UniProtKB - Q9Y2K2 (SIK3_HUMAN)
Serine/threonine-protein kinase SIK3
SIK3
Functioni
Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230).
Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).
By similarity1 Publication1 PublicationCatalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 95 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 188 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 72 – 80 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- magnesium ion binding Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- tau-protein kinase activity Source: GO_Central
GO - Biological processi
- intracellular signal transduction Source: GO_Central
- microtubule cytoskeleton organization Source: GO_Central
- positive regulation of TORC1 signaling Source: UniProtKB
- positive regulation of TORC2 signaling Source: UniProtKB
- protein phosphorylation Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2K2 |
SignaLinki | Q9Y2K2 |
SIGNORi | Q9Y2K2 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase SIK3Curated (EC:2.7.11.11 Publication)Alternative name(s): Salt-inducible kinase 3 Short name: SIK-3 Serine/threonine-protein kinase QSK |
Gene namesi | ORF Names:L19 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29165, SIK3 |
MIMi | 614776, gene |
neXtProti | NX_Q9Y2K2 |
VEuPathDBi | HostDB:ENSG00000160584 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Locates to punctate structures within the cytoplasm on binding to YWHAZ.1 Publication
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Spondyloepimetaphyseal dysplasia, Krakow type (SEMDK)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081542 | 187 | R → C in SEMDK; decreased protein expression; decreased kinase activity; no effect on the interaction with DEPTOR, MLST8/GbetaL, RICTOR and RPTOR. 1 PublicationCorresponds to variant dbSNP:rs1565460853EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 221 | T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication | 1 | |
Mutagenesisi | 469 | T → A: Loss of interaction with 14-3-3 proteins in response to cAMP signaling; inhibits cAMP signaling. 1 Publication | 1 | |
Mutagenesisi | 469 | T → E: Loss of interaction with 14-3-3 proteins in response to cAMP signaling; inhibits cAMP signaling. 1 Publication | 1 | |
Mutagenesisi | 551 | S → A: Loss of interaction with 14-3-3 proteins in response to cAMP signaling; inhibits cAMP signaling. 1 Publication | 1 | |
Mutagenesisi | 551 | S → E: Loss of interaction with 14-3-3 proteins in response to cAMP signaling; inhibits cAMP signaling. 1 Publication | 1 | |
Mutagenesisi | 626 | S → A: No effect on interaction with 14-3-3 proteins, nor on cAMP signaling. 1 Publication | 1 | |
Mutagenesisi | 626 | S → E: No effect on cAMP signaling. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, DwarfismOrganism-specific databases
DisGeNETi | 23387 |
MalaCardsi | SIK3 |
MIMi | 618162, phenotype |
OpenTargetsi | ENSG00000160584 |
PharmGKBi | PA165543631 |
Miscellaneous databases
Pharosi | Q9Y2K2, Tchem |
Chemistry databases
ChEMBLi | CHEMBL6149 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9Y2K2 |
GuidetoPHARMACOLOGYi | 2199 |
Genetic variation databases
BioMutai | SIK3 |
DMDMi | 115502238 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000252257 | 1 – 1321 | Serine/threonine-protein kinase SIK3Add BLAST | 1321 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 71 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 221 | Phosphothreonine; by LKB1Combined sources2 Publications | 1 | ||
Modified residuei | 469 | PhosphothreonineCombined sources1 Publication | 1 | ||
Modified residuei | 551 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 591 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 592 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 626 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 647 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 866 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 978 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 986 | Omega-N-methylarginineBy similarity | 1 | ||
Isoform 2 (identifier: Q9Y2K2-6) | |||||
Modified residuei | 113 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q9Y2K2 |
jPOSTi | Q9Y2K2 |
MassIVEi | Q9Y2K2 |
MaxQBi | Q9Y2K2 |
PaxDbi | Q9Y2K2 |
PeptideAtlasi | Q9Y2K2 |
PRIDEi | Q9Y2K2 |
ProteomicsDBi | 108 34706 |
PTM databases
iPTMneti | Q9Y2K2 |
PhosphoSitePlusi | Q9Y2K2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000160584, Expressed in corpus callosum and 242 other tissues |
ExpressionAtlasi | Q9Y2K2, baseline and differential |
Organism-specific databases
HPAi | ENSG00000160584, Low tissue specificity |
Interactioni
Subunit structurei
Binds to and is activated by YWHAZ when phosphorylated on Thr-221 (PubMed:16306228).
Interacts with 14-3-3 proteins (PubMed:29211348).
Interacts with HDAC4; this interaction leads to HDAC4 retention in the cytoplasm (By similarity).
Interacts with DEPTOR, MLST8/GbetaL, RICTOR and RPTOR (PubMed:30232230).
By similarity3 PublicationsBinary interactionsi
Q9Y2K2
With | #Exp. | IntAct |
---|---|---|
YWHAZ [P63104] | 5 | EBI-1181460,EBI-347088 |
Isoform 3 [Q9Y2K2-7]
With | #Exp. | IntAct |
---|---|---|
HTT [P42858] | 3 | EBI-17172855,EBI-466029 |
TRAF1 [Q13077] | 3 | EBI-17172855,EBI-359224 |
TRIP6 [Q15654] | 3 | EBI-17172855,EBI-742327 |
Protein-protein interaction databases
BioGRIDi | 116963, 33 interactors |
IntActi | Q9Y2K2, 19 interactors |
MINTi | Q9Y2K2 |
STRINGi | 9606.ENSP00000364449 |
Chemistry databases
BindingDBi | Q9Y2K2 |
Miscellaneous databases
RNActi | Q9Y2K2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 66 – 317 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 252 | |
Domaini | 344 – 384 | UBAPROSITE-ProRule annotationAdd BLAST | 41 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 59 | DisorderedSequence analysisAdd BLAST | 59 | |
Regioni | 585 – 614 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 727 – 772 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 894 – 945 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 1256 – 1289 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 597 – 614 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 740 – 772 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 897 – 916 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0586, Eukaryota |
GeneTreei | ENSGT00940000157259 |
InParanoidi | Q9Y2K2 |
OMAi | PRQRVGW |
OrthoDBi | 1127668at2759 |
PhylomeDBi | Q9Y2K2 |
TreeFami | TF315213 |
Family and domain databases
CDDi | cd14071, STKc_SIK, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR034672, SIK IPR015940, UBA |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAAASGAG GAAGAGTGGA GPAGRLLPPP APGSPAAPAA VSPAAGQPRP
60 70 80 90 100
PAPASRGPMP ARIGYYEIDR TIGKGNFAVV KRATHLVTKA KVAIKIIDKT
110 120 130 140 150
QLDEENLKKI FREVQIMKML CHPHIIRLYQ VMETERMIYL VTEYASGGEI
160 170 180 190 200
FDHLVAHGRM AEKEARRKFK QIVTAVYFCH CRNIVHRDLK AENLLLDANL
210 220 230 240 250
NIKIADFGFS NLFTPGQLLK TWCGSPPYAA PELFEGKEYD GPKVDIWSLG
260 270 280 290 300
VVLYVLVCGA LPFDGSTLQN LRARVLSGKF RIPFFMSTEC EHLIRHMLVL
310 320 330 340 350
DPNKRLSMEQ ICKHKWMKLG DADPNFDRLI AECQQLKEER QVDPLNEDVL
360 370 380 390 400
LAMEDMGLDK EQTLQSLRSD AYDHYSAIYS LLCDRHKRHK TLRLGALPSM
410 420 430 440 450
PRALAFQAPV NIQAEQAGTA MNISVPQVQL INPENQIVEP DGTLNLDSDE
460 470 480 490 500
GEEPSPEALV RYLSMRRHTV GVADPRTEVM EDLQKLLPGF PGVNPQAPFL
510 520 530 540 550
QVAPNVNFMH NLLPMQNLQP TGQLEYKEQS LLQPPTLQLL NGMGPLGRRA
560 570 580 590 600
SDGGANIQLH AQQLLKRPRG PSPLVTMTPA VPAVTPVDEE SSDGEPDQEA
610 620 630 640 650
VQSSTYKDSN TLHLPTERFS PVRRFSDGAA SIQAFKAHLE KMGNNSSIKQ
660 670 680 690 700
LQQECEQLQK MYGGQIDERT LEKTQQQHML YQQEQHHQIL QQQIQDSICP
710 720 730 740 750
PQPSPPLQAA CENQPALLTH QLQRLRIQPS SPPPNHPNNH LFRQPSNSPP
760 770 780 790 800
PMSSAMIQPH GAASSSQFQG LPSRSAIFQQ QPENCSSPPN VALTCLGMQQ
810 820 830 840 850
PAQSQQVTIQ VQEPVDMLSN MPGTAAGSSG RGISISPSAG QMQMQHRTNL
860 870 880 890 900
MATLSYGHRP LSKQLSADSA EAHSLNVNRF SPANYDQAHL HPHLFSDQSR
910 920 930 940 950
GSPSSYSPST GVGFSPTQAL KVPPLDQFPT FPPSAHQQPP HYTTSALQQA
960 970 980 990 1000
LLSPTPPDYT RHQQVPHILQ GLLSPRHSLT GHSDIRLPPT EFAQLIKRQQ
1010 1020 1030 1040 1050
QQRQQQQQQQ QQQEYQELFR HMNQGDAGSL APSLGGQSMT ERQALSYQNA
1060 1070 1080 1090 1100
DSYHHHTSPQ HLLQIRAQEC VSQASSPTPP HGYAHQPALM HSESMEEDCS
1110 1120 1130 1140 1150
CEGAKDGFQD SKSSSTLTKG CHDSPLLLST GGPGDPESLL GTVSHAQELG
1160 1170 1180 1190 1200
IHPYGHQPTA AFSKNKVPSR EPVIGNCMDR SSPGQAVELP DHNGLGYPAR
1210 1220 1230 1240 1250
PSVHEHHRPR ALQRHHTIQN SDDAYVQLDN LPGMSLVAGK ALSSARMSDA
1260 1270 1280 1290 1300
VLSQSSLMGS QQFQDGENEE CGASLGGHEH PDLSDGSQHL NSSCYPSTCI
1310 1320
TDILLSYKHP EVSFSMEQAG V
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y4E8 | H0Y4E8_HUMAN | Non-specific serine/threonine prote... | SIK3 | 1,369 | Annotation score: | ||
H7C038 | H7C038_HUMAN | Serine/threonine-protein kinase SIK... | SIK3 | 151 | Annotation score: | ||
H7C3X8 | H7C3X8_HUMAN | Serine/threonine-protein kinase SIK... | SIK3 | 506 | Annotation score: | ||
H7C042 | H7C042_HUMAN | Serine/threonine-protein kinase SIK... | SIK3 | 71 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081542 | 187 | R → C in SEMDK; decreased protein expression; decreased kinase activity; no effect on the interaction with DEPTOR, MLST8/GbetaL, RICTOR and RPTOR. 1 PublicationCorresponds to variant dbSNP:rs1565460853EnsemblClinVar. | 1 | |
Natural variantiVAR_035634 | 389 | H → L in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs376144593Ensembl. | 1 | |
Natural variantiVAR_051662 | 1098 | D → E. Corresponds to variant dbSNP:rs11216163Ensembl. | 1 | |
Natural variantiVAR_051663 | 1136 | P → R1 PublicationCorresponds to variant dbSNP:rs12225230Ensembl. | 1 | |
Natural variantiVAR_035635 | 1161 | A → V in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059412 | 1 – 760 | MAAAA…MIQPH → MACSTPHGSNRRLPRKCHFS LPTRTPTLCTSLRSVSPLCA GSQMGLRASRPSKLTWKKWA TTAASNSCSRSVSSCRRCTG GRLMKEPWRRPSSSICYTSR SSTIKFSSNKFKTLSVLLSH LHLFRLHVKISQPSLPISSR in isoform 2. Add BLAST | 760 | |
Alternative sequenceiVSP_059413 | 365 – 412 | Missing in isoform 4. Add BLAST | 48 | |
Alternative sequenceiVSP_059414 | 603 | S → RYLANRSKRHTLAMTNPTAE IPPDLQRQLGQQPFRSRVWP PHLVPDQHR in isoform 4. | 1 | |
Alternative sequenceiVSP_059415 | 874 – 933 | Missing in isoform 2 and isoform 4. Add BLAST | 60 | |
Alternative sequenceiVSP_059416 | 1171 – 1187 | EPVIG…PGQAV → GKCLLTVEVLGQSALIN in isoform 3. Add BLAST | 17 | |
Alternative sequenceiVSP_059417 | 1188 – 1321 | Missing in isoform 3. Add BLAST | 134 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023216 mRNA Translation: BAA76843.2 Different initiation. AP000936 Genomic DNA No translation available. AP003070 Genomic DNA No translation available. AP006216 Genomic DNA No translation available. BC035583 mRNA Translation: AAH35583.3 BC063887 mRNA Translation: AAH63887.1 Different initiation. BC086858 mRNA Translation: AAH86858.1 BC128510 mRNA Translation: AAI28511.1 Different initiation. AB209327 mRNA Translation: BAD92564.1 AK022302 mRNA Translation: BAB14006.1 Different initiation. AY598338 mRNA Translation: AAT06749.1 |
CCDSi | CCDS60974.1 [Q9Y2K2-8] CCDS8379.2 [Q9Y2K2-5] |
RefSeqi | NP_001268678.1, NM_001281749.1 [Q9Y2K2-8] NP_079440.3, NM_025164.4 [Q9Y2K2-5] |
Genome annotation databases
Ensembli | ENST00000375300; ENSP00000364449; ENSG00000160584 ENST00000446921; ENSP00000390442; ENSG00000160584 [Q9Y2K2-8] |
GeneIDi | 23387 |
KEGGi | hsa:23387 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023216 mRNA Translation: BAA76843.2 Different initiation. AP000936 Genomic DNA No translation available. AP003070 Genomic DNA No translation available. AP006216 Genomic DNA No translation available. BC035583 mRNA Translation: AAH35583.3 BC063887 mRNA Translation: AAH63887.1 Different initiation. BC086858 mRNA Translation: AAH86858.1 BC128510 mRNA Translation: AAI28511.1 Different initiation. AB209327 mRNA Translation: BAD92564.1 AK022302 mRNA Translation: BAB14006.1 Different initiation. AY598338 mRNA Translation: AAT06749.1 |
CCDSi | CCDS60974.1 [Q9Y2K2-8] CCDS8379.2 [Q9Y2K2-5] |
RefSeqi | NP_001268678.1, NM_001281749.1 [Q9Y2K2-8] NP_079440.3, NM_025164.4 [Q9Y2K2-5] |
3D structure databases
SMRi | Q9Y2K2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116963, 33 interactors |
IntActi | Q9Y2K2, 19 interactors |
MINTi | Q9Y2K2 |
STRINGi | 9606.ENSP00000364449 |
Chemistry databases
BindingDBi | Q9Y2K2 |
ChEMBLi | CHEMBL6149 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9Y2K2 |
GuidetoPHARMACOLOGYi | 2199 |
PTM databases
iPTMneti | Q9Y2K2 |
PhosphoSitePlusi | Q9Y2K2 |
Genetic variation databases
BioMutai | SIK3 |
DMDMi | 115502238 |
Proteomic databases
EPDi | Q9Y2K2 |
jPOSTi | Q9Y2K2 |
MassIVEi | Q9Y2K2 |
MaxQBi | Q9Y2K2 |
PaxDbi | Q9Y2K2 |
PeptideAtlasi | Q9Y2K2 |
PRIDEi | Q9Y2K2 |
ProteomicsDBi | 108 34706 |
Protocols and materials databases
ABCDi | Q9Y2K2, 6 sequenced antibodies |
Antibodypediai | 56803, 160 antibodies from 26 providers |
DNASUi | 23387 |
Genome annotation databases
Ensembli | ENST00000375300; ENSP00000364449; ENSG00000160584 ENST00000446921; ENSP00000390442; ENSG00000160584 [Q9Y2K2-8] |
GeneIDi | 23387 |
KEGGi | hsa:23387 |
Organism-specific databases
CTDi | 23387 |
DisGeNETi | 23387 |
GeneCardsi | SIK3 |
HGNCi | HGNC:29165, SIK3 |
HPAi | ENSG00000160584, Low tissue specificity |
MalaCardsi | SIK3 |
MIMi | 614776, gene 618162, phenotype |
neXtProti | NX_Q9Y2K2 |
OpenTargetsi | ENSG00000160584 |
PharmGKBi | PA165543631 |
VEuPathDBi | HostDB:ENSG00000160584 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0586, Eukaryota |
GeneTreei | ENSGT00940000157259 |
InParanoidi | Q9Y2K2 |
OMAi | PRQRVGW |
OrthoDBi | 1127668at2759 |
PhylomeDBi | Q9Y2K2 |
TreeFami | TF315213 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2K2 |
SignaLinki | Q9Y2K2 |
SIGNORi | Q9Y2K2 |
Miscellaneous databases
BioGRID-ORCSi | 23387, 22 hits in 989 CRISPR screens |
ChiTaRSi | SIK3, human |
GeneWikii | KIAA0999 |
GenomeRNAii | 23387 |
Pharosi | Q9Y2K2, Tchem |
PROi | PR:Q9Y2K2 |
RNActi | Q9Y2K2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160584, Expressed in corpus callosum and 242 other tissues |
ExpressionAtlasi | Q9Y2K2, baseline and differential |
Family and domain databases
CDDi | cd14071, STKc_SIK, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR034672, SIK IPR015940, UBA |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SIK3_HUMAN | |
Accessioni | Q9Y2K2Primary (citable) accession number: Q9Y2K2 Secondary accession number(s): A1A5A8 Q9HA50 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | March 28, 2018 | |
Last modified: | February 23, 2022 | |
This is version 172 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families