Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9Y2K2 (SIK3_HUMAN)

Protein

Serine/threonine-protein kinase SIK3

Gene

SIK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+

Activity regulationi

Activated by phosphorylation on Thr-221.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95ATPPROSITE-ProRule annotation1
Active sitei188Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi72 – 80ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB
  • tau-protein kinase activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9Y2K2
SIGNORiQ9Y2K2

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SIK3Curated (EC:2.7.11.1)
Alternative name(s):
Salt-inducible kinase 3
Short name:
SIK-3
Serine/threonine-protein kinase QSK
Gene namesi
Name:SIK3Imported
Synonyms:KIAA09991 Publication, QSK1 Publication
ORF Names:L19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000160584.15
HGNCiHGNC:29165 SIK3
MIMi614776 gene
neXtProtiNX_Q9Y2K2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi221T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication1

Organism-specific databases

DisGeNETi23387
OpenTargetsiENSG00000160584
PharmGKBiPA165543631

Chemistry databases

ChEMBLiCHEMBL6149
GuidetoPHARMACOLOGYi2199

Polymorphism and mutation databases

BioMutaiSIK3
DMDMi115502238

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002522571 – 1321Serine/threonine-protein kinase SIK3Add BLAST1321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71PhosphothreonineCombined sources1
Modified residuei221Phosphothreonine; by LKB1Combined sources1 Publication1
Modified residuei469PhosphothreonineCombined sources1
Modified residuei551PhosphoserineCombined sources1
Modified residuei591PhosphoserineBy similarity1
Modified residuei592PhosphoserineBy similarity1
Modified residuei626PhosphoserineCombined sources1
Modified residuei647PhosphoserineBy similarity1
Modified residuei866PhosphoserineCombined sources1
Modified residuei978PhosphoserineCombined sources1
Modified residuei986Omega-N-methylarginineBy similarity1
Isoform 2 (identifier: Q9Y2K2-6)
Modified residuei113PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated at Thr-221 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2K2
PaxDbiQ9Y2K2
PeptideAtlasiQ9Y2K2
PRIDEiQ9Y2K2
ProteomicsDBi85820

PTM databases

iPTMnetiQ9Y2K2
PhosphoSitePlusiQ9Y2K2

Expressioni

Gene expression databases

BgeeiENSG00000160584 Expressed in 231 organ(s), highest expression level in corpus callosum

Organism-specific databases

HPAiHPA045245
HPA048161

Interactioni

Subunit structurei

Binds to and is activated by YWHAZ when phosphorylated on Thr-221.

Binary interactionsi

Protein-protein interaction databases

BioGridi116963, 21 interactors
IntActiQ9Y2K2, 11 interactors
MINTiQ9Y2K2
STRINGi9606.ENSP00000292055

Structurei

3D structure databases

ProteinModelPortaliQ9Y2K2
SMRiQ9Y2K2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 317Protein kinasePROSITE-ProRule annotationAdd BLAST252
Domaini344 – 384UBAPROSITE-ProRule annotationAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 54Ala-richPROSITE-ProRule annotationAdd BLAST53
Compositional biasi650 – 1016Gln-richPROSITE-ProRule annotationAdd BLAST367

Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0586 Eukaryota
ENOG410XNQ0 LUCA
GeneTreeiENSGT00900000140806
HOGENOMiHOG000154056
HOVERGENiHBG079682
InParanoidiQ9Y2K2
KOiK19009
PhylomeDBiQ9Y2K2
TreeFamiTF315213

Family and domain databases

CDDicd14071 STKc_SIK, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR034672 SIK
IPR015940 UBA
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50030 UBA, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2K2-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAASGAG GAAGAGTGGA GPAGRLLPPP APGSPAAPAA VSPAAGQPRP 
        60         70         80         90        100
PAPASRGPMP ARIGYYEIDR TIGKGNFAVV KRATHLVTKA KVAIKIIDKT 
       110        120        130        140        150
QLDEENLKKI FREVQIMKML CHPHIIRLYQ VMETERMIYL VTEYASGGEI 
       160        170        180        190        200
FDHLVAHGRM AEKEARRKFK QIVTAVYFCH CRNIVHRDLK AENLLLDANL 
       210        220        230        240        250
NIKIADFGFS NLFTPGQLLK TWCGSPPYAA PELFEGKEYD GPKVDIWSLG 
       260        270        280        290        300
VVLYVLVCGA LPFDGSTLQN LRARVLSGKF RIPFFMSTEC EHLIRHMLVL 
       310        320        330        340        350
DPNKRLSMEQ ICKHKWMKLG DADPNFDRLI AECQQLKEER QVDPLNEDVL 
       360        370        380        390        400
LAMEDMGLDK EQTLQSLRSD AYDHYSAIYS LLCDRHKRHK TLRLGALPSM 
       410        420        430        440        450
PRALAFQAPV NIQAEQAGTA MNISVPQVQL INPENQIVEP DGTLNLDSDE 
       460        470        480        490        500
GEEPSPEALV RYLSMRRHTV GVADPRTEVM EDLQKLLPGF PGVNPQAPFL 
       510        520        530        540        550
QVAPNVNFMH NLLPMQNLQP TGQLEYKEQS LLQPPTLQLL NGMGPLGRRA 
       560        570        580        590        600
SDGGANIQLH AQQLLKRPRG PSPLVTMTPA VPAVTPVDEE SSDGEPDQEA 
       610        620        630        640        650
VQSSTYKDSN TLHLPTERFS PVRRFSDGAA SIQAFKAHLE KMGNNSSIKQ 
       660        670        680        690        700
LQQECEQLQK MYGGQIDERT LEKTQQQHML YQQEQHHQIL QQQIQDSICP 
       710        720        730        740        750
PQPSPPLQAA CENQPALLTH QLQRLRIQPS SPPPNHPNNH LFRQPSNSPP 
       760        770        780        790        800
PMSSAMIQPH GAASSSQFQG LPSRSAIFQQ QPENCSSPPN VALTCLGMQQ 
       810        820        830        840        850
PAQSQQVTIQ VQEPVDMLSN MPGTAAGSSG RGISISPSAG QMQMQHRTNL 
       860        870        880        890        900
MATLSYGHRP LSKQLSADSA EAHSLNVNRF SPANYDQAHL HPHLFSDQSR 
       910        920        930        940        950
GSPSSYSPST GVGFSPTQAL KVPPLDQFPT FPPSAHQQPP HYTTSALQQA 
       960        970        980        990       1000
LLSPTPPDYT RHQQVPHILQ GLLSPRHSLT GHSDIRLPPT EFAQLIKRQQ 
      1010       1020       1030       1040       1050
QQRQQQQQQQ QQQEYQELFR HMNQGDAGSL APSLGGQSMT ERQALSYQNA 
      1060       1070       1080       1090       1100
DSYHHHTSPQ HLLQIRAQEC VSQASSPTPP HGYAHQPALM HSESMEEDCS 
      1110       1120       1130       1140       1150
CEGAKDGFQD SKSSSTLTKG CHDSPLLLST GGPGDPESLL GTVSHAQELG 
      1160       1170       1180       1190       1200
IHPYGHQPTA AFSKNKVPSR EPVIGNCMDR SSPGQAVELP DHNGLGYPAR 
      1210       1220       1230       1240       1250
PSVHEHHRPR ALQRHHTIQN SDDAYVQLDN LPGMSLVAGK ALSSARMSDA 
      1260       1270       1280       1290       1300
VLSQSSLMGS QQFQDGENEE CGASLGGHEH PDLSDGSQHL NSSCYPSTCI 
      1310       1320 
TDILLSYKHP EVSFSMEQAG V
Length:1,321
Mass (Da):144,851
Last modified:March 28, 2018 - v4
Checksum:i84FA57F6BB5505DA
GO
Isoform 2 (identifier: Q9Y2K2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-760: MAAAAASGAG...PMSSAMIQPH → MACSTPHGSN...SQPSLPISSR
     874-933: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:641
Mass (Da):69,736
Checksum:iA07CFF76C242F373
GO
Isoform 3 (identifier: Q9Y2K2-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1171-1187: EPVIGNCMDRSSPGQAV → GKCLLTVEVLGQSALIN
     1188-1321: Missing.

Note: No experimental confirmation available.
Show »
Length:1,187
Mass (Da):130,347
Checksum:i3158F58032EC7E9B
GO
Isoform 4 (identifier: Q9Y2K2-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     365-412: Missing.
     603-603: S → RYLANRSKRHTLAMTNPTAEIPPDLQRQLGQQPFRSRVWPPHLVPDQHR
     874-933: Missing.

Note: No experimental confirmation available.
Show »
Length:1,261
Mass (Da):138,586
Checksum:i36FE1ABFEB26690E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y4E8H0Y4E8_HUMAN
Serine/threonine-protein kinase SIK...
SIK3
1,363Annotation score:
H7C3X8H7C3X8_HUMAN
Serine/threonine-protein kinase SIK...
SIK3
506Annotation score:
H7C038H7C038_HUMAN
Serine/threonine-protein kinase SIK...
SIK3
151Annotation score:
H7C042H7C042_HUMAN
Serine/threonine-protein kinase SIK...
SIK3
71Annotation score:

Sequence cautioni

The sequence AAH63887 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI28511 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA76843 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB14006 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035634389H → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0516621098D → E. Corresponds to variant dbSNP:rs11216163Ensembl.1
Natural variantiVAR_0516631136P → R1 PublicationCorresponds to variant dbSNP:rs12225230Ensembl.1
Natural variantiVAR_0356351161A → V in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0594121 – 760MAAAA…MIQPH → MACSTPHGSNRRLPRKCHFS LPTRTPTLCTSLRSVSPLCA GSQMGLRASRPSKLTWKKWA TTAASNSCSRSVSSCRRCTG GRLMKEPWRRPSSSICYTSR SSTIKFSSNKFKTLSVLLSH LHLFRLHVKISQPSLPISSR in isoform 2. Add BLAST760
Alternative sequenceiVSP_059413365 – 412Missing in isoform 4. Add BLAST48
Alternative sequenceiVSP_059414603S → RYLANRSKRHTLAMTNPTAE IPPDLQRQLGQQPFRSRVWP PHLVPDQHR in isoform 4. 1
Alternative sequenceiVSP_059415874 – 933Missing in isoform 2 and isoform 4. Add BLAST60
Alternative sequenceiVSP_0594161171 – 1187EPVIG…PGQAV → GKCLLTVEVLGQSALIN in isoform 3. Add BLAST17
Alternative sequenceiVSP_0594171188 – 1321Missing in isoform 3. Add BLAST134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023216 mRNA Translation: BAA76843.2 Different initiation.
AP000936 Genomic DNA No translation available.
AP003070 Genomic DNA No translation available.
AP006216 Genomic DNA No translation available.
BC035583 mRNA Translation: AAH35583.3
BC063887 mRNA Translation: AAH63887.1 Different initiation.
BC086858 mRNA Translation: AAH86858.1
BC128510 mRNA Translation: AAI28511.1 Different initiation.
AB209327 mRNA Translation: BAD92564.1
AK022302 mRNA Translation: BAB14006.1 Different initiation.
AY598338 mRNA Translation: AAT06749.1
CCDSiCCDS60974.1 [Q9Y2K2-8]
CCDS8379.2 [Q9Y2K2-5]
RefSeqiNP_001268678.1, NM_001281749.1 [Q9Y2K2-8]
NP_079440.3, NM_025164.4 [Q9Y2K2-5]
UniGeneiHs.167451

Genome annotation databases

EnsembliENST00000375300; ENSP00000364449; ENSG00000160584 [Q9Y2K2-5]
ENST00000446921; ENSP00000390442; ENSG00000160584 [Q9Y2K2-8]
GeneIDi23387
KEGGihsa:23387

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023216 mRNA Translation: BAA76843.2 Different initiation.
AP000936 Genomic DNA No translation available.
AP003070 Genomic DNA No translation available.
AP006216 Genomic DNA No translation available.
BC035583 mRNA Translation: AAH35583.3
BC063887 mRNA Translation: AAH63887.1 Different initiation.
BC086858 mRNA Translation: AAH86858.1
BC128510 mRNA Translation: AAI28511.1 Different initiation.
AB209327 mRNA Translation: BAD92564.1
AK022302 mRNA Translation: BAB14006.1 Different initiation.
AY598338 mRNA Translation: AAT06749.1
CCDSiCCDS60974.1 [Q9Y2K2-8]
CCDS8379.2 [Q9Y2K2-5]
RefSeqiNP_001268678.1, NM_001281749.1 [Q9Y2K2-8]
NP_079440.3, NM_025164.4 [Q9Y2K2-5]
UniGeneiHs.167451

3D structure databases

ProteinModelPortaliQ9Y2K2
SMRiQ9Y2K2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116963, 21 interactors
IntActiQ9Y2K2, 11 interactors
MINTiQ9Y2K2
STRINGi9606.ENSP00000292055

Chemistry databases

ChEMBLiCHEMBL6149
GuidetoPHARMACOLOGYi2199

PTM databases

iPTMnetiQ9Y2K2
PhosphoSitePlusiQ9Y2K2

Polymorphism and mutation databases

BioMutaiSIK3
DMDMi115502238

Proteomic databases

EPDiQ9Y2K2
PaxDbiQ9Y2K2
PeptideAtlasiQ9Y2K2
PRIDEiQ9Y2K2
ProteomicsDBi85820

Protocols and materials databases

DNASUi23387
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375300; ENSP00000364449; ENSG00000160584 [Q9Y2K2-5]
ENST00000446921; ENSP00000390442; ENSG00000160584 [Q9Y2K2-8]
GeneIDi23387
KEGGihsa:23387

Organism-specific databases

CTDi23387
DisGeNETi23387
EuPathDBiHostDB:ENSG00000160584.15
GeneCardsiSIK3
H-InvDBiHIX0004310
HGNCiHGNC:29165 SIK3
HPAiHPA045245
HPA048161
MIMi614776 gene
neXtProtiNX_Q9Y2K2
OpenTargetsiENSG00000160584
PharmGKBiPA165543631
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0586 Eukaryota
ENOG410XNQ0 LUCA
GeneTreeiENSGT00900000140806
HOGENOMiHOG000154056
HOVERGENiHBG079682
InParanoidiQ9Y2K2
KOiK19009
PhylomeDBiQ9Y2K2
TreeFamiTF315213

Enzyme and pathway databases

SignaLinkiQ9Y2K2
SIGNORiQ9Y2K2

Miscellaneous databases

ChiTaRSiSIK3 human
GeneWikiiKIAA0999
GenomeRNAii23387
PROiPR:Q9Y2K2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160584 Expressed in 231 organ(s), highest expression level in corpus callosum

Family and domain databases

CDDicd14071 STKc_SIK, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR034672 SIK
IPR015940 UBA
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50030 UBA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSIK3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2K2
Secondary accession number(s): A1A5A8
, H0Y494, J3KPC8, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 150 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again