UniProtKB - Q9Y2K5 (R3HD2_HUMAN)
Protein
R3H domain-containing protein 2
Gene
R3HDM2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q9Y2K5 |
Names & Taxonomyi
Protein namesi | Recommended name: R3H domain-containing protein 2 |
Gene namesi | Name:R3HDM2 Synonyms:KIAA1002 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29167, R3HDM2 |
neXtProti | NX_Q9Y2K5 |
VEuPathDBi | HostDB:ENSG00000179912.20 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 22864 |
OpenTargetsi | ENSG00000179912 |
PharmGKBi | PA143485590 |
Miscellaneous databases
Pharosi | Q9Y2K5, Tdark |
Genetic variation databases
BioMutai | R3HDM2 |
DMDMi | 148887413 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050787 | 1 – 976 | R3H domain-containing protein 2Add BLAST | 976 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 37 | PhosphoserineCombined sources | 1 | |
Modified residuei | 143 | PhosphoserineBy similarity | 1 | |
Modified residuei | 330 | PhosphoserineCombined sources | 1 | |
Modified residuei | 333 | PhosphoserineBy similarity | 1 | |
Modified residuei | 349 | PhosphoserineCombined sources | 1 | |
Modified residuei | 853 | PhosphoserineCombined sources | 1 | |
Modified residuei | 855 | PhosphoserineCombined sources | 1 | |
Modified residuei | 856 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 860 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Y2K5 |
jPOSTi | Q9Y2K5 |
MassIVEi | Q9Y2K5 |
PaxDbi | Q9Y2K5 |
PeptideAtlasi | Q9Y2K5 |
PRIDEi | Q9Y2K5 |
ProteomicsDBi | 7212 85824 [Q9Y2K5-1] 85825 [Q9Y2K5-2] |
PTM databases
iPTMneti | Q9Y2K5 |
PhosphoSitePlusi | Q9Y2K5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000179912, Expressed in cerebellum and 254 other tissues |
ExpressionAtlasi | Q9Y2K5, baseline and differential |
Genevisiblei | Q9Y2K5, HS |
Organism-specific databases
HPAi | ENSG00000179912, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9Y2K5
Isoform 2 [Q9Y2K5-2]
Protein-protein interaction databases
BioGRIDi | 116532, 119 interactors |
IntActi | Q9Y2K5, 30 interactors |
STRINGi | 9606.ENSP00000317903 |
Miscellaneous databases
RNActi | Q9Y2K5, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9Y2K5 |
SMRi | Q9Y2K5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y2K5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 169 – 232 | R3HPROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 233 – 310 | SUZPROSITE-ProRule annotationAdd BLAST | 78 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 288 – 369 | Ser-richAdd BLAST | 82 | |
Compositional biasi | 404 – 694 | Gln-richAdd BLAST | 291 | |
Compositional biasi | 908 – 912 | Poly-Gly | 5 |
Phylogenomic databases
eggNOGi | KOG2953, Eukaryota |
GeneTreei | ENSGT00940000155609 |
InParanoidi | Q9Y2K5 |
OrthoDBi | 137913at2759 |
PhylomeDBi | Q9Y2K5 |
TreeFami | TF315915 |
Family and domain databases
Gene3Di | 3.30.1370.50, 1 hit |
InterProi | View protein in InterPro IPR001374, R3H_dom IPR036867, R3H_dom_sf IPR024771, SUZ |
Pfami | View protein in Pfam PF01424, R3H, 1 hit |
SMARTi | View protein in SMART SM00393, R3H, 1 hit |
SUPFAMi | SSF82708, SSF82708, 1 hit |
PROSITEi | View protein in PROSITE PS51061, R3H, 1 hit PS51673, SUZ, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y2K5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSNSNTTQET LEIMKESEKK LVEESVNKNK FISKTPSKEE IEKECEDTSL
60 70 80 90 100
RQETQRRTSN HGHARKRAKS NSKLKLVRSL AVCEESSTPF ADGPLETQDI
110 120 130 140 150
IQLHISCPSD KEEEKSTKDV SEKEDKDKNK EKIPRKMLSR DSSQEYTDST
160 170 180 190 200
GIDLHEFLVN TLKKNPRDRM MLLKLEQEIL EFINDNNNQF KKFPQMTSYH
210 220 230 240 250
RMLLHRVAAY FGMDHNVDQT GKAVIINKTS NTRIPEQRFS EHIKDEKNTE
260 270 280 290 300
FQQRFILKRD DASMDRDDNQ TGQNGYLNDI RLSKEAFSSS SHKRRQIFRG
310 320 330 340 350
NREGLSRTSS SRQSSTDSEL KSLEPRPWSS TDSDGSVRSM RPPVTKASSF
360 370 380 390 400
SGISILTRGD SIGSSKGGSA GRISRPGMAL GAPEVCNQVT SSQSVRGLLP
410 420 430 440 450
CTAQQQQQQQ QQQLPALPPT PQQQPPLNNH MISQADDLSN PFGQMSLSRQ
460 470 480 490 500
GSTEAADPSA ALFQTPLISQ HPQQTSFIMA STGQPLPTSN YSTSSHAPPT
510 520 530 540 550
QQVLPPQGYM QPPQQIQVSY YPPGQYPNSN QQYRPLSHPV AYSPQRGQQL
560 570 580 590 600
PQPSQQPGLQ PMMPNQQQAA YQGMIGVQQP QNQGLLSSQR SSMGGQMQGL
610 620 630 640 650
VVQYTPLPSY QVPVGSDSQN VVQPPFQQPM LVPVSQSVQG GLPAAGVPVY
660 670 680 690 700
YSMIPPAQQN GTSPSVGFLQ PPGSEQYQMP QSPSPCSPPQ MPQQYSGVSP
710 720 730 740 750
SGPGVVVMQL NVPNGPQPPQ NPSMVQWSHC KYYSMDQRGQ KPGDLYSPDS
760 770 780 790 800
SPQANTQMSS SPVTSPTQSP APSPVTSLSS VCTGLSPLPV LTQFPRPGGP
810 820 830 840 850
AQGDGRYSLL GQPLQYNLSI CPPLLHGQST YTVHQGQSGL KHGNRGKRQA
860 870 880 890 900
LKSASTDLGT ADVVLGRVLE VTDLPEGITR TEADKLFTQL AMSGAKIQWL
910 920 930 940 950
KDAQGLPGGG GGDNSGTAEN GRHSDLAALY TIVAVFPSPL AAQNASLRLN
960 970
NSVSRFKLRM AKKNYDLRIL ERASSQ
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB5MCG9 | B5MCG9_HUMAN | R3H domain-containing protein 2 | R3HDM2 | 1,010 | Annotation score: | ||
B5MCU0 | B5MCU0_HUMAN | R3H domain-containing protein 2 | R3HDM2 | 990 | Annotation score: | ||
A0A0U1RRA6 | A0A0U1RRA6_HUMAN | R3H domain-containing protein 2 | R3HDM2 | 966 | Annotation score: | ||
H0YIX9 | H0YIX9_HUMAN | R3H domain-containing protein 2 | R3HDM2 | 280 | Annotation score: | ||
H7C0E9 | H7C0E9_HUMAN | R3H domain-containing protein 2 | R3HDM2 | 741 | Annotation score: | ||
C9J7N6 | C9J7N6_HUMAN | R3H domain-containing protein 2 | R3HDM2 | 29 | Annotation score: |
Sequence cautioni
The sequence AAI04996 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI12227 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA76846 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 359 | G → S in AAH41857 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059713 | 35 | T → A. Corresponds to variant dbSNP:rs11832661Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057391 | 1 – 339 | Missing in isoform 3. 1 PublicationAdd BLAST | 339 | |
Alternative sequenceiVSP_026087 | 1 – 295 | Missing in isoform 2. 1 PublicationAdd BLAST | 295 | |
Alternative sequenceiVSP_026088 | 296 – 298 | QIF → MIT in isoform 2. 1 Publication | 3 | |
Alternative sequenceiVSP_057392 | 434 | Q → QPVPALQPSPQPVQFSPSSC PQVLLPVSPPQQYNM in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023219 mRNA Translation: BAA76846.2 Frameshift. AC126614 Genomic DNA No translation available. AC137834 Genomic DNA No translation available. BC041857 mRNA Translation: AAH41857.1 BC104995 mRNA Translation: AAI04996.2 Different initiation. BC112226 mRNA Translation: AAI12227.2 Different initiation. BC143605 mRNA Translation: AAI43606.1 |
CCDSi | CCDS8937.2 [Q9Y2K5-1] |
RefSeqi | NP_001317050.1, NM_001330121.1 NP_001317051.1, NM_001330122.1 NP_001317052.1, NM_001330123.1 NP_055740.3, NM_014925.4 [Q9Y2K5-1] XP_016874520.1, XM_017019031.1 [Q9Y2K5-3] XP_016874521.1, XM_017019032.1 XP_016874522.1, XM_017019033.1 |
Genome annotation databases
Ensembli | ENST00000347140; ENSP00000317903; ENSG00000179912 [Q9Y2K5-1] ENST00000358907; ENSP00000351784; ENSG00000179912 [Q9Y2K5-1] ENST00000441731; ENSP00000408536; ENSG00000179912 [Q9Y2K5-3] |
GeneIDi | 22864 |
KEGGi | hsa:22864 |
UCSCi | uc001sns.3, human [Q9Y2K5-1] uc001snu.3, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023219 mRNA Translation: BAA76846.2 Frameshift. AC126614 Genomic DNA No translation available. AC137834 Genomic DNA No translation available. BC041857 mRNA Translation: AAH41857.1 BC104995 mRNA Translation: AAI04996.2 Different initiation. BC112226 mRNA Translation: AAI12227.2 Different initiation. BC143605 mRNA Translation: AAI43606.1 |
CCDSi | CCDS8937.2 [Q9Y2K5-1] |
RefSeqi | NP_001317050.1, NM_001330121.1 NP_001317051.1, NM_001330122.1 NP_001317052.1, NM_001330123.1 NP_055740.3, NM_014925.4 [Q9Y2K5-1] XP_016874520.1, XM_017019031.1 [Q9Y2K5-3] XP_016874521.1, XM_017019032.1 XP_016874522.1, XM_017019033.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WHR | NMR | - | A | 147-257 | [»] | |
BMRBi | Q9Y2K5 | |||||
SMRi | Q9Y2K5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116532, 119 interactors |
IntActi | Q9Y2K5, 30 interactors |
STRINGi | 9606.ENSP00000317903 |
PTM databases
iPTMneti | Q9Y2K5 |
PhosphoSitePlusi | Q9Y2K5 |
Genetic variation databases
BioMutai | R3HDM2 |
DMDMi | 148887413 |
Proteomic databases
EPDi | Q9Y2K5 |
jPOSTi | Q9Y2K5 |
MassIVEi | Q9Y2K5 |
PaxDbi | Q9Y2K5 |
PeptideAtlasi | Q9Y2K5 |
PRIDEi | Q9Y2K5 |
ProteomicsDBi | 7212 85824 [Q9Y2K5-1] 85825 [Q9Y2K5-2] |
Protocols and materials databases
Antibodypediai | 28556, 51 antibodies |
Genome annotation databases
Ensembli | ENST00000347140; ENSP00000317903; ENSG00000179912 [Q9Y2K5-1] ENST00000358907; ENSP00000351784; ENSG00000179912 [Q9Y2K5-1] ENST00000441731; ENSP00000408536; ENSG00000179912 [Q9Y2K5-3] |
GeneIDi | 22864 |
KEGGi | hsa:22864 |
UCSCi | uc001sns.3, human [Q9Y2K5-1] uc001snu.3, human |
Organism-specific databases
CTDi | 22864 |
DisGeNETi | 22864 |
GeneCardsi | R3HDM2 |
HGNCi | HGNC:29167, R3HDM2 |
HPAi | ENSG00000179912, Low tissue specificity |
neXtProti | NX_Q9Y2K5 |
OpenTargetsi | ENSG00000179912 |
PharmGKBi | PA143485590 |
VEuPathDBi | HostDB:ENSG00000179912.20 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2953, Eukaryota |
GeneTreei | ENSGT00940000155609 |
InParanoidi | Q9Y2K5 |
OrthoDBi | 137913at2759 |
PhylomeDBi | Q9Y2K5 |
TreeFami | TF315915 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2K5 |
Miscellaneous databases
BioGRID-ORCSi | 22864, 12 hits in 995 CRISPR screens |
ChiTaRSi | R3HDM2, human |
EvolutionaryTracei | Q9Y2K5 |
GenomeRNAii | 22864 |
Pharosi | Q9Y2K5, Tdark |
PROi | PR:Q9Y2K5 |
RNActi | Q9Y2K5, protein |
Gene expression databases
Bgeei | ENSG00000179912, Expressed in cerebellum and 254 other tissues |
ExpressionAtlasi | Q9Y2K5, baseline and differential |
Genevisiblei | Q9Y2K5, HS |
Family and domain databases
Gene3Di | 3.30.1370.50, 1 hit |
InterProi | View protein in InterPro IPR001374, R3H_dom IPR036867, R3H_dom_sf IPR024771, SUZ |
Pfami | View protein in Pfam PF01424, R3H, 1 hit |
SMARTi | View protein in SMART SM00393, R3H, 1 hit |
SUPFAMi | SSF82708, SSF82708, 1 hit |
PROSITEi | View protein in PROSITE PS51061, R3H, 1 hit PS51673, SUZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R3HD2_HUMAN | |
Accessioni | Q9Y2K5Primary (citable) accession number: Q9Y2K5 Secondary accession number(s): B7ZL65, Q2M1T9, Q3ZCT5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2002 |
Last sequence update: | June 12, 2007 | |
Last modified: | April 7, 2021 | |
This is version 148 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references