWPRHLKES QTESTNAILE MQYPKVQKYC
210 220 230 240 250
LMSVRGCYTD FHVDFGGTSV WYHIHQGGKV FWLIPPTAHN LELYENWLLS
260 270 280 290 300
GKQGDIFLGD RVSDCQRIEL KQGYTFVIPS GWIHAVYTPT DTLVFGGNFL
310 320 330 340 350
HSFNIPMQLK IYNIEDRTRV PNKFRYPFYY EMCWYVLERY VYCITNRSHL
360 370 380 390 400
TKEFQKESLS MDLELNGLES GNGDEEAVDR EPRRLSSRRS VLTSPVANGV
410 420 430 440 450
NLDYDGLGKT CRSLPSLKKT LAGDSSSDCS RGSHNGQVWD PQCAPRKDRQ
460 470 480 490 500
VHLTHFELEG LRCLVDKLES LPLHKKCVPT GIEDEDALIA DVKILLEELA
510 520 530 540 550
NSDPKLALTG VPIVQWPKRD KLKFPTRPKV RVPTIPITKP HTMKPAPRLT
560 570 580 590 600
PVRPAAASPI VSGARRRRVR CRKCKACVQG ECGVCHYCRD MKKFGGPGRM
610 620 630 640 650
KQSCVLRQCL APRLPHSVTC SLCGEVDQNE ETQDFEKKLM ECCICNEIVH
660 670 680 690 700
PGCLQMDGEG LLNEELPNCW ECPKCYQEDS SEKAQKRKME ESDEEAVQAK
710 720 730 740 750
VLRPLRSCDE PLTPPPHSPT SMLQLIHDPV SPRGMVTRSS PGAGPSDHHS
760 770 780 790 800
ASRDERFKRR QLLRLQATER TMVREKENNP SGKKELSEVE KAKIRGSYLT
810 820 830 840 850
VTLQRPTKEL HGTSIVPKLQ AITASSANLR HSPRVLVQHC PARTPQRGDE
860 870 880 890 900
EGLGGEEEEE EEEEEEDDSA EEGGAARLNG RGSWAQDGDE SWMQREVWMS
910 920 930 940 950
VFRYLSRREL CECMRVCKTW YKWCCDKRLW TKIDLSRCKA IVPQALSGII
960 970 980 990 1000
KRQPVSLDLS WTNISKKQLT WLVNRLPGLK DLLLAGCSWS AVSALSTSSC
1010 1020 1030 1040 1050
PLLRTLDLRW AVGIKDPQIR DLLTPPADKP GQDNRSKLRN MTDFRLAGLD
1060 1070 1080 1090 1100
ITDATLRLII RHMPLLSRLD LSHCSHLTDQ SSNLLTAVGS STRYSLTELN
1110 1120 1130 1140 1150
MAGCNKLTDQ TLIYLRRIAN VTLIDLRGCK QITRKACEHF ISDLSINSLY
1160
CLSDEKLIQK IS
Length:1,162
Mass (Da):132,793
Last modified:November 7, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88620A363A5C5842
GO
Isoform 2 (identifier: Q9Y2K7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-306: Missing.

Note: No experimental confirmation available.
Show »
Length:856
Mass (Da):96,859
Checksum:iC1351A450B4482E0
GO
Isoform 4 (identifier: Q9Y2K7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-542: Missing.

Show »
Length:620
Mass (Da):69,898
Checksum:i48020F8357601D46
GO
Isoform 5 (identifier: Q9Y2K7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-439: Missing.
     440-492: DPQCAPRKDR...EDEDALIADV → MCSGRFQNIQ...PRQLQSDGKR

Show »
Length:723
Mass (Da):81,678
Checksum:iBC40E0405B687BB9
GO
Isoform 3 (identifier: Q9Y2K7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     774-782: REKENNPSG → LRQETLDKN
     783-1162: Missing.

Show »
Length:782
Mass (Da):89,948
Checksum:i667E9A3E503C6550
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3VM54I3VM54_HUMAN
Lysine-specific demethylase 2A
KDM2A
1,145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD56012 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA76848 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB15795 differs from that shown. Reason: Frameshift at position 410.Curated
The sequence BAJ05817 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti518K → I in AAH47371 (PubMed:15489334).Curated1
Sequence conflicti657D → G in AAH47371 (PubMed:15489334).Curated1
Sequence conflicti1128Missing in AAH01203 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0469381 – 542Missing in isoform 4. 1 PublicationAdd BLAST542
Alternative sequenceiVSP_0469391 – 439Missing in isoform 5. 1 PublicationAdd BLAST439
Alternative sequenceiVSP_0174681 – 306Missing in isoform 2. 1 PublicationAdd BLAST306
Alternative sequenceiVSP_046940440 – 492DPQCA…LIADV → MCSGRFQNIQVNPDFPRGRI SNSFRRTSSTENKTKTLGKL HQEPRQLQSDGKR in isoform 5. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_017469774 – 782REKENNPSG → LRQETLDKN in isoform 3. 2 Publications9
Alternative sequenceiVSP_017470783 – 1162Missing in isoform 3. 2 PublicationsAdd BLAST380

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB023221 mRNA Translation: BAA76848.2 Different initiation.
AB490246 mRNA Translation: BAJ05817.1 Different initiation.
JQ710743 mRNA Translation: AFK81542.1
JQ710744 mRNA Translation: AFK81543.1
AK024505 mRNA Translation: BAB15795.1 Frameshift.
AP000729 Genomic DNA No translation available.
AP001885 Genomic DNA No translation available.
BC001203 mRNA Translation: AAH01203.1
BC047371 mRNA Translation: AAH47371.1
BC047486 mRNA Translation: AAH47486.1
BC064360 mRNA Translation: AAH64360.1
AF179221 mRNA Translation: AAD56012.1 Different initiation.
AL117517 mRNA Translation: CAH10721.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44657.1 [Q9Y2K7-1]
CCDS58148.1 [Q9Y2K7-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001243334.1, NM_001256405.1 [Q9Y2K7-5]
NP_036440.1, NM_012308.2 [Q9Y2K7-1]
XP_011543163.1, XM_011544861.1 [Q9Y2K7-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.124147

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000398645; ENSP00000381640; ENSG00000173120 [Q9Y2K7-3]
ENST00000529006; ENSP00000432786; ENSG00000173120 [Q9Y2K7-1]
ENST00000530342; ENSP00000435776; ENSG00000173120 [Q9Y2K7-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22992

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22992

UCSC genome browser

More...
UCSCi
uc001ojw.4 human [Q9Y2K7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023221 mRNA Translation: BAA76848.2 Different initiation.
AB490246 mRNA Translation: BAJ05817.1 Different initiation.
JQ710743 mRNA Translation: AFK81542.1
JQ710744 mRNA Translation: AFK81543.1
AK024505 mRNA Translation: BAB15795.1 Frameshift.
AP000729 Genomic DNA No translation available.
AP001885 Genomic DNA No translation available.
BC001203 mRNA Translation: AAH01203.1
BC047371 mRNA Translation: AAH47371.1
BC047486 mRNA Translation: AAH47486.1
BC064360 mRNA Translation: AAH64360.1
AF179221 mRNA Translation: AAD56012.1 Different initiation.
AL117517 mRNA Translation: CAH10721.1
CCDSiCCDS44657.1 [Q9Y2K7-1]
CCDS58148.1 [Q9Y2K7-5]
RefSeqiNP_001243334.1, NM_001256405.1 [Q9Y2K7-5]
NP_036440.1, NM_012308.2 [Q9Y2K7-1]
XP_011543163.1, XM_011544861.1 [Q9Y2K7-2]
UniGeneiHs.124147

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YU1X-ray2.70A1-517[»]
2YU2X-ray2.70A1-517[»]
4BBQX-ray2.24A/B567-681[»]
6BYHX-ray2.61E/F/I888-932[»]
6C16X-ray3.27C/F888-932[»]
ProteinModelPortaliQ9Y2K7
SMRiQ9Y2K7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116639, 38 interactors
DIPiDIP-34596N
IntActiQ9Y2K7, 21 interactors
MINTiQ9Y2K7
STRINGi9606.ENSP00000432786

Chemistry databases

BindingDBiQ9Y2K7
ChEMBLiCHEMBL1938210
GuidetoPHARMACOLOGYi2671

PTM databases

CarbonylDBiQ9Y2K7
iPTMnetiQ9Y2K7
PhosphoSitePlusiQ9Y2K7

Polymorphism and mutation databases

BioMutaiKDM2A
DMDMi38257795

Proteomic databases

EPDiQ9Y2K7
jPOSTiQ9Y2K7
PaxDbiQ9Y2K7
PeptideAtlasiQ9Y2K7
PRIDEiQ9Y2K7
ProteomicsDBi85827
85828 [Q9Y2K7-2]
85829 [Q9Y2K7-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398645; ENSP00000381640; ENSG00000173120 [Q9Y2K7-3]
ENST00000529006; ENSP00000432786; ENSG00000173120 [Q9Y2K7-1]
ENST00000530342; ENSP00000435776; ENSG00000173120 [Q9Y2K7-5]
GeneIDi22992
KEGGihsa:22992
UCSCiuc001ojw.4 human [Q9Y2K7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22992
DisGeNETi22992
EuPathDBiHostDB:ENSG00000173120.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KDM2A
HGNCiHGNC:13606 KDM2A
HPAiCAB012272
HPA044251
MIMi605657 gene
neXtProtiNX_Q9Y2K7
OpenTargetsiENSG00000173120
PharmGKBiPA164721195

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1633 Eukaryota
KOG1947 Eukaryota
ENOG410XQXU LUCA
GeneTreeiENSGT00940000155484
HOGENOMiHOG000007396
InParanoidiQ9Y2K7
KOiK10276
OMAiRNMIDFR
OrthoDBi1537996at2759
PhylomeDBiQ9Y2K7
TreeFamiTF106480

Enzyme and pathway databases

ReactomeiR-HSA-3214842 HDMs demethylate histones
SIGNORiQ9Y2K7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KDM2A human
EvolutionaryTraceiQ9Y2K7

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KDM2A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22992

Protein Ontology

More...
PROi
PR:Q9Y2K7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000173120 Expressed in 240 organ(s), highest expression level in vagina
CleanExiHS_FBXL11
ExpressionAtlasiQ9Y2K7 baseline and differential
GenevisibleiQ9Y2K7 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001810 F-box_dom
IPR003347 JmjC_dom
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF16866 PHD_4, 1 hit
PF02008 zf-CXXC, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
SM00367 LRR_CC, 3 hits
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKDM2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2K7
Secondary accession number(s): D4QA03
, E9PIL6, I3VM55, Q49A21, Q4G0M3, Q69YY8, Q9BVH5, Q9H7H5, Q9UK66
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 7, 2003
Last modified: January 16, 2019
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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