Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein-arginine deiminase type-2

Gene

PADI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the deimination of arginine residues of proteins.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+2 PublicationsNote: Binding of Ca2+ triggers a conformation change that is essential for catalytic activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi123Calcium 1Combined sources1 Publication1
Metal bindingi125Calcium 1Combined sources1 Publication1
Metal bindingi127Calcium 1Combined sources1 Publication1
Metal bindingi129Calcium 1; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi131Calcium 1Combined sources1 Publication1
Metal bindingi154Calcium 2Combined sources1 Publication1
Metal bindingi156Calcium 2Combined sources1
Metal bindingi156Calcium 3Combined sources1 Publication1
Metal bindingi158Calcium 2Combined sources1
Metal bindingi158Calcium 3Combined sources1 Publication1
Metal bindingi166Calcium 2Combined sources1
Metal bindingi166Calcium 4; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi169Calcium 4Combined sources1 Publication1
Metal bindingi171Calcium 4; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi177Calcium 2Combined sources1
Metal bindingi180Calcium 2Combined sources1
Metal bindingi180Calcium 3Combined sources1 Publication1
Metal bindingi354Calcium 5Combined sources1 Publication1
Metal bindingi389Calcium 3Combined sources1 Publication1
Metal bindingi408Calcium 5; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi411Calcium 5; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi412Calcium 5Combined sources1 Publication1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei647Nucleophile1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • estrogen receptor binding Source: UniProtKB
  • protein-arginine deiminase activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS04094-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.3.15 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein-arginine deiminase type-2 (EC:3.5.3.152 Publications)
Alternative name(s):
PAD-H19
Peptidylarginine deiminase II1 Publication
Protein-arginine deiminase type II
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PADI2
Synonyms:KIAA0994, PAD2, PDI2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000117115.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18341 PADI2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607935 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2J8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi123D → N: Mildly reduced enzyme activity. 1 Publication1
Mutagenesisi125D → A: Mildly reduced enzyme activity. 1 Publication1
Mutagenesisi166D → A: Reduced enzyme activity. 1 Publication1
Mutagenesisi169D → A: Mildly reduced enzyme activity. 1 Publication1
Mutagenesisi177D → A: Reduced enzyme activity. 1 Publication1
Mutagenesisi348W → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi350Q → A: Strongly reduced enzyme activity. 1 Publication1
Mutagenesisi354E → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi370D → A: Reduced enzyme activity. 1 Publication1
Mutagenesisi373R → A: Strongly reduced enzyme activity. 1 Publication1
Mutagenesisi374D → A: Reduced enzyme activity. 1 Publication1
Mutagenesisi389D → A: Reduced enzyme activity. 1 Publication1
Mutagenesisi412E → A: Strongly reduced enzyme activity. 1 Publication1
Mutagenesisi647C → A: Loss of enzyme activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
11240

Open Targets

More...
OpenTargetsi
ENSG00000117115

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32900

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1909487

Drug and drug target database

More...
DrugBanki
DB00155 L-Citrulline

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PADI2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
7531171

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002200261 – 665Protein-arginine deiminase type-2Add BLAST665

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y2J8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2J8

PeptideAtlas

More...
PeptideAtlasi
Q9Y2J8

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2J8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85817

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2J8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2J8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in keratinocytes in epidermis (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000117115 Expressed in 203 organ(s), highest expression level in medial globus pallidus

CleanEx database of gene expression profiles

More...
CleanExi
HS_PADI2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2J8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2J8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047735

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9Y2J8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364635

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9Y2J8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1665
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Y2J8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y2J8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF3F Eukaryota
ENOG410ZKF3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153217

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220908

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053016

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2J8

KEGG Orthology (KO)

More...
KOi
K01481

Identification of Orthologs from Complete Genome Data

More...
OMAi
CTFVDDI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02QG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2J8

TreeFam database of animal gene trees

More...
TreeFami
TF331952

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1700, 1 hit
2.60.40.1860, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008972 Cupredoxin
IPR004303 PAD
IPR013530 PAD_C
IPR036556 PAD_central_sf
IPR013732 PAD_N
IPR038685 PAD_N_sf
IPR013733 Prot_Arg_deaminase_cen_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10837 PTHR10837, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03068 PAD, 1 hit
PF08527 PAD_M, 1 hit
PF08526 PAD_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001247 Protein-arginine_deiminase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF110083 SSF110083, 1 hit
SSF49503 SSF49503, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y2J8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRERTVRLQ YGSRVEAVYV LGTYLWTDVY SAAPAGAQTF SLKHSEHVWV
60 70 80 90 100
EVVRDGEAEE VATNGKQRWL LSPSTTLRVT MSQASTEASS DKVTVNYYDE
110 120 130 140 150
EGSIPIDQAG LFLTAIEISL DVDADRDGVV EKNNPKKASW TWGPEGQGAI
160 170 180 190 200
LLVNCDRETP WLPKEDCRDE KVYSKEDLKD MSQMILRTKG PDRLPAGYEI
210 220 230 240 250
VLYISMSDSD KVGVFYVENP FFGQRYIHIL GRRKLYHVVK YTGGSAELLF
260 270 280 290 300
FVEGLCFPDE GFSGLVSIHV SLLEYMAQDI PLTPIFTDTV IFRIAPWIMT
310 320 330 340 350
PNILPPVSVF VCCMKDNYLF LKEVKNLVEK TNCELKVCFQ YLNRGDRWIQ
360 370 380 390 400
DEIEFGYIEA PHKGFPVVLD SPRDGNLKDF PVKELLGPDF GYVTREPLFE
410 420 430 440 450
SVTSLDSFGN LEVSPPVTVN GKTYPLGRIL IGSSFPLSGG RRMTKVVRDF
460 470 480 490 500
LKAQQVQAPV ELYSDWLTVG HVDEFMSFVP IPGTKKFLLL MASTSACYKL
510 520 530 540 550
FREKQKDGHG EAIMFKGLGG MSSKRITINK ILSNESLVQE NLYFQRCLDW
560 570 580 590 600
NRDILKKELG LTEQDIIDLP ALFKMDEDHR ARAFFPNMVN MIVLDKDLGI
610 620 630 640 650
PKPFGPQVEE ECCLEMHVRG LLEPLGLECT FIDDISAYHK FLGEVHCGTN
660
VRRKPFTFKW WHMVP
Length:665
Mass (Da):75,564
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D417A87A02D6839
GO
Isoform 2 (identifier: Q9Y2J8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-665: Missing.

Note: No experimental confirmation available.
Show »
Length:437
Mass (Da):49,310
Checksum:i912B81FDA3DAC1A4
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76838 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti661W → L in BAA82557 (PubMed:12392711).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056385438 – 665Missing in isoform 2. 1 PublicationAdd BLAST228

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB030176 mRNA Translation: BAA82557.1
AJ549502 Genomic DNA Translation: CAE47740.1
AB023211 mRNA Translation: BAA76838.1 Different initiation.
AL049569 Genomic DNA No translation available.
BC009701 mRNA Translation: AAH09701.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS177.1 [Q9Y2J8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_031391.2, NM_007365.2 [Q9Y2J8-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.33455

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375481; ENSP00000364630; ENSG00000117115 [Q9Y2J8-2]
ENST00000375486; ENSP00000364635; ENSG00000117115 [Q9Y2J8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11240

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11240

UCSC genome browser

More...
UCSCi
uc001baf.4 human [Q9Y2J8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030176 mRNA Translation: BAA82557.1
AJ549502 Genomic DNA Translation: CAE47740.1
AB023211 mRNA Translation: BAA76838.1 Different initiation.
AL049569 Genomic DNA No translation available.
BC009701 mRNA Translation: AAH09701.1
CCDSiCCDS177.1 [Q9Y2J8-1]
RefSeqiNP_031391.2, NM_007365.2 [Q9Y2J8-1]
UniGeneiHs.33455

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4N20X-ray1.66A1-665[»]
4N22X-ray1.89A1-665[»]
4N24X-ray1.97A1-665[»]
4N25X-ray1.93A1-665[»]
4N26X-ray1.94A1-665[»]
4N28X-ray1.88A1-665[»]
4N2AX-ray1.70A1-665[»]
4N2BX-ray1.69A1-665[»]
4N2CX-ray3.02A1-665[»]
4N2DX-ray2.00A1-665[»]
4N2EX-ray1.86A1-665[»]
4N2FX-ray1.80A1-665[»]
4N2GX-ray1.85A1-665[»]
4N2HX-ray1.81A1-665[»]
4N2IX-ray1.90A1-665[»]
4N2KX-ray1.57A1-665[»]
4N2LX-ray2.10A1-665[»]
4N2MX-ray1.60A1-665[»]
4N2NX-ray1.80A1-665[»]
ProteinModelPortaliQ9Y2J8
SMRiQ9Y2J8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Y2J8, 1 interactor
STRINGi9606.ENSP00000364635

Chemistry databases

BindingDBiQ9Y2J8
ChEMBLiCHEMBL1909487
DrugBankiDB00155 L-Citrulline

PTM databases

iPTMnetiQ9Y2J8
PhosphoSitePlusiQ9Y2J8

Polymorphism and mutation databases

BioMutaiPADI2
DMDMi7531171

Proteomic databases

EPDiQ9Y2J8
PaxDbiQ9Y2J8
PeptideAtlasiQ9Y2J8
PRIDEiQ9Y2J8
ProteomicsDBi85817

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375481; ENSP00000364630; ENSG00000117115 [Q9Y2J8-2]
ENST00000375486; ENSP00000364635; ENSG00000117115 [Q9Y2J8-1]
GeneIDi11240
KEGGihsa:11240
UCSCiuc001baf.4 human [Q9Y2J8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11240
DisGeNETi11240
EuPathDBiHostDB:ENSG00000117115.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PADI2
HGNCiHGNC:18341 PADI2
HPAiHPA047735
MIMi607935 gene
neXtProtiNX_Q9Y2J8
OpenTargetsiENSG00000117115
PharmGKBiPA32900

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF3F Eukaryota
ENOG410ZKF3 LUCA
GeneTreeiENSGT00940000153217
HOGENOMiHOG000220908
HOVERGENiHBG053016
InParanoidiQ9Y2J8
KOiK01481
OMAiCTFVDDI
OrthoDBiEOG091G02QG
PhylomeDBiQ9Y2J8
TreeFamiTF331952

Enzyme and pathway databases

BioCyciMetaCyc:HS04094-MONOMER
BRENDAi3.5.3.15 2681
ReactomeiR-HSA-3247509 Chromatin modifying enzymes
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PADI2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PADI2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11240

Protein Ontology

More...
PROi
PR:Q9Y2J8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000117115 Expressed in 203 organ(s), highest expression level in medial globus pallidus
CleanExiHS_PADI2
ExpressionAtlasiQ9Y2J8 baseline and differential
GenevisibleiQ9Y2J8 HS

Family and domain databases

Gene3Di2.60.40.1700, 1 hit
2.60.40.1860, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR004303 PAD
IPR013530 PAD_C
IPR036556 PAD_central_sf
IPR013732 PAD_N
IPR038685 PAD_N_sf
IPR013733 Prot_Arg_deaminase_cen_dom
PANTHERiPTHR10837 PTHR10837, 1 hit
PfamiView protein in Pfam
PF03068 PAD, 1 hit
PF08527 PAD_M, 1 hit
PF08526 PAD_N, 1 hit
PIRSFiPIRSF001247 Protein-arginine_deiminase, 1 hit
SUPFAMiSSF110083 SSF110083, 1 hit
SSF49503 SSF49503, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPADI2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2J8
Secondary accession number(s): Q96DA7, Q9UPN2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: December 5, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again